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Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study

World Journal of Gastrointestinal Surgery 2021年第5期13卷 476-492页

作者： chao-Wei Lee Ming-Chin Yu Chih-Chi Wang Wei-Chen Lee Hsin-I Tsai Feng-Che Kuan Chun-Wei Chen Yi-Chung Hsieh hsing-Yu Chen Division of General Surgery Department of SurgeryLinkou Chang Gung Memorial HospitalGuishan 333TaoyuanTaiwan College of Medicine Chang Gung UniversityGuishan 333TaoyuanTaiwan Graduate Institute of Clinical Medical Sciences Chang Gung UniversityGuishan 333TaoyuanTaiwan Department of Surgery New Taipei Municipal Tu-Cheng Hospital(Built and Operated by Chang Gung Medical Foundation)Tu-Cheng 236017New Taipei CityTaiwan Division of General Surgery Department of SurgeryKaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Division of General Surgery Department of SurgeryChiayi Chang Gung Memorial HospitalChiayi 613Taiwan Department of Anesthesiology Linkou Chang Gung Memorial HospitalGuishan 333TaoyuanTaiwan Department of Hematology and Oncology Chiayi Chang Gung Memorial HospitalChiayi 613Taiwan Department of Gastroenterology and Hepatology Linkou Chang Gung Memorial HospitalGuishan 333TaoyuanTaiwan Division of Chinese Internal Medicine Center for Traditional Chinese MedicineTaoyuan Chang Gung Memorial HospitalGuishan 33378TaoyuanTaiwan School of Traditional Chinese Medicine College of MedicineChang Gung UniversityGuishan 333TaoyuanTaiwan

BACKGROUND The treatment of hepatocellular carcinoma(HCC)≥10 cm remains a *** To consolidate the role of surgical resection for HCC larger than 10 *** Eligible HCC patients were identified from the Chang Gung Research Database,the largest multi-institution database,which collected medical records of all patients from Chang Gung Memorial *** surgical outcome of HCC≥10 cm(L-HCC)was compared to that of HCC<10 cm(S-HCC)(model 1).The survival of L-HCC after either liver resection or transarterial chemoembolization(TACE)was also analyzed(model 2).The long-term risks of all-cause mortality and recurrence were assessed to consolidate the role of surgery for *** From January 2004 to July 2015,a total of 32403 HCC patients were identified from the Chang Gung Research *** 3985 patients who received liver resection,3559(89.3%)had S-HCC,and 426 had *** L-HCC patients had a worse disease-free survival(0.27 for L-HCC vs 0.40 for S-HCC)and overall survival(0.18 for L-HCC vs 0.45 for S-HCC)than the S-HCC after liver resection(both P<0.001).However,the surgical and long-term outcome of resected L-HCC had improved dramatically in the recent *** adjusting for covariates,surgery could provide a better outcome for L-HCC than TACE(adjusted hazard ratio of all-cause mortality:0.46,95%confidence interval:0.38-0.56 for surgery).Subgroup analysis stratified by different stages showed similar trend of survival benefit among L-HCC patients receiving *** Our study demonstrated an improving surgical outcome for HCC larger than 10 *** selected conditions,surgery is better than TACE in terms of disease control and survival and should be *** to inferior survival,a subclassification within T1 stage should be *** studies are mandatory to confirm our findings.

关键词： Hepatocellular carcinoma 10 cm Liver resection Transarterial chemoembolization Chang Gung Research Database

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A Dual-Mode Step-up DC/DC Converter IC with Current-Limiting and EMI Reduction Techniques

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Journal of Electronic Science and Technology of China 2008年第3期6卷 279-283页

作者： Wan-Rone Liou Ping-hsing Chen Marynelle L. Z. Rosales yeh Chun-Ting Kuo Mei-Ling yeh the Graduate Institute of Electrical Engineering National Taipei University San Shia Taipei 23741 Taiwan China the Department of Electrical Engineering National Taiwan Ocean University Keelung Taiwan China

This paper presents a novel dual-mode step-up （boost） DC/DC converter. Pulse-frequency modulation （PFM） is used to improve the efficiency at light load. This converter can operate between pulse-width modulation （PWM） and pulse-frequency modulation. The converter will operate in PFM mode at light load and in PWM mode at heavy load. The maximum conversion efficiency of this converter is 96%. The conversion efficiency is greatly improved when load current is below 100 mA. Additionally, a soft-start circuit and a variable-sawtooth frequency circuit are proposed in this paper. The former is used to avoid the large switching current at the start up of the converter and the latter is utilized to reduce the EMI of the converter.

关键词： Boost converter dual-mode converter integrated power management pulse-frequency modulation (PFM) pulse-width modulation (PWM)

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CyberKnife stereotactic radiosurgery for skull base meningiomas:3-year results from two CyberKnife centers in Taiwan

CyberKnife stereotactic radiosurgery for skull base meningio...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Dueng-Yuan Hueng hsing-Lung chao Jia-Wei Lin Da-Tong Ju Department of Neurological Surgery Tri-Service General HospitalNational Defense Medical CenterTaipeiTaiwanROC Stereotactic Radiosurgery Center Tri-Service General HospitalNational Defense Medical CenterTaipeiTaiwanROC Department of Radiation-Oncology Tri-Service General HospitalNational Defense Medical CenterTaipeiTaiwanROC Department of Neurosurgery Taipei Medical University-Wan Fang HospitalTaipeiTaiwanROC

＜正＞Purpose:CyberKnife stereotactic radiosurgery（CKS） has been proved to be effective in the treatment of intracranial ***,whether CKS is effective on the management of skull base meningiomas is not *** aim of t...

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The measurement of the methanol concentration of liquid solution based on laser interferometer

The measurement of the methanol concentration of liquid solu...

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2010 International Symposium on Computer,Communication, Control and Automation

作者： Yen-Liang yeh Ming-Jyi Jang Chia-hsing Shen Po-Jen Cheng Chih-Chia Wang Department of Automation and Control Engineering Far East University Department of Mechanical Engineering Far East University

This study develops a high-precision,nondestructive measurement technique based on a laser interferometer for determining the methanol concentration of a liquid solution from its refractive *** optical metrology system is employed to measure the refractive indexes of samples with known methanol concentrations ranging from 0～90%.The error between the experimental refractive index and the literature refractive index is small than *** error between the measured value of the refractive index and the analytically derived value is reduced form 0.00064 to *** decreased error ratio is about 89%.When the relative function between the refractive index and methyl alcohol concentration is cubic,this can reduce the regressional analysis *** applying regressional analysis to the experimental results,an analytical expression is derived to describe the cubic relationship between the refractive index and the methanol *** excellent agreement is observed between the experimentally determined values of the methanol concentration and the analytically predicted results.

关键词： The measurement of the methanol concentration of liquid solution based on laser interferometer

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A Plant SMALL RNA-BINDING PROTEIN 1 Family Mediates Cell-to-Cell Trafficking of RNAi Signals

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Molecular Plant 2020年第2期13卷 321-335页

作者： Yan Yan Byung-Kook Ham Yee Hang Chong Shyi-Dong yeh William J.Lucas Department of Plant Biology College of Biological SciencesUniversity of CaliforniaDavisCA 95616USA Department of Plant Pathology National Chung-Hsing UniversityTaichung Present address:Global Institute for Food Security University of SaskatchewanSaskatoonSK S7N 4J8Canada Present address:Department of Biology University of Saskatchewan112 Science PlaceSaskatoonSK S7N 5E2Canada

In plants,RNA interference(RNAi)plays a pivotal role in growth and development,and responses to environmental inputs,including pathogen *** intercellular and systemic trafficking of small interfering RNA(siRNA)/microRNA(miRNA)is a central component in this regulatory ***,little is known with regards to the molecular agents involved in the movement of these si/*** address this situation,we employed a biochemical approach to identify and characterize a conserved SMALL RNA-BINDING PROTEIN 1(SRBP1)family that mediates non-cell-autonomous small RNA(sRNA)*** Arabidopsis,AtSRBP1 is a glycine-rich(GR)RNA-binding protein,also known as AtGRP7,which we show binds single-stranded siRNA.A viral vector,Zucchini yellow mosaic virus(ZYMV),was employed to functionally characterized the AtSRBP1-4(AtGRP7/2/4/8)RNA recognition motif and GR ***-based studies revealed the GR domain as being necessary and sufficient for SRBP1 cell-to-cell *** together,our findings provide a foundation for future research into the mechanism and function of mobile sRNA signaling agents in plants.

关键词： RNAi small RNA-binding protein family small RNA movement non-cell-autonomous protein glycinerich protein

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A Decision Tree Approach for Predicting Smokers’Quit Intentions

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Journal of Electronic Science and Technology of China 2008年第3期6卷 284-288页

作者： Xiao-Jiang Ding Susan Bedingfield Chung-hsing yeh Ron Borland David Young Jian-Ying Zhang Sonja Petrovic-Lazarevic Ken Coghill Clayton School of Information Technology Monash University Victoria 3800 Australia VicHealth Centre for Tobacco Control The Cancer Council Victoria Victoria 3053 Australia Department of Management Caulfield Campus Monash University Victoria 3145 Australia

This paper presents a decision tree approach for predicting smokers＇ quit intentions using the data from the International Tobacco Control Four Country Survey. Three rule-based classification models are generated from three data sets using attributes in relation to demographics, warning labels, and smokers＇ beliefs. Both demographic attributes and warning label attributes are important in predicting smokers＇ quit intentions. The model＇s ability to predict smokers＇ quit intentions is enhanced, if the attributes regarding smokers＇ internal motivation and beliefs about quitting are included.

关键词： Decision tree prediction quit attempt tobacco control tobacco smoking

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Using a consensus acupoints regimen to explore the relationship between acupuncture sensation and lumbar spinal postoperative analgesia: A retrospective analysis of prospective clinical cooperation

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Journal of Integrative Medicine 2022年第4期20卷 329-337页

作者： Yen-Lin chao Yi-Ai Rau Hong-Sheng Shiue Jiun-Lin Yan Yuan-Yun Tang Shao-Wen Yu Bo-Yan yeh Yen-Lung Chen Tsung-Hsien Yang Shu-Chen Cheng Yi-Wen Hsieh Hsin-Chia Huang Fu-Kuang Tsai Yu-Sheng Chen Geng-Hao Liu Division of Acupuncture and Moxibustion Department of Traditional Chinese MedicineChang Gung Memorial HospitalTaoyuan 333TaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 333TaiwanChina Department of Neurosurgery Keelung Chang Gung Memorial HospitalKeelung 204TaiwanChina Department of Traditional Chinese Medicine New Taipei Municipal TuCheng HospitalChang Gung Memorial HospitalNew Taipei 236TaiwanChina Sleep Center Chang Gung Memorial HospitalTaoyuan 333TaiwanChina

Objective: This study evaluated the effectiveness of acupuncture treatment on postoperative pain in patients with degenerative lumbar spine disease, and explored the relationship between the postoperative analgesic effect of acupuncture and the sensation of acupuncture experienced by the ***: This retrospective study analyzed the medical records of 97 patients who had undergone an operation by the same surgeon due to degenerative lumbar disease. These patients were divided into acupuncture group(n = 32), patient-controlled analgesia(PCA) group(n = 27), and oral analgesia group(n = 38) according to the different postoperative analgesic methods. During their hospitalization, patients completed daily evaluations of their pain using a visual analogue scale(VAS), and injection times of supplemental meperidine were recorded. Also, the Chinese version of the Massachusetts General Hospital Acupuncture Sensation Scale(C-MASS) was used in the acupuncture ***: Each of the three treatment groups showed significant reductions in postoperative pain, as shown by reduced VAS scores. The acupuncture group, however, had less rebound pain(P < 0.05) than the other two groups. Both the acupuncture and PCA groups experienced acute analgesic effects that were superior to those in the oral analgesia group. In addition, the higher the C-MASS index on the second day after surgery, the lower the VAS score on the fourth day after surgery. There was also a significant difference in the“dull pain” in the acupuncture ***: The results demonstrated that acupuncture was beneficial for postoperative pain and discomfort after simple surgery for degenerative spinal disease. It is worth noting that there was a disproportionate relevance between the patient’s acupuncture sensation and the improvement of pain VAS score.

关键词： Acupuncture analgesia Postoperative period Neurodegenerative diseases Lumbosacral region Acupuncture sensation De-qi

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Typhoon-dominated Influence on Wood Debris Distribution and Transportation in a High Gradient Headwater Catchment

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Journal of Mountain Science 2013年第4期10卷 509-521页

作者： CHEN Su-Chin chao Yi-Chiung CHAN Hsun-Chuan Department of Soil and Water Conservation National Chung Hsing University

Wood debris is an important component of mountain streams. It causes serious damage and renders difficulty of water resource management in Taiwan. In this study, the quantity of wood debris and variation of migratory wood debris during flood events were examined. The downstream of Gaoshan Creek and Qijiawan Creek, located at Central Taiwan, was selected as the study area. The distribution and dynamic of wood debris in a high gradient headwater catchment were quantified using field surveys. A formula of critical depth for wood debris entrainment was used to evaluate the wood debris migration during three flooding events. In the study area, wood abundance and unit volume increased downstream, and wood density decreased downstream within a channel network. The channel morphology, riparian vegetation, and wood debris characteristics were found to influence the wood storage. As a result, the wood debris has an irregular accumulative distribution in the steep stream, and it migrates easily in the stream because of a high flow discharge. Strong relationships between the channel width and wood debris variables are discovered. Moreover, wood debris has a tendency to accumulate at sites with low stream power and wood debris dams, topographical notches, and unique geological structures. Our findings assist in the understanding of the effects of channel characteristics on distributions of wood debris in steep stream systems.

关键词： Wood debris Spatial distribution

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Evaluation of the effect of partial splenic embolization on platelet values for liver cirrhosis patients with thrombocytopenia

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World Journal of Gastroenterology 2007年第4期13卷 619-622页

作者： Chi-Ming Lee Ting-Kai Leung Hung-Jung Wang Wei-hsing Lee Li-Kuo Shen Jean-Dean Liu Chun-chao Chang Ya-Yen Chen Department of Diagnostic Radiology Taipei Medical University Hospital Taipei Taiwan China Department of Medicine Taipei Medical University Taipei Taiwan China Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan China

AIM： TO investigate the effect of partial splenic embolization （PSE） on platelet values in liver cirrhosis patients with thrombocytopenia and to determine the effective embolization area for platelet values improvement.METHODS： Blood parameters and liver function indicators were measured on 10 liver cirrhosis patients （6 in Child-Pugh grade A and 4 in grade B） with thrombocytopenia （platelet values 〈 80 × 10^3/μL） before embolization. Computed tomography scan was also needed in advance to acquire the splenic baseline. After 2 to 3 d, angiography and splenic embolization were performed. A second computed tomography scan was made to confirm the embolization area after 2 to 3 wk of embolization. The blood parameters of patients were also examined biweekly during the 1 year follow-up period. RESULTS： According to the computed tomography images after partial splenic embolization, we divided all paUents into two groups： low （〈 30%）, and high （≥ 30%） embolization area groups. The platelet values were increased by 3 times compared to baseline levels after 2 wk of embolization in high embolization area group. In addition, there were significant differences in platelet values between low and high embolization area groups. GPT values decreased significantly in all patients after 2 wk of embolization. The improvement in platelet and GPT values still persisted until 1 year after PSE. In addition, 3 of 4 （75%） Child-Pugh grade B patients progressed to grade A after 2 mo of PSE. The complication rate in 〈 30% and ≥30% embolization area groups was 50% and 100%, respectively. CONCLUSION： Partial splenic embolization is an effective method to improve platelet values and GPT values in liver cirrhosis patients with thrombocytopenia and the ≥ 30% embolization area is meaningful for platelet values improvement. The relationship between the complication rate and embolization area needs further studies.

关键词： Partial splenic embolization Liver cirrhosis Thrombocytopenia

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对台湾青少年日常生活、网络使用和抑郁情绪的调查

对台湾青少年日常生活、网络使用和抑郁情绪的调查

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第四届泛亚太地区心理卫生学术研讨会

作者： Ya-hsing,yeh Yu-Chun,Tseng 精神卫生部John Tung基金会精神卫生部John Tung基金会

＜正＞本项研究的目的是探讨台湾青少年日常生活的特点,并了解他们的抑郁情绪、日常活动及网络使用这三者间的关系。方法:我们从台湾北部、中部、南部、和东部地区的60 所学校中随机抽取低年级和高年级中学生入组,获得6341份有效数据。...

＜正＞本项研究的目的是探讨台湾青少年日常生活的特点,并了解他们的抑郁情绪、日常活动及网络使用这三者间的关系。方法:我们从台湾北部、中部、南部、和东部地区的60 所学校中随机抽取低年级和高年级中学生入组,获得6341份有效数据。他们每人都填写了“青少年日常生活和网络使用”量表及“青少年抑郁情绪自检量表（ADMSS）”。结果:结果表明27．8％的研究对象有严重的抑郁情绪并

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