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Symptom distress and interference among cancer patients with osteoradionecrosis of jaw: A cross-sectional study

International Journal of Nursing Sciences 2019年第3期6卷 278-282页

作者： Dongye Yang Feng Zhou Xinyu Fu Jinsong Hou Liting Lin Qiuyu Huang chao hsing yeh Guanghua School of Stomatology Hospital of StomatologySun Yat-sen UniversityGuangdong Provincial Key Laboratory of StomatologyGuangzhouChina Center for Adverse Drug Reaction Monitoring of Chengdu SichuanChina Johns Hopkins School of Nursing BaltimoreUSA

Objective:Osteoradionecrosis of the jaws(ORNJ)is among the most serious oral complications of head and neck cancer treatment with radiation *** study aimed to examine the level of symptom distress and interference of ORNJ in head and neck cancer patients in ***:A cross-sectional study was conducted to profile patient reported symptom *** hospitalized ORNJ patients were *** completed the MD Anderson Symptom Inventory-Head and Neck Module-Chinese ***:The percentage of participants who reported that they experienced at least one type of symptom was 97.9%,and 85.2%patients reported *** 10 most severe symptoms were as follows:limited mouth opening,problem with teeth/gums,difficulty swallowing/chewing,dry mouth,oral malodor,difficulty with voice/speech,dental ulcer,tinnitus/ear obstruction,skin pain/burning/rash,and difficulty *** problem of limited mouth opening was more severe in patients with longer time to onset of ORNJ after *** interference of patients positively correlated with core symptoms(r=0.612),head and neck symptoms(r=0.709),and ORNJ symptoms(r=0.440)(P<0.01).The longer time to the onset of ORNJ after radiotherapy was positively and significantly correlated with symptom distress(r=0.479,P<0.001),and mouth opening correlated negatively with symptom distress(r=-0.298,P=0.003).Conclusions:ORNJ patients suffered mainly from limited mouth opening and other maxillofacial *** problem of limited mouth opening was more severe in patients with longer time to onset of ORNJ after *** patients commonly had symptom distress,which influenced their quality of life.

关键词： Head and neck neoplasms Nursing care Signs and symptoms Osteoradionecrosis of jaws

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A Multi-Objective Optimization for Locating Maintenance Stations and Operator Dispatching of Corrective Maintenance

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Computers, Materials & Continua 2024年第6期79卷 3519-3547页

作者： chao-Lung Yang Melkamu Mengistnew Teshome Yu-Zhen yeh Tamrat Yifter Meles Department of Industrial Management National Taiwan University of Science and TechnologyTaipie106Taiwan Department of Industrial Engineering University of Gondar Institute of TechnologyGondar196Ethiopia

In this study,we introduce a novel multi-objective optimization model tailored for modern manufacturing,aiming to mitigate the cost impacts of operational disruptions through optimized corrective *** to our approach is the strategic placement of maintenance stations and the efficient allocation of personnel,addressing a crucial gap in the integration of maintenance personnel dispatching and station *** model uniquely combines the spatial distribution of machinery with the expertise of operators to achieve a harmonious balance between maintenance efficiency and *** core of our methodology is the NSGA Ⅲ+Dispatch,an advanced adaptation of the Non-Dominated Sorting Genetic Algorithm Ⅲ(NSGA-Ⅲ),meticulously designed for the selection of maintenance stations and effective operator *** method integrates a comprehensive coding process,crossover operator,and mutation operator to efficiently manage multiple *** empirical testing,including a detailed analysis from a taiwan region electronic equipment manufacturer,validated the effectiveness of our approach across various scenarios of machine failure frequencies and operator *** findings reveal that the proposed model significantly outperforms current practices by reducing response times by up to 23%in low-frequency and 28.23%in high-frequency machine failure scenarios,leading to notable improvements in efficiency and cost ***,it demonstrates significant improvements in oper-ational efficiency,particularly in selective high-frequency failure contexts,while ensuring substantial manpower cost savings without compromising on operational *** research significantly advances maintenance strategies in production environments,providing the manufacturing industry with practical,optimized solutions for diverse machine malfunction ***,the methodologies and principles developed in this study have pote

关键词： Corrective maintenance multi-objective optimization non-dominated sorting genetic algorithmⅢ operator allocation maintenance station location

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Oxidation mechanism of aluminum nitride revisited

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Journal of Advanced Ceramics 2017年第1期6卷 27-32页

作者： Chun-Ting yeh Wei-hsing TUAN Department of Materials Science and Engineering 'National Taiwan University' Taipei Taiwan 106 China

Different from the oxidation kinetics of other nitrides,the oxide layer on AlN can easily reach tens of micrometers at a temperature above 1200 ℃.In the present study,the oxidation mechanism of AlN is investigated through microstructure *** analysis indicates that the oxide layer is full of small *** formation of pores generates additional surface area to induce further *** reaction thus controls the oxidation in the temperature range from 1050 to 1350 ℃.The oxidation rate becomes slow as the oxide layer reaches a critical thickness.

关键词： oxidation mechanism aluminum nitride diffusion reaction

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Designing a Secure and Scalable Data Sharing Mechanism Using Decentralized Identifiers(DID)

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 809-822页

作者： Iuon-Chang Lin I-Ling yeh Ching-Chun Chang Jui-Chuan Liu Chin-Chen Chang Department of Management Information Systems National Chung Hsing UniversityTaichung402TaiwanChina Information and Communication Security Research Center Feng Chia UniversityTaichung407TaiwanChina Department of Information Engineering and Computer Science Feng Chia UniversityTaichung407TaiwanChina

Centralized storage and identity identification methods pose many risks,including hacker attacks,data misuse,and single points of ***,existing centralized identity management methods face interoperability issues and rely on a single identity provider,leaving users without control over their ***,this paper proposes a mechanism for identity identification and data sharing based on decentralized *** scheme utilizes blockchain technology to store the identifiers and data hashed on the chain to ensure permanent identity recognition and data *** is stored on InterPlanetary File System(IPFS)to avoid the risk of single points of failure and to enhance data persistence and *** the same time,compliance with World Wide Web Consortium(W3C)standards for decentralized identifiers and verifiable credentials increases the mechanism’s scalability and interoperability.

关键词： Self-sovereign identity decentralized identifier blockchain

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Tumor microenvironment-responsive hyaluronate-calcium carbonate hybrid nanoparticle enables effective chemo-therapy for primary and advanced osteosarcomas

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Nano Research 2018年第9期11卷 4806-4822页

作者： Yi Zhang Lulu Cai Di Li yeh-hsing Lao Dingzhuo Liu Mingqiang Li Jianxun Ding Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Department of Orthopedics the Fourth Affiliated Hospital of China Medical University Shenyang 110032 China Personalized Drug Therapy Key Laboratory of Sichuan Province Hospital of the University of Electronic Science and Technology of China Sichuan Provincial People's Hospital Chengdu 610072 China Department of Biomedical Engineering Columbia University New York NY 10027 USA Guangdong Provincial Key Laboratory of Liver Disease The Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510630 China

Osteosarcoma is the most common malignancy in the bone. Current chemotherapy offers limited efficacy with significant side effects, especially for advanced and relapsed osteosarcomas. Nanoparticle-formulated chemotherapeutic drugs may be used to resolve these issues, but several aspects of these formulations remain unsatisfactory, such as how to improve their stability in the bloodstream, prevent undesirable drug leakage, and enhance targeted drug accumulation in the tumor. In this study, a tumor microenvironment-responsive calcium carbonate （CaCO3）- crosslinked hyaluronate （HA） nanopartide was prepared via a ＂green＂ process to effectively deliver doxorubicin （DOX） for the treatment of various stages of osteosarcoma. The DOX-loaded hyaluronate-calcium carbonate hybrid nanoparfide （HA-DOX/CaCO3） demonstrated superior stability both in vitro and in vivo, and rapidly released DOX at the tumor site when triggered by the acidic tumor microenvironment. Compared with free DOX and a non-crosslinked nanoparficle （HA-DOX）, HA-DOX]CaCO3 exhibited the most potent inhibition efficacy toward both primary and advanced models of routine osteosarcoma, resulting in effective tumor inhibition, improved survival time, and reduced adverse effects. Most importantly, in the advanced osteosarcoma model, HA-DOX/CaCO3 potently suppressed tumor growth by 84.6%, which indicates the potential of this platform for osteosarcoma treatment, particularly for advanced and relapsed cases. The proposed polysaccharide nanopartide would be a promising drug delivery platform to advance osteosarcoma nanomedicine.

关键词： hybrid nanomedicine tumor-aridity responsiveness controlled drug delivery multi-stage osteosarcoma chemotherapy

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Effect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study

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Asian Journal of Urology 2024年第3期11卷 486-496页

作者： Chin-Heng Lu Hung-Min Chang Kuang-Hsi Chang Yen-Chuan Ou chao-Yu Hsu Min-Che Tung Frank Cheau-Feng Lin Stella Chin-Shaw Tsai Division of Urology Department of SurgeryTungs’Taichung Metroharbor HospitalTaichungTaiwanChina Rong hsing Research Center for Translational Medicine Chung Hsing UniversityTaichungTaiwanChina College of Life Sciences Chung Hsing UniversityTaichungTaiwanChina Department of Otolaryngology Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina Department of Medical Research Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichungTaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Department of Surgery Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Chung Shan Medical UniversityTaichungTaiwanChina

Patients with suspected OSA were examined using *** were divided into two groups based on the presence of *** was defined as a patient who needed to void at least *** index(AHI)was employed to classify patients according to degrees of severity:AHI<5 events/h,5 events/hAHI<15 events/h,15 events/hAHI<30 events/h,and AHI30 events/h,defined as normal,mild OSA,moderate OSA,and severe OSA,*** variables,PSG parameters,International Prostate Symptom Scores(IPSSs),and quality of life scores due to urinary symptoms were ***:In total 140 patients,114 patients had OSA(48 had mild OSA;34 had moderate OSA;and 32 had severe OSA)and 107 patients had *** total IPSS was significantly higher in nocturia patients in all groups except the group of severe OSA *** the increasing severity of OSA,more correlated factors related to nocturia were *** mild OSA patients,nocturia related to increased age(p=0.025),minimum arterial blood oxygenation saturation(p=0.046),and decreased AHI of non-rapid eye movement(p=0.047),AHI of total sleep time(p=0.010),and desaturation index(p=0.012).In moderate OSA patients,nocturia related to increased age(p<0.001),awake time(p=0.025),stage 1 sleep(p=0.033),and sleep latency(p=0.033),and decreased height(p=0.044),weight(p=0.025),and sleep efficiency(p=0.003).In severe OSA patients,nocturia related to increased weight(p=0.011),body mass index(p=0.009),awake time(p=0.008),stage 1 sleep(p=0.040),arousal number(p=0.030),arousal index(p=0.013),periodic limb movement number(p=0.013),and periodic limb movement index(p=0.004),and decreased baseline arterial blood oxygenation saturation(p=0.046).Conclusion:Our study revealed that there were more correlated factors related to nocturia with increasing severity of *** study helps in clinical education and treatment for OSA patients with different severity.

关键词： Nocturia Obstructive sleep apnea Polysomnography Apneaehypopnea index International Prostate Symptom Score

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The experimental study for the allocation of ground-sills downstream of check dams

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International Journal of Sediment Research 2008年第1期23卷 28-43页

作者： Bing-Shyan LIN chao-Hsien yeh Hui-Pang LIEN Candidate Department of Civil and Hydraulic Engineering Institute and Construction and Disaster Prevention Research Center Feng-Chia University Department of Water Resources Engineering Feng-Chia University

The main purpose of this study is to understand the stabilizing effect of ground-sills on the riverbed through a series of flume model experiments. From results, although check dams have the ability to control upstream sediment transport, the mass energy produced by the free fall of the overtopping discharge still causes strong local scour downstream of the structure, and this scour leads to the instability of the check dam. Therefore, this study conducted model experiments on various types of serial ground-sills to determine the appropriate spacing to best protect the downstream bed. Based on the observations and analysis of channel geomorphology and sedimentation, this study concluded the following results: 1) Serial ground-sills reduces the sediment transport ability perfectly, especially under a mild channel gradient equipped with 2-4 times the average channel width interval. But for steep slopes, it is suggested that the proper spacing should be shortened to 1-2 times the average channel width. 2) Ground-sills can effectively protect the streambed from scouring under a suitable equipped condition and the concepts of guiding scour and riverbed inertia were used in the analysis of optimal ground-sill spacing.

关键词： Serial ground-sills Sedimentation Strong scour area Riverbed inertia Guiding scour

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Increased susceptibility of algal symbionts to photo-inhibition resulting from the perturbation of coral gastrodermal membrane trafficking

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Science China(Life Sciences) 2012年第7期55卷 599-611页

作者： CHEN Chii-Shiarng yeh Shih-Pin WANG Li-Hsueh LI hsing-Hui CHEN Uang Wan-Nan Taiwan Coral Research Center "National" Museum of Marine Biology & AquariumPingtung 944TaiwanChina Institute of Marine Biotechnology "National" Dong Hwa UniversityPingtung 944TaiwanChina Department of Marine Biotechnology and Resources "National" Sun Yat-Sen UniversityKaohsiung 804TaiwanChina Department of Biological Science and Technology I-Shou UniversityKaohsiung 824TaiwanChina

The stability of cnidarian-dinoflagellate endosymbioses is dependent upon communication between the host gastrodermal cell and the symbionts housed within it. Although the molecular mechanisms remain to be elucidated, existing evidence suggests that the establishment of these endosymbioses may involve the sorting of membrane proteins. The present study examined the role of host gastrodermal membranes in regulating symbiont （genus Symbiodinium） photosynthesis in the stony coral Euphyllia glabrescens. In comparison with the photosynthetic behavior of Symbiodinium in culture, the Symbiodinium populations within isolated symbiotic gastrodermal cells （SGCs） exhibited a significant degree of photo-inhibition, as determined by a decrease in the photochemical efficiency of photosystem II （Fv/Fm）. This photo-inhibition coincided with increases in plasma membrane perturbation and oxidative activity in the SGCs. Membrane trafficking in SGCs was examined using the metabolism of a fluo- rescent lipid analog, N-[5-（5,7-dimethyl boron dipyrromethene difluoride）-l-pentanoyl]-D-erythro-Sphingosylpbosphoryl- choline （BODIPY-Sphingomyelin or BODIPY-SM）. Light irradiation altered both membrane distribution and trafficking of BODIPY-SM, resulting in metabolic changes. Cholesterol depletion of the SGC plasma membranes by methyl-13-cyclodextrin retarded BODIPY-SM degradation and further augmented Symbiodinium photo-inhibition. These results indicate that Symbio- dinium photo-inhibition may be related to perturbation of the host gastrodermal membrane, providing evidence for the pivotal role of host membrane trafficking in the regulation of this environmentally important coral-dinoflagellate endosymbiosis.

关键词： Cnidaria endosymbiosis fluorescent lipids lipid trafficking PAM photosynthesis Symbiodinium

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Successful management of delirium with dexmedetomidine in a patient with haloperidol-induced neuroleptic malignant syndrome:A case report

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World Journal of Clinical Cases 2022年第2期10卷 625-630页

作者： Chi-Ju Yang Ching-Tang Chiu Yu-Chang yeh Anne chao Department of Pharmacy National Taiwan University HospitalTaipei 100220Taiwan Department of Anesthesiology National Taiwan University HospitalTaipei 100220Taiwan

BACKGROUND We report a case of lorazepam-induced agitated delirium treated with haloperidol,which in turn triggered the onset of neuroleptic malignant syndrome(NMS).The latter condition,a medical emergency,was effectively treated with medical treatment and dexmedetomidine,a versatile and highly selective shortacting alpha-2 adrenergic agonist with sedative-hypnotic and anxiolytic *** SUMMARY A 65-year-old man with a history of bipolar disorder presented to the emergency department with severe abdominal discomfort after binge *** his hospital stay,he received intravenous lorazepam for *** the next day,he became delirious and was thus treated with seven doses(5 mg each)of haloperidol over a 48 h *** of NMS(hyperthermia,rigidity,myoclonus of upper limbs,impaired consciousness,tachypnea,and dark urine)became apparent and haloperidol was immediately suspended and brisk diuresis was *** intensive care unit admission,he was confused,disoriented,and markedly *** infusion was started with the goal of achieving a Richmond Agitation-Sedation Scale score of-1 or *** was resolved gradually and the patient stabilized,permitting discontinuation of dexmedetomidine after 3 *** Dexmedetomidine may be clinically helpful for the management of NMS,most likely because of its sympatholytic activity.

关键词： Haloperidol Dexmedetomidine Delirium Neuroleptic malignant syndrome Alpha-2 adrenergic agonists Case report

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Local anesthesia with ropivacaine for patients undergoing laparoscopic cholecystectomy

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World Journal of Gastroenterology 2009年第19期15卷 2376-2380页

作者： Chun-Nan yeh Hsiang-Lin Lee Chun-Yi Tsai Chih-Chung Lin Tzu-Chieh chao Ta-Sen yeh Yi-Yin Jan Department of Surgery Chang Gung Memorial HospitalChang Gung University5 Fu-Hsing StreetKwei-ShanTaoyuan 33375TaiwanChina Department of Anesthesiology Chang Gung Memorial HospitalChang Gung University5 Fu-Hsing StreetKwei-ShanTaoyuan 33375TaiwanChina

AIM:To investigate the effect of pain relief after infu-sion of ropivacaine at port sites at the end of ***:From October 2006 to September 2007,72 patients undergoing laparoscopic cholecystectomy(LC) were randomized into two groups of 36 *** group received ropivacaine infusion at the port sites at the end of LC and the other received normal saline.A visual analog scale was used to assess postoperative pain when the patient awakened in the operating room,6 and 24 h after surgery,and before *** amount of analgesics use was also *** demographics,laboratory data,hospital stay,and perioperative complications were compared between the two ***:There was no difference between the two groups preoperatively in terms of demographic and lab-oratory *** surgery,similar operation time,blood loss,and no postoperative morbidity and mortality were observed in the two ***,a significantly lower pain score was observed in the patients undergo-ing LC with local anesthesia infusion at 1 h after LC and at *** analgesic use,the amount of meperidine used 1 h after LC and the total used during admission were lower in patients undergoing LC with local anesthesia *** group also had a shorter hospital ***:Local anesthesia with ropivacaine at the port site in LC patients signif icantly decreased post-operative pain *** explains the lower meperidine use and earlier discharge for these patients.

关键词： Prospective randomized trial Localanesthesia Ropivacaine Normal saline Laparoscopic cholecystectomy

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