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2022年NSFC心血管领域中、西医申请资助情况分析

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天津中医药 2024年第1期41卷 130-136页

作者：李超张冬梅赵京霞耿子涵陈澈熊俊何怡瀚王蕊毕明刚山东中医药大学中医药创新研究院济南250355 北京中医药大学东直门医院中医内科学教育部重点实验室北京100700 首都医科大学附属北京中医医院银屑病中医临床基础研究北京市重点实验室北京100010 中国中医科学院中药研究所北京100700 宁夏医科大学中医学院银川750004 江西中医药大学附属医院针灸科南昌330006 广州中医药大学第二附属医院/广州省中医院肿瘤科广州510120 国家自然科学基金委员会北京100085

系统梳理分析2022年国家自然科学基金心血管领域中、西医学面上项目、青年科学基金项目和地区科学基金项目3类常规项目的申请和资助情况、所涉及主要病种、研究热点和研究思路。结果显示,两个领域研究的主要病种相似,研究热点也基本一... 详细信息

系统梳理分析2022年国家自然科学基金心血管领域中、西医学面上项目、青年科学基金项目和地区科学基金项目3类常规项目的申请和资助情况、所涉及主要病种、研究热点和研究思路。结果显示,两个领域研究的主要病种相似,研究热点也基本一致。均以动脉粥样硬化、冠心病、心力衰竭、高血压、继发性心肌损伤和心律失常为主,主要开展表观遗传学、外泌体、细胞焦亡或铁死亡、细胞自噬、肠道微生物群以及线粒体功能方面的研究,思路呈现多样化的特点。但西医心血管领域的病种更为广泛,还包括心脏移植等中医心血管领域不涉及的病种。在科学问题导向和研究内容方面,中医心血管领域要求在中医药理论的指导下,以解决中医学科的关键科学问题为导向,体现中医药的特色。此外,研究热点只是探索科学问题的技术手段,应深入凝练科学问题,避免盲目追求结合研究热点反而缺乏了创新性思想和科学依据,鼓励原创性基础研究。

关键词：国家自然科学基金心血管领域中医学科循环系统申请与资助

Analysis of Strain Clamp Failure on 500 kV Transmission Line

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Journal of Materials Science and che.ical Engineering 2018年第4期6卷 47-56页

作者： Mingche.g Sun che.Tan chaoqun Zhang chao Yang Hongqiang Li State Grid Liaoning Electric Power Research Institute Shenyang China State Grid Shenyang Electric Power Supply Company Shenyang China

In this work, the main reasons for the breakage of 500 kV transmission line are studied. Under low temperature condition, the coverage of the ice results in the disconnection between the aluminum tube and the steel anchor of strain clamp. Using macroscopic analysis, structure stress analysis, force analysis and mechanical property test, the fractured strain clamps are investigated. The crimping of the aluminum tube on the polished rod not on the grooves of the steel anchor leads to the damage of the strain clamps, which is defined as improper crimping. When improper crimping emerges, there will be only friction force between the aluminum tube and the steel anchor without shear force, and the tension of the conductor will be mainly supported by the steel strands which should be supported by both the aluminum tube and steel stands. Therefore, the breaking force of the strain clamp will greatly decrease. The failure analysis helps to promote the proper hydraulic crimping process and the safe operation of the transmission line.

关键词： Transmission Line Strain Clamp Hydraulic Crimping Process

Maternal organic selenium supplementation during gestation enhances muscle fiber area and muscle fiber maturation of offspring in porcine model

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Journal of Animal Science and Biotechnology 2023年第2期14卷 654-665页

作者： Yan Lin Hui Yan Lei Cao Daolin Mou Dajiang Ding Binting Qin Lianqiang che.Zhengfeng Fang Shengyu Xu Yong Zhuo Jian Li Jianping Wang chao Huang Yuanfeng Zou Lixia Li De Wu Bin Feng Animal Nutrition Institute Sichuan Agricultural UniversityChengduChina Key Laboratory of Animal Disease‑Resistant Nutrition of Ministry of Education Sichuan Agricultural UniversityChengduChina College of Veterinary Medicine Sichuan Agricultural UniversityChengdu 611130SichuanChina

Background:Organic selenium supplementation during gestation improves the antioxidant status and reproduc-tive performance of sows and increases the antioxidative capacity of the intestines of their *** study was conducted to investigate the effect of maternal basel diet(control)supplemented with an organic Se,2-hydroxy-4-methylselenobutanoic acid(HMSeBA),or inorganic sodium selenite(Na_(2)SeO_(3))during gestation on the antioxidant status and development of muscle in newborn and weaned *** piglets before colostrum intake and weaned piglets were selected for longissimus dorsi(LD)muscle collection and ***:The results showed that maternal HMSeBA supplementation increased the muscle area and content of Se in the LD muscle of newborn piglets,improved gene expression of selenoproteins,and decreased oxidative status in the LD muscle of both newborn and weaned piglets compared with the *** expression of muscle development-related genes of newborn piglets in the HMSeBA group was lower than in the control group,whereas the expression of MRF4 in weaned piglets was higher in the HMSeBA group than in the control and Na_(2)SeO_(3)*** addition,HMSeBA supplementation decreased the mRNA expressions of myosin heavy chains(MyHC)IIx and MyHC IIb and the percentage of MyHC IIb;increased the expression of PGC-1αin the LD muscle of newborn piglets;increased the gene expression of MyHC IIa;and decreased the protein expression of slow MyHC and the activity of malate dehydrogenase in the LD muscle of weaned piglets compared with the control ***:Maternal HMSeBA supplementation during gestation can improve the antioxidative capacity of the muscle of their offspring and promote the maturity of muscle fibres in weaned offspring.

关键词： Antioxidation HMSeBA Muscle Offspring Sows

SURGICAL MANAGEMENT OF PSEUDOANEURYSM COMPLICATING ARTERIOVENOUS FISTULA FOR HEMODIALYSIS

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Chinese Medical Sciences Journal 2007年第3期22卷 196-198页

作者： Yue-hong Zheng Chang-wei Liu Heng Guan Hong-bing Gan UI Kuok chao-liang Li Jian Zhang Dias che.Sok In Furtado Rui Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Nephrology Central Hospital Conde S. Januário of Macao Caixa Postal 3002 Macao

Objective To report surgical experience in pseudoaneurysm (PA) repair of arteriovenous fistula (AVF) for renal hemodialysis. Methods Twenty patients undergoing PA repair of AVF for renal hemodialysis were treated in Central Hospital Conde S. Januario of Macao. Sixteen patients had PAs of AVF in upper extremities, 4 in lower extremities. All patients were treated with surgical therapy. Results All operations were finished without death. One patient suffered from acute thrombosis, recovered without any complication through instant thrombectomy. One patient with postoperative incision bleeding recovered after low molecular weight heparin was ceased. And one AVF could not be mature six weeks later, was recovered after ligation of branch vein. And one patient died due to recurrent cerebral infarction. Conclusion Surgical repair is the best choice for PA of AVF for renal hemodialysis.

关键词： pseudoaneurysm surgical management arteriovenous fistula hemodialysis

Hibernate Combined TableViewer in the Application of Medicines Inventory Management System

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Computer Aided Drafting,Design and Manufacturing 2014年第2期24卷 48-53页

作者： HONG Wen-qiang che.chao ZHANG Qiang WEI Xiao-peng Key Lab of Advanced Design and Intelligent Computing (Dalian University) Ministry of Education

To solve the data persistence problem in the management system, this paper used the popular object-relational mapping framework Hibernate to achieve the persistence layer which in a medicines inventory management system. This paper described the advantages and principles of the Hibernate, and then showed the written work of the configuration files, mapping files, persistent classes, etc. Finally, the paper showed how to display the specific data information in the TableViewer based on the Eclipse RCP framework. It is observed that, operating the objects in the Hibernate framework is more flexible and efficient than using JDBC directly. Ad in addition, the application based on Eclipse RCP framework can take over many excellent features of Eclipse, and the developers can improve their efficiency by these features.

关键词： Hibernate data persistence O/R mapping Eclipse RCP TableViewer database

Active vaccination to prevent de novo hepatitis B virus infection in liver transplantation

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World Journal of Gastroenterology 2015年第39期21卷 11112-11117页

作者： Chih-che.Lin che.-Chien Yong chao-Long che. Liver Transplantation Center Department of Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

The shortage of organ donors mandates the use of liver allograft from anti-HBc(+) donors, especially in areas highly endemic for hepatitis B virus(HBV) infection. Theincidence of de novo hepatitis B infection(DNH) is over 30%-70% among recipients of hepatitis B core antibody(HBcA b)(+) grafts without any prophylaxis after liver transplantation(LT). Systematic reviews showed that prophylactic therapy [lamivudine and/or hepatitits B immunoglobulin(HBIG)] dramatically reduces the probability of DNH. However, there are limited studies regarding the effects of active immunization to prevent DNH, and the role of active vaccination is not welldefined. This review focuses on the feasibility and efficacy of pre- and post-LT HBV vaccination to prevent DNH in HBsA g(-) recipient using HBcA b(+) grafts. The presence of HBs Ab in combination with lamivudine or HBIG results in lower incidence of DNH and may reduce the requirement of HBIG. There was a trend towards decreasing incidence of DNH with higher titers of HBs Ab. High titers of HBs Ab(> 1000 IU/L) achieved after repeated vaccination could eliminate the necessity for additional antiviral prophylaxis in pediatric recipients. In summary, active vaccination with adequate HBsA b titer is a feasible, cost-effective strategy to prevent DNH in recipients of HBc Ab(+) grafts. HBV vaccination is advised for candidates on waiting list and for recipients after withdrawal of steroids and onset of low dose immunosuppression after transplantation.

关键词： De novo hepatitis B Vaccination Liver transplantat

A Note on 3-Divisibility of Class Number of Quadratic Field

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Chinese Annals of Mathematics,Series B 2022年第2期43卷 307-318页

作者： Jianfeng XIE Kuok Fai chao Wu Wen-Tsun Key Laboratory of Mathematics School of Mathematical SciencesUniversity of Science and Technology of ChinaHefei 230026China Lui che.Woo College University of MacaoMacaoChina

In this paper,the authors show that there exists infinitely many family of pairs of quadratic fields Q(√D)and Q((√D+n)(1/2))with D,n∈Z whose class numbers are both divisible by 3.

关键词： Quadratic field Class number Hilbert class field

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喷洒型彩色沥青的制备

石化技术与应用 2024年第4期42卷 252-255页

作者：裴晓光刘延军薛岩王志超车金良王伟王衍法姜有山中国海油化工与新材料科学研究院山东青岛266500

以基础油、苯乙烯-丁二烯-苯乙烯(SBS)和石油树脂C9为原料,以乙酸乙酯和溶剂油为复合溶剂,制备了喷洒型彩色沥青,并对其性能进行了评价。结果表明:当SBS和石油树脂C9加入质量分数分别为9%,45%时,制备的机动车道用70号彩色沥青可满足GB/T... 详细信息

以基础油、苯乙烯-丁二烯-苯乙烯(SBS)和石油树脂C9为原料,以乙酸乙酯和溶剂油为复合溶剂,制备了喷洒型彩色沥青,并对其性能进行了评价。结果表明:当SBS和石油树脂C9加入质量分数分别为9%,45%时,制备的机动车道用70号彩色沥青可满足GB/T 32984—2016要求;当乙酸乙酯和溶剂油溶剂质量比为1∶9,配制溶液中彩色沥青质量分数为50%,白云石粉加入质量分数为50%时,制备的喷洒型彩色沥青黏度小于1.0 Pa·s,干燥时间短于60 min,且具有良好的黏结性、耐磨性、不透水性和低温柔性,可达到易喷洒、短期开放交通的效果。

关键词：彩色沥青复合溶剂喷洒型苯乙烯-丁二烯-苯乙烯(SBS) 石油树脂C9

复方罗布麻颗粒UPLC特征图谱及6个成分含量测定

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中国现代中药 2024年第3期26卷 499-506页

作者：傅咏梅卢伟玲王欢黄后楷陈静车轸潮罗锦波梁砚康国药集团广东环球制药有限公司广东佛山528303

目的:建立复方罗布麻颗粒的超高效液相色谱法(UPLC)特征图谱,同时对新绿原酸、绿原酸、隐绿原酸、金丝桃苷、异槲皮苷、木犀草苷进行含量测定。方法:以乙腈-0.1%磷酸水溶液为流动相,梯度洗脱,色谱柱为Waters CORTECS T3(100 mm×2.1 mm,... 详细信息

目的:建立复方罗布麻颗粒的超高效液相色谱法(UPLC)特征图谱,同时对新绿原酸、绿原酸、隐绿原酸、金丝桃苷、异槲皮苷、木犀草苷进行含量测定。方法:以乙腈-0.1%磷酸水溶液为流动相,梯度洗脱,色谱柱为Waters CORTECS T3(100 mm×2.1 mm,1.6μm),流速为0.33 mL·min^(–1),检测波长为360 nm,柱温为30℃。结果:得到15批复方罗布麻颗粒特征图谱,确定特征峰14个,相似度值均大于0.95。新绿原酸、绿原酸、隐绿原酸、金丝桃苷、异槲皮苷、木犀草苷分别在相应质量浓度范围内与其峰面积呈良好线性关系(r≥0.9999);平均回收率分别为99.9%、100.8%、99.9%、97.6%、101.1%、100.6%,RSD均小于2.0%。结论:该方法具有较高的灵敏度、良好的重复性,可为科学、全面地评价和控制复方罗布麻颗粒的质量提供参考。

关键词：复方罗布麻颗粒含量测定特征图谱