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Increases in Height among Chinese Children and Adolescents by Gender: An Age-Period-Cohort Analysis

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Biomedical and Environmental Sciences 2021年第5期34卷 348-355页

作者： HU Yue hua wang Xin Yu YAO hong Yan ZHANG Jian YIN Da Peng FENG Guo Shuang Epidemiology Office Chinese Center for Disease Control and PreventionBeijing 102206China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang University&Capital Medical UniversityBeijing 100045China Big Data and Engineering Research Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China National Institute Nutrition and Health Chinese Center for Disease Control and Prevention Beijing 100050China

Objective To examine increases in average height among Chinese children and *** The data were obtained from the china Health and Nutrition Survey conducted during the period 1989–2015. A stratified multistage cluster sampling method was utilized to select participants aged 2–22 years in each province. linear regression was used to examine the effects of age, birth cohort, and survey period on *** A total of 15,227 males and 13,737 females were included in the final analysis. Age(A) showed a continuous effect on height. The average heights of the investigated groups increased continuously during the investigation period. By 2015, the average height of the overall group increased by 7.87 cm compared to the average height during the 1989 survey. Moreover, birth year(cohort, C) also had a stable effect on height. Using the height of individuals born in or before 1975 as a reference, the average height of each birth cohort increased in comparison to the previous birth *** The height of Chinese children and adolescents was affected by age, period, and cohort effects, and this effect is governed by certain rules. The age-period-cohort model can be used to analyze the trends of children’s and adolescent’s heights. The findings provide a scientific basis for the formulation of children’s and adolescents’ growth and development policies in china.

关键词： Age-period-cohort analysis Children and adolescents Height

柔肝健脾法联合美沙拉嗪灌肠液治疗远端型溃疡性结肠炎肝郁脾虚证的临床研究

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国际中医中药杂志 2024年第4期46卷 444-450页

作者：黄华马俊杰华秋雯金超季利江南京中医药大学附属常熟医院肛肠科常熟215500 南京中医药大学中医学院•中西医结合学院南京210046 南京中医药大学附属常熟医院消化内科常熟215500 南京中医药大学附属常熟医院内分泌科常熟215500

目的评价柔肝健脾法联合美沙拉嗪灌肠液治疗远端型溃疡性结肠炎(DUC)肝郁脾虚证的临床疗效。方法本研究为前瞻性平行随机对照研究。选择2021年11月-2022年5月南京中医药大学附属常熟医院115例DUC患者作为观察对象,采用随机数字表法分为... 详细信息

目的评价柔肝健脾法联合美沙拉嗪灌肠液治疗远端型溃疡性结肠炎(DUC)肝郁脾虚证的临床疗效。方法本研究为前瞻性平行随机对照研究。选择2021年11月-2022年5月南京中医药大学附属常熟医院115例DUC患者作为观察对象,采用随机数字表法分为对照组58例和研究组57例。对照组给予美沙拉嗪灌肠液灌肠治疗,研究组在对照组基础上服用柔肝健脾方。2组均治疗8周。分别于治疗前后采用改良Mayo量表评估疾病严重程度,依据其治疗前后的评分变化评估临床疗效与内镜疗效;从腹痛腹泻、黏液脓血便、里急后重、肛门灼热4个方面进行中医证候评分;采用IBD生活质量量表(IBDQ)评价患者生活质量;采用EliSA法检测血清TNF-α、IL-10水平。观察记录治疗期间的不良反应,评价临床疗效。结果研究组总有效率为91.23%(52/57)、对照组为79.31%(46/58),2组比较差异无统计学意义(Z=1.47,P=0.143)。研究组临床疗效中临床应答[40.35%(23/57)比51.72%(30/58)]及临床缓解[59.65%(34/57)比43.11%(25/58)]患者总占比[100.00%(57/57)比94.83%(55/58)]高于对照组(Z=1.97,P=0.049);内镜疗效中内镜应答[52.63%(30/57)比56.90%(33/58)]及黏膜愈合[33.33%(19/57)比17.24%(10/58)]患者总占比[85.96%(49/57)比74.14%(43/58)]高于对照组(Z=2.23,P=0.026)。治疗后,研究组IBDQ评分[(194.3±15.1)分比(172.6±18.4)分,t=6.90]高于对照组(P1);中医证候积分中黏液脓血便[(1.7±0.8)分比(2.0±0.6)分,t=2.03]、里急后重[(1.5±0.6)分比(1.8±0.6)分,t=2.32]、肛门灼热[(1.3±0.6)分比(1.6±0.7)分,t=2.38]积分低于对照组(P10水平[(53.3±8.0)ng/L比(49.0±6.7)ng/L,t=3.10]高于对照组(P1),TNF-α水平[(28.3±7.9)ng/L比(36.8±8.1)ng/L,t=3.58]低于对照组(P1)。2组治疗过程中未见明显不良反应。结论柔肝健脾法联合美沙拉秦灌肠液可有效改善DUC患者的临床症状,提高临床疗效,且安全性好。

关键词：结肠炎,溃疡性柔肝健脾方灌肠疗法肝郁脾虚证

Mesenchymal stem cell-derived exosomes as a new drug carrier for the treatment of spinal cord injury:A review

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Chinese Journal of Traumatology 2024年第3期27卷 134-146页

作者： lin-Fei Cheng chao-Qun You Cheng Peng Jia-ji Ren Kai Guo Tie-Long liu medical College.Anhui university of Science and Technology Huainan232000Anhui provinceChina department of Orthopaedic Oncology Changzheng HospitalNavy Medical UniversityShanghai200003China department of Orthopaedics The Central Hospital of Shanghai Putuo DistrictShanghai200333China

Spinal cord injury(SCI)is a devastating traumatic disease seriously impairing the quality of life in *** to allow the hopeless central nervous system to repair itself after injury are *** new approaches to regenerate the central nervous system is still the *** derived from mesenchymal stem cells(MSC-Exo)have been proven to robustly quench the inflammatory response or oxidative stress and curb neuronal apoptosis and autophagy following SCI,which are the key processes to rescue damaged spinal cord neurons and restore their ***,MSC-Exo in SCI received scant *** this review,we reviewed our previous work and other studies to summarize the roles of MSC-Exo in SCI and its underlying ***,we also focus on the application of exosomes as drug carrier in *** particular,it combs the advantages of exosomes as a drug carrier for SCI,imaging advantages,drug types,loading methods,etc.,which provides the latest progress for exosomes in the treatment of SCI,especially drug carrier.

关键词： Spinal cord injury Mesenchymal stem cell Exosomes Mechanism Drug carrier

Eosinophilia complicated with venous thromboembolism:A case report

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World Journal of Clinical Cases 2022年第6期10卷 1952-1960页

作者： Wei-Qiang Su Yan-Zhong Fu Shu-Yan liu Meng-jie Cao Ya-Bin xue Fei-Fei Suo Wen-chao liu department of Vascular Surgery The Second People’s Hospital of Jiaozuo CityJiaozuo 454000Henan ProvinceChina department of Endocrine The Second People’s Hospital of Jiaozuo CityJiaozuo 454000Henan ProvinceChina department of Neurology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Clinical Laboratory The Second People’s Hospital of Jiaozuo CityJiaozuo 454000Henan ProvinceChina

BACKGROUND Eosinophilia is an increase of more than 0.5×109/L in the number of eosinophils;it is a systemic condition with an unknown etiology and is often accompanied by multiple impaired organ *** clinical manifestations of the disease are highly variable and diverse,rendering identification of the diagnosis challenging;hence,diagnosis and treatment are often *** few reports of this disease exist globally,especially with rare manifestations of cerebral venous sinus thrombosis and *** SUMMARY A 32-year-old woman with eosinophilia presented to the hospital with bilateral lower-limb edema as the first clinical manifestation,followed by an extensive maculopapular rash throughout the *** subsequently developed cerebral venous sinus thrombosis along with bilateral lower-limb deep vein *** weeks earlier,she had received a single course of antibiotics from a local hospital for a low-grade fever and sore *** various treatments were administered for anticoagulation,maintaining blood circulation,and relieving blood stasis,the lower extremity edema improved significantly;however,the patient’s eosinophil count gradually *** experienced cerebral venous sinus thrombosis,cerebral hemorrhage,and deep vein thrombosis of the lower limbs before being declared brain *** this case report,we have elaborated the diagnosis and management of deep vein thrombosis manifested as eosinophilia,thrombocytopenia,and elevated D-dimer *** Because proper diagnosis is challenging,clinical vigilance is required for patients with eosinophilia,as it can lead to thrombus formation.

关键词： Eosinophilia Venous thromboembolism Diagnosis Management Venous thrombosis Case report

新冠疫情前后中国内地重大疫情防控工作职责明确程度变化分析

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中国公共卫生 2024年第3期40卷 274-279页

作者：朱浩施培武沈群红蒲川胡志王磐石汪华李程跃周庆誉郝模复旦大学公共卫生学院卫生事业管理学教研室上海200032 复旦大学卫生发展战略研究中心上海200032 浙江省医学科学院杭州310012 清华大学公共管理学院北京100084 重庆医科大学公共卫生与管理学院重庆400016 安徽医科大学合肥230032 上海市卫生健康委员会上海200031 江苏省预防医学会南京210009 健康风险预警治理协同创新中心上海200032

目的评价新冠疫情发生前后中国内地重大疫情防控工作的职责明确程度差异,探讨疫情对职责明确程度的影响。方法系统收集2000年1月1日-2020年12月31日中国内地31个省(自治区、直辖市)涉及重大疫情防控工作的政策文件,从中提取相关信息,从... 详细信息

目的评价新冠疫情发生前后中国内地重大疫情防控工作的职责明确程度差异,探讨疫情对职责明确程度的影响。方法系统收集2000年1月1日-2020年12月31日中国内地31个省(自治区、直辖市)涉及重大疫情防控工作的政策文件,从中提取相关信息,从职责覆盖、清晰、可考核3个方面量化分析各地职责明确程度,并用配对t检验或配对秩和检验对疫情前后的指标差异进行统计检验。结果共收集3864份文件。中国内地31省(自治区、直辖市)平均职责覆盖程度由2019年的80.93%(18.61/23.00)升至2020年的89.62%(20.61/23.00),职责可考核程度由26.16%(4.81/18.61)升至30.93%(6.39/20.61),职责明确程度从44.00%升至54.58%,差异均有统计学意义(P0.05)。分部门看,业务条线部门职责明确程度升至87.10%,关键支撑部门升至20.97%,差异均有统计学意义(P<0.05),其他支撑部门无明显提升。结论我国重大疫情防控工作职责明确程度显著提升,但在部门职责可考核方面仍需强化。

关键词：新型冠状病毒感染疫情重大疫情防控职责明确

The regulatory impact of immune inhibitors on T cells of SD rats

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Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 305-308页

作者： chao-hua Zhang Yan huang Gang Han Uropoiesis Surgical department First Hospital of Baoding Medicine Clinical Hebei University College The People's liberation Army 252 hospital

Objective:To observe the regulatory impact of immune inhibitors on T cells in ***:Forty SD rats were selected and randomly divided into experimental group and control ***(SRL)0.4 mg/d to fill the stomach of the former one,saline lavage was used with the latter one for two *** flow cytometry to detect the two groups of rats with spleen and thymus level of CD4+CD25+T cells;and the spleen cells FoxP3 mRNA expression;Using EliSA method to detect TGF-β,IL-10 ***:The peripheral blood,spleen and thymus of CD4+CD25+T cells accounted for the proportion of mononuclear cells were significantly higher than that of control group(P10 levels are significantly higher than control group(Pliferation.

关键词： Immune inhibitors Regulatory T cells Influence Research

Regulatory Role of miR-15a/16 in Gastric Cancer Treatment

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生物组学研究杂志(英文) 2024年第02期07卷 77-80页

作者： Song Ge Luo Shuang liu Yanhong hua Yunqi Shao Guo Baotou medical College Inner Mongolia University of Science and Technology Baotou Inner Mongolia China Baotou Cancer hospital Baotou Inner Mongolia China department of Public Health International College Krirk University Bangkok Thailand Center for Translational Medicine Third People’s Hospital of Longgang District Shenzhen China

Gastric cancer has a high incidence rate worldwide; it is particularly important to determine the therapeutic efficacy of available treatments and to determine the prognosis of gastric cancer due to its insidious onset and lack of specific symptoms in the early stage (most patients are diagnosed in the middle or late stage). Recent studies have revealed that altered expression of microRNAs plays a pivotal role in immune checkpoints and various cellular processes in gastric cancer. miRNAs have gradually become biomarkers and therapeutic targets in cancer because of their specificity and high sensitivity. In this article, we review the expression ofmiR-15a/16 and its therapeutic efficacy in gastric cancer and discuss its impact on signaling pathways and its prognostic importance to provide better clinical treatment options for patients.

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2020年全国医院感染监控网丙型肝炎病毒感染监测报告

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中国感染控制杂志 2024年第1期23卷 1-8页

作者：文细毛任南李福琴战榕方旭孟庆兰杨怀李卫光刘丁郭凤玲鲜于舒铭赖晓全逄崇杰黄勋吴安华中南大学湘雅医院医院感染控制中心湖南长沙410008 中南大学湘雅医院临床护理学教研室湖南长沙410008 郑州大学第一附属医院医院感染管理科河南郑州450052 福建医科大学附属协和医院医院感染管理科福建福州350001 云南省第一人民医院感染管理科云南昆明650032 内蒙古医科大学附属医院医院感染管理部内蒙古呼和浩特010017 贵州省人民医院医院感染管理科贵州贵阳550002 山东第一医科大学附属省立医院医院感染管理办公室山东济南250021 陆军特色医学中心疾病预防控制科重庆400042 河南省中医院(河南中医药大学第二附属医院河南中医药大学第二临床医学院)感染管理科河南郑州450002 海南省人民医院医院感染管理办公室海南海口570311 华中科技大学同济医学院附属同济医院医院感染管理科湖北武汉430030 天津医科大学总医院感染科天津300052

目的了解医疗机构住院患者丙型肝炎病毒(HCV)感染情况及变化趋势,为制定HCV感染防控策略提供参考依据。方法对2020年上报至全国医院感染监控网医院感染横断面调查资料中HCV感染监测结果进行汇总分析,HCV阳性为血清抗-HCV阳性或HCV RNA阳... 详细信息

目的了解医疗机构住院患者丙型肝炎病毒(HCV)感染情况及变化趋势,为制定HCV感染防控策略提供参考依据。方法对2020年上报至全国医院感染监控网医院感染横断面调查资料中HCV感染监测结果进行汇总分析,HCV阳性为血清抗-HCV阳性或HCV RNA阳性,并与2003年调查结果进行比较。结果2020年1573所医院调查住院患者1071368例,其中738535例患者进行了HCV相关检测,4014例存在HCV感染,检测率为68.93%,HCV阳性率为0.54%。男性患者HCV阳性率为0.60%,女性患者为0.48%,两者比较差异有统计学意义(χ^(2)=47.18,P1)。年龄段以50~1%,各年龄段比较差异有统计学意义(χ^(2)=696.74,P1)。2003年调查住院患者91113例,35145例进行HCV相关检测,检测率为38.57%,775例存在HCV感染,HCV阳性率为2.21%。2020年不同规模医院HCV阳性率为0.46%~0.63%,以医院床位数600~899张者最高,不同规模医院患者HCV阳性率比较,差异有统计学意义(χ^(2)=35.34,P1)。2020年有12个省/直辖市/自治区HCV相关检测患者人数>10000例,HCV阳性率为0.19%~0.81%,以海南省最高;不同科室HCV阳性率为0.06%~0.82%,以儿科HCV阳性率最低,内科HCV阳性率最高。2003、2020年HCV阳性率均以感染病科最高,分别为7.95%、3.48%,2003年其次为整形科(7.72%)、消化科(3.77%)、肾病科(3.57%)、综合重症监护病房(ICU,3.10%),2020年其次为消化科(1.35%)、肾病科(1.18%)、内分泌科(0.91%)、综合ICU(0.79%)。结论与2003年相比,2020年HCV阳性率明显下降。HCV感染患者主要分布在感染病科,其次为消化科、肾病科及综合ICU,HCV感染阳性率存在性别、年龄、地域的差异。

关键词：肝炎病毒,丙型丙型肝炎病毒流行病学调查住院患者发病率

Cryoablation combined with radiotherapy for hepatic malignancy:Five case reports

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World Journal of Gastrointestinal Oncology 2020年第2期12卷 237-247页

作者： Yue-E liu jie Zong xue-Ji Chen Rui Zhang Xiao-Cang Ren Zhi-Jun Guo Qiang lin chao-Xing liu department of Oncology North China Petroleum Bureau General HospitalHebei Medical UniversityRenqiu 062552Hebei ProvinceChina department of Radiology North China Petroleum Bureau General HospitalHebei Medical UniversityRenqiu 062552Hebei ProvinceChina department of Oncology No.1 Hospital of Shijiazhuang CityShijiazhuang 050000China

BACKGROUND The survival of patients treated with monotherapy for hepatic malignancies is not ideal.A comprehensive program of cryoablation combined with radiotherapy for the treatment of hepatic malignancies results in less trauma to the *** may provide an option for the treatment of patients with advanced hepatic *** SUMMARY We reported 5 cases of advanced-stage hepatic malignancies treated in our hospital from 2017-2018,including 3 cases of primary hepatocellular carcinoma and 2 cases of metastatic hepatic *** first received cryoablation therapy on their liver *** procedure consisted of 2 freeze-thaw cycles,and for each session,the duration of freezing was 13-15 min,and the natural rewarming period was 2-8 *** on the tumor size,the appropriate cryoprobes were selected to achieve complete tumor ablation to the greatest extent *** cryoablation surgery,intensity-modulated radiotherapy(IMRT)for liver lesions was performed,and the radiotherapy regimen was 5400 cGy/18f and 300 cGy/*** of the 5 patients had adverse events above grade II,and their quality of life was significantly *** them,4 patients were free of disease progression in the liver lesions under local control,and their survival was prolonged;3 patients are still *** Our clinical practice demonstrated that cryoablation combined with IMRT could be implemented *** definitive efficacy for hepatic malignancies needs to be confirmed in larger-size sample prospective studies.

关键词： Hepatic malignancies Primary hepatocellular carcinoma Metastatic hepatic carcinoma Cryoablation Intensity-modulated radiotherapy Case report