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Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation

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Cellular & Molecular Immunology 2021年第5期18卷 1172-1185页

作者： Huidong Guo Ying-Jun Chang Yan hong Lan-Ping Xu Yu wang Xiao-Hui Zhang Ming wang huan Chen Yu-hong Chen Feng-Rong wang Wei-Han Yu-Qian Sun Chen-hua Yan Fei-Fei tang Xiao-Dong Mo Kai-Yan liu Xiao-Jun huang Peking university People’s hospital&Peking university Institute of Hematology National Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationNo.11 South Street of XizhimenXicheng District100044BeijingChina Peking-Tsinghua Center for life Sciences 100871BeijingChina Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences2019RU029BeijingChina

Haploidentical stem cell transplantation(haplo-SCT)achieves superior or at least comparable clinical outcomes to HLA-matched sibling donor transplantation(MSDT)in treating hematological *** define the underlying regulatory dynamics,we analyzed time courses of leukemia burden and immune abundance of haplo-SCT or MSDT from multiple ***,we employed two nonirradiated leukemia mouse models which carried human AML-ETO or MLL-AF9 fusion gene to establish haplo-identical and major histocompatibility(MHC)-matched transplantation models and investigated the immune cell dynamic response during leukemia development in *** found that haplo-matching the MHCs of leukemia cells with recipient mouse T cells prolonged leukemic mice survival and reduced leukemia *** stronger graft-versus-leukemia activity in haplo-SCT group mainly induced by decreased apoptosis and increased cytotoxic cytokine secretion including tumor necrosis factor–α,interferon-γ,pore-forming proteins and CD107a secreted by T cells or natural killer ***,we conducted a prospective clinical trial which enrolled 135 patients with t(8;21)acute myeloid leukemia that displayed minimal residual disease before transplantation and underwent either haplo-SCT or *** results showed that the haplo-SCT slowed the kinetics of the leukemia burden in vivo and reduced the cumulative incidence of relapse compared with *** vivo experiments showed that,1 year after transplantation,cytotoxic T lymphocytes from the haplo-SCT group had higher cytotoxicity than those from the MSDT group during the same *** results unraveled the role of immune cells in superior antileukemia effects of haplo-SCT compared with MSDT.

关键词： Graft-versus-leukemia Haplo-SCT MSDT AML MRD

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日间化疗改良全预约模式的实施与效果评价

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复旦学报（医学版） 2024年第2期51卷 205-210页

作者：刘玉华陆海燕曾晶王伟英复旦大学附属肿瘤医院护理部上海200032 复旦大学上海医学院肿瘤学系上海200032

目的探讨门诊患者日间化疗改良全预约模式的运行效果,为进一步完善就诊流程提供参考依据。方法在复旦大学附属肿瘤医院门诊信息系统中实施改良全预约模式,将日间化疗评估与信息嵌合,制定化疗预约规则并集成信息管理。比较优化后(2022年1... 详细信息

目的探讨门诊患者日间化疗改良全预约模式的运行效果,为进一步完善就诊流程提供参考依据。方法在复旦大学附属肿瘤医院门诊信息系统中实施改良全预约模式,将日间化疗评估与信息嵌合,制定化疗预约规则并集成信息管理。比较优化后(2022年1—9月)与优化前同期(2021年1—9月)患者就诊花费时间、人力运营情况、患者化疗期间的安全性、护士及患者满意度的差异。结果优化前患者就诊花费时间52.12(32.73~83.05)min,优化后减少至20.04(11.87~41.10)min,优化前后比较差异有统计学意义(z=-78.144,P1),且优化前后患者就诊花费时间在60 min的分布差异有统计学意义(χ2=5958.455,P1)。优化前日间化疗中心预约窗口须安排1名护士及2~3名保安人员,优化后无须安排预约护士,保安人数减少至1名,人力运营得到优化。优化后化疗输液反应例数降低(从59例降低至46例)且抢救留观患者数量减少(从4例降低至1例),非白班时段无抢救事件发生,提升了患者治疗期间的安全性。优化前后护士及患者满意度比较差异均有统计学意义(P<0.05)。结论改良全预约模式的采用降低了患者就诊花费时间,优化了人力运营,并提高了患者化疗期间的安全性,护士和患者对此模式满意度均增加。日间化疗改良全预约模式有利于日间化疗中心运营。

关键词：门诊患者日间化疗全预约模式就诊花费时间

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硫铁矿焙烧系统中三氧化硫含量与pH的关系

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广州化工 2024年第15期52卷 146-148,157页

作者：水海华林天云许立信万超铜陵有色金属集团股份有限公司铜冠冶化分公司安徽铜陵244001 安徽工业大学化学与化工学院安徽马鞍山243032

硫铁矿是重要的冶金原料之一,在冶炼工业中应用广泛,它的主要化学成分为二硫化亚铁,是一种重要的化学矿物原料,常用来制造硫酸,其矿渣可用来炼铁、炼钢,若炉渣含硫量较高,含铁量不高时,可以用作水泥的附属原料;硫铁矿也会用于制造硫磺... 详细信息

硫铁矿是重要的冶金原料之一,在冶炼工业中应用广泛,它的主要化学成分为二硫化亚铁,是一种重要的化学矿物原料,常用来制造硫酸,其矿渣可用来炼铁、炼钢,若炉渣含硫量较高,含铁量不高时,可以用作水泥的附属原料;硫铁矿也会用于制造硫磺或者其他含硫的化合物。在实际生产过程中,转化氛围对产品性能和过程能耗有显著影响,基于此,本文主要研究了硫铁矿焙烧中pH-硫酸浓度之间的关系,为硫酸类溶液体系的pH和酸碱度分析提供了试验依据和预测理论模型。

关键词：硫铁矿三氧化硫 pH 焙烧二氧化硫

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Tryptase activates AP in inflammatory reaction in ECV304 cells

Tryptase activates AP in inflammatory reaction in ECV304 cel...

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中国微循环学会第五届中国微循环学术大会

作者： Bin Zhang, Ruizhe Qian~*, chao Lu, Fengdi Zhao, lianhua Yin department of Physiology and Pathophysiology, Shanghai medical College, Fudan university, Shanghai 200032, china)

＜正＞Tryptase, a serine protease, is stored in mast cell granules and secreted by degranulation after activation of the cells. Tryptase was reported to be involved in proteinase-activated receptor-2 （PAR-2） mediated up-regulation of IL-8 expression. In the present report, the effects of tryptase on PAR-2 mediated-downstream signal transduction elements for the up-regulation have been studied. The expressions of the downstream elements, NF-κB, AP-1 and protein kinase B （PKB）, JNK, and p38MAPK were monitored by RT-PCR following tryptase treatment in human umbilical endothelial cell line （ECV304）. The expression of NF-κB started to increase at the first hr in ECV304 cells after tryptase treatment （1 ng/ml）. At 4 hr, the increase reached the plateau, the NF-κB expression increased by 3.1-fold （n=3, p＜0.05）, AP-1 by 2-fold （n=3, p＜0.05）, and PKB by 10.6-fold （n=3, p＜0.05）. However, the treatment does not affect the expression of JNK and p38MAPK comparing with control cells. Furthermore, the tryptase treatment also increased phosphorylation of PKB by 2-fold at 15min following the treatment. The up-regulation of the expression and phosphorylation of PKB by tryptase could be abolished by either phosphoinositol-3-kinase （PI3K） inhibitor （LY294002） at 10μM or antisense PKB cDNA transfection. The up-regulation of NF-κB expression could be inhibited by LY294002 and antisense PKB cDNA. These results indicate that tryptase can induce PI3K-Akt pathway through PAR2 receptor, then NF-κB and IL-8 expression.

关键词： tryptase PAR-2 PKB NF-κB inflammation mast cell

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VARICOCELE CAUSED BY DIFFUSE LARGE B-CELL LYMPHOMA: A CASE REPORT

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medical Bulletin of Shanghai Jiaotong university 2011年第2期23卷 83-85页

作者：李超徐月敏 department of Urology Shanghai Sixth People's Hospital Shanghai Jiaotong University

Varicocele caused by diffuse large B-cell lymphoma is rare. Here, we reported our findings in a 48-year-old man, who was admitted to our hospital because of left varicocele for 5 months. The operation of high ligation of the left spermatic vein was performed. However, we found a 6.0 cm×3.0 cm×3.0 cm solid mass in the region of the inside of the left iliac vessels. The lump was removed and the histopathologic diagnosis was diffuse malignant large B-cell lymphoma. The patient was started on a CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) definitive therapy.

关键词： diffuse large B-cell lymphoma varicocele

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Diagnostic approaches for pancreatic tuberculosis

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 107-110页

作者： Chang-Xin wu li-Bing Xiao Zhong-Fei Luo Shao-hua Shi department of Hepatobiliary and Pancreatic Surgery Jinjiang Municipal HospitalJinjiang 362200China department of Hand Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310000China department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310000China

To the Editor:Pancreatic tuberculosis refers to tuberculosis of pancreas and peripancreatic lymph nodes due to both conditions having similar clinical manifestations and therapeutic regimens[1,2].It is a rare entity worldwide,which is often shown as mass and treated by the unnecessary surgery due to misdiagnosis as pancreatic malignancy[1,2].

关键词： tuberculosis clinical surgery

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Vestigial like family member 3 is a novel prognostic biomarker for gastric cancer

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World Journal of Clinical Cases 2019年第15期7卷 1954-1963页

作者： li-hua Zhang Zhuo wang Long-Hai li Yan-Kui liu lin-Fang Jin Xiao-Wei Qi Chun Zhang Teng wang Dong hua School of Pharmaceutical Sciences Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina department of Oncology Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina department of Geriatrics Affiliated Wuxi First People's Hospital of Nanjing Medical UniversityWuxi 214122Jiangsu ProvinceChina wuxi medical College Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina department of Pathology Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina

BACKGROUND Vestigial like family member 3(VGLL3)is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma,but its role in gastric cancer(GC)is *** To explore the expression pattern and clinical significance of VGLL3 in *** Integrative analysis was performed on the GC transcriptome profiles and survival information deposited in the ONCOMINE,GEPIA,and ONCOLNC *** expression levels of VGLL3 mRNA and protein were analyzed in the freshly resected tumor and normal gastric tissues from GC patients by quantitative RT-PCR and Western blot,*** addition,the in situ expression of VGLL3 in the GC tissues was determined by immunohistochemistry(IHC),and the patients were accordingly classified into the high and low expression *** correlation of VGLL3 expression status with patient prognosis was then determined by univariate and multivariate Cox regression *** Analysis of the ONCOMINE and GEPIA databases showed that VGLL3 was significantly up-regulated in GC tissues(P=0.003),and associated with the tumor TNM stage(P=0.0163).The high VGLL3 expression group had a significantly worse prognosis compared to the low expression group,as per both GEPIA(P=0.0057)and ONCOLNC(P=0.01).The bioinformatics results were validated by the significantly higher VGLL3 mRNA and protein levels in the GC tissues compared to the adjacent normal tissues(P1)in a cohort of 30 GC ***,high in situ expression of VGLL3 protein was associated with more advanced N and TNM stages and HER2 mutation(P172 ***-Meier analysis showed that the high VGLL3 expression group had a worse prognosis compared to the low expression group(P=0.019).Multivariate analysis showed that VGLL3 expression status was an independent risk factor for *** addition,the prognostic risk model nomogram showed that VGLL3 was the most important indicator,with an area under the receiver operating character

关键词： Vestigial like family member 3 Stomach adenocarcinoma HER2 mutation Gastric cancer Bioinformatics analysis

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基于网络药理学和实验验证探讨毛菊苣治疗肝纤维化作用机制

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中国现代应用药学 2024年第3期41卷 303-312页

作者：杨建华耿若愚臧薇李茜杜超胡君萍新疆医科大学第一附属医院乌鲁木齐830054 新疆医科大学药学院乌鲁木齐830017 河北廊坊市药品检验所河北廊坊065000

目的采用网络药理学和实验验证的方法探究毛菊苣抗肝纤维化的作用机制。方法借助TCMSP、Pubchem、SwissTargetPrediction、Genecards等数据库构建“成分-靶点-通路”作用网,STRING数据库预测毛菊苣抗肝纤维化作用靶点,应用DAVID数据库进... 详细信息

目的采用网络药理学和实验验证的方法探究毛菊苣抗肝纤维化的作用机制。方法借助TCMSP、Pubchem、SwissTargetPrediction、Genecards等数据库构建“成分-靶点-通路”作用网,STRING数据库预测毛菊苣抗肝纤维化作用靶点,应用DAVID数据库进行KEGG和GO富集分析,AUTODOCK对活性成分和关键靶点进行分子对接。用PDGFBB诱导活化细胞,验证秦皮甲素、秦皮乙素、菊苣酸、咖啡酸、绿原酸和异绿原酸等6个化合物对HSC-T6细胞的增殖、凋亡以及对肝纤维化指标的影响,Western blotting检测各成分对HSC-T6细胞中Ras、ERK1、ERK2、C-fos、JNK蛋白表达。结果网络药理学筛选到成分与肝纤维化的共同靶点239个,PPI分析显示SRC、STAT3、HSP90AA1等靶点为关键靶点,KEGG分析结果显示毛菊苣影响的通路包括癌症通路、代谢通路等,GO分析预测毛菊苣主要影响信号转导等过程,分子对接结果显示与成分能够良好结合的靶点蛋白为MAPK1,与蛋白能够良好结合的成分为秦皮乙素、咖啡酸和绿原酸。6种化合物对PDGF-BB诱导HSC-T6细胞活化增殖的抑制作用均强于模型组,且均具有逆转肝纤维化指标的作用,其中秦皮乙素活性最强(P1)。与模型组相比,6种化合物干预后HSC-T6细胞中的Ras、ERK1、ERK2、C-fos、JNK表达量均有所下降。结论毛菊苣中各成分均有不同的抗肝纤维化作用,其作用与抑制ERK/RAS通路激活的有关。

关键词：毛菊苣肝纤维化网络药理学分子对接实验验证

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西京医院信息化建设及应用

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计算机工程 2000年第S1期26卷 35-39页

作者：高东怀骆晔蔡宏伟第四军医大学网络中心西安710032 西京医院网络中心西安710032

本文从一般医科院校附属医院承担的医疗、教学和科研任务出发，介绍在此类医院建立综合信息管理网和教学、科研网两套网络的必要性，着重介绍了西京医院两套网络的建设方案、结构和应用情况。

关键词：校园网局域网医院信息系统

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Gut microbiotad-a positive contributor in the process of intermittent fasting-mediated obesity control

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Animal Nutrition 2021年第4期7卷 1283-1295页

作者： Bohan Rong Qiong wu Muhammad Saeed chao Sun College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi712100China department of Pathophysiology Qinghai University Medical CollegeXiningQinghaiChina Faculty of Animal Production&Technology Cholistan University of Veterinary and Animal SciencesBahawalpur63100Pakistan

Historically,intermittent fasting(IF)has been considered as an effective strategy for controlling the weight of athletes before *** with excellent insight into its application in various spaces by numerous studies,increasing IF-mediated positive effects have been reported,including anti-aging,neuro protect ion,especially obesity ***,the gut microbiota has been considered as an essential manipulator for host energy metabolism and its structure has been reported to be sensitive to dietary structure and habits,indicating that there is a potential and strong association between IF and gut *** this paper,we focus on the crosstalk between these symbionts and energy metabolism during IF which hold the promise to optimize host energy metabolism at various physical positions,including adipose tissue,liver and intestines,and further improve milieu internal ***,this paper also discusses the positive function of a potential recommendatory strain(Akkermansia muciniphila)based on the observational data for IF-mediated alternated pattern of gut microbiota and a hopefully regulatory pathway(circadian rhythm)for gut microbiota in IF-involved improvement on host energy ***,this review addresses the limitation and perspective originating from these studies,such as the association with tissue-specific bio-clock and single strain research,which may continuously reveal novel viewpoints and mechanisms to understand the energy metabolism and develop new strategies for treating obesity,diabetes,and metabolic disorders.

关键词： Intermittent fasting Gut microbiota Obesity Akkermansia muciniphila

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