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Boundary effect of toppling failure based on three-dimensional mechanical model

Journal of Mountain Science 2022年第11期19卷 3314-3322页

作者： CAI Jun-chao ZHENG Da JU Neng-pan HUANG Run-qiu ZHAO Wei-hua School of Civil Engineering Henan University of Science and TechnologyLuoyang 471023China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Environment and Civil Engineering Chengdu University of TechnologyChengdu 610059China

Previous researches on the mechanical model of toppling failure mainly concentrated on twodimensional mechanical model(TwDM) analysis. The TwDM analysis assumes the width of the slab beam is unit width without considering the lateral constraint force. The assumed conditions are obviously different from the site conditions, thus there is a certain difference between the calculated results and the field work. A three-dimensional mechanical model(ThDM)of toppling failure was established, considering that the slab beam was mainly subject to self-weight, the frictional resistance of interlayer and lateral constraint force. Due to the progressive characteristics of toppling failure, the concept and the formula of the first fracture depth(FFD) of toppling was raised and constructed. The case study indicates that the ThDM is more effective and can be accurately used to calculate the toppling fracture depth of the slab beam. The FFD decreases proportionally with the increase of slab beam width. FFD grows fast when the slab beam width is less than 2.0 m and it tends to be stable when the slab beam width is above 2.0 m. The FFD decreases with the increase of the lateral constraint coefficient, indicating that the boundary condition of the free space is positively correlated with the stability and depth of toppling. This is a good explanation of the free space effect. This study provides a reference for the stability evaluation and prevention-control design of toppling slope in the future.

关键词： Boundary effect Toppling failure Three-dimensional mechanical model(ThDM) First fracture depth(FFD) Free face Slope failure

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Electrochemical Selective Oxidative Synthesis of Diversified Sulfur Heterocycles fromβ-Ketothioamides

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Chinese Journal of Chemistry 2021年第7期39卷 1831-1837页

作者： Li-Rong Wen Ning-Ning Wang Wu-Bo Du Ming-Zhe Zhu Chao Pan Lin-Bao Zhang Ming Li State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science&TechnologyQingdaoShandong266042 China

Main observation and conclusion A general and practical protocol for the construction of diversified sulfur heterocycles has been described through organic electrosynthesis means.In undivided cell,dihydrothiophenes,thiazolines and 1,4-dithiines could be easily generated from various availableβ-ketothioamides under metal-free and external oxidant-free conditions.

关键词： Sulfur Synthesis design Annulation Metal-free Electrosynthesis

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Fgf8^(P2A-3×GFP/+):A New Genetic Mouse Model for Specifically Labeling and Sorting Cochlear Inner Hair Cells

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Neuroscience Bulletin 2023年第12期39卷 1762-1774页

作者： Yi pan Shuting Li Shunji He Guangqin Wang chao Li Zhiyong Liu Mingliang Xiang Department of Otolaryngology and Head and Neck Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai201210China

The cochlear auditory epithelium contains two types of sound receptors,inner hair cells(IHCs)and outer hair cells(OHCs).Mouse models for labelling juvenile and adult IHCs or OHCs exist;however,labelling for embryonic and perinatal IHCs or OHCs are lacking.Here,we generated a new knock-in Fgf8^(P2A-3×GFP/+)(Fgf8^(GFP)/+)strain,in which the expression of a series of three GFP fragments is controlled by endogenous Fgf8 cis-regulatory elements.After confirming that GFP expression accurately reflects the expression of Fgf8,we successfully obtained both embryonic and neonatal IHCs with high purity,highlighting the power of Fgf8^(GFP)/+.Furthermore,our fate-mapping analysis revealed,unexpectedly,that IHCs are also derived from inner ear progenitors expressing Insm1,which is currently regarded as an OHC marker.Thus,besides serving as a highly favorable tool for sorting early IHCs,Fgf8^(GFP)/+will facilitate the isolation of pure early OHCs by excluding IHCs from the entire hair cell pool.

关键词： Fgf8 Inner Hair Cell Inner Ear-Cochlea

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Potential roles of vitamin D binding protein in attenuating liver injury in sepsis

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Military Medical Research 2022年第5期9卷 543-552页

作者： Kun Xiao Du-chao Zhang Ye Hu Li-Cheng Song Jian-Qiao Xu Wan-Xue He pan pan Yu-Wei Wang Li-Xin Xie Center of Pulmonary and Critical Care Medicine Chinese People's Liberation Army(PLA)General HospitalNo.28Fuxing StreetHaidian DistrictBeijing 100853China Department of Pulmonary and Critical Care Medicine Beijing Shijitan HospitalBeijing 100071China Medical School of Chinese People's Liberation Army(PLA) Chinese PLA General HospitalBeijing 100853China Department of Geriatric Comprehensive Surgery the Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalNo.28Fuxing StreetHaidian DistrictBeijing 100853China

Background:In sepsis,vitamin D binding protein(VDBP)has been shown to be low-expressed.The current study examined the relationship between serum VDBP level and liver injury in sepsis patients,as well as in a mouse model for sepsis and in cultured liver epithelial cell line exposed to lipopolysaccharide(LPS).Methods:The human study included 78 sepsis patients and 50 healthy volunteers.Sepsis patients were categorized into sepsis survivor group(n=43)and sepsis non-survivor group(n=35)based on 28-day mortality for data analysis.Adult male C57BL/6 mice were subjected to cecal ligation and puncture(CLP).Serum samples were collected on day 1,3,5 and 7 to determine the levels of VDBP,25-hydroxyvitamin D[25(OH)D_(3)],1,25-dihydroxyvitamin D[1,25(OH)_(2)D_(3)],interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α).Potential protective effects of VDBP overexpression against LPS-induced liver damage were examined in cultured THLE2 cells.Results:Serum levels of VDBP,25(OH)D_(3),and 1,25(OH)_(2)D_(3)were significantly lower in sepsis patients vs.the healthy control(P<0.001),as well as in the sepsis non-survivor group vs.the sepsis survivor group(P<0.001,P=0.0338,or P=0.0013,respectively).Lower serum VDBP level was associated with higher Acute Physiology and Chronic Health Evaluation(APACHE)II score(r=−0.2565,P=0.0234)and Sequential Organ Failure Assessment score(r=−0.3522,P=0.0016),but lower serum albumin(ALB,r=0.4628,P<0.001)and total protein(TP,r=0.263,P=0.02).In CLP mice,there was a 5-day period of serum VDBP reduction,followed by return towards the baseline on day 7.VDBP was also decreased in LPS-treated THLE2 cells(P<0.001).VDBP overexpression reduced LPS-induced THLE2 damage.Reduced damage was associated with decreased oxidative stress and inactivation of the c-Jun N-terminal kinase signaling pathway.Conclusion:VDBP may be protective against sepsis-induced liver injury.

关键词： Vitamin D binding protein Sepsis Human Mouse Liver Injury c-Jun N-terminal kinase

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Vapor growth of V‑doped MoS_(2)monolayers with enhanced B‑exciton emission and broad spectral response

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Frontiers of Optoelectronics 2023年第4期16卷 109-120页

作者： Biyuan Zheng Xingxia Sun Weihao Zheng Chenguang Zhu chao Ma Anlian pan Dong Li Shengman Li Key Laboratory for Micro-Nano Physics and Technology of Hunan Province State Key Laboratory of Chemo/Biosensing and ChemometricsHunan Institute of Optoelectronic IntegrationCollege of Materials Science and EngineeringHunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies and Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and Technology(HUST)Wuhan 430074China

Dynamically engineering the optical and electrical properties in two-dimensional(2D)materials is of great signifcance for designing the related functions and applications.The introduction of foreign-atoms has previously been proven to be a feasible way to tune the band structure and related properties of 3D materials;however,this approach still remains to be explored in 2D materials.Here,we systematically demonstrate the growth of vanadium-doped molybdenum disulfde(V-doped MoS_(2))monolayers via an alkali metal-assisted chemical vapor deposition method.Scanning transmission electron microscopy demonstrated that V atoms substituted the Mo atoms and became uniformly distributed in the MoS_(2)monolayers.This was also confrmed by Raman and X-ray photoelectron spectroscopy.Power-dependent photoluminescence spectra clearly revealed the enhanced B-exciton emission characteristics in the V-doped MoS_(2)monolayers(with low doping concentration).Most importantly,through temperature-dependent study,we observed efcient valley scattering of the B-exciton,greatly enhancing its emission intensity.Carrier transport experiments indicated that typical p-type conduction gradually arisen and was enhanced with increasing V composition in the V-doped MoS_(2),where a clear n-type behavior transited frst to ambipolar and then to lightly p-type charge carrier transport.In addition,visible to infrared wide-band photodetectors based on V-doped MoS_(2)monolayers(with low doping concentration)were demonstrated.The V-doped MoS_(2)monolayers with distinct B-exciton emission,enhanced p-type conduction and broad spectral response can provide new platforms for probing new physics and ofer novel materials for optoelectronic applications.

关键词： Atomic substitution.V-doped MoS_(2) Distinct B-exciton Broad spectral response

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Microneedles for Enhanced Topical Treatment of Skin Disorders:Applications,Challenges,and Prospects

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Engineering 2023年第11期30卷 170-189页

作者： Tingting Peng Yangyan Chen Wanshan Hu Yao Huang Minmin Zhang chao Lu Xin pan Chuanbin Wu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development Ministry of Education of the People’s Republic of ChinaCollege of PharmacyJinan UniversityGuangzhou 511436China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Faculty of Pharmacy University of HelsinkiHelsinki 00014Finland

Microneedles(MNs)can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions,resulting in increased therapeutic efficacy while having minimum side effects.MNs are used to deliver different kinds of therapeutics(e.g.,small molecules,macromolecules,nanomedicines,living cells,bacteria,and exosomes)for treating various skin disorders,including superficial tumors,wounds,skin infections,inflammatory skin diseases,and abnormal skin appearance.The therapeutic efficacy of MNs can be improved by integrating the advantages of multiple therapeutics to perform combination therapy.Through careful designing,MNs can be further modified with biomimetic structures for the responsive drug release from internal and external stimuli and to enhance the transdermal delivery efficiency for robust therapeutic outcomes.Some studies have proposed the use of drug-free MNs as a promising mechanotherapeutic strategy to promote wound healing,scar removal,and hair regeneration via a mechanical communication pathway.Although MNs have several advantages,the practical application of MNs suffers from problems related to industrial manufacture and clinical evaluation,making it difficult for clinical translation.In this study,we summarized the various applications,emerging challenges,and developmental prospects of MNs in skin disorders to provide information on ways to advance clinical translation.

关键词： Microneedles Transdermal drug delivery system Skin disorders Treatments Challenges Prospects

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Synthesis and combined properties of novel fluorinated cationic surfactants derived from hexafluoropropylene dimer

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Chinese Chemical Letters 2018年第11期29卷 1613-1616页

作者： chao Lin Renming pan Ping Xing Biao Jiang School of Chemical Engineering Nanjing University of Science and Technology CAS Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic ChemistryChinese Academy of Sciences

Three novel fluorinated cationic surfactants were prepared by adopting perfluoro-2-methy1-2-pentene as raw substrate. The as-obtained fluorinated cationic surfactants exhibited excellent surface properties, all of them can reduce the surface tension of water to below 20.00mN/m at the critical micelle concentrations （CMC）. The incorporation of SDS, AOS, APG or LAB into 2-（4-（3,3,4,4,5,5,5-heptafluoro- 2,2-bis（trifluoromethyl）pentyl）benzamido）-N,N-dimethylethana-mine oxide 4a could generate much lower CMC and surface tension value at the CMC than individual 4a. Especially, the surface tension values of that combined APG/4a can be reduced to 17.31 mN/m. The excellent surface activities and their remarkable compatibility to various types of hydrocarbon surfactants make them as sustainable alternatives to PFOA （perfluorooctanoic acid, C7F15CO2H） and PFOS （perfluorooctane sulphonate, C8F17SO3X, with X = K, Na, H）.

关键词： Fluorinated cationic surfactants Surface tension Combined properties Fire fighting Aqueous film forming foams

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Down-regulation of extracellular signal-regulated kinase 1/2 activity in P-glycoprotein-mediated multidrug resistant hepatocellular carcinoma cells

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World Journal of Gastroenterology 2009年第12期15卷 1443-1451页

作者： Feng Yan Xiao-Min Wang Chao Pan Quan-Ming Ma Department of Hepatobiliary Surgery Postdoctoral Station Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China Department of Hepatobiliary Surgery Digestive Diseases Institute Xiamen University Xiamen 361004 Fujian Province China Department of Pathology Zhongshan HospitalXiamen university Xiamen 361004 Fujian Province China Department of Hepatobiliary Surgery Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China

AIM:To study the expression and phosphorylation of extracellular signal-regulated kinase(ERK)1 and ERK2 in multidrug resistant(MDR)hepatocellular carcinoma(HCC)cells.METHODS:MDR HCC cell lines,HepG2/adriamycin(ADM)and SMMC7721/ADM,were developed by exposing parental cells to stepwise increasing concentrations of ADM.MTT assay was used to determine drug sensitivity.Flow cytometry was employed to analyze cell cycle distribution and measure cell P-glycoprotein(P-gp)and multidrug resistant protein 1(MRP1)expression levels.ERK1 and ERK2 mRNA expression levels were measured by quantitative real-time PCR(QRTPCR).Expression and phosphorylation of ERK1 and ERK2 were analyzed by Western blot.SMMC7721/ADM were resistant not only to ADM,but also to multiple anticancer drugs.The P-gp expression was over 10-fold higher in HepG2/ADM cells than in HepG2 cells(8.92%±0.22%vs 0.88%±0.05%,P<0.001)and over 4-fold higher in SMMC7721/ADM cells than in SMMC7721 cells(7.37%±0.26%vs 1.74%±0.25%,P<0.001).However,the MRP1 expression was not significantly higher in HepG2/ADM and SMMC7721/ADM cells than in parental cells.In addition,the percentage of MDR HepG2/ADM and SMMC7721/ADM cells was significantly decreased in the G0/G1 phase and increased in the the S phase or G2/M phase.QRT-PCR analysis demonstrated that the ERK1 and ERK2 mRNA expression increased apparently in HepG2/ADM cells and decreased significantly in SMMC7721/ADM cells.Compared with the expression of parental cells,ERK1 and ERK2 protein expressions were markedly decreased in SMMC7721/ADM cells.However,ERK2 protein expression was markedly increased while ERK1 protein expression had no significant change in HepG2/ADM cells.Phosphorylation of ERK1 and ERK2 was markedly decreased in both HepG2/ADM and SMMC7721/ADM MDR cells.CONCLUSION:ERK1 and ERK2 activities are downregulated in P-gp-mediated MDR HCC cells.ERK1 or ERK2 might be a potential drug target for circumventing MDR HCC cells.

关键词：细胞外信号调节激酶1 多药耐药蛋白肝癌细胞株糖蛋白 SMMC7721 HepG2细胞介导 Western印迹

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Relationship between population competitive intensity and yield in maize cultivars

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Journal of Integrative Agriculture 2017年第6期16卷 1312-1321页

作者： ZHAI Li-chao XIE Rui-zhi LI Shao-kun FAN pan-pan Institute of Crop Sciences Chinese Academy of Agricultural Sciences/Key Laboratory of Crop Physiology and Ecology Ministry of Agriculture Center for Agricultural Resources Research Institute of Genetics and Development Biology Chinese Academy of Sciences

Competition is a common phenomenon in agriculture production.Research on the relationship between competitive ability and crop yield is extensive,but the results have been inconsistent.Few studies have focused on the relationship between population competitive intensity and yield of maize（Zea mays L.）cultivars.The main objective of this study was to determine if a consistent relationship exists between maize yield and competitive ability.A two-year field experiment was conducted,employing a de Wit replacement series design.When two maize cultivars were grown in a mixture,yield was reduced for the modern cultivar and increased for the older cultivar.In each replacement series,per plant level yield of each cultivar,and population level yield of the mixture,decreased with increasing proportion of the older cultivar.Competitive ratio（CR）reflected differences in competitive ability of the three maize cultivars.In each replacement series,population competition pressure（PCP）increased with increasing proportion of the older cultivar,indicating that the older cultivar was a strong competitor.Biomass yield,grain yield,harvest index,thousand-kernel weight,and kernel number per plant,were negatively correlated with PCP.Our results demonstrated that inter-cultivar competition affects maize productivity,and increasing PCP will decrease translocation of assimilates to grain and,ultimately,reduce yield.Therefore,there is a negative correlation between population competitive intensity and yield performance in maize,breeders should develop a communal ideotype that would not perform well in competition in future.

关键词： maize competition competitive ability population competitive pressure yield

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Orthogonal modular biosynthesis of nanoscale conjugate vaccines for vaccination against infection

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Nano Research 2022年第2期15卷 1645-1653页

作者： Xin Li Chao Pan Peng Sun Zhehui Peng Erling Feng Jun Wu Hengliang Wang Li Zhu State Key Laboratory of Pathogen and Biosecurity Beijing Institute of BiotechnologyBeijing 100071China

Conjugate vaccines represent one of the most effective means for controlling the occurrence of bacterial diseases.Although nanotechnology has been greatly applied in the field of vaccines,it is seldom used for conjugate vaccine research because it is very difficult to connect polysaccharides and nanocarriers.In this work,an orthogonal and modular biosynthesis method was used to produce nanoconjugate vaccines using the SpyTag/SpyCatcher system.When SpyTag/SpyCatcher system is combined with protein glycosylation technology,bacterial O-polysaccharide obtained from Shigela flexneri 2a can be conjugated onto the surfaces of different virus-like particles(VLPs)in a biocompatible and controlled manner.After confirming the excellent lymph node targeting and humoral immune activation abilities,these nanoconjugate vaccines further induced efficient prophylactic effects against infection in a mouse model.These results demonstrated that natural polysaccharide antigens can be easily connected to VLPs to prepare highly efficient nanoconjugate vaccines.To the best of the researchers1 knowledge,this is the first time VLP-based nanoconjugate vaccines are produced efficiently,and this strategy could be applied to develop various pathogenic nanoconjugate vaccines.

关键词： Shigela flexneri 2a O-polysaccharide virus-like particle SpyTag/SpyCatcher system nanoconjugate vaccines

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