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Design,synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus

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Chinese Chemical Letters 2007年第4期18卷 421-423页

作者： Qiu Qin He chao mei liu Ke Li Yong Bing Cao School of Pharmacy Second Military Medical University Shanghai 200433 China

Based on the active site of Aspergillus fumigatus lanosterol 14α-demethylase （AF-CYP51）, novel triazole compounds were designed. Their chemical synthesis and the antifungal activities were reported. The results showed that all the target compounds exhibited excellent activities with broad spectrum; in which compounds 4, 12 and 15 showed comparable activities against A. fumigatus to the control drug itraconazole.

关键词： CYP51 Antifungal Triazole Synthesis Aspergillus fumigatus

Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

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Chinese Chemical Letters 2007年第11期18卷 1323-1326页

作者： Hong Gang Hu Ming Juan Wang Qing Jie Zhao Shi Chong Yu chao mei liu Qiu Ye Wu Department of Chemistry College of Science Wayne State University Detroit MI 48202 United States Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

Protein tyrosine phosphatase 1 B （PTP1 B） has received considerable attention from the drug industry as a potential treatment for diabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized and evaluated for their PTP1B inhibitory activity. Some of them displayed good inhibitory activity on PTP1B.

关键词： Mangiferin Protein tyrosine phosphatase 1B Dedvates Inhibition

First total synthesis of (±)-trolline

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Chinese Chemical Letters 2007年第6期18卷 651-652页

作者： Qiu Qin He[a] chao mei liu[a]&Email:anrry_lcm@*** Ke Li[a] [a]School of Pharmacy Second Military Medical University Shanghai 200433 China

Trolline, a new bioactive alkaloid was isolated in 2004. We reported herein the first total synthesis of (±)-trolline, in two steps and 18.0% overall yield.

关键词： Total synthesis Trolline Alkaloid

Design, synthesis and molecular docking studies of novel triazole antifungal compounds

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Chinese Chemical Letters 2007年第6期18卷 663-666页

作者： Qiu Qin He Ke Li Yong Bing Cao Huan Wen Dong Li Hua Zhao chao mei liu Chun Quan Sheng School of Pharmacy Second Military Medical University Shanghai 200433 China

Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities. In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi.

关键词： Lanosterol 14α-demethylase Triazole tert-Butyl Antifungal activity Fluconazole-resistant

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海绵城市系统构建模式

水利学报 2017年第9期48卷 1009-1014,1022页

作者：王浩梅超刘家宏中国水利水电科学研究院流域水循环模拟与调控国家重点实验室北京100038 水利部水资源与水生态工程技术研究中心北京100044

海绵城市是我国城市水问题综合治理的一种新理念。目前科学界和实践部门因各自的专业所限和视角不同,对于海绵城市的本质内涵、构建模式和建设途径还存在诸多不同观点,缺乏统一认识,在一定程度上阻碍了海绵城市研究与实践的深入。本文... 详细信息

海绵城市是我国城市水问题综合治理的一种新理念。目前科学界和实践部门因各自的专业所限和视角不同,对于海绵城市的本质内涵、构建模式和建设途径还存在诸多不同观点,缺乏统一认识,在一定程度上阻碍了海绵城市研究与实践的深入。本文试从对城市水问题的基本判断出发,分析指出海绵城市的科学内涵,综合提出海绵城市构建的系统模式。该模式从系统思维出发,总结了海绵城市建设的本质内涵、系统诊断、基本途径和耦合平衡,并统合于海绵城市"一片天对一片地"核心思想,突破专业限制,从宏观上提出了涵盖海绵城市全要素全过程的系统科学范式,可为海绵城市研究、规划与建设提供基础理论支撑。

关键词：海绵城市城市水问题构建模式城市水文城市化

Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

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Tungsten 2025年第1期7卷 80-87页

作者： Fang-Qian Wang Yin Zhang Wei-Wei Wang mei-Qian Fu Hong-Bing Mo Wei-Dong Yu chao liu Jun Yan College of Chemistry and Chemical Engineering Central South University Junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

关键词： Arsenic CO2 conversion Oxazolidinone Polyoxometalates Vanadium

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-chao Chen Xie liu Changqing Xu Da-Jian Wu Ying Cheng Xiao-Jun liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

Preparation and Performance of Ternary Early Strength Agent and Quercetin Composite Cement Sealing Material

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 130-140页

作者： liu Jian CHEN meiting JI Xiaoli XU chao WANG Chunmei Department of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001China Key Laboratory of Mine Safety and High Efficient Mining Jointly Built by Province and Education Ministry Anhui University of Science and TechnologyHuainan 232001China Department of Chemical Engineering and Explosives Anhui University of Science and TechnologyHuainan 232001China

A ternary early-strengthening agent consisting of calcium formate+triethanolamine+lithium sulfate was compounded with quercetin to shorten the setting time of cementitious materials while ensuring their early *** optimum ratio of the three early-strengthening agents was determined as 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate by response surface *** effects of the ternary early-strengthening agent composed of calcium formate+triethanolamine(TEA)+lithium sulfate on cementitious pore sealing materials under the synergistic effect of quercetin were studied by means of the performance tests of compressive strength,fluidity,and setting time,and the microstructural characterizations of X-ray powder diffractometer(XRD),thermogravimetry(TG-DSC)and scanning electron microscopy(SEM).The study shows that the synergistic effect of ternary early-strengthening agent and quercetin forms a multi-performance composite admixture for cementitious *** best performance was obtained with the compounding scheme of 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate ternary early-strengthening agent and 0.05%*** compressive strength of 1,3,7,and 28 d are 94.8%,39.8%,42%,and 28%higher than those of the blank group,*** initial time and final setting time are 41 and 57 minutes,*** to the microscopic analysis,the network and fibrous C-S-H gels generated by ternary early-strengthening agents are attached to the surface promoted by quercetin,which forms skeleton support while thickening and solidifying the cement slurry,which enhances the early compressive strength of the cement-based materials.

关键词： sealing material ternary early-strengthening agent quercetin synergetic effect response surface methodology

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu chao Fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway