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Hereditary Transthyretin Amyloidosis in Eight Chinese Families

Chinese Medical Journal 2015年第21期128卷 2902-2905页

作者： ling-chao Meng He Lyu Wei Zhang Jing Liu Zhao-Xia Wang Yun Yuan Department of Neurology Peking University First Hospital Beijing 100034 China

Background： Mutations of transthyretin （TTR） cause the most common type of autosomal-dominant hereditary systemic amyloidosis, which occurs worldwide. To date, more and more mutations in the TTR gene have been reported. Some variations in the clinical presentation are often observed in patients with the same mutation or the patients in the same family. The purpose of this study was to find out the clinicopathologic and genetic features of Chinese patients with hereditary TTR amyloidosis. Methods： Clinical and necessary examination materials were collected from nine patients of eight families with hereditary TTR amyloidosis at Peking University First Hospital from January 2007 to November 2014. Sural nerve biopsies were taken for eight patients and skin biopsies were taken in the calf/upper arm for two patients, for light and electron microscopy examination. The TTR genes from the nine patients were analyzed. Results： The onset age varied from 23 to 68 years. The main manifestations were paresthesia, proximal and/or distal weakness, autonomic dysfunction, cardiomyopathy, vitreous opacity, hearing loss, and glossohypertrophia. Nerve biopsy demonstrated severe loss ofmyelinated fibers in seven cases and amyloid deposits in three. One patient had skin amyloid deposits which were revealed from electron microscopic examination. Genetic analysis showed six kinds of mutations of TTR gene, including Val30Met, Phe33Leu, Ala36Pro, Val30Ala, Phe33Val, and Glu42Gly in exon 2. Conclusions： Since the pathological examinations ofsural nerve were negative for amyloid deposition in most patients, the screening for TTR mutations should be performed in all the adult patients, who are clinically suspected with hereditary TTR amyloidosis.

关键词： Amyloidosis Autonomic Nervous Dysfunction Cardiomyopathy: Sensory-motor Neuropathy Transthyretin

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Predictive performance of the variation rate of the driving pressure on the outcome of invasive mechanical ventilation in patients with acute respiratory distress syndrome

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Chinese Journal of Traumatology 2024年第2期27卷 107-113页

作者： Hui-Dan Jing Jun-Ying Tian Wei Li Bing-ling He Hong-chao Li Fu-Xia Jian Cui Shang Feng Shen Department of Intensive Care Unit The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Intensive Care Unit Army Medical Center of PLAChongqing400042China College of Foreign Languges Chongqing Medical UniversityChongqing400016China

Purpose:To assess the value of the driving pressure variation rate(ΔP%)in predicting the outcome of weaning from invasive mechanical ventilation in patients with acute respiratory distress ***:In this case-control study,a total of 35 patients with moderate-severe acute respiratory distress syndrome were admitted to the intensive care unit between January 2022 and December 2022 and received invasive mechanical ventilation for at least 48 h were *** were divided into successful weaning group and failed weaning group depending on whether they could be removed from ventilator support within 14 *** measures including driving pressure,PaO2:FiO2,and positive end-expiratory pressure,*** assessed every 24 h from day 0 to day 14 until successful weaning was *** measurement data of non-normal distribution were presented as median(Q1,Q3),and the differences between groups were compared by Wilcoxon rank sum *** categorical data use the Chi-square test or Fisher's exact test to *** predictive value ofΔP%in predicting the outcome of weaning from the ventilator was analyzed using receiver operating characteristic ***:Of the total 35 patients included in the study,17 were successful vs.18 failed in weaning from a ventilator after 14 days of mechanical *** cut-off values of the medianΔP%measured by Operator 1 *** 2 in the first 4 days were≥4.17%and 4.55%,respectively(p<0.001),with the area under curve of 0.804(sensitivity of 88.2%,specificity of 64.7%)and 0.770(sensitivity of 88.2%,specificity of 64.7%),*** was a significant difference in mechanical ventilation duration between the successful weaning group and the failure weaning group(8(6,13)vs.12(7.5,17.3),p=0.043).The incidence of ventilator-associated pneumonia in the successful weaning group was significantly lower than in the failed weaning group(0.2‰vs.2.3‰,p=0.001).There was a significant difference noted between these

关键词： Driving pressure Driving pressure variation rate Acute respiratory distress syndrome Mechanical ventilation

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Intensive Radiosonde Measurements of Summertime Convection over the Inner Mongolia Grassland in 2014:Difference between Shallow Cumulus and Other Conditions

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Advances in Atmospheric Sciences 2017年第6期34卷 783-790页

作者： Hongrong SHI Hongbin CHEN Xiang'ao XIA Xuehua FAN Jinqiang ZHANG Jun LI chao ling Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China University of Chinese Academy of Sciences Beijing 100049 China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology Nanjing 210044 China

Using radiosonde measurements from 26 July to 30 July 2014 at Baiqi over the Inner Mongolia grassland of China, the vertical structure of shallow cumulus （SCu） clouds and associated environmental conditions were investigated. The cloud base height and the cloud top height of SCu was 3.4 km and 5 km, respectively. The temperature of the SCu layer was less than 0℃. The horizontal advection of specific humidity was smaller than the vertical transport in the atmosphere below 5 km. Above 5 km, the thermodynamic structure of the atmosphere remained stable. At the interface of the cloud layer and free air atmosphere, there was obvious wind shear and a temperature inversion （-2.9~C）. Comparisons of environmental parameters associated with cumulus congestus, rain and clear days, showed that the formation of SCu was characterized by a higher Bowen ratio （high sensible heat flux and low latent heat flux）, which indicated intensive turbulence in the boundary layer. The formation of SCu was associated with the boundary layer height exceeding the lifting condensation level. The maintenance of SCu was likely associated with the lower convective available potential energy, weak wind shear, and weak subsidence of the synoptic system, which did not favor the dramatic vertical development of SCu and thereby the transformation of SCu to cumulus congestus.

关键词： shallow cumulus sounding measurement environmental parameter Inner Mongolia grassland

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Prediction of Toxicity of Phenols and Anilines to Algae by Quantitative Structure-activity Relationship

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Biomedical and Environmental Sciences 2008年第3期21卷 193-196页

作者： GUANG-HUA LU chao WANG XIAO-ling GUO State Key Laboratory for Hydrology-water Resources and Hydraulic Engineering College of Environmental Science and Engineering Hohai University Nanjing 210098 Jiangsu China

Objective To measure the toxicity of phenol, aniline, and their derivatives to algae and to assess, model, and predict the toxicity using quantitative structure-activity relationship （QSAR） method. Methods Oxygen production was used as the response endpoint for assessing the toxic effects of chemicals on algal photosynthesis. The energy of the lowest unoccupied molecular orbital （ELUMO） and the energy of the highest occupied molecular orbital （EHOMO） were obtained from the ChemOffice 2004 program using the quantum chemical method MOPAC, and the frontier orbital energy gap （△E） was obtained. Results The compounds exhibited a reasonably wide range of algal toxicity. The most toxic compound was α-naphthol, whereas the least toxic one was aniline. A two-descriptor model was derived from the algal toxicity and structural parameters： logl/EC50=0.2681ogKow-1.006△E＋11.769 （n=20, r^2=0.946）. This model was stable and satisfactory for predicting toxicity. Conclusion Phenol, aniline, and their derivatives are polar narcotics. Their toxicity is greater than estimated by hydrophobicity only, and addition of the frontier orbital energy gap AE can significantly improve the prediction of logKow-dependent models.

关键词： Toxicity QSARs Frontier orbital energy gap Prediction

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Efficient solar-driven CO_(2)-to-fuel conversion via Ni/MgAlO_(x)@SiO_(2)nanocomposites at low temperature

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Fundamental Research 2024年第1期4卷 131-139页

作者： Xianglei Liu Yueyue ling Chen Sun Hang Shi Hangbin Zheng chao Song Ke Gao Chunzhuo Dang Nan Sun Yimin Xuan Yulong Ding School of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Birmingham Centre for Energy Storage School of Chemical EngineeringUniversity of BirminghamBirmingham B152TTUnited Kingdom

Solar-driven CO_(2)-to-fuel conversion assisted by another major greenhouse gas CH_(4)is promising to concurrently tackle energy shortage and global warming ***,current techniques still suffer from drawbacks of low efficiency,poor stability,and low ***,a novel nanocomposite composed of interconnected Ni/MgAlOx nanoflakes grown on SiO_(2)particles with excellent spatial confinement of active sites is proposed for direct solar-driven CO_(2)-to-fuel *** ultrahigh light-to-fuel efficiency up to 35.7%,high production rates of H_(2)(136.6 mmol min^(-1)g^(-1))and CO(148.2 mmol min^(-1)g^(-1)),excellent selectivity(H_(2)/CO ratio of 0.92),and good stability are reported *** outstanding performances are attributed to strong metal-support interactions,improved CO_(2)absorption and activation,and decreased apparent activation energy under direct light ***_(x)@SiO_(2)support helps to lower the activation energy of CH^(*) oxidation to CHO^(*) and improve the dissociation of CH_(4)to CH_(3)^(*) as confirmed by DFT ***,the lattice oxygen of MgAlO_(x) participates in the reaction and contributes to the removal of carbon *** work provides promising routes for the conversion of greenhouse gasses into industrially valuable syngas with high efficiency,high selectivity,and benign sustainability.

关键词： Solar fuel CO_(2)reduction Dry reforming of methane Photothermocatalysis Stability

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Association between Helicobacter pylori seropositivity and digestive tract cancers

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World Journal of Gastroenterology 2009年第43期15卷 5465-5471页

作者： I-Chen Wu Deng-Chyang Wu Fang-Jung Yu Jaw-Yuan Wang chao-Hung Kuo Sheau-Fang Yang chao-ling wang Ming-Tsang Wu Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsitmg 807 Taiwan China Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan China Department of Pathology Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan China Graduate Institute of Occupational Safety and Health Kaohsiung Medical University Kaohsiung 807 Taiwan China

AIM:To explore the role of Helicobacter pylori(H pylori) infection on the risk of digestive tract cancers. METHODS:In total,199 oral squamous-cell carcinoma(SCC),317 esophageal SCC,196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori *** hospital-and one community-based control groups were used for the comparisons.H pyloriseropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG. RESULTS:Presence of H pylori infection was significantly inversely associated with esophageal SCC[adjusted odds ratio(AOR):0.315-0.472,all P-value< 0.05]but positively associated with gastric adenocarcinoma(both cardia and non-cardia)(AOR:1.636-3.060, all P-value<0.05)in comparison to the three control *** results were not found in cancers of the oral cavity and colon. CONCLUSION:Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk,but increases the risk of gastric cardia adenocarcinoma.

关键词：幽门螺杆菌阳性反应消化道癌症血清酶联免疫吸附试验幽门螺旋杆菌协会

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基于茎段外植体的茶树组培苗快繁技术研究

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茶叶学报 2024年第1期65卷 28-36页

作者：李家兴朱俊彦张有泽朱木兰陈泓蓉任露露刘升锐姚明哲韦朝领安徽农业大学茶树生物学与资源利用国家重点实验室/农业农村部茶树生物学与茶叶加工重点实验室安徽合肥230036 中国农业科学院茶叶研究所浙江杭州310024 中国科学院分子植物科学卓越创新中心上海200032

【目的】目前,茶树组培苗繁育存在诱导出芽效率不高、繁殖系数较低等问题。因此,为提高茶树种质资源保存繁育效率,丰富保存手段与技术,建立一种高效、快速、实用的基于茎段外植体的茶树组织培养高效快繁技术体系非常必要。【方法】选用... 详细信息

【目的】目前,茶树组培苗繁育存在诱导出芽效率不高、繁殖系数较低等问题。因此,为提高茶树种质资源保存繁育效率,丰富保存手段与技术,建立一种高效、快速、实用的基于茎段外植体的茶树组织培养高效快繁技术体系非常必要。【方法】选用来自安徽省六安市舒城县鲍家村群体种的一个国家级品种‘报春1号’作为研究试材,对该品种进行组织培养快繁技术的探索,包括消毒、定芽诱导、不定芽诱导(I期和II期)、芽伸长、以及生根等阶段。【结果】离体快繁:最佳定芽诱导培养基为MS+3 mg·L^(-1)6-苄基腺嘌呤(6-BA),诱导率达82.2%;不定芽增殖I期最佳培养基为MS基础培养基(MS)+2 mg·L^(-1)6-BA+0.2 mg·L^(-1)萘乙酸(NAA),诱导率为77.78%,平均芽数为5.4个;不定芽增殖II期最佳培养基为MS+1 mg·L^(-1)6-BA+0.3 mg·L^(-1)NAA+2 mg·L^(-1)噻苯隆(TDZ),诱导芽数最多(平均值为10.43个),芽苗呈绿色,叶片舒展;不定芽伸长最佳培养基为MS+0.8 mg·L^(-1)6-BA+0.08 mg·L^(-1)NAA,伸长率为63.33%;不定根诱导培养基以1/2MS培养基+3 mg·L^(-1)IBA效果较佳。【结论】本研究结果建立了一种基于茎段外植体的茶树组织培养高效快繁技术,将对优良茶树品种的保存繁育及其高效利用提供理论基础。

关键词：茶树组培苗组织培养茎段外植体高效快繁

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Multiorgan dysfunction syndrome due to high-dose cantharidin poisoning:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2074-2078页

作者： Wan-ling Xu Wen-Jing Tang Wei-Ying Yang Li-chao Sun Ze-Qun Zhang Wei Li Xiu-Xian Zang Department of Emergency Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Chinese Traditional Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome(MODS).Particular emphasis is placed on the comprehensive elucidation of the clinical manifestations of high-dose cantharidin poisoning,the intricate path to diagnosis,and the exploration of potential underlying *** SUMMARY A patient taking 10 g of cantharidin powder orally subsequently developed *** patient was treated with supportive care,fluid hydration and antibiotics,and hemoperfusion and hemofiltration therapy for 24 h and successfully recovered 8 d after hospital *** poisoning can cause lifethreatening MODS and is rare *** case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt *** This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of high-dose cantharidin poisoning resulting in MODS and reviewed the relevant literature to improve the clinical understanding of this rare condition.

关键词： Cantharidin Poisoning Multiorgan dysfunction syndrome Clinical treatment and management Case report

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An analysis on the effect of mining height and floor lithology on pressure relief of upper protective layers

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Journal of Coal Science & Engineering(China) 2013年第1期19卷 46-50页

作者： Xu-chao HUANG Dong-ling SUN Kang-wu FENG National Key Laboratory of Gas Disaster Detecting Preventing and Emergency Controlling Chongqing 400037 ChinaChongqing Research Institute China Coal Technology and Engineering Group Chongqing 400037 China

In order to understand the effect of mining height and floor lithology at the upper protective layer face on the pressure relief of protected coal seams, this paper uses a numerical simulation method to model the pressure changes at protected coal seam during mining upper protective layer. The results show that the taller the mining height at the upper protective layer face, the greater the protection on protected coal seam due to the higher level of pressure release; the upper protective layer face with hard rock floor impedes the pressure release at the protected coal seam, which affects the overall effect of the pressure release at protected coal seam using the protective layer mining method.

关键词：保护层岩性分析开采高度地板卸压数值模拟方法压力释放开采过程

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Ecology and risks of the global plastisphere as a newly expanding microbial habitat

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The Innovation 2024年第1期5卷 49-58页

作者： Changchao Li Michael RGillings chao Zhang Qinglin Chen Dong Zhu Jie Wang Kankan Zhao Qicheng Xu Polly Hangmei Leung Xiangdong Li Jian Liu ling Jin Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Environment Research Institute Shandong UniversityQingdao 266237China State Key Laboratory of Marine Pollution City University of Hong KongKowloon TongHong KongChina ARC Centre of Excellence in Synthetic Biology Faculty of Science and EngineeringMacquarie UniversitySydneyNSW 2109Australia Key Laboratory of Urban Environment and Health Ningbo Urban Environment Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China Institute of Soil and Water Resources and Environmental Science College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural UniversityNanjing 210095China Department of Health Technology and Informatics and Research Institute for Future Food The Hong Kong Polytechnic UniversityKowloonHong KongChina Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China

Plastic offers a new niche for microorganisms,the *** everincreasing emission of plastic waste makes it critical to understand the microbial ecology of the plastisphere and associated ***,we present a global fingerprint of the plastisphere,analyzing samples collected from freshwater,seawater,and terrestrial *** plastisphere assembles a distinct microbial community that has a clearly higher heterogeneity and a more deterministically dominated assembly compared to natural *** coexistence patterns—loose and fragile networks with mostly specialist linkages among microorganisms that are rarely found in natural habitats—are seen in the *** microbiomes generally have a great potential to metabolize organic compounds,which could accelerate carbon *** involved in the nitrogen cycle are also altered in the plastisphere,especially in freshwater plastispheres,where a high abundance of denitrifiers may increase the release of nitrite(aquatic toxicant)and nitrous oxide(greenhouse gas).Enrichment of animal,plant,and human pathogens means that the plastisphere could become an increasingly mobile reservoir of harmful *** findings highlight that if the trajectory of plastic emissions is not reversed,the expanding plastisphere could pose critical planetary health challenges.

关键词： reservoir mostly habitat

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