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Single probes and resonant four-wave-mixing enabling novel correlative light electron microscopy workflow

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Light(Science & Applications) 2023年第6期12卷 933-934页

作者： Long Chen Chao He Division of Structural Biology Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxford OX37BNUK Department of Engineering Science University of OxfordOxford OX13PJUK

Correlative light electron microscopy prefers single probes with stable performance in both optical and electron microscopy.Now researchers have shown how to harness gold nanoparticles featuring exceptional photostabi... 详细信息

关键词： mixing wave exceptional

Sleep Disturbance: An Early Sign of Alzheimer’s Disease

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Neuroscience Bulletin 2020年第4期36卷 449-451页

作者： Chao He Zhian Hu Chenggang Jiang Department of Physiology Institute of Brain and IntelligenceThird Military Medical UniversityChongqing 400038China Department of Medical Psychology Chongqing Health Center for Women and ChildrenChongqing 400021China Department of Sleep and Psychology Daping HospitalThird Military Medical UniversityChongqing 400042China

Alzheimer's disease(AD)is a progressive neurodegenerative disorder associated with cognitive impairment in older adults.The accumulation of insoluble forms of amyloid-β(Aβ)in plaques in extracellular spaces and the aggregation of hyperphosphorylated microtubule-associated protein tau in neurofibrillary tangles in neurons are considered to be central pathological features of A D[1,2].

关键词： Alzheimer Aβ tau

Enhanced mechanical properties of Mg-3Al-1Zn alloy sheets through slope extrusion

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International Journal of Minerals,Metallurgy and Materials 2022年第7期29卷 1343-1350页

作者： Huabao Yang Yanfu Chai Bin Jiang Chao He Junjie he Qingshan Yang Ming Yuan School of Mechanical and Electrical Engineering Shaoxing UniversityShaoxing 312000China Tianjin Key Laboratory of Composite&Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300072China State Key Laboratory of Mechanical Transmissions College of Materials Science and EngineeringChongqing UniversityChongqing 400044China College of Materials Science and Engineering Yunnan UniversityKunming 650091China School of Metallurgy and Material Engineering Chongqing University of Science and TechnologyChongqing 401331China

A novel extrusion approach,entitled slope extrusion(SE),was employed to manufacture AZ31(Mg-3Al-1 Zn,wt%)alloy sheets.The microstructures,textures,and mechanical properties were investigated,compared with those of the AZ31 sheet fabricated by conventional extrusion(CE).Through the combination of finite element simulation and actual experiment,the ultimate results indicated that significant grain refinement(from 9.1 to 7.7 and 5.6μm)and strong basal texture(from 12.6 to 17.6 and 19.5 mrd)were achieved by the SE process.The essence was associated with the additional introduced inclined interface in the process of SE,which could bring about more asymmetric deformation and stronger accumulated strain along the ND when compared with the process of CE.As a consequence,the SE sheets exhibited a higher yield strength(YS)and ultimate tensile strength(UTS)than the counterparts of the CE sheet,which was mainly assigned to the synergistic effects from grain refining and texture strengthening.

关键词： AZ31 Mg alloy sheets slope extrusion microstructure texture strength

Homeostasis of Synapses:Expansion During Wakefulness,Contraction During Sleep

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Neuroscience Bulletin 2017年第3期33卷 359-360页

作者： Chao He Zhian Hu Department of Physiology Collaborative Innovation Centerfor Brain ScienceThird Military Medical UniversityChongqing 400038China

Sleep is a universal biological process occurring in almost every species of animal,and the loss of sleep has detrimental effects,especially impairments in cognition[1,2].Yet,the neuronal function of sleep is still on... 详细信息

关键词： synaptic neuronal homeostasis universal potentiation hypothesis cognition Homer shrinkage greatest

On inertial navigation and attitude initialization in polar areas

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Satellite Navigation 2020年第1期1卷 40-45页

作者： Yuanxin Wu Chao He Gang Liu Shanghai Key Laboratory of Navigation and Location-based Services School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Flight Automatic Control Research Institute Xi’an 710065China

Inertial navigation and attitude initialization in polar areas become a hot topic in recent years in the navigation community,as the widely-used navigation mechanization of the local level frame encounters the inherent singularity when the latitude approaches 90°.Great endeavors have been devoted to devising novel navigation mechanizations such as the grid or transversal frames.This paper highlights the fact that the common Earth-frame mechanization is sufficiently good to handle the singularity problem in polar areas.Simulation results are reported to demonstrate the singularity problem and the effectiveness of the Earth-frame mechanization.

关键词： Inertial navigation Mechanization Polar areas Attitude initialization

Towards higher-dimensional structured light

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Light(Science & Applications) 2022年第8期11卷 1650-1666页

作者： Chao He Yijie Shen Andrew Forbes Department of Engineering Science University of OxfordParks RoadOxfordOX13PJUK Optoelectronics Research Centre University of SouthamptonSouthamptonSO171BJUK School of Physics University of the WitwatersrandPrivate Bag 3Johannesburg2050South Africa

Structured light refers to the arbitrarily tailoring of optical fields in all their degrees of freedom(DoFs),from spatial to temporal.Although orbital angular momentum(OAM)is perhaps the most topical example,and celebrating 30 years since its connection to the spatial structure of light,control over other DoFs is slowly gaining traction,promising access to higher-dimensional forms of structured light.Nevertheless,harnessing these new DoFs in quantum and classical states remains challenging,with the toolkit still in its infancy.In this perspective,we discuss methods,challenges,and opportunities for the creation,detection,and control of multiple DoFs for higher-dimensional structured light.We present a roadmap for future development trends,from fundamental research to applications,concentrating on the potential for larger-capacity,higher-security information processing and communication,and beyond.

关键词： light dimensional slowly

β-C(sp^(3))−H chlorination of amide derivatives via photoinduced copper charge transfer catalysis

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Chinese Chemical Letters 2024年第2期35卷 361-365页

作者： Yuhang he chao Tian Guanghui An Guangming Li Key Laboratory of Functional Inorganic Material Chemistry (MOE) School of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

An atom economicβ-C(sp^(3))−H chlorination of amide derivatives has been developed.This mild protocol employs CuCl_(2) instead of palladium catalysts with atom-economic HCl as chlorine sources and enables the late-stage functionalization of medicine derivatives.Mechanism studies suggest a plausible visible light triggered ligand-to-metal charge transfer(LMCT)/1,4-hydrogen atom transfer(HAT)cascade.

关键词： Photoinduced copper catalysis Ligand-to-metal charge transfer 1,4-Hydrogen atom transfer β-Halogenated amide Late-stage functionalization

OsPDR20 is an ABCG metal transporter regulating cadmium accumulation in rice

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Journal of Environmental Sciences 2024年第2期136卷 21-34页

作者： he Li chao Li Di Sun Zhi Min Yang Department of Biochemistry and Molecular Biology College of Life SciencesNanjing Agricultural UniversityNanjing 210095China

Cadmium(Cd)is a non-essential toxic heavy metal,seriously posing high environmental risks to human health.Digging genetic resources relevant to functional genes is important for understanding the metal absorption and accumulation in crops and bioremediation of Cd-polluted environments.This study investigated a functionally uncharacterized ATP binding cassette transporter G family(ABCG)gene encoding a Pleiotropic Drug Resistance 20(PDR20)type metal transporter which is localized to the plasma membrane of rice.OsPDR20 was transcriptionally expressed in almost all tissues and organs in lifespan and was strongly induced in roots and shoots of young rice under Cd stress.Ectopic expression of OsPDR20 in a yeast mutant ycf1 sensitive to Cd conferred cellular tolerance with less Cd accumulation.Knockdown of OsPDR20 by RNA interference(RNAi)moderately attenuated root/shoot elongation and biomass,with reduced chlorophylls in rice grown under hydroponic medium with 2 and 10μmol/L Cd,but led to more Cd accumulation.A field trial of rice grown in a realistic Cd-contaminated soil(0.40 mg/kg)showed that RNAi plants growth and development were also compromised compared to wild-type(WT),with smaller panicles and lower spikelet fertility but little effect on yield of grains.However,OsPDR20 suppression resulted in unexpectedly higher levels of Cd accumulation in rice straw including lower leaves and culm and grain.These results suggest that OsPDR20 is actively involved in Cd accumulation and homeostasis in rice crops.The increased Cd accumulation in the RNAi plants has the potential application in phytoremediation of Cd-polluted wetland soils.

关键词： Rice ABCG transporter Cadmium accumulation Phytoremediation

Recent progress in the study of methylated tumor suppressor genes in gastric cancer

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Chinese Journal of Cancer 2013年第1期32卷 31-41页

作者： Xiao-Tong Hu Chao He Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Department of Colorectal Surgery Sir Run Run Shaw Hospital

Gastric cancer is one of the most common malignancies and a leading cause of cancer mortality worldwide.The pathogenesis mechanisms of gastric cancer are still not fully clear.Inactivation of tumor suppressor genes and activation of oncogenes caused by genetic and epigenetic alterations are known to play significant roles in carcinogenesis.Accumulating evidence has shown that epigenetic silencing of the tumor suppressor genes,particularly caused by hypermethylation of CpG islands in promoters,is critical to carcinogenesis and metastasis.here,we review the recent progress in the study of methylations of tumor suppressor genes involved in the pathogenesis of gastric cancer.We also briefly describe the mechanisms that induce tumor suppressor gene methylation and the status of translating these molecular mechanisms into clinical applications.

关键词：抑癌基因甲基化胃癌肿瘤抑制基因癌组织发病机制表观遗传恶性肿瘤