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Selective laser melting of near-α titanium alloy Ti-6Al-2Zr-1Mo-1V:Parameter optimization, heat treatment and mechanical performance

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Journal of Materials Science & Technology 2020年第22期54卷 51-64页

作者： chao cai Xu Wu Wan Liu Wei Zhu Hui Chen Jasper Chu Dong Qiu Chen-Nan Sun Jie Liu Qingsong Wei Yusheng Shi State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China Hubei Rehabilitation Assistive Technology Centre Wuhan430074China Department of Mechanical Engineering National University of SingaporeSingapore117575Singapore Singapore Institute of Manufacturing Technology A*STAR73 Nanyang DriveSingapore637662Singapore

This paper presents a comprehensive study conducted to optimize the selective laser melting(SLM)parameters and subsequent heat-treatment temperatures for near-α high-temperature titanium alloy Ti-6 Al-2 Zr-1 Mo-1 V(TA15),which is widely used in the aerospace *** on the surface morphology and relative density analysis,the optimized process parameters were:laser power from 230 W to 380 W,scan speed from 675 mm/s to 800 mm/s,scan spacing of 0.12 mm,and layer thickness of0.03 *** effects of the laser power and the layer thickness on the phase constitutions,microstructure features,as well as room-temperature and high-temperature(500℃) tensile properties,were then studied to obtain an in-depth understanding of SLM-built *** typical temperatures(650,750,850,950,1000 and 1100℃) covering three representative temperature ranges,i.e.,martensite partial decomposition temperature range,martensite complete decomposition temperature range and above βtransus temperature,were subsequently selected as heat-treatment *** heat treatmentmicrostructure-mechanical property relationships of SLM-built TA15 were elucidated in *** results provide valuable information on the development of SLM-built TA15 alloy for industrial applications,and these findings are also beneficial to additive manufacturing of other near-α Ti alloys with desirable high-temperature properties.

关键词： Selective laser melting Near-αtitanium Heat treatment High-temperature tensile properties

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Sepsis-associated liver injury:Mechanisms and potential therapeutic targets

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World Journal of Gastroenterology 2024年第42期30卷 4518-4522页

作者： Jia-Wen Chen Chen-Yi Liu Shu Li Shi-Wen Wu chao cai Ming-Qin Lu Department of Infectious Diseases The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

In this editorial,we examined a recent article in the World Journal of Gastroenterology that focused on sepsis-associated liver injury(SLI)and its *** is a serious complication of sepsis,primarily caused by microcirculatory disturbances,the gut-liver axis,and inflammatory *** treatment recommendations for SLI are *** gut-liver axis represents a potential therapeutic target,with metformin showing promise in modulating the gut microbiome and enhancing intestinal barrier *** immunomodulatory therapies are being explored,anti-tumor necrosis factor agents and interleukin-1 receptor antagonists have not demonstrated significant clinical *** may reduce liver inflammation and prevent injury in sepsis,but their clinical application is *** D-related human leucocyte antigen expression on monocytes and lymphocytes suggests immune suppression in patients,indicating that corticosteroids could reverse clinical deterioration in severe infections and address adrenal cortical *** large-scale studies on glucocorticoid therapy for sepsis have yielded mixed results,likely due to inadequate assessment of the immune status of the *** research should prioritize the development of personalized immunotherapy tailored to patients’immune profiles,focusing on identifying novel indicators of immune status and advancing immunomodulatory targets and therapeutics for septic patients.

关键词： Sepsis Sepsis-associated liver injury Gut-liver axis Immunosuppression Inflammation Immune dysregulation Glucocorticoid Adrenal cortical insufficiency

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A Novel Acetyl Migration

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Chinese Chemical Letters 1998年第7期9卷 619-620页

作者： Xi Han WU A. A. Haji Wei LU Jun chao cai (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031) Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China

In our effort to asymmetric synthesis of R-(+)-shikonin, a novel acetyl migration was found, and the mechanism of the migration was considered to be mediated by a 6 atom-ring intermediate.

关键词： acetyl migration intermediate

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Synthesis of 3(R)-(t-Butyldiphenylsilyloxy)-1-penten-4-yne, via an Improved Procedure for Aldehyde-to-Alkyne Homologation

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Chinese Chemical Letters 1998年第7期9卷 621-623页

作者： Wei LU Guang Rong ZHENG A. A.HAJI Jun chao cai(Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031) Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China

3(R)-(t-Butyldiphenylsilyloxy)-1-penten-4-yne was prepared using D-xylose as the chiral template via an improved procedure for aldehyde-to-alkyne homologation in high yield.

关键词： 3(R)-(t-Butyldiphenylsilyloxy) 1-penten-4-yne aldehyde-to-alkyne homologation

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STUDIES ON THE CRINUM ALKALOIDS PART I: SYNTHESIS OF ANHYDROLYCORINE-7-ONE

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Chinese Chemical Letters 1996年第1期7卷 13-14页

作者： Hua Wu SHAO Jun chao cai (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031) Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 200031

Palladium acetate catalyzed Cyclization of 1-[(6-bromo-1, 3 -benzodioxol- 5-yl)carbonyl 2, 3-dihydro-1H-indole(7a) leading to the anhydrolycorine- 7-one (1a) as the key step inanew Synthesis of Crinum alkaloids is de...

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Synthesis of the (3R, 9S, 10S)-Diastereoisomer of Panaxytriol,a Potent Antitumor Polyacetylene from Panax ginseng

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Chinese Chemical Letters 1999年第3期10卷 201-204页

作者： Wei LU Guang Rong ZHENG Jing Shan SHEN Jun chao cai(Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 200031) Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China

(3R, 9S, 10S)-Heptadec-1-ene-4,6-diyne-3, 9, 10-triol 2, a diastereoisomer of panaxytriol 1 was synthesized using L-(+)-diethyl tartrate 5 as a chiral template, through the Cadiot-Chodkiczwicz coupling of the terminal... 详细信息

关键词： diastereoisomer panaxytriol Cadiot-Chodkiczwicz coupling

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Delayed diagnosis of prosopagnosia following a hemorrhagic stroke in an elderly man:A case report

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World Journal of Clinical Cases 2020年第24期8卷 6487-6498页

作者： Yin Yuan Feng Huang Jia-Xin Xiao Yue-Er Yang Peng-Li Zhu Zhong-Hai Gao Wen-chao cai Department of Geriatric Medicine Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350100Fujian ProvinceChina Fujian Provincial Institute of Clinical Geriatrics Fuzhou 350001Fujian ProvinceChina Fujian Provincial Key Laboratory of Geriatrics Fuzhou 350001Fujian ProvinceChina Fujian Provincial Center for Geriatrics Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Radiology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND Acquired prosopagnosia is a rare condition characterized by the loss of familiarity with previously known faces and the inability to recognize new *** usually occurs after the onset of brain lesions such as in a *** initial identification of prosopagnosia generally relies on a patient’s self-report,which can be challenging if it lacks an associated chief *** were few cases of prosopagnosia presenting purely as eye symptoms in the previous literature confirmed by functional magnetic resonance imaging(MRI).CASE SUMMARY We present a case of delayed diagnosis of prosopagnosia after a right hemisphere stroke in an elderly man whose chief complaint was persistent and progressive"blurred vision"without facial recognition *** tests revealed a homonymous left upper quadrantanopia,with normal visual *** was found by accident to barely recognize familiar *** patient showed severe deficit in face recognition and perception tests,and mild memory loss in neuropsychological *** functional MRI revealed the visual recognition deficits were *** behavioral intervention,the patient started to rely on other cues to compensate for poor facial *** prosopagnosia showed no obvious improvement eight months after the stroke,which had negative impact on his social *** Our case demonstrates that the presentation of prosopagnosia can be atypical,and visual difficulties might be a clinical manifestation solely of prosopagnosia,which emphasizes the importance of routinely considering face recognition impairment among elderly patients with brain lesions.

关键词： Prosopagnosia Blurred vision Stroke Diagnosis Functional magnetic resonance imaging Elderly Case report

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Characteristics of distribution of Mycobacterium tuberculosis lineages in China

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Science China(Life Sciences) 2018年第6期61卷 651-659页

作者： Haixia Chen Li He chao cai Jingyi Liu Junnan Jia Liang Ma Hairong Huang Lixia Wang Xumin Ni Jimin Gao Weimin Li Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms School of Laboratory Medicine and Life Science Wenzhou Medical University Wenzhou 325035 China National Tuberculosis Clinical Lab of China Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital Capital Medical University Beijing 101149 China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China School of Mathematical Sciences Univsersity of Chinese Academy of Sciences Beijing 100049 China Beijing Key Laboratory in Drug Resistance Tuberculosis Research Beijing Chest Hospital Capital Medical University Beijing 101149 China Beijing Municipal Key Laboratory of Clinical Epidemiology School of Public Health Capital Medical University Beijing 100069 China Beijing Institute of Genomies Chinese Academy of Sciences Bering 100101 China National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Department of Mathematics School of Science Beijing Jiaotong University Beijing 100044 China

The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905(2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases(975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages(Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation(farmer), and degree of education(non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment.

关键词： Mycobacterium tuberculosis Lineage 2 Lineage 4 large sequence polymorphism fever

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Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue

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Chinese Chemical Letters 2006年第1期17卷 5-8页

作者： Hong Xia DING Wei LU Lei Xiang YANG Hai Bo LI Hua BAI Xiu Mei WU Jun chao cai Yu ZHAO Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310031 Shanghai Institute of Material Medica Chinese Academy of Sciences SIBS Shanghai 200031 Zhejiang Hisun Naturelite Pharmaceutical R＆D Co. Ltd. Hangzhou 310007

Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carded out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.

关键词： Artabotrine aporphine alkaloid cytotoxicity synthesis.

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Preliminary Experimental Study of Ion Beam Extraction of EAST Neutral Beam Injector

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Chinese Physics Letters 2012年第3期29卷 139-141页

作者： XU Yong-Jian HU Chun-Dong LIU Sheng XIE Ya-Hong LIANG Li-Zhen JIANG cai-chao Institute of Plasma Physics Chinese Academy of SciencesHefei 230031

Neutral beam injection is recognized as one of the most effective means for plasma *** preliminary data of ion beam extraction is obtained on the EAST neutral beam injector *** extraction from the ion source of EAST-NBI is verified by measuring the beam current with a Faraday cup and by analyzing the results obtained by means of water calorimetric measurement on the temperature rises of water cooling the accelerator electrodes.

关键词： beam injection verified

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