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Failure transition of shear-to-dilation band of rock salt under triaxial stresses

Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 56-64页

作者： Jianfeng Liu Xiaosong Qiu Jianxiong Yang chao Liang Jingjing Dai Yu bian State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China CNPC Key Laboratory of Oil and Gas Underground Storage Engineering Langfang065007China College of Water Resource and Hydropower Sichuan UniversityChengdu610065China

Great potential of underground gas/energy storage in salt caverns seems to be a promising solution to support renewable energy.In the underground storage method,the operating cycle unfortunately may reach up to daily or even hourly,which generates complicated pressures on the salt cavern.Furthermore,the mechanical behavior of rock salt may change and present distinct failure characteristics under different stress states,which affects the performance of salt cavern during the time period of full service.To reproduce a similar loading condition on the cavern surrounding rock mass,the cyclic triaxial loading/unloading tests are performed on the rock salt to explore the mechanical transition behavior and failure characteristics under different confinement.Experimental results show that the rock salt samples pre-sent a diffused shear failure band with significant bulges at certain locations in low confining pressure conditions(e.g.5 MPa,10 MPa and 15 MPa),which is closely related to crystal misorientation and grain boundary sliding.Under the elevated confinement(e.g.20 MPa,30 MPa and 40 MPa),the dilation band dominates the failure mechanism,where the large-size halite crystals are crushed to be smaller size and new pores are developing.The failure transition mechanism revealed in the paper provides additional insight into the mechanical performance of salt caverns influenced by complicated stress states.

关键词： Rock salt Cyclic mechanical loading Shear band Dilation band Underground gas storage(UGS)

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Electrostatically connected nanoarchitected electrocatalytic films for boosted water splitting

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Nano Research 2024年第3期17卷 1114-1122页

作者： chao-Peng Wang Hao Sun Gang bian Jia-Xi Wang Xixi Pang Guoqi Wang Jian Zhu Xian-He Bu School of Materials Science and Engineering National Institute for Advanced MaterialsNankai UniversityTianjin 300350China Tianjin Key Laboratory of Metal and Molecule-Based Material Chemistry Nankai UniversityTianjin 300350China Tianjin Key Laboratory for Rare Earth Materials and Applications Nankai UniversityTianjin 300350China

Active sites of two-dimensional(2D)electrocatalysts are often partially blocked owing to their inevitable stacking and hydrophobic polymeric binders in macroscale electrodes,therefore impeding their applications in efficient electrolyzers.Here,using layered double hydroxide(LDH)nanosheets as a model 2D electrocatalyst,we demonstrate that their performance toward water splitting can be boosted when they are electrostatically assembled into an organized structure pillared by hydrophilic polyelectrolytes or nanoparticles in a layer-by-layer(LbL)fashion.In particular,their mass activity on a planar electrode can be as large as 2.267 mA·μg^(-1) toward oxygen evolution reaction(OER),when NiFe-LDH nanosheets are electrostatically connected by poly(sodium 4-styrenesulfonate)(PSS),while drop-casted NiFe-LDH nanosheets only have a mass activity of 0.116 mA·μg^(-1).In addition,these homogeneous NiFe-LDH nanofilms can be easily deposited on three-dimensional(3D)surfaces with high areas,such as carbon cloths,to serve as practical electrodes with overpotentials of 328 mV at a current density of 100 mA·cm^(-2),and stability for 40 h.Furthermore,Pt nanoparticles can be LbL assembled with NiFe-LDH as bifunctional electrodes for synergistically boosted oxygen and hydrogen evolution reactions(HER),leading to successful overall water splitting powered by a 1.5 V battery.This study heralds the spatial control of 2D nanomaterials in nanoscale precision as an efficient strategy for the design of advanced electrocatalysts.

关键词： layer-by-layer(LbL)assembly layered double hydroxides(LDH) two-dimensional(2D)electrocatalysts oxygen evolution reaction(OER) water splitting

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Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

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World Journal of Gastroenterology 2024年第5期30卷 471-484页

作者： Hui Hua Qian-Qian Zhao Miriam Nkesichi Kalagbor Guo-Zhi Yu Man Liu Zheng-Rui bian Bei-Bei Zhang Qian Yu Yin-Hai Xu Ren-Xian Tang Kui-Yang Zheng chao Yan Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Demonstration Center for Experimental Basic Medical Science EducationLaboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Primary sclerosing cholangitis(PSC)is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment options.Recombinant adeno-associated virus(rAAV)provides a promising platform for gene therapy on such kinds of diseases.A microRNA(miRNA)let-7a has been reported to be associated with the progress of PSC but the potential therapeutic implication of inhibition of let-7a on PSC has not been evaluated.AIM To investigate the therapeutic effects of inhibition of a miRNA let-7a transferred by recombinant adeno-associated virus 8(rAAV8)on a xenobiotic-induced mouse model of sclerosing cholangitis.METHODS A xenobiotic-induced mouse model of sclerosing cholangitis was induced by 0.1% 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine(DDC)feeding for 2 wk or 6 wk.A single dose of rAAV8-mediated anti-let-7a-5p sponges or scramble control was injected in vivo into mice onset of DDC feeding.Upon sacrifice,the liver and the serum were collected from each mouse.The hepatobiliary injuries,hepatic inflammation and fibrosis were evaluated.The targets of let-7a-5p and downstream molecule NF-κB were detected using Western blot.RESULTS rAAV8-mediated anti-let-7a-5p sponges can depress the expression of let-7a-5p in mice after DDC feeding for 2 wk or 6 wk.The reduced expression of let-7a-5p can alleviate hepato-biliary injuries indicated by serum markers,and prevent the proliferation of cholangiocytes and biliary fibrosis.Furthermore,inhibition of let-7a mediated by rAAV8 can increase the expression of potential target molecules such as suppressor of cytokine signaling 1 and Dectin1,which consequently inhibit of NF-κB-mediated hepatic inflammation.CONCLUSION Our study demonstrates that a rAAV8 vector designed for liver-specific inhibition of let-7a-5p can potently ameliorate symptoms in a xenobiotic-induced mouse model of sclerosing cholangitis,which provides a possible clinical translation of PSC of human.

关键词： Primary sclerosing cholangitis Recombinant adeno-associated virus 8 Let-7a-5p Therapeutic effects Inflammation

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High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development

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BioDesign Research 2022年第1期2022卷 38-51页

作者： Bingmiao Gao Yu Huang chao Peng Bo Lin Yanling Liao chao bian Jiaan Yang Qiong Shi Key Laboratory of Tropical Translational Medicine of Ministry of Education School of PharmacyHainan Medical UniversityHaikouHainan 570102China Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic AnimalsBGI Academy of Marine SciencesBGI MarineShenzhenGuangdong 518081China BGI-Marine Research Institute for Biomedical Technology Shenzhen Huahong Marine Biomedicine Co.Ltd.ShenzhenGuangdong 518119China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical UniversityHaikouHainan 570102China Research and Development Department Micro Pharmtech Ltd.WuhanHubei 430075China

Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to theirpharmacological applications in development of marine drugs for treatment of various human diseases. To date, around 800Conus species are recorded, and each of them produces over 1,000 venom peptides (termed as conopeptides or conotoxins).This reflects the high diversity and complexity of cone snails, although most of their venoms are still uncharacterized.Advanced multiomics (such as genomics, transcriptomics, and proteomics) approaches have been recently developed to minediverse Conus venom samples, with the main aim to predict and identify potentially interesting conopeptides in an efficientway. Some bioinformatics techniques have been applied to predict and design novel conopeptide sequences, related targets, andtheir binding modes. This review provides an overview of current knowledge on the high diversity of conopeptides andmultiomics advances in high-throughput prediction of novel conopeptide sequences, as well as molecular modeling and designof potential drugs based on the predicted or validated interactions between these toxins and their molecular targets.

关键词： drugs Con prediction

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On the robustness of median sampling in noisy evolutionary optimization

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Science China(Information Sciences) 2021年第5期64卷 32-44页

作者： chao bian chao QIAN Yang YU Ke TANG State Key Laboratory for Novel Software Technology Nanjing University Shenzhen Key Laboratory of Computational Intelligence Department of Computer Science and EngineeringSouthern University of Science and Technology

Evolutionary algorithms(EAs) are a sort of nature-inspired metaheuristics, which have wide applications in various practical optimization problems. In these problems, objective evaluations are usually inaccurate, because noise is almost inevitable in real world, and it is a crucial issue to weaken the negative effect caused by noise. Sampling is a popular strategy, which evaluates the objective a couple of times, and employs the mean of these evaluation results as an estimate of the objective value. In this work, we introduce a novel sampling method, median sampling, into EAs, and illustrate its properties and usefulness theoretically by solving OneMax, the problem of maximizing the number of 1 s in a bit string. Instead of the mean, median sampling employs the median of the evaluation results as an estimate. Through rigorous theoretical analysis on OneMax under the commonly used onebit noise, we show that median sampling reduces the expected runtime exponentially. Next, through two special noise models, we show that when the 2-quantile of the noisy fitness increases with the true fitness, median sampling can be better than mean sampling; otherwise,it may fail and mean sampling can be better. The results may guide us to employ median sampling properly in practical applications.

关键词： evolutionary algorithms noisy optimization median sampling computational complexity runtime analysis

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Microbial community composition and environmental response characteristics of typical brackish groundwater in the North China Plain

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China Geology 2023年第3期6卷 383-394页

作者： Huai-sheng Zhang Wu-tian Cai Feng Guo chao bian Fu-dong Liu Lei Zhang Jin-wei Liu Miao Zhao Center for Hydrogeology and Environmental Geology Survey CGSBaoding 071051China National Research Center for Geoanalysis Key Laboratory of Eco-GeochemistryMinistry of Natural ResourcesBeijing 10037China Third Hydrological Engineering Geological Brigade Hebei Bureau of Geology and Mineral ResourcesHengshui 053000China

To reveal the microbial community composition of regional shallow porous brackish groundwater and its response characteristics to groundwater environment,the first and second aquifers in Taocheng District,Hengshui City were selected,and 10 groundwater source samples were collected for hydrochemical analysis and microbial 16S RNA gene V4-V5 regional sequencing.The results showed that the shallow brackish groundwater in the study area is weakly alkaline and has high ion content.The hydrochemical types are SO_(4)·Cl-Na·Mg type and HCO3·Cl-Na·Mg type as a whole.The spatial zonation of the abundance and diversity of groundwater microorganisms is obvious.The number of endemic bacteria in groundwater from upstream,midstream to downstream is 11,135 and 22 respectively,with a total of 22 bacteria.Proteobacteria is the most dominant in groundwater level(38.82%-86.88%),and there are obvious differences in different sections.At the genus level,the main dominant species in each group and sample are Pseudomonas and Hydrogenophaga.In terms of composition difference,Pseudohongiella,Pseudorhodobacter and Limnohabitans are the representatives of UR,MR and LR.On the whole,the composition of flora in groundwater in the study area is sensitive and closely related to hydrochemical processes.Species abundance is affected by alkaline and high salinity environmental indicators,while species diversity is related to depth and dissolved oxygen in weak reduction environment.

关键词： Groundwater microorganism Microbial Endemic bacteria Biochemistry Pseudomonas Hydrogenophage Brackish groundwater Environmental response Hydrogeological survey engineering Environmental geological survey engineering

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基于主轴扭矩—转角特性的高压隔离开关缺陷分析仿真

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高压电器 2024年第1期60卷 48-54页

作者：关为民卞超李东风国网江苏省电力有限公司超高压分公司南京211102

高压隔离开关的工作环境较为恶劣,导致其经常出现各种故障问题,为电网运行带来巨大安全隐患。为提高高压隔离开关的检修质量,提出基于主轴扭矩—转角特性的高压隔离开关缺陷分析仿真。搭建仿真平台,利用非植入式主轴扭矩—转角检测系统... 详细信息

高压隔离开关的工作环境较为恶劣,导致其经常出现各种故障问题,为电网运行带来巨大安全隐患。为提高高压隔离开关的检修质量,提出基于主轴扭矩—转角特性的高压隔离开关缺陷分析仿真。搭建仿真平台,利用非植入式主轴扭矩—转角检测系统测量分闸与合闸过程中主轴扭矩—转角特性曲线,分析高压隔离开关的运动特性。仿真结果证明,卡涩状态下根据主轴扭矩—转角特性曲线得知合闸段的相关系数为0.81,证明高压隔离开关远远偏离正常状态,能够直观反映其存在卡涩缺陷;平衡弹簧疲劳状态下根据主轴扭矩—转角特性曲线得知合闸面积低于分闸面积,合闸段的相关系数远远低于正常值,说明平衡弹簧处于疲劳状态,文中方法具有一定的应用价值。

关键词：主轴扭矩主轴转角高压隔离开关运动特性卡涩缺陷

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基于深度强化学习和大邻域搜索的矿山巡检机器人路径规划算法

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金属矿山 2024年第2期 212-218页

作者：边艳华解路苗超许昌电气职业学院公共教学部河南许昌461000 郑州大学水利与土木工程学院河南郑州450001

当前大多数矿山巡检机器人采用激光雷达作为矿山环境探测方法,该方法对于一些小目标物体和反照率小的物体检测不明显,容易造成误检或漏检,从而引发矿山安全事故。为了提高矿山巡检机器人的识别精度,将基于强化学习结合大邻域搜索的路径... 详细信息

当前大多数矿山巡检机器人采用激光雷达作为矿山环境探测方法,该方法对于一些小目标物体和反照率小的物体检测不明显,容易造成误检或漏检,从而引发矿山安全事故。为了提高矿山巡检机器人的识别精度,将基于强化学习结合大邻域搜索的路径规划方法引入矿山巡检机器人路径规划工作中,提高矿山巡检机器人对场景的感知能力。首先,提出了基于LSTM的时序性路径规划模型,能够从机器人的RGB相机中提取图像特征,通过深度学习方式进行场景感知。其次,将激光雷达设备采集的信息进行处理,使用大邻域搜索算法找到空间中的多个最优路径,用于后续场景导航。最终通过深度强化学习和大邻域搜索方法实现矿山巡检机器人精准导航,选择最佳的机器人巡检路径。为了验证所提算法性能,在二维和三维空间中进行了场景搭建、导航模拟、模型训练和测试。结果表明:该方法在仿真环境和真实场景中具有较好的路径规划能力。

关键词：深度学习大邻域搜索时间序列机器人路径规划

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Modeling of Amperometric Immunosensor for CMOS Integration

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稀有金属材料与工程 2006年第A3期35卷 439-442页

作者： Ce Li Haigang Yang Shanhong Xia chao bian The State Key Lab of Transducer Technology Institute of Electronics CAS Beijing 100080 China Graduate University of Chinese Academy of Sciences Beijing 100039 China

A circuit model of the Amperometric immunosensor for use in the biosensor system-on-chip simulation is proposed in this paper.The model parameters are extracted with several methods and verified by MATLAB and SPICE simulation.A CMOS potentiostat circuit required for conditioning the Amperometric immunosensor is also included in the circuit model.The mean square error norm of the simulated curve against the measured one is 8.65×10^(-17) The whole circuit has been fabricated in a 0.35μm CMOS process.

关键词： amperometric microelectrode circuit model potentiostat folded-cascode

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Divergence, evolution and adaptation in ray-finned fish genomes

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Science China(Life Sciences) 2019年第8期62卷 1003-1018页

作者： chao bian Yu Huang Jia Li Xinxin You Yunhai Yi Wei Ge Qiong Shi Center of Reproduction Development and AgingFaculty of Health SciencesUniversity of MacaoMacaoChina Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic AnimalsBGI Academy of Marine SciencesBGI MarineBGIShenzhen518083China Laboratory of Aquatic Genomics College of Life Sciences and OceanographyShenzhen UniversityShenzhen518060China

With the rapid development of next-generation sequencing technologies and bioinformatics, over 50 ray-finned fish genomes by far have been sequenced with high quality. The genomic work provides abundant genetic resources for deep understanding of divergence, evolution and adaptation in the fish genomes. They are also instructive for identification of candidate genes for functional verification, molecular breeding, and development of novel marine drugs. As an example of other omics data, the Fish-T1 K project generated a big database of fish transcriptomes to integrate with these published fish genomes for potential applications. In this review, we highlight the above-mentioned recent investigations and core topics on the ray-finned fish genome research, with a main goal to obtain a deeper understanding of fish biology for theoretical and practical applications.

关键词： ray-finned fish genome transcriptome application

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