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Food Production, Processing and Nutrition 2022年第1期4卷 408-419页

作者： chao ai aijun Tong Jiahui Wen Ruoxin Chen Yajun Huang chao Zhao College of Food Science Fujian Agriculture and Forestry University350002 FuzhouChina College of Food Science and Technology Guangdong Ocean University524088 ZhanjiangChina College of Marine Sciences Fujian Agriculture and Forestry University350002 FuzhouChina Key Laboratory of Marine Biotechnology of Fujian Province Institute of OceanologyFujian Agriculture and Forestry UniversityFuzhouChina

Enteromorpha prolifera is a nutrient-rich green alga and abound in the Yellow Sea and the Bohai Sea of China. In this study, E. prolifera was anaerobically digested for biogas production. The variations of chemical compositions and microbial community structure as well as the physical structure of E. prolifera in anaerobic digestion process were investigated. This is the first report of multiple ways to deeply analysis the process of E. prolifera anaerobic digestion. Results from the present work showed that the biogas obtained from E. prolifera anaerobic digestion could achieve 409.7 mL•g− 1 TS with an average methane concentration of 53.2%, and the VFAs content in substrate played a vital role for driving the biogas production of flora. Moreover, S1 of Thermotogaceae and Cenarchaeum, the dominant bac-teria and archaea in digestion flora, respectively, played important roles in degrading E. prolifera, acidizing slurry, and providing methanogenic substrate for methanogens.

关键词： Enteromorpha prolifera Anaerobic digestion High-throughput sequencing

Discovery of small molecule degraders for modulating cell cycle

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Frontiers of Medicine 2023年第5期17卷 823-854页

作者： Liguo Wang Zhouli Yang Guangchen Li Yongbo Liu chao ai Yu Rao MOE Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing100084China Beijing Tsinghua Changgung Hospital School of Clinical MedicineTsinghua UniversityBeijing102218China

The cell cycle is a complex process that involves DNA replication,protein expression,and cell *** of the cell cycle is associated with various ***-dependent kinases(CDKs)and their corresponding cyclins are major proteins that regulate the cell *** contrast to inhibition,a new approach called proteolysis-targeting chimeras(PROTACs)and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins,achieving targeted *** field of PROTACs and molecular glues has developed rapidly in recent *** this article,we aim to summarize the latest developments of CDKs and cyclin protein *** selectivity,application,validation and the current state of each CDK degrader will be ***,possible methods are discussed for the development of degraders for CDK members that still lack ***,this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders,which will be helpful for researchers working on this topic.

关键词： PROTAC molecular glue degrader cell cycle CDK cyclin

Health benefits of Grifola frondosa polysaccharide on intestinal microbiota in type 2 diabetic mice

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Food Science and Human Wellness 2022年第1期11卷 68-73页

作者： Xiaoxiang Gao Dan Liu Luying Gao Yuezhen Ouyang Yuxi Wen chao ai Yuqing Chen chao Zhao College of Food Science Fujian Agriculture and Forestry UniversityFuzhou 350002China Department of Pediatrics Nanjing First HospitalNanjing Medical UniversityNanjing 210006China School of Food Science and Engineering South China University of TechnologyGuangzhou 510641China Department of Food Science&Technology National University of SingaporeSingapore 117543Singapore Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition Ministry of Education Fuzhou 350002China

Grifola frondosa polysaccharide(GFP)as the natural compounds have been reported to exert diverse *** aim of this study was to investigate the regulatory effects of GFP on intestinal microbiota in type 2 diabetic *** changes of microbiota in faeces of the diabetic mice upon high fat diet were determined and the V3 region of the 16S rRNA was sequenced by Illumina MiSeq high-throughput sequencing *** operational taxonomic unit were identified to be shared by all samples,and the quality and richness of sequencing were assessed via rarefaction and rank abundance *** diversity of gut flora was slightly improved in diabetic mice after GFP *** composition and relative abundance of gut microbiota at phylum and genus levels were altered by *** abundance of Robinsoniella,Flavonifractor,Anaerotruncus,and Desulfvibrio were found to concentrate on diabetic mice through LEfSe ***,Alloprevotella and Burkholderia had strong relevancy with other gut *** on the findings,GFP might be a desired candidate on ameliorating the intestinal unbalance in diabetes.

关键词： Maitake Grifola frondosa polysaccharide Diabetes Gut microbiota

Photoproductionγp→K^(+)Λ(1690)in an effective Lagrangian approach

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Chinese Physics C 2022年第5期46卷 44-51页

作者： Neng-Chang Wei ai-chao Wang Fei Huang School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 101408China

A gauge-invariant model is constructed for theγp→K^(+)Λ(1690)reaction within a tree-level effective Lagrangian approach to understand the underlying production mechanisms and study the resonance contributions in this *** addition to the t-channel K and K^(∗)exchanges,s-channel nucleon exchange,and interaction current,the s-channel nucleon resonance exchanges are included in constructing the reaction amplitudes to describe the *** is found that the contributions from the s-channel N(2570)5/2^(−)exchange are required to describe the most recently measured total cross-section data forγp→K^(+)Λ(1690)from the CLAS *** analysis indicates that the interaction current dominates the γ p→K^(+)Λ(1690)reaction near the threshold as a result of gauge *** t-channel K exchange contributes significantly,while the contributions from the t-channel K^(∗)exchange and s-channel nucleon exchange are ultimately *** contributions from the s-channel N(2570)5/2^(−)exchange are found to be responsible for the bump structure shown in the CLAS total cross-section data above the center-of-mass energy W≈2.7 *** predictions of the differential cross sections forγp→K^(+)Λ(1690)are presented and discussed,which can provide theoretical guidance for future experiments.

关键词： K^(+)Λ(1690)photoproduction effective Lagrangian approach gauge invariance

Adaptive friction compensation for large diameter electro-hydraulic proportional valve cores based on LuGre

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High Technology Letters 2015年第4期21卷 371-378页

作者：孔祥东 Song Yu ai chao Li Yanpeng Tian Dezhi Key Laboratory of Advanced Forging & Stamping Technology and Science(Yanshan University) Ministry of Education of China Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Yanshan University School of Mechanical Engineering Yanshan University

This paper presents an adaptive friction compensation method based on LuGre model for large diameter electric-hydraulic proportional valves in which the valve core contains friction.A mathematic model of the electric-hydraulic proportional valve is established,and the friction characteristics are described based on the LuGre *** global asymptotic stability of the control system with the adaptive friction compensation controller is guaranteed over Lyapunov *** adaptive compensation of the friction on LuGre friction model is verified by simulation and *** steady-state error is about [-4.23 × 10^(-5)m,5.91 × 10^(-5)m]and[-2.5 × 10^(-4)m,2.6 ×10^(-4) m] on simulation and experiment,the position tracking accuracy is higher,and the lag time of the main valve through the dead zone is *** result proves that the adaptive friction compensation method can effectively compensate for the negative effects of nonlinear friction.

关键词： electric-hydraulic proportional valve pilot stage LuGre adaptive friction com- pensation experimental identification

Prevotella oris-caused meningitis and spinal canal infection:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3830-3836页

作者： Wei-Wei Zhang chao ai Chien-Tai Mao Dong-Kang Liu Yi Guo Department of Clinical Pharmacy Beijing Tsinghua Changgung HospitalSchool of MedicineTsinghua UniversityBeijing 102218China Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of MedicineTsinghua UniversityBeijing 102218China

BACKGROUND Prevotella oris-induced meningitis and Prevotella oris-induced meningitis concomitant with spinal canal infection are extremely *** the best of our knowledge,only 1 case of Prevotella oris-induced central system infection has been *** is the second report on meningitis combined with spinal canal infection due to Prevotella *** SUMMARY We report a case of a 9-year-old boy suffering from meningitis and spinal canal *** patient presented to the neurosurgery department with lumbosacral pain for 1 mo and headache and vomiting for 1 *** had been treated with cephalosporin and nonsteroidal anti-inflammatory drugs for fever,otalgia and pharyngalgia in a local hospital 2 mo prior to this *** hospitalization,magnetic resonance imaging suggested meningitis and L3-S1 lumbosacral dural sac *** cerebrospinal fluid and blood cultures were negative,but the cerebrospinal fluid specimen indicated the presence of Prevotella oris by metagenomic next-generation *** cases of Prevotella oris infection were retrieved from PubMed to characterize the clinicopathological features and identify the prognostic factors and related antimicrobial treatment of infection due to Prevotella *** This report shed light on the characteristics of Prevotella oris infection and highlighted the role of metagenomic next-generation sequencing in pathogen detection.

关键词： Prevotella oris Meningitis Spinal canal infection Metagenomic next-generation sequencing Central nervous system infection Case report

Effect of thermophysical property and coating thickness on microstructure and characteristics of a casting

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China Foundry 2017年第1期14卷 46-54页

作者： ai-chao Cheng Bo-lin Jia Ren-fei Guo Xiu-ping Ren Hui-bin Xuan Tie-tao Zhou School of Materials Science and Engineering Beihang UniversityBeijing 100191China Yuneheng Guanlv Equipment Material Co. LtdShanxi 444501China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China

A new improved investment casting technology （IC） has been presented and compared with the existing IC technology such as lost foam casting （LFC）. The effect of thermophysical property and coating thickness on casting solidification temperature field, microstructure and hardness has been investigated. The results show that the solidification rate decreases inversely with the coating thickness when the coating contains silica sol, zircon powder, mullite powder and defoaming agent. In contrast, the solid cooling rate increases as the coating thickness increases. However, the solidification rate and solid cooling rate of the casting produced by the existing IC and the improved IC are very similar when the coating thickness is 5 mm, so the microstructure and hardness of a container corner fitting produced by the improved IC and the existing IC are similar. The linear regression equation for the grain size （d） and cooling rate （v） of the castings is d= -0.41v＋206.1. The linear regression equation for the content of pearlite （w） and solid cooling rate （t） is w=1.79t ＋ 6.71. The new improved IC can greatly simplify the process and decrease the cost of production compared with the existing IC. Contrasting with LI=C, container corner fittings produced by the new improved IC have fewer defects and better properties. It was also found that the desired microstructure and properties can be obtained by changing the thermophysical property and thickness of the coating.

关键词： improved investment casting thermophysical property coating thickness microstructure property

Postoperative decrease of serum albumin predicts shortterm complications in patients undergoing gastric cancer resection

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World Journal of Gastroenterology 2017年第27期23卷 4978-4985页

作者： Zhi-Jian Liu Xiao-Long Ge Shi-chao ai Hong-Kan Wang Feng Sun Li Chen Wen-Xian Guan Department of Gastrointestinal Surgery Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical School Sir Run Run Shaw Hospital Zhejiang University School of Medicine First Affiliated Hospital of Zhejiang University School of Medicine

aiM To find an accurate and simple predictor for postoperative short-term complications after gastrectomy. METHODS Two hundred and twenty-three patients undergoing gastric cancer resection between October 1,2015 and September 30,2016 were enrolled in this study. Univariate and multivariate analyses were used toidentify risk factors for complications after gastrectomy. The cutoff values and diagnostic accuracy were examined by receiver operating characteristic *** Sixty-two(27.8%) patients had short-term complications after gastric cancer resection. The postoperative decrease in serum albumin(?ALB) was an independent risk factor for complications(OR = 17.957,95%CI: 6.073-53.095,P < 0.001). The cutoff value was 14.0% and the area under the curve was higher than that of C-reactive protein on postoperative day 3(area under the curve: 0.806 vs 0.709). Patients with ?ALB ≥ 14.0% were more likely to have short-term complications after gastrectomy(46.7% vs 5.0%,P < 0.001),prolonged hospital stay(17.2 ± 10.8 d vs 14.1 ± 4.2 d,P = 0.007) and higher comprehensive complication index(P < 0.001) than those with ?ALB < 14.0%.CONCLUSION Postoperative ?ALB with a cutoff of 14.0% can be used to recognize patients who have high risk of short-term complications following gastric cancer resection.

关键词： Gastric cancer Postoperative complications Gastrectomy Serum albumin Predictor

Soil Quality Assessment of Acid Sulfate Paddy Soils with Different Productivities in Guangdong Province,China

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Journal of Integrative Agriculture 2014年第1期13卷 177-186页

作者： LIU Zhan-jun ZHOU Wei SHEN Jian-bo LI Shu-tian LIANG Guo-qing WANG Xiu-bin SUN Jing-wen ai chao Key Laboratory of Plant Nutrition and Fertilization Ministry of Agriculture/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural Sciences College of Resources and Environmental Sciences China Agricultural University

Land conversion is considered an effective measure to ensure national food security in China, but little information is available on the quality of low productivity soils, in particular those in acid sulfate soil regions. In our study, acid sulfate paddy soils were divided into soils with high, medium and low levels based on local rice productivity, and 60 soil samples were collected for analysis. Twenty soil variables including physical, chemical and biochemical properties were determined. Those variables that were significantly different between the high, medium and low productivity soils were selected for principal component analysis, and microbial biomass carbon （MBC）, total nitrogen （TN）, available silicon （ASi）, pH and available zinc （AZn） were retained in the minimum data set （MDS）. After scoring the MDS variables, they were integrated to calculate a soil quality index （SQI）, and the high, medium and low productivity paddy soils received mean SQI scores of 0.95, 0.83 and 0.60, respectively. Low productivity paddy soils showed worse soil quality, and a large discrepancy was observed between the low and high productivity paddy soils. Lower MBC, TN, ASi, pH and available K （AK） were considered as the primary limiting factors. Additionally, all the soil samples collected were rich in available P and AZn, but deficient in AK and ASi. The results suggest that soil AK and ASi deficiencies were the main limiting factors for all the studied acid sulfate paddy soil regions. The application of K and Si on a national basis and other sustainable management approaches are suggested to improve rice productivity, especially for low productivity paddy soils. Our results indicated that there is a large potential for increasing productivity and producing more cereals in acid sulfate paddy soil regions.

关键词： soil quality assessment acid sulfate paddy soil soil quality index different productivity

Analysis of data for γp → f1(1285)p photoproduction

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Chinese Physics C 2024年第2期48卷 141-152页

作者：王爱超韦能昌黄飞 College of Science China University of Petroleum(East China)Qingdao 266580China School of Physics Henan Normal UniversityXinxiang 453007China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 101408China

The photoproduction of the f1(1285)meson off the proton target is investigated within an effective Lagrangian *** t-channelρ-andω-exchange diagrams,u-channel nucleon-exchange diagram,generalized contact term,and s-channel pole diagrams of the nucleon and a minimal number of nucleon resonances are taken into account in constructing the reaction amplitudes to describe the experimental *** different models,that is,the Feynman,Regge,and interpolated Regge models,are employed,where the t-channel reaction amplitudes are constructed in Feynman,Regge,and interpolated Regge types,*** results show that neither the Feynman model with two nucleon resonances nor the interpolated Regge model with one nucleon resonance can satisfactorily reproduce the available data forγp→f1(1285)***,in the Regge model,when any one of the N(1990)7/2^(+),N(2000)5/2^(+),N(2040)3/2^(+),N(2060)5/2^(-),N(2100)1/2^(+),N(2120)3/2^(-),N(2190)7/2^(-),N(2300)1/2^(+),and N(2570)5/2^(-)resonances is considered,the data can be well *** resulting resonance parameters are consistent with those advocated in the Particle Data Group(PDG)*** analysis shows that,in the high-energy region,the peaks of γp→f1(1285)p differential cross sections at forward angles are dominated by the contributions from t-channelρ-andω-exchange diagrams,while in low-energy region,the s-channel pole diagrams of resonances also provide significant contributions to theγp→f1(1285)p cross sections.

关键词： photoproduction reactions effective Lagrangian approach nucleon resonances