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老年肌少症与吞咽障碍相关性研究进展

中国骨质疏松杂志 2024年第4期30卷 560-564页

作者：李雨洁李娟郝明青薛超赵雪姣卢婷贵州中医药大学贵州贵阳550002 贵州省人民医院贵州贵阳550001

肌少症与吞咽障碍是老年群体常见的病理状况。老年肌少症患者往往出现与吞咽相关肌群的质量和力量下降而导致吞咽障碍。营养物质因吞咽功能下降而吸收减少,进一步加剧营养不良和肌肉分解,加速肌少症的过程,这两者之间为因果循环。现已... 详细信息

肌少症与吞咽障碍是老年群体常见的病理状况。老年肌少症患者往往出现与吞咽相关肌群的质量和力量下降而导致吞咽障碍。营养物质因吞咽功能下降而吸收减少,进一步加剧营养不良和肌肉分解,加速肌少症的过程,这两者之间为因果循环。现已成为老年群体主要健康问题之一。但现国内对该领域关注有限,具体的病理生理机制还尚未明确,两者间的相关性需进一步研究。因此,本文对老年肌少症与吞咽障碍的相关性进行综述,以期提高医护人员对两者相关性之间的认识,为相关研究提供参考。

关键词：肌少症吞咽障碍相关性综述

Radicle pruning by seed-eating animals helps oak seedlings absorb more soil nutrient

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Integrative Zoology 2021年第5期16卷 637-645页

作者： Xianfeng YI Minghui WANG chao xue Mengyao JU College of Life Sciences Qufu Normal UniversityQufuChina

Although radicle pruning has well been observed in plant-animal interactions,research has not been conducted to determine how radicle pruning by seed-eating animals regulates nutrition mobilization of cotyledonary reserves and absorption of soil *** used stable nitrogen isotopes to test how acorns of early-germinating oak species(Quercus variabilis,***,and ***)trade off nutrients in the cotyledons and those in the soil in response to radicle pruning by seed-eating *** pruning by rodents resulted in root branching in the 3 early-germinating oak ***,radicle pruning increased shoot dry weight and substantially reduced the root-to-shoot ratio of oak *** to the decreased dry weight of roots and root-to-shoot ratio,the dry weight of the remnant cotyledons was higher after radicle pruning in the 3 oak *** provided first evidence that radicle pruning by seed-eating animals improved seedling performance of early-germinating oaks by increasing absorption of nutrients from *** results indicate that early-germinating oak seedlings trade off nutrition budget by altering nutrient absorption from soil and reserve mobilization from cotyledons in response to radicle pruning by seed-eating *** study provided new insight into the nutrition allocation mechanism of young seedlings in response to radicle pruning by seed-eating animals,reflecting a mutualistic interaction between early-germinating oak and food-hoarding animals.

关键词： ^(15)N labeling biomass allocation oak radicle pruning seedling development

Derivation and analysis on the analytical structure of interval type-2 fuzzy controller with two nonlinear fuzzy sets for each input variable

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Frontiers of Information Technology & Electronic Engineering 2016年第6期17卷 587-602页

作者： Bin-bin LEI xue-chao DUAN Hong BAO Qian XU MOE Key Laboratory of Electronic Equipment Structure Design Xidian University Xinjiang Observatory National Astronomical ObservatoriesChinese Academy of Sciences

Type-2 fuzzy controllers have been mostly viewed as black-box function generators. Revealing the analytical structure of any type-2 fuzzy controller is important as it will deepen our understanding of how and why a type-2 fuzzy controller functions and lay a foundation for more rigorous system analysis and design. In this study, we derive and analyze the analytical structure of an interval type-2 fuzzy controller that uses the following identical elements: two nonlinear interval type-2 input fuzzy sets for each variable, four interval type-2 singleton output fuzzy sets, a Zadeh AND operator, and the Karnik-Mendel type reducer. Through dividing the input space of the interval type-2 fuzzy controller into 15 partitions, the input-output relationship for each local region is derived. Our derivation shows explicitly that the controller is approximately equivalent to a nonlinear proportional integral or proportional differential controller with variable gains. Furthermore, by comparing with the analytical structure of its type-1 counterpart, potential advantages of the interval type-2 fuzzy controller are analyzed. Finally, the reliability of the analysis results and the effectiveness of the interval type-2 fuzzy controller are verified by a simulation and an experiment.

关键词： Interval type-2 fuzzy controller Analytical structure Karnik-Mendel type reducer

Current LC-MS-based strategies for characterization and quantification of antibody-drug conjugates

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Journal of Pharmaceutical Analysis 2020年第3期10卷 209-220页

作者： Xiaoyu Zhu Shihan Huo chao xue Bo An Jun Qu Department of Pharmaceutical Sciences School of Pharmacy&Pharmaceutical SciencesUniversity at BuffaloState University of New YorkBuffaloNY14214USA New York State Center of Excellence in Bioinformatics&Life Sciences BuffaloNY14203USA Department of Chemical and Biological Engineering School of Engineering and Applied ScienceUniversity at BuffaloState University of New YorkBuffaloNY14260USA Exploratory Biomarker In-vitro/In-vivo TranslationR&D ResearchGlaxoSmithKline Pharmaceuticals1250 South Collegeville RdCollegevillePA19426USA

The past few years have witnessed enormous progresses in the development of antibody-drug conjugates(ADCs).Consequently,comprehensive analysis of ADCs in biological systems is critical in supporting discovery,development and evaluation of these *** chromatography-mass spectrometry(LC-MS)has eme rged as a promising and versatile tool for ADC analysis across a wide range of scenarios,owing to its multiplexing ability,rapid method development,as well as the capability of analyzing a variety of targets ranging from small-molecule payloads to the intact protein with a high,molecular ***,despite this tremendous potential,challenges persist due to the high complexity in both the ADC molecules and the related biological *** review summarizes the up-to-date LC-MS-based strategies in ADC analysis and discusses the challenges and opportunities in this rapidly-evolving field.

关键词： Antibody-drug conjugate(ADC) Liquid chromatography-mass spectrometry(LCMS) Drug-to-antibody ratio(DAR)

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腕管综合征诊治研究进展

国际骨科学杂志 2024年第2期45卷 100-104页

作者：薛超徐克钢李永平山西医科大学第二临床医学院山西太原030001 山西医科大学第二临床医院骨科山西太原030001

腕管综合征(CTS)是发病率最高的周围神经卡压疾病综合征,常累及手桡侧三指半的感觉和大鱼际的运动功能,轻者仅指端麻木,加重可影响睡眠和日常生活,甚至影响手的抓捏功能。CTS虽然体征极为典型,但疑难病例常需与神经根型颈椎病、胸廓出... 详细信息

腕管综合征(CTS)是发病率最高的周围神经卡压疾病综合征,常累及手桡侧三指半的感觉和大鱼际的运动功能,轻者仅指端麻木,加重可影响睡眠和日常生活,甚至影响手的抓捏功能。CTS虽然体征极为典型,但疑难病例常需与神经根型颈椎病、胸廓出口综合征及其他外周神经卡压性疾病、脊髓病变等相鉴别,才能准确诊断,精准治疗。对轻中度CTS患者可行夹板固定、局部药物注射等保守治疗。对于经保守治疗无效、缓解后又复发、合并大鱼际肌萎缩或腕管内出现病理改变的CTS患者,都应考虑手术治疗。目前临床上治疗CTS的主要手术方式有开放性腕管松解减压术(OCTR)、微创小切口腕管松解减压术(MICTR)及内镜辅助下腕管松解减压术(ECTR),这3种术式各有优劣,但在临床疗效上没有显著差异。该文就CTS诊治研究进展进行综述。

关键词：腕管综合征正中神经腕横韧带诊断治疗

子宫宫腔病变应用经阴道三维超声的诊断价值探讨

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实用妇科内分泌电子杂志 2024年第16期11卷 92-94页

作者：徐华勤吴小云薛超江苏省宜兴市人民医院超声科江苏无锡214200

目的研究经阴道三维超声诊断子宫宫腔病变的临床价值。方法选取88例疑似子宫宫腔病变患者,对所有患者进行经阴道三维超声诊断,以最终的确诊结果作为金标准,评价经阴道三维超声在诊断子宫宫腔病变中的价值。结果在所有患者中最终确诊为... 详细信息

目的研究经阴道三维超声诊断子宫宫腔病变的临床价值。方法选取88例疑似子宫宫腔病变患者,对所有患者进行经阴道三维超声诊断,以最终的确诊结果作为金标准,评价经阴道三维超声在诊断子宫宫腔病变中的价值。结果在所有患者中最终确诊为子宫宫腔病变患者50例,而经阴道三维超声检出52例,对比差异无统计学意义(P>0.05)。经阴道三维超声诊断子宫宫腔病变患者的子宫内膜容积明显比非子宫宫腔病变患者的更小(P<0.05)。绘制ROC曲线,经计算可得经阴道三维超声诊断子宫内膜息肉内膜容积的AUC为0.893(95%CI0.825,0.962),诊断宫腔粘连内膜容积的AUC为0.946(95%CI0.905,0.987),诊断子宫肌瘤内膜容积的AUC为0.902(95%CI0.836,0.968)。结论将经阴道三维超声应用在子宫宫腔病变患者诊断中具有较高的检出率,值得临床应用。

关键词：子宫宫腔病变经阴道三维超声子宫内膜容积诊断价值

花生-棉花间作田蚜虫的发生及其对新烟碱类杀虫剂抗性水平评价

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农药 2024年第5期63卷 376-381页

作者：薛超王爱玉张芸张建华杨媛雪赵鸣山东省农业科学院经济作物研究所济南250100

[目的]旨在明确花生-棉花间作模式下蚜虫的发生情况,评价其对吡虫啉、噻虫嗪、噻虫胺和呋虫胺这4种新烟碱类农药的抗性水平,指导该种植模式下蚜虫防控的合理用药。[方法]采用目测法对山东省临清市花生-棉花间作田中花生蚜(Aphis cracciv... 详细信息

[目的]旨在明确花生-棉花间作模式下蚜虫的发生情况,评价其对吡虫啉、噻虫嗪、噻虫胺和呋虫胺这4种新烟碱类农药的抗性水平,指导该种植模式下蚜虫防控的合理用药。[方法]采用目测法对山东省临清市花生-棉花间作田中花生蚜(Aphis craccivora Koch)和棉蚜(Aphis gossypii Glover)种群进行田间调查;通过浸叶法测定花生蚜和棉蚜田间种群及室内敏感品系对4种新烟碱类杀虫剂的生物活性;通过喷雾法测定4种杀虫剂对龟纹瓢虫(Propylaea japonica Thunberg)幼虫和成虫的毒力。[结果]棉蚜的发生较花生蚜严重,棉蚜具有苗蚜期和伏蚜期2个发生高峰期,而花生蚜只有1个发生高峰期,与棉蚜的苗蚜期相近;临清花生蚜种群对吡虫啉、噻虫嗪、噻虫胺、呋虫胺的抗性倍数依次为3.89、1.58、6.55、1.46,分别处于敏感、敏感、低抗及敏感水平,而临清棉蚜种群对吡虫啉、噻虫嗪、噻虫胺、呋虫胺的抗性倍数依次为105.56、29.57、117.33、7.99,分别处于高抗、中抗、高抗和低抗水平;4种新烟碱类杀虫剂对龟纹瓢虫与花生蚜的选择毒力比大于1,都具有正向及以上的选择性;而吡虫啉和噻虫胺对龟纹瓢虫与棉蚜、噻虫嗪对龟纹瓢虫幼虫与棉蚜的选择毒力比小于1,都具有负向选择性,只有呋虫胺对龟纹瓢虫与棉蚜均具有正向选择性。[结论]对花生-棉花种植模式蚜虫防控,可在5月下旬适时使用呋虫胺,同时为减缓蚜虫对新烟碱类杀虫剂抗药性的升高,应轮换使用对天敌安全性较高的其他种类的杀虫剂。

关键词：花生-棉花间作花生蚜棉蚜龟纹瓢虫新烟碱类杀虫剂抗药性选择毒力比

Molecular identification and enzymatic properties of laccase2 from the diamondback moth Plutella xylostella (Lepidoptera:Plutellidae)

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Journal of Integrative Agriculture 2018年第10期17卷 2310-2319页

作者： LIU Zhen-gang WANG Huan-huan xue chao-bin Key Laboratory of Pesticide Toxicology and Application Technique College of Plant Protection Shandong Agricultural University

Laccase（EC 1.***.3.2）is known to oxidize various aromatic and nonaromatic compounds via a radical-catalyzed reaction,which generally includes two types of laccase,Lac1 and ***1 oxidizes toxic compounds in the diet,and Lac2 is known to play an important role in melanizing the insect *** this study,we cloned and sequenced the cDNA of the diamondback moth,Plutella xylostella Lac2（PxLac2）,from the third instar larvae using polymerase chain reaction（PCR）and rapid amplification of cDNA ends *** results showed that the full-length PxLac2 cDNA was 1 944 bp long and had an open reading frame of 1 794 ***2 encoded a protein with 597 amino acids and had a molecular weight of 66.09 ***,we determined the expression levels of PxLac2 in different stages by quantitative PCR（qPCR）.The results indicated that PxLac2 was expressed differently in different *** observed the highest expression level in pupae and the lowest expression level in fourth instar *** also investigated the enzymatic properties of laccase,which had optimal activity at pH 3.0 and at 35°*** these optimal conditions,laccase had a Michaelis constant（Km）of 0.97 mmol L-1,maximal reaction speed（Vm）of 56.82 U mL-1,and activation energy（Ea）of 17.36 kJ mol-1 to oxidize2,2＇-azino-bis（3-ethylbenzothiazoline-6-sulfonic acid ammonium salt）.Type II copper enhanced laccase activity below 0.8mmol L-1 and reduced enzyme activity above 0.8 mmol L-1 with an IC50 concentration of 1.26 mmol *** study provides insights into the biological function of laccase.

关键词： laccase melanization in vivo expression enzymatic properties Plutella xylostella

An Improved Iterative Nonlinear Sliding Mode Control for Tethered Satellite

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An Improved Iterative Nonlinear Sliding Mode Control for Tet...