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Nature:科学家鉴别出调节机体睡眠的两个关键基因

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现代生物医学进展 2017年第6期17卷 I0002-I0002页

作者： Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama, Takeshi Kanda, Makito Sato, Zhiqiang Wang, Jing Ma, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta-Hirashima, Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J. Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, shinichi Miyazaki, Linzi Connor, Yu Hayashi, Qinghua Liu, Joseph S. Takahashi Masashi Yanagisawa Hiromasa Funato Makito Sato Masashi Yanagisawa shin Nakane, Jun Tomita Kazuhiko Kume Seiya Mizuno, Fumihiro Sugiyama Satoru Takahashi Vivek Kumar Joseph S. Takahashi Vivek Kumar Ikuo Miura, Tomohiro Suzuki Shigeharu Wakana Atsushi Watanabe Manabu Abe Kenji Sakimura Yu Hayashi Qinghua Liu Joseph S. Takahashi Masashi Yanagisawa Masashi Yanagisawa International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba Ibaraki 305-8575 Japan Department of Anatomy Faculty of Medicine Toho University Ota-ku Tokyo 143-8540 Japan Department of Molecular Genetics University of Texas Southwestern Medical Center Dallas Texas 75390 USA Department of Neuropharmacology Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Aichi 467-8603 Japan Laboratory Animal Resource Center University of Tsukuba Tsukuba Ibaraki 305-8575 Japan Department of Neuroscience University of Texas Southwestern Medical Center Dallas Texas 75390 USA The Jackson Laboratory Bar Harbor Maine 04609 USA Technology and Development Team for Mouse Phenotype Analysis RIKEN Bioresource Center Tsukuba Ibaraki 305-0074 Japan Laboratory of Research Advancement National Center for Geriatrics and Gerontology Obu Aichi 474-8511 Japan Department of Cellular Neurobiology Brain Research Institute Niigata University Niigata 951-8585 Japan PRESTO Japan Science and Technology Agency Kawaguchi Saitama 332-0012 Japan Department of Biochemistry University of Texas Southwestern Medical Center Dallas Texas 75390 USA Howard Hughes Medical Institute University of Texas Southwestern Medical Center Dallas Texas 75390 USA Life Science Center Tsukuba Advanced Research Alliance University of Tsukuba Tsukuba Ibaraki 305-8575 Japan

近日，刊登在国际杂志Nature上的一项研究报告中，来自西南医学中心等机构的研究人员通过研究鉴别出了两个关键的核心基因，这两个基因能够帮助调节机体深度睡眠和做梦的水平，相关研究或为阐明相关的基因控制睡眠的网络提供新的线索。... 详细信息

近日，刊登在国际杂志Nature上的一项研究报告中，来自西南医学中心等机构的研究人员通过研究鉴别出了两个关键的核心基因，这两个基因能够帮助调节机体深度睡眠和做梦的水平，相关研究或为阐明相关的基因控制睡眠的网络提供新的线索。此前研究者通过对小鼠进行研究发现了能够控制机体快速眼动睡眠的基因，同时该基因还能够诱导深度睡眠。而第二个基因能够控制机体对快速眼动睡眠的需求量，相关研究为科学家们提供了一个关键的切入点来帮助解释睡眠工作的机制，同时研究者还鉴别出了治疗睡眠障碍的潜在靶点。

关键词：睡眠障碍核心基因科学家机体鉴别基因控制研究人员需求量

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人鼻咽癌组织的体外培养和类淋巴母细胞建株

实验生物学报 1978年第2期 219-227页

作者：沈立美潘玉芝张君奎金心梅孙燮钧姚曾序唐忠怀张有望中国科学院上海细胞生物学研究所上海第一医学院眼耳鼻喉科医院上海肿瘤医院

鼻咽癌是我国南方一些地区的高发肿瘤,对人民健康危害较大,为了贯彻预防为主的方针,我国有关医疗科研单位正在其病因学方面进行了很多工作。从最近有关资料来看,鼻咽癌病毒病因的研究,主要是与疱疹病毒族中的EB病毒关系的研究,值得重视... 详细信息

鼻咽癌是我国南方一些地区的高发肿瘤,对人民健康危害较大,为了贯彻预防为主的方针,我国有关医疗科研单位正在其病因学方面进行了很多工作。从最近有关资料来看,鼻咽癌病毒病因的研究,主要是与疱疹病毒族中的EB病毒关系的研究,值得重视。这对于逐步弄清我国鼻咽癌的致病因素和条件是有益的。我们从1973年开始进行鼻咽部临床活检组织的体外培养工作,并对已建株的细胞作了电子显微镜下病毒颗粒的检查。本文报道了这项工作的一些结果。

关键词：淋巴母细胞鼻咽部活检人鼻咽癌体外培养

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伊森伯格管理学院商业创新中心

城市环境设计 2019年第2期118卷 54-61页

作者： Alice Cladet Amina Blacksher Barbara Stallone Beat Schenk Cheyenne Vandevoorde Daniel Kidd Davide Maggio Deborah Campbell Denys Kozak Derek Wong Domenic Schmid Douglass Alligood Elena Bresciani Emily Mohr Fabian Lorenz Francesca Portesine Ibrahim Salman Jan Leenknegt Justyna Mydlak Kai-Uwe Bergmann Kristoffer Negendahl Ku Hun Chung Linda Halim Lucas Hong Manon Otto Maria Eugenia Dominguez Mustafa Khan Nicolas Gustin Pei Pei Yang Peter Lee Seoyoung shin Simon Lee Terrence Chew Tianqi Zhang Tore Banke Yehezkiel Wiliardy Yixin Li Max Touhey Laurian Ghinitoiu 曲鸿

这座有着铜质外观的商业创新中心坐落于马萨诸塞大学阿默斯特分校的核心地带,是由BIG建筑事务所和建筑师Goody Clancy共同设计的。它的建成为这所全美排名前30的商学院增加了70000平方英尺(约6503平方米)的学习合作和社交的空间。新的... 详细信息

这座有着铜质外观的商业创新中心坐落于马萨诸塞大学阿默斯特分校的核心地带,是由BIG建筑事务所和建筑师Goody Clancy共同设计的。它的建成为这所全美排名前30的商学院增加了70000平方英尺(约6503平方米)的学习合作和社交的空间。新的扩建和部分翻新使伊森伯格管理学院现有的空间扩大了近一倍,为学院过去十

关键词：建筑事务所阿默斯特商业创新

Phase Ⅱ study of R-CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma:consortium for improving survival of lymphoma(CISL)study

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Cancer Communications 2019年第1期39卷 526-535页

作者： Sung Yong Oh Won Seog Kim Jin Seok Kim Seok Jin Kim Dok Hyun Yoon Deok-Hwan Yang Won Sik Lee Hyo Jung Kim Ho-Young Yhim Seong Hyun Jeong Jong Ho Won Suee Lee Jee Hyun Kong Sung-Nam Lim Jun Ho Ji Kyung A.Kwon Gyeong-Won Lee Jae Hoon Lee Ho Sup Lee Ho-Jin shin Cheolwon Suh Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Division of Hematology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Republic of Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Republic of Korea Department of Hematology-Oncology Chonnam National University Hwasun HospitalHwasun 58128Republic of Korea Department of Hematology Busan Paik HospitalInje University College of MedicineBusan 04511Republic of Korea Department of Internal Medicine Hallym University Sacred Heart HospitalHallym University College of MedicineAnyang 14068Republic of Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907Republic of Korea Department of Hematology-Oncology Ajou University School of MedicineSuwon 16499Republic of Korea Department of Internal Medicine Soonchunhyang University Seoul HospitalSoonchunhyang University College of MedicineSeoul 04401Republic of Korea Division of Hematology-Oncology Department of Internal MedicineWonju Severance Christian HospitalYonsei University College of MedicineWonju 26426Republic of Korea Department of Internal Medicine Haeundae Paik HospitalInje University College of MedicineBusan 48108Republic of Korea Division of Hematology and Oncology Department of Internal MedicineSamsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Republic of Korea Division of Hematology-Oncology Department of Internal MedicineDongnam Institute of Radiological and Medical SciencesBusan 46033Republic of Korea Division of Hematology-Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Republic of Korea Department of Internal Medicine Gachon University Gil Medical CenterIncheon 21565Republic of

Background:The response rate and survival improvement for rituximab,a CD20-targeting monoclonal antibody,have been demonstrated in marginal zone lymphoma(MZL)as monotherapy and in combination with chemotherapeutic regimens,yet relapses still occur despite treatment ***,extending the period of remission in MZL patients remains an essential *** multicenter,single-arm,open-label phase II study evaluated the survival efficacy of 2 years of rituximab-maintenance therapy in patients with stage III-IV CD20-positive MZL who had responded to first-line R-CVP(rituximab,cyclophosphamide,vincristine,and prednisolone).The objective of this study was to determine whether rituximab maintenance following R-CVP warrants further ***:Prior to rituximab-maintenance therapy,patients received 6-8 cycles of first-line R-CVP therapy for stage III-IV ***(375 mg/m^(2)),cyclophosphamide(750 mg/m^(2)),and vincristine(1.4 mg/m^(2);maximum 2 mg)were administered via an intravenous infusion on day 1 of each 3-week cycle,while oral prednisolone(100 mg)was given on days 1-5 of each 3-week *** patients who achieved complete response(CR),partial response(PR),or stable disease(SD)to R-CVP treatment,were prescribed rituximab-maintenance therapy which was administered intravenously at a dose of 375 mg/m^(2) every 8 weeks for up to 12 *** primary endpoint was progression-free survival(PFS).Secondary endpoints were overall survival(OS)and treatment ***:47 patients were enrolled,of whom,45(96%)received rituximab-maintenance ***(33%)patients had nodal *** R-CVP first-line therapy,20(44%),22(49%),and 3(7%)patients achieved CR,PR,and SD,*** a median follow-up of 38.2 months,their observed 3-year PFS rate was 81%.During the rituximab-maintenance,6 PR and 1 SD patients achieved CR following the administration of *** LDH and the presence of B symptoms were found to be significant prognostic fac

关键词： Marginal zone Lymphoma Advanced stage Rituximab Cyclophosphamide Vincristine Maintenance Multicenter Open label Survival

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气体色谱法分析丙烯腈中的杂质

吉林大学自然科学学报 1965年第3期 95-102页

作者：賈树賢邓丽媛刘兴邦徐明义胡尔金刘玺玉侯福禎那崇武沈雨生郭績群楊景秋吉林大学吉林电石厂吉林电石厂 1965年畢业生

1.用聚己二酸乙二醇酯和聚乙二醇1000两种固定液可使丙烯腈中的主要杂质完全分离.用聚己二酸乙二醇酯固定液可完全分离乙炔、氯乙烯、乙烯基乙炔、乙醛、氯丁二烯、氢氰酸、二乙烯基乙炔、丙烯腈+甲基乙烯基酮、顺-1-氰基丁二烯-[1,3]和... 详细信息

1.用聚己二酸乙二醇酯和聚乙二醇1000两种固定液可使丙烯腈中的主要杂质完全分离.用聚己二酸乙二醇酯固定液可完全分离乙炔、氯乙烯、乙烯基乙炔、乙醛、氯丁二烯、氢氰酸、二乙烯基乙炔、丙烯腈+甲基乙烯基酮、顺-1-氰基丁二烯-[1,3]和反-1-氰基丁二烯-[1,3](按逸出顺序排列).用聚乙二醇1000为固定液时可分出乙炔、氯乙烯、乙烯基乙炔、乙醛、氯丁二烯、二乙烯基乙炔、甲基乙烯基酮、丙烯氰、氢氰酸、顺-1-氰基丁二烯-[1.3]和反-1-氰基丁二烯-[1.3].其中乙烯基乙炔与乙醛不能完全分离. 2.用气体密度检定器时可按理论计算的校正因子进行定量计算.当浓度在1％以上时误差约为3％.

关键词：乙烯基乙炔乙醛氯乙烯脂肪族醛乙烯基氯氯丁二烯氯代烃甲基乙烯基酮丙烯睛一元腈

评估大气细颗粒物暴露所致全球疾病负担的一个综合风险函数

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环境与职业医学 2014年第7期31卷 554-554页

作者： Richard T.Burnett C.Arden Pope Ⅲ Majid Ezzati Casey Olives Stephen S.Lim Sumi Mehta Hwashin H.shin Gitanjali Singh Bryan Hubbell Michael Brauer H.Ross erson Kirk R.Smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner Susan M.Gapstur W.Ryan Diver Aaron Cohen

[背景]评估归因于环境空气中细颗粒物（PM2.5）长期暴露所致的疾病负担，需要具备相对风险（RR）函数形状和幅度两方面的知识。然而，在世界上很多观察到高PM2.5环境浓度的地方，都缺乏足够的直接证据确定死亡率RR函数的形状。

关键词：大气细颗粒物疾病负担相对风险函数评估 PM2 5 长期暴露环境空气

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添加壳聚寡糖对肉仔鸡生产性能、血液参数、相对器官重和肉质的影响

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饲料与畜牧（新饲料） 2009年第3期 59-59页

作者：刘冰 T.X.Zhou Y.J.Chen J.S.Yoo Y.Huang J.H.Lee H.D.Jang S.O.shin H.J.Kim J.H.Cho I.H.Kim

本研究的目的是评估在肉仔鸡日粮中添加壳聚寡糖对生长性能、血液参数、相对器官重和肉质的影响。480只肉仔鸡，平均初始体重45．04g，随机分成4个日粮处理组（每个处理6个重复，每个重复20只肉鸡）：①对照组（基础日粮）；②ANT组（基... 详细信息

本研究的目的是评估在肉仔鸡日粮中添加壳聚寡糖对生长性能、血液参数、相对器官重和肉质的影响。480只肉仔鸡，平均初始体重45．04g，随机分成4个日粮处理组（每个处理6个重复，每个重复20只肉鸡）：①对照组（基础日粮）；②ANT组（基础13粮＋44mg／kg阿维霉素）；

关键词：血液参数肉仔鸡器官重生产性能寡糖肉质日粮处理基础日粮

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塑料晶体的庞压卡效应

家电科技 2019年第3期 9-9页

作者： Bing Li Yukinobu Kawakita Seiko Ohira-Kawamura Takeshi Sugahara Hui Wang Jingfan Wang Yanna Chen Saori I.Kawaguchi Shogo Kawaguchi Koji Ohara Kuo Li Dehong Yu Richard Mole Takanori Hattori Tatsuya Kikuchi shin-ichiro Yano Zhao Zhang Zhe Zhang Weijun Ren Shangchao Lin Osami Sakata Kenji Nakajima Zhidong Zhang 李巧红中科院金属研究所

制冷对现代社会至关重要,世界上25%到30%的电力用于制冷。例如,食品储存和空调的使用等都需要耗费大量的电力。目前的制冷技术主要还是以传统蒸汽压缩循环为主,但由于具有加剧全球变暖的潜力危险,人们一直尝试找到更好的替代方案。在这... 详细信息

制冷对现代社会至关重要,世界上25%到30%的电力用于制冷。例如,食品储存和空调的使用等都需要耗费大量的电力。目前的制冷技术主要还是以传统蒸汽压缩循环为主,但由于具有加剧全球变暖的潜力危险,人们一直尝试找到更好的替代方案。在这背景下,基于固态相变热效应的制冷技术作为一种很有前途的替代技术,在近几十年来一直是研究者们关注的重点。但是,由于其等温爛变化小,所需驱动动能大以及材料性能有限等种种劣势均限制了其应用推广。

关键词：制冷技术晶体塑料蒸汽压缩全球变暖固态相变材料性能热效应

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid