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立体定向脑电图在难治性癫痫患者术前评估中的应用价值

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实用心脑肺血管病杂志 2022年第5期30卷 135-140页

作者：周笋董长征刘星曹姗河北北方学院研究生院河北省张家口市075000 河北省人民医院神经外二科河北省石家庄市050051

癫痫是一种严重的慢性神经系统疾病,其治疗重点在于控制患者癫痫发作。大多数患者口服抗癫痫药物即可有效缓解病情,但对于难治性癫痫患者来说,口服抗癫痫药物往往不能有效控制癫痫发作,需进一步手术切除致痫区域。立体定向脑电图(SEEG)... 详细信息

癫痫是一种严重的慢性神经系统疾病,其治疗重点在于控制患者癫痫发作。大多数患者口服抗癫痫药物即可有效缓解病情,但对于难治性癫痫患者来说,口服抗癫痫药物往往不能有效控制癫痫发作,需进一步手术切除致痫区域。立体定向脑电图(SEEG)检查是一项安全有效的侵入性术前评估方法,在难治性癫痫患者致痫灶的精确定位及治疗方面具有重要作用。本文简述了SEEG电极植入术、SEEG检查结果分析、SEEG电极植入术的优缺点、SEEG引导下射频热凝损毁术、SEEG电极植入方案的规划及具体应用,以期深入、全面地了解SEEG在难治性癫痫患者术前评估中的应用价值。

关键词：耐药性癫痫难治性癫痫立体定向脑电图术前评估

历史建筑更新思考——以哈尔滨绝缘厂职工小区改造创意设计为例

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林业科技情报 2013年第2期45卷 26-27页

作者：董长铮张剑锋黑龙江省林业设计研究院黑龙江东方学院

以老工业区历史住宅建筑为创意改造设计案例,分析了人、自然与建筑的相互依存关系;采用早前工业城市常见的管道形态联结新老建筑,对管道进行细节处理,用以实现水体循环及人员穿行,解决了老旧建筑中存在的公共交流活跃度和社区文体活动... 详细信息

以老工业区历史住宅建筑为创意改造设计案例,分析了人、自然与建筑的相互依存关系;采用早前工业城市常见的管道形态联结新老建筑,对管道进行细节处理,用以实现水体循环及人员穿行,解决了老旧建筑中存在的公共交流活跃度和社区文体活动缺失的问题,勾勒了新老建筑自然沟通融合、物质能源在建筑生态系统内有序循环、建筑环境低碳环保的设计远景。

关键词：历史建筑工业厂区改造更新思考

低剂量伽玛刀照射对癫痫大鼠皮层及海马NMDA受体亚基表达的影响

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中国神经精神疾病杂志 2019年第7期45卷 416-421页

作者：李卫泊尹昱梁传栋吕佩源赵振彪董长征河北医科大学第二医院石家庄050000 河北省人民医院

目的观察低剂量伽玛刀照射对癫痫大鼠皮层和海马N-甲基-D-天氡氨酸(N-methyl-D-aspartate,NMDA)受体亚基表达的影响。方法根据动物是否致痫及接受伽玛刀照射,将大鼠分为4组:对照组、伽玛刀组、药物致痫组、伽玛刀+药物组。腹腔连续注射... 详细信息

目的观察低剂量伽玛刀照射对癫痫大鼠皮层和海马N-甲基-D-天氡氨酸(N-methyl-D-aspartate,NMDA)受体亚基表达的影响。方法根据动物是否致痫及接受伽玛刀照射,将大鼠分为4组:对照组、伽玛刀组、药物致痫组、伽玛刀+药物组。腹腔连续注射戊四氮(pentylenetetrazole,PTZ)制备癫痫大鼠模型,以双侧额叶为照射靶区对大鼠进行低剂量伽玛刀照射,边缘剂量为15Gy。观察并记录各组大鼠伽玛刀照射前、后癫痫发作情况,并于伽玛刀照射后12周后留取脑组织,分别利用免疫组化及免疫蛋白印迹法对大鼠皮层及海马NMDA受体亚基NR1、NR2A和NR2B进行检测。结果对照组及伽玛刀组大鼠无痫性发作表现,与药物致痫组大鼠相比,伽玛刀+药物组大鼠经低剂量伽玛刀照射后12周,痫性发作明显减轻(P0.05)。结论癫痫大鼠额叶皮层及海马NR1、NR2A及NR2B亚单位蛋白表达增强,低剂量伽玛刀照射可能引起癫痫大鼠皮层及海马NMDA受体亚基表达减少,这可能是低剂量伽玛刀抑制癫痫发作的分子机制之一。

关键词： NMDA受体伽玛刀癫痫戊四氮认知功能

Mechanisms and Efficacy of Chinese Herbal Medicines in Benign Prostatic Hyperplasia

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Chinese Journal of Integrative Medicine 2025年第1期31卷 73-82页

作者： WANG Fu MA dong-yue YANG Jiu-tian LYU dong-fang GAO Qing-he LI Chun-lei ZHONG Chong-fu Department of Andrology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing100091China Graduate School Beijing University of Chinese MedicineBeijing100029China Department of Andrology The Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan250014China Faculty of Medicine Linyi UniversityLinyiShandong Province276000China

Benign prostatic hyperplasia(BPH) is one of the most common diseases in elderly men, the incidence of which gradually increases with age and leads to lower urinary tract symptoms(LUTS), which seriously affects the quality of life of patients. Chinese herbal medicines(CHMs) are widely used for the treatment of BPH in China and some other countries. To explore the molecular mechanisms of CHMs for BPH, we conducted a review based on peer-reviewed English-language publications in Pub Med and Web of Science databases from inception to December 31, 2023. This article primarily reviewed 32 papers on the use of CHMs and its active compounds in the treatment of BPH, covering animal and cell experiments, and identified relevant mechanisms of action. The results suggest that the mechanisms of action of CHMs in treating BPH may involve the regulation of sex hormones,downregulation of cell growth factors, anti-inflammatory and antioxidative effects, inhibition of cell proliferation, and promotion of apoptosis. CHMs also exhibit α-blocker-like effects, with the potential to relax urethral smooth muscle and alleviate LUTS. Additionally, we also reviewed 4 clinical trials and meta-analyses of CHMs for the treatment of BPH patients, which provided initial evidence of the safety and effectiveness of CHMs treatment. CHMs treatment for BPH shows advantages as a multi-component, multi-target, and multi-pathway therapy, which can mitigate the severity of the disease, improve LUTS, and may become a reliable treatment option in the future.

关键词： herbal treatment promotion

Event-Triggered Robust Parallel Optimal Consensus Control for Multiagent Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 40-53页

作者： Qinglai Wei Shanshan Jiao Qi dong Fei-Yue Wang IEEE the Institute of Systems Engineering Macau University of Science and Technology the State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation Chinese Academy of Sciences the School of Artificial Intelligence University of Chinese Academy of Sciences China Academy of Electronics and Information Technology the State Key Laboratory of Multimodal Artificial Intelligence Systems the School of Artificial Intelligence University of Chinese Academy of Sciences

This paper highlights the utilization of parallel control and adaptive dynamic programming(ADP) for event-triggered robust parallel optimal consensus control(ETRPOC) of uncertain nonlinear continuous-time multiagent systems(MASs).First, the parallel control system, which consists of a virtual control variable and a specific auxiliary variable obtained from the coupled Hamiltonian, allows general systems to be transformed into affine systems. Of interest is the fact that the parallel control technique's introduction provides an unprecedented perspective on eliminating the negative effects of disturbance. Then, an eventtriggered mechanism is adopted to save communication resources while ensuring the system's stability. The coupled HamiltonJacobi(HJ) equation's solution is approximated using a critic neural network(NN), whose weights are updated in response to events. Furthermore, theoretical analysis reveals that the weight estimation error is uniformly ultimately bounded(UUB). Finally,numerical simulations demonstrate the effectiveness of the developed ETRPOC method.

关键词： Adaptive dynamic programming (ADP) critic neural network (NN) event-triggered control optimal consensus control robust control

神经肽Y对海马神经元“癫痫样”动作电位的影响

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中国神经精神疾病杂志 2012年第8期38卷 473-476页

作者：董长征董秀芳孔艳莉陈尧赵磊李哲赵文清李文玲河北省人民医院功能神经外科石家庄050051 邢台市第一医院神经内科

目的探讨神经肽Y(neuropeptide Y,NPY)对海马神经元"癫痫样"动作电位的影响。方法用无镁细胞外液处理原代培养12 d的海马神经元3 h,诱导海马神经元癫痫样放电,建立海马神经元癫痫样放电模型;用全细胞膜片钳电流钳模式检测神经元动作电位... 详细信息

目的探讨神经肽Y(neuropeptide Y,NPY)对海马神经元"癫痫样"动作电位的影响。方法用无镁细胞外液处理原代培养12 d的海马神经元3 h,诱导海马神经元癫痫样放电,建立海马神经元癫痫样放电模型;用全细胞膜片钳电流钳模式检测神经元动作电位,分别给予0.1μmol/L和1μmol/L NPY各1μL,给药时间10 s,观察其对神经元动作电位频率及波幅的影响。结果无镁细胞外液处理神经元3 h,可以形成稳定的海马神经元癫痫样放电模型,频率16～23 Hz,波幅75～96 mV。模型组神经元动作电位频率为(18.00±2.32)Hz,而0.1μmol/L和1μmol/L NPY组分别为(4.75±1.04)Hz和(1.50±0.75)Hz。与模型组相比较,两种浓度NPY组均降低了动作电位发放的频率(P<0.05)。模型组神经元动作电位波幅为(82.25±5.17)mV,而0.1μmol/L和1μmol/L NPY组分别为(49.75±2.49)mV和(40.00±2.20)mV。与模型组相比较,两种浓度NPY组均降低了动作电位发放的波幅(P<0.05)。两种浓度NPY之间相比较,也有统计学差异(P<0.05)。1μmol/LNPY明显抑制了动作电位发放的频率和波幅。结论 NPY能够抑制无镁细胞外液诱发的神经元癫痫样电活动,为应用NPY抑制癫痫发作提供了细胞电生理学证据。

关键词：神经肽Y 癫痫神经元动作电位全细胞膜片钳记录

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao Li Yangfei Chen Yang Jiang Xiaofei Guo Han dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

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超高性能混凝土柱的抗震性能分析

公路工程 2021年第5期46卷 9-14,30页

作者：方志方文昌胡锐董长征湖南大学土木工程学院湖南长沙410082 湖北省交通投资集团有限公司湖北武汉430050

为分析超高性能混凝土(Ultra-High Performance Concrete,UHPC)柱的抗震性能,采用有限元程序OpenSees建立了UHPC柱的分析模型,以试验结果验证了分析模型的适用性。基于被验证的有限元模型,分析了轴压比、纵筋配筋率和UHPC强度对UHPC柱... 详细信息

为分析超高性能混凝土(Ultra-High Performance Concrete,UHPC)柱的抗震性能,采用有限元程序OpenSees建立了UHPC柱的分析模型,以试验结果验证了分析模型的适用性。基于被验证的有限元模型,分析了轴压比、纵筋配筋率和UHPC强度对UHPC柱受力变形性能的影响。结果表明:柱的极限承载能力随柱轴压比、纵筋配筋率和UHPC强度的增大而增大;延性系数随柱轴压比、UHPC强度的增大而减小,随纵筋配筋率的增大而增大。就所分析的情形而言,轴压比从0.1提高到0.4,极限承载能力增大75%,延性系数减小66%;纵筋配筋率从1.54%增大到2.54%,极限承载能力增大28%,延性系数增大5%;UHPC强度等级从UC120增大到UC180,极限承载能力增大21%,延性系数减小17%。若以位移延性系数不小于3为目标,则UHPC柱的设计轴压比限值可取为0.8。

关键词：超高性能混凝土(UHPC) 柱承载能力延性系数