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Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong zheng Du Wang Rongjie Lin Weihong Xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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Defect Engineering with Rational Dopants Modulation for High‑Temperature Energy Harvesting in Lead‑Free Piezoceramics

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Nano-Micro Letters 2025年第3期17卷 87-101页

作者： Kaibiao Xi Jianzhe Guo Mupeng zheng Mankang Zhu Yudong Hou Key Laboratory of Advanced Functional Materials Ministry of EducationCollege of Materials Science and EngineeringBeijing University of TechnologyBeijing 100124People’s Republic of China

High temperature piezoelectric energy harvester(HTPEH)is an important solution to replace chemical battery to achieve independent power supply of HT wireless ***,simultaneously excellent performances,including high figure of merit(FOM),insulation resistivity(ρ)and depolarization temperature(Td)are indispensable but hard to achieve in lead-free piezoceramics,especially operating at 250°C has not been reported ***,well-balanced performances are achieved in BiFeO3–BaTiO3 ceramics via innovative defect engineering with respect to delicate manganese *** to the synergistic effect of enhancing electrostrictive coefficient by polarization configuration optimization,regulating iron ion oxidation state by high valence manganese ion and stabilizing domain orientation by defect dipole,comprehensive excellent electrical performances(Td=340°C,ρ250°C>10^(7)Ωcm and FOM_(250°C)=4905×10^(–15)m^(2)N^(−1))are realized at the solid solubility limit of manganese *** HT-PEHs assembled using the rationally designed piezoceramic can allow for fast charging of commercial electrolytic capacitor at 250°C with high energy conversion efficiency(η=11.43%).These characteristics demonstrate that defect engineering tailored BF-BT can satisfy high-end HT-PEHs requirements,paving a new way in developing selfpowered wireless sensors working in HT environments.

关键词： Lead-free piezoceramic Defect engineering Dopants modulation High-temperature Piezoelectric energy harvester

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AI-Enhanced Secure Data Aggregation for Smart Grids with Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong Wang Chen Wang Wenying zheng Wei Gu School of Software Nanjing University of Information Science and TechnologyNanjing210044China School of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China School of Computer Science and Technology(School of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China School of Computer Science(School of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy *** research emphasizes data security and user privacy concerns within smart ***,existing methods struggle with efficiency and security when processing large-scale *** efficient data processing with stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation method designed to enhance aggregation efficiency and security by standardizing and normalizing various data *** approach optimizes data preprocessing,integrates Long Short-Term Memory(LSTM)networks for handling time-series data,and employs homomorphic encryption to safeguard user *** also explores the application of Boneh Lynn Shacham(BLS)signatures for user *** proposed scheme’s efficiency,security,and privacy protection capabilities are validated through rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan zheng Qingming Lin Yan You zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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刚果(金)Kipushi铜多金属矿床地质特征及成因

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河南科技 2020年第4期39卷 75-80页

作者：孙宁詹勇曾旭郑长友刘洋中色地科矿产勘查股份有限公司北京100012 北京中资环钻探有限公司北京100080 浙江华友钴业股份有限公司浙江桐乡314500

刚果(金)上加丹加省Kipushi铜多金属矿床产于中非铜钴矿带。通过对矿床地质特征以及Pb、Rb-Sr和Re-Os同位素、Nchanga花岗岩侵入年龄等进行综合分析可知,该矿床是在新元古界730~760Ma期间恩古巴地层完成初始沉积,伴随卢菲利安构造运动... 详细信息

刚果(金)上加丹加省Kipushi铜多金属矿床产于中非铜钴矿带。通过对矿床地质特征以及Pb、Rb-Sr和Re-Os同位素、Nchanga花岗岩侵入年龄等进行综合分析可知,该矿床是在新元古界730~760Ma期间恩古巴地层完成初始沉积,伴随卢菲利安构造运动发生褶皱作用,在下古生界奥陶纪450Ma期间受卢菲利安后期构造运动完成矿体定位,后期主要为次生氧化作用。因此,该矿床应为受地层、构造、褶皱改造、次生氧化富集作用形成的沉积改造型矿床。

关键词：铜多金属矿床地质特征成因

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"阶梯复位法"治疗髂骨骨折合并骶髂关节前脱位

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中华骨科杂志 2023年第15期43卷 1007-1012页

作者：温磊陈戈侯开宇季建华陈长顺刘琨邓永成陈仲郑常友云南大学附属医院骨与创伤外科昆明650000 昆明医科大学第一附属医院麻醉科昆明650000

目的探讨"阶梯复位法"治疗髂骨骨折合并骶髂关节前脱位的临床疗效.方法回顾性分析云南大学附属医院2010年2月至2022年1月收治的10例骶髂关节前脱位患者资料,男5例、女5例,年龄22~52岁,平均38.8岁.均为车祸伤,骨盆骨折Tile分型,C1.2型... 详细信息

目的探讨"阶梯复位法"治疗髂骨骨折合并骶髂关节前脱位的临床疗效.方法回顾性分析云南大学附属医院2010年2月至2022年1月收治的10例骶髂关节前脱位患者资料,男5例、女5例,年龄22~52岁,平均38.8岁.均为车祸伤,骨盆骨折Tile分型,C1.2型5例、C2型3例、C3型2例.采用"阶梯复位法"复位及钢板螺钉固定.第一步,于髂嵴置入1~2枚Schanz针控制髂骨,向外侧适当牵拉Schanz针;第二步,使用骨膜剥离器在骶骨与髂骨间进行撬拨复位;第三步,对仍无法复位者,在骶骨上紧贴髂骨内缘由前上向后下置入1枚直径2.5 mm的克氏针,并于骶骨与髂骨间插入一把骨膜剥离器,用其尖端顶住克氏针,以髂骨为支点进行撬拨使两者分离;第四步,维持撬拨,再紧贴髂骨内缘在骶骨上置入另1枚直径2.5 mm克氏针,继续使用骨膜剥离器于骶骨与髂骨间撬拨,重复操作,同时结合牵引下肢复位骶髂关节前脱位.术后使用Matta评分评估复位质量,使用Majeed评分评估骨盆骨折后功能恢复程度.结果 4例患者通过第一、二步即完成复位,6例难复性骶髂关节前脱位通过第一至四步操作成功复位.6例难复性骶髂关节前脱位患者的骨折复位时间为(39.67±3.09)min(范围 35~44min),术中失血量为(300.00±141.42)ml(范围 150~600 ml);另 4例骨折复位时间为(36.75± 4.38)min(范围30~42 min),术中失血量为(225.00±44.30)ml(范围200~300 ml).10例患者均获得随访,随访时间为(12.9±3.7)个月(范围9~20个月).所有患者骨盆前后环骨折均获得愈合,骨折愈合时间为(12.77±1.62)周(范围10.71~15.28周).末次随访时6例难复性骶髂关节前脱位患者Matta评价优5例、良1例,另4例均为优.6例Majeed功能评分为(86.50±6.08)分(范围74~92分),其中5例为优、1例为良;另4例为(81.5±9.39)分(范围71~94分),其中优2例、良2例.结论 "阶梯复位法"是一种安全有效、易于操作的治疗髂骨骨折合并骶髂关节前脱位的方法,对难复性骶髂关节前脱位可以获得满意的复位和疗效.

关键词：骶髂关节关节脱位骨折切开复位骨折固定术

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Luminescence: a new perspective for investigating perovskite precursors

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Science China Materials 2025年第01期 312-313页

作者： Haofeng zheng Shaocong Hou School of Electrical Engineering and Automation Wuhan University Wuhan University Shenzhen Research Institute

In the past two decades, perovskite materials have made significant progress in optoelectronic semiconductors, emerging as formidable candidates for the next generation of commercial solar cells, light-emitting diodes (LEDs), and *** the fundamental solution chemistry and photophysics in solution-processed perovskite devices is crucial for comprehending to achieve highly efficient optoelectronic devices.

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Impact of Bubbles on Mechanical Performances in a Borosilicate Glass

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 25-29页

作者： LI Chengxing LI Dongfeng MA Shilong QIAO Ang zheng Qingshuang China Helicopter Research and Development Institute Jingdezhen 333001China State Key Laboratory of Silicate Materials for Ar-chitectures Wuhan University of TechnologyWuhan 430070China

To analyze the impact of bubbles on the mechanical behavior of glasses,by controlling the refining time,we prepared three borosilicate glasses with the same composition and different *** the analysis software integrated within the optical microscope,the diameter and number of the bubbles on the surface of three borosilicate glasses were *** the hardness and crack initiation resistance(CR),we built the relationship between the porosity and the mechanical performance of these borosilicate glasses.

关键词： bubbles oxide glass hardness creak initiation resistance

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