检索结果-南通市图书馆

护理研究 2024年第12期38卷 2178-2182页

作者：李巧丽杨长永河南大学护理与健康学院河南475000

主要从食物口感质地改良、食物流变学质地改良、质地改良中的标准及方法、质地改良过程中的营养补充、以人为本的改良理念5个方面综述食物质地改良的研究进展,为基于循证的吞咽障碍食物质构调整提供参考。

关键词：吞咽障碍质地改良增稠剂食物性状改变综述护理

2023年ERAS在妇科肿瘤患者中的应用指南更新解读

在线全文

学校读者我要写书评

暂无评论

中华现代护理杂志 2024年第20期30卷 2661-2666页

作者：马飞飞冯宪凌杨长永白杨史子月河南大学护理与健康学院开封475000 河南省人民医院妇科郑州450000

加速康复外科(ERAS)是一种标准化的围手术期护理计划,目的是通过一系列具有循证医学证据的处理措施优化围手术期的管理。近年来针对妇科肿瘤ERAS相关的指南相继更新,在2016、2019年,国际ERAS协会发布了ERAS在妇科肿瘤患者中的应用指南... 详细信息

加速康复外科(ERAS)是一种标准化的围手术期护理计划,目的是通过一系列具有循证医学证据的处理措施优化围手术期的管理。近年来针对妇科肿瘤ERAS相关的指南相继更新,在2016、2019年,国际ERAS协会发布了ERAS在妇科肿瘤患者中的应用指南。随着循证证据以及研究的深入,在2023年对该指南进行了更新。本文就2023年ERAS在妇科肿瘤患者中的应用指南更新要点进行解读,以期更好实现围手术期的管理。

关键词：加速康复外科围手术期妇科肿瘤指南解读

Grinding force and surface quality in creep feed profile grinding of turbine blade root of nickel-based superalloy with microcrystalline alumina abrasive wheels

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2021年第2期34卷 576-585页

作者： Qing MIAO Wenfeng DING Weijie KUANG changyong yang National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Creep feed profile grinding of the fir-tree blade root forms of single crystal nickel-based superalloy was conducted using microcrystalline alumina abrasive wheels in the present study. The grinding force and the surface quality in terms of surface topography, subsurface microstructure,microhardness and residual stress obtained under different grinding conditions were evaluated comparatively. Experimental results indicated that the grinding force was influenced significantly by the competing predominance between the grinding parameters and the cross-sectional root workpiece profile. In addition, the root workpiece surface, including the root peak and valley regions, was produced with the large difference in surface quality due to the nonuniform grinding loads along the root workpiece profile in normal section. Detailed results showed that the surface roughness, subsurface plastic deformation and work hardening level of the root valley region were higher by up to25%, 20% and 7% in average than those obtained in the root peak region, respectively, in the current investigation. Finally, the superior parameters were recommended in the creep feed profile grinding of the fir-tree blade root forms. This study is helpful to provide industry guidance to optimize the machining process for the high-valued parts with complicated profiles.

关键词： Creep feed profile grinding Fir-tree blade root Grinding force Single crystal nickel-based superalloy Surface quality

Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2021年第4期11卷 472-479页

作者： Yuxiong Gao Zhendong Chen changyong yang Dafang Zhong State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201210China University of Chinese Academy of Sciences Beijing100049China Preclinical Department Hengrui Medicine Co.Ltd.LianyungangJiangsu Province222047China

Liquid chromatography tandem mass spectrometry(LC-MS/MS)has gradually become a promising alternative to ligand binding assay for the bioanalysis of biotherapeutic molecules,due to its rapid method development and high *** this study,we established a new LC-MS/MS method for the determination of the anti-sclerostin monoclonal antibody(SHR-1222)in cynomolgus monkey serum,and compared it to a previous electrochemiluminescence *** antibody was quantified by detecting the surrogate peptide obtained by trypsin *** surrogate peptide was carefully selected by investigating its uniqueness,stability and MS *** quantitative range of the proposed method was 2.00-500μg/mL,and this verified method was successfully applied to the toxicokinetic assessment of SHR-1222 in cynomolgus monkey *** was found that the concentrations of SHR-1222 in cynomolgus monkeys displayed an excellent agreement between the LC-MS/MS and electrochemiluminescence methods(ratios of drug exposure,0.8-1.0).Notably,two monkeys in the60 mg/kg dose group had abnormal profiles with a low detection value of SHR-1222 in their individual *** the high-level anti-drug antibodies(ADAs)in these samples and the consistent quantitative results of the two methods,we found that the decreased concentration of SHR-1222 was due to the accelerated clearance mediated by ADAs rather than the interference of ADAs to the detection *** together,we successfully developed an accurate,efficient and cost-effective LC-MS/MS method for the quantification of SHR-1222 in serum samples,which could serve as a powerful tool to improve the preclinical development of antibody drugs.

关键词： Anti-sclerostin monoclonal antibody (SHR-1222) LC-MS/MS Anti-drug antibody Toxicokinetic

Investigation on the Grindability of CSS-42L Stainless Steel

在线全文

学校读者我要写书评

暂无评论

Transactions of Nanjing University of Aeronautics and Astronautics 2016年第6期33卷 -页

作者： yang changyong Xu Jiuhua Fu Yucan Ding Wenfeng Su Honghua College of Mechanical and Electrical Engineering Nanjing University of Aeronautics & Astronautics

Plunge grinding experiments were carried out on CSS-42L stainless steel with the white fused alumina *** grinding forces were measured with variations in accumulated material removal *** the morphological features of worn grinding wheel were analyzed by optical microscopy and the grinding temperatures were measured with a *** comparison,C45 steel was ground under the same *** results indicated that the grinding forces of CSS-42L were at least twice that of C45 *** the accumulated removal volume overcame 375mm^3,strong adhesion was found between the abrasives and workpiece ***,adhesion was hardly found after 800mm^3 workpiece C45 steel was *** order to enhance the machining property of CSS-42L,a brazed CBN wheel was incorporated into the grinding of CSS-42L,and the grinding forces and temperatures were found significantly decreased,whose maximum decreasing amplitude was about 70%and 80%,respectively.

关键词： CSS-42L grinding force temperature adhesion

Grinding behavior and surface appearance of(TiC_p+ TiB_w)/Ti-6Al-4V titanium matrix composites

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2014年第5期27卷 1334-1342页

作者： Ding Wenfeng Zhao Biao Xu Jiuhua yang changyong Fu Yucan Su Honghua College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology

（TiCp＋ TiBw）/Ti-6Al-4V titanium matrix composites（PTMCs） have broad application prospects in the aviation and nuclear field. However, it is a typical difficult-to-cut material due to high hardness of the reinforcements, high strength and low thermal conductivity of Ti-6Al-4V alloy matrix. Grinding experiments with vitrified CBN wheels were conducted to analyze comparatively the grinding performance of PTMCs and Ti-6Al-4V alloy. Grinding force and force ratios, specific grinding energy, grinding temperature, surface roughness, ground surface appearance were discussed. The results show that the normal grinding force and the force ratios of PTMCs are much larger than that of Ti-6Al-4V alloy. Low depth of cut and high workpiece speed are generally beneficial to achieve the precision ground surface for PTMCs. The hard reinforcements of PTMCs are mainly removed in the ductile mode during grinding. However, the removal phenomenon of the reinforcements due to brittle fracture still exists, which contributes to the lower specific grinding energy and grinding temperature of PTMCs than Ti-6Al-4V alloy.

关键词： Grinding force Grinding temperature Particles Surface appearance Titanium matrix composites

Characterization and life prediction of single-pass honing tool for fuel injection nozzle

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2021年第4期34卷 225-240页

作者： changyong yang Hao SU Shaowu GAO Qingfeng AI Yucan FU Wenfeng DING Jiuhua XU College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Kompetenzzentrum für Spanende Fertigung Furtwangen UniversityTuttlingen 78532Germany

Single-pass honing is an important machining method for finish machining of holes,which can meet the requirement for high efficiency and consistency of *** and life prediction of single-pass honing tool are necessary to improve the machining accuracy of holes honed,especially dimension ***-pass honing tool is a single layer abrasive tool with fixed dimension,which still remains problematic for characterization and life *** fuel injection nozzles with bore diameter under 1 mm,the stiffness of the single-pass honing tool is *** article presents a novel analytical model that predicts life of the tool with poor ***,according to the bore diameter and dimension tolerance,the single-pass honing tool is designed and *** on the prepared single-pass honing tool,the measurement and characterization methods are ***,the tool wear tests are carried out,and the tool contour evolution model is established to predict the tool life.

关键词： Fuel injection nozzle Life prediction Single-pass honing tool Tool contour evolution Tool stiffness

Prediction on grinding force during grinding powder metallurgy nickel-based superalloy FGH96 with electroplated CBN abrasive wheel

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2021年第8期34卷 65-74页

作者： Benkai LI Chenwei DAI Wenfeng DING changyong yang Changhe LI Olga KULIK Vyacheslav SHUMYACHER National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Mechanical Engineering Suzhou University of Science and TechnologySuzhou 215009China School of Mechanical Engineering Qingdao University of TechnologyQingdao 266520China Volzhsky Polytechnic Institute(Branch)Volgograd State Technical University 42a Engelsa StreetVolzhskyVolgograd Region 404121Russia

In this article,a grinding force model,which is on the basis of cutting process of single abrasive grains combined with the method of theoretical derivation and empirical formula by analyzing the formation mechanism of grinding force,was *** key factors have been taken into accounts in this model,such as the contact friction force between abrasive grains and materials,the plastic deformation of material in the process of abrasive plowing,and the shear strain effect of material during the process of cutting chips *** model was finally validated by the orthogonal grinding experiment of powder metallurgy nickel-based superalloy FGH96 by using the electroplated CBN abrasive *** force values of prediction and experiment were in good *** errors of tangential grinding force and normal grinding force were 9.8%and 13.6%,*** contributions of sliding force,plowing force and chip formation force were also *** addition,the tangential forces of sliding,plowing and chip formation are 14%,19%and 11%of the normal forces on average,*** pro-posed grinding forcemodel is not only in favor of optimizing the grinding parameters and improving grinding efficiency,but also contributes to study some other grinding subjects(*** wheel wear,grinding heat,residual stress).

关键词： Electro-plated CBN abrasive wheel Grinding force model Grinding mechanism Orthogonal experiment Powder metallurgy nickel-based superalloy FGH96

Tryptophan-specific peptide modification through metal-free photoinduced N-H alkylation employing N-aryl glycines

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 316-319页

作者： Jianhui Yin Wenjing Huang changyong Guo Chao Liu Fei Gao Honggang Hu School of Medicine or Institute of Translation Medicine Shanghai UniversityShanghai 200444China

Tryptophan(Trp)carries a unique heteroaromatic indole side chain and plays a critical role in peptide or protein ***,we have reported a metal-free photoinduced N-H alkylation strategy using N-aryl glycines for specific modification of tryptophan-containing *** robustness of our approach is demonstrated by its wide substrate scope,excellent isolated yields,as well as almost unobservable side *** this highly efficiently metal-free condition,alkylated Trp-containing peptides can be smoothly *** study provides a reliable and practical tool for the chemo-selective modification of various tryptophan containing oligopeptides.

关键词： Tryptophan Peptide Modification Glycine Photoinduced

A prognosis model for predicting immunotherapy response of esophageal cancer based on oxidative stress-related signatures

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第1期32卷 199-212页

作者： JING GUO changyong TONG JIANGUANG SHI XINJIAN LI XUEQIN CHEN Department of Thoracic Surgery The First Affiliated Hospital of Ningbo UniversityNingboChina Department of Chinese Traditional Medicine The First Affiliated Hospital of Ningbo UniversityNingboChina

Oxidative stress(OS)is intimately associated with tumorigenesis and has been considered a potential therapeutic ***,the OS-associated therapeutic target for esophageal squamous cell carcinoma(ESCC)remains *** our study,gene expression data of ESCC and clinical information from public databases were *** LASSO-Cox regression analysis,a risk score(RS)signature map of prognosis was constructed and performed external verification with the GSE53625 *** ESTIMATE,xCell,CIBERSORT,TIMER,and ImmuCellAI algorithms were employed to analyze infiltrating immune cells and generate an immune microenvironment(IM).Afterward,functional enrichment analysis clarified the underlying mechanism of the *** was utilized for forecasting the survival rate of individual ESCC *** a result,we successfully constructed an OS-related genes(OSRGs)model and found that the survival rate of high-risk groups was lower than that of low-risk *** AUC of the ROC verified the strong prediction performance of the signal in these two cohorts *** to independent prognostic analysis,the RS was identified as an independent risk factor for *** nomogram and follow-up data revealed that the RS possesses favorable predictive value for the prognosis of ESCC ***-PCR detection demonstrated increased expression of MPC1,COX6C,CYB5R3,CASP7,and CYCS in esophageal cancer *** conclusion,we have constructed an OSRGs model for ESCC to predict patients’prognosis,offering a novel insight into the potential application of the OSRGs model in ESCC.

关键词： Esophageal carcinoma OS Prognosis Risk markers Immune cell infiltration