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Neural Regeneration Research 2011年第28期6卷 2203-2210页

作者： changyan fan Xiuhua Shi Qingfang Sun Liuguan Bian Weiguo Zhao Jiankang Shen Hua Zhang Tingwei Su Weiqing Wang Xiaoying Li Guang Ning Liang Kong Lingling Hu Department of Neurology Wuxi No. 3 People＇s Hospital Wuxi 241043 Jiangsu Province China Department of Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Endocrine and Metabolism Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

The present study analyzed data from 108 Cushing＇s disease patients, who underwent transsphenoidal surgery in one hospital between January 2003 and April 2010, to investigate the performance value of bilateral inferior petrosal sinus sampling （BIPSS）. Of the 108 patients 52 underwent BIPSS prior to surgery and 56 did not. Results showed that BIPSS accuracy for the diagnosis of Cushing＇s disease was 86.5% （45/52）, and accuracy for adenoma lateralization during surgery was 76.9% （40/52）. In addition, early remission rate was significantly greater compared to patients without BIPSS. Results demonstrated that BIPSS facilitated localization and diagnosis of Cushing＇s disease and helped to predict adenoma lateralization.

关键词： bilateral inferior petrosal sinus Cushing's disease Cushing's syndrome pituitary adenoma transsphenoidal surgery

Diagnosis and treatment of pituitary abscess:a review of 8 cases

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Diagnosis and treatment of pituitary abscess:a review of 8 c...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Xiuhua Shi,changyan fan,Qing-fang* Sun,Liuguan Bian,et al.(Department of Neurosurgery,Ruijin Hospital,Shanghai Jiao tong University School of Medicine,Shanghai,200025,China)

Object:To better explore preoperative and intraoperative diagnosis of pituitary abscess（PA） and to evaluate the significance of treatment with surgery and ***:we respective analysis 8 PA cases were finely analyzed including routine test,endocrine assays,imaging studies and vision *** were all treated by transsphenoidal ***:although including clinical syndrome and signs,endocrinology and imaging changes,all patients were misdiagnoses as other sella lesions *** all convinced by intraoperative finding and postoperative pathology,transsphenoidal surgery and antibiotic therapy performed ***:pituitary abscess is a rare but potentially life-threatening disease and preoperative diagnosis is still *** clues as clinical features,laboratory examinations,imaging studies diagnosis and therapy are helpful to quandary of pituitary abscess.

关键词： Pituitary abscess(PA) diagnosis treatment

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航拍视频车辆检测目标关联与时空轨迹匹配

交通信息与安全 2021年第2期39卷 61-69,77页

作者：冯汝怡李志斌吴启范范昌彦东南大学交通学院南京210096

高解析度轨迹数据蕴含丰富车辆行驶与交通流时空信息。为从航拍视频中提取车辆轨迹,构建了车辆检测目标跨帧关联与轨迹匹配融合方法。采用卷积神经网络YOLOv5构建视频全域车辆目标检测,提出车辆动力学与轨迹置信度约束下跨帧目标关联算... 详细信息

高解析度轨迹数据蕴含丰富车辆行驶与交通流时空信息。为从航拍视频中提取车辆轨迹,构建了车辆检测目标跨帧关联与轨迹匹配融合方法。采用卷积神经网络YOLOv5构建视频全域车辆目标检测,提出车辆动力学与轨迹置信度约束下跨帧目标关联算法,建立了基于最大相关性的断续轨迹匹配与融合构建算法,实现轨迹车辆唯一编号。将轨迹从图像坐标转换为车道基准下Frenet坐标,构建集合经验模态分解(EEMD)模型进行轨迹数据噪声消除。采用南京市快速路无人机拍摄的2组开源航拍视频,涵盖拥堵与自由流交通状态,对轨迹提取算法进行效果测试。结果表明,在自由流和拥挤条件下轨迹准确率分别为98.86%和98.83%,轨迹召回率为93.00%和86.69%,构建算法的轨迹提取速度为0.07 s/辆/m。该方法处理得到的详细车辆时空轨迹信息能为交通流、交通安全、交通管控研究提供广泛的数据支撑,数据公开于http://***/。

关键词：车辆轨迹车辆检测航拍视频轨迹构建轨迹数据

细胞遗传学在急性早幼粒细胞白血病的诊断及预后评估中的作用

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河北医药 2010年第1期32卷 23-24页

作者：侯继申谢守军范常艳承德医学院附属医院胸外科河北省承德市067000 承德医学院附属医院检验科河北省承德市067000 承德医学院临床学院内科教研室

目的探讨细胞遗传学在急性早幼粒细胞白血病(APL)的诊断及预后评估中的应用价值。方法应用常规细胞遗传学分析APL初诊患者39例,采用R显带技术进行染色体核型分析。随访分析完全缓解率、复发率。结果39例APL患者中,染色体异常38例,其中3... 详细信息

目的探讨细胞遗传学在急性早幼粒细胞白血病(APL)的诊断及预后评估中的应用价值。方法应用常规细胞遗传学分析APL初诊患者39例,采用R显带技术进行染色体核型分析。随访分析完全缓解率、复发率。结果39例APL患者中,染色体异常38例,其中30例为典型t(15;17)易位,8例为涉及15和17号染色体的复杂核型。形态学误诊为M2和M5各1例,经核型分析确诊。经全反式维甲酸和(或)化疗联合诱导治疗,37例获完全缓解,2例具有复杂核型者未取得完全缓解,6例具有复杂核型者第1次完全缓解后3年内复发,复发率86%(6/7),其他核型组完全缓解后3年内复发率仅10%(3/31)。结论细胞遗传学对细胞形态不典型APL具有确诊价值,复杂染色体异常者预后不佳。

关键词：急性早幼粒细胞白血病细胞遗传学诊断预后

醒脑静注射液对Beagle犬心血管和呼吸系统功能的影响

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药物评价研究 2020年第12期43卷 2422-2428页

作者：李莎莎王虎斌丁亚军刘晶樊昌艳中国药科大学江苏南京211198 江苏省药物研究所有限公司江苏南京210009

目的研究醒脑静注射液对Beagle犬心血管和呼吸系统的影响。方法已成功埋入植入子的Beagle犬6只,拉丁方设计给药,设溶媒对照组,辅料对照组,醒脑静注射液1(XNJI1,含人工麝香)高、中、低剂量(1.41、0.71、0.35 mg/kg)组和醒脑静注射液2(XNJ... 详细信息

目的研究醒脑静注射液对Beagle犬心血管和呼吸系统的影响。方法已成功埋入植入子的Beagle犬6只,拉丁方设计给药,设溶媒对照组,辅料对照组,醒脑静注射液1(XNJI1,含人工麝香)高、中、低剂量(1.41、0.71、0.35 mg/kg)组和醒脑静注射液2(XNJI2,含天然麝香)高、中、低剂量(1.46、0.73、0.36 mg/kg)组,XNJI1高、中、低剂量均约为人临床等效剂量的5.2、2.6、1.3倍;XNJI2高、中、低剂量均约为人临床等效剂量的5.1、2.6、1.3倍。辅料对照组给予等体积的0.5%聚山梨酯80溶液;溶媒对照组给予等体积氯化钠注射液。前肢iv给药,每2个给药组设1 d洗脱期。利用DSI遥测系统连续测量给药前1 h至给药后4 h的心电、血压、呼吸等指标。结果各给药组及辅料对照组部分Beagle犬出现明显过敏症状,在给药后均出现持续10~45 min的口鼻部发红肿胀、瘙痒,部分表现烦躁不安,辅料对照组最为明显。与溶媒对照组比较,XNJI1高剂量组及辅料对照组心率显著升高(P<0.05、0.01),分别于给药后30 min、1 h恢复至给药前水平;辅料对照组给药后5、10、30 min QTc间期显著延长(P<0.01);XNJI1高剂量组给药后10 min、0.5 h呼吸频率(BPM)显著升高,XNJI2高剂量组给药后5 min BPM显著升高(P<0.05、0.01),辅料对照组给药后BPM明显升高但无显著差异。XNJI1比XNJI2在心率、QTc间期、BPM等方面波动较大,但二者无显著差异。结论给予大剂量醒脑静注射液,Beagle犬出现不同程度类过敏反应症状及心电呼吸影响可能与辅料聚山梨酯80有关,临床使用应密切监测相关指标以确保用药安全。

关键词：醒脑静注射液 Beagle犬安全药理学人工麝香天然麝香聚山梨酯80

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库欣病术后相关缓解因素的研究

中国微侵袭神经外科杂志 2011年第5期16卷 193-196页

作者：范长燕施秀华孙青芳卞留贯赵卫国沈健康苏颋为王卫庆李小英宁光上海交通大学医学院附属瑞金医院神经外科 200025 上海市内分泌代谢病临床医学中心

目的探讨库欣病经蝶手术后相关缓解因素。方法回顾性分析104例经蝶手术的库欣病的临床资料。根据术后早期缓解情况分为缓解组与未缓解组,统计分析两组间的差异,判断影响库欣病术后缓解的因素。结果缓解组与未缓解的术后血皮质醇水平差... 详细信息

目的探讨库欣病经蝶手术后相关缓解因素。方法回顾性分析104例经蝶手术的库欣病的临床资料。根据术后早期缓解情况分为缓解组与未缓解组,统计分析两组间的差异,判断影响库欣病术后缓解的因素。结果缓解组与未缓解的术后血皮质醇水平差异在各时间段均有统计学意义(P50%者,在缓解组占85.5%,在未缓解组占62.5%;术前MRI检查阳性者术后缓解率为86.8%,阴性缓解率为61.5%;术后病理酶标染色阳性者缓解率为87.2%,阴性缓解为66.7%,其差异均有统计学意义(P<0.05)。结论术前8 mg地塞米松抑制试验、术前MRI检查、术后血皮质醇水平和病理检查等可作为库欣病经蝶手术后,判断预后的指导。

关键词：垂体肿瘤库欣综合征预后神经外科手术

首乌活血颗粒联合双联抗血小板治疗大动脉粥样硬化性脑梗死的临床观察

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实用临床医药杂志 2022年第3期26卷 59-62,67页

作者：李超生孔亮狄美琪范长燕惠振胡玲玲江南大学附属医院神经内科江苏无锡214000

目的观察首乌活血颗粒联合双联抗血小板治疗大动脉粥样硬化性脑梗死(ATCI)的临床效果。方法选取127例ATCI患者为研究对象,根据随机数字表法分为对照组(63例,双联抗血小板治疗)和观察组(64例,首乌活血颗粒联合双联抗血小板治疗),均治疗21... 详细信息

目的观察首乌活血颗粒联合双联抗血小板治疗大动脉粥样硬化性脑梗死(ATCI)的临床效果。方法选取127例ATCI患者为研究对象,根据随机数字表法分为对照组(63例,双联抗血小板治疗)和观察组(64例,首乌活血颗粒联合双联抗血小板治疗),均治疗21 d;治疗结束后,评估并比较2组疗效;治疗前、治疗21 d,评估并比较2组症候积分,检测2组血脂水平与炎症指标;记录2组治疗期间不良反应。结果观察组整体疗效优于对照组,总有效率高于对照组,差异有统计学意义(P0.05)。结论ATCI患者采用首乌活血颗粒联合双联抗血小板治疗效果较好,可降低血脂水平、炎症指标水平,且安全性好。

关键词：动脉粥样硬化性脑梗死首乌活血颗粒双联抗血小板血脂炎症指标

Monaural speech enhancement using U-net fused with multi-head self-attention

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Chinese Journal of Acoustics 2023年第1期42卷 98-118页

作者： fan Junyi YANG Jibin ZHANG Xiongwei ZHENG changyan Graduate School Army Engineering UniversityNanjing 210007 College of Command and Control Engineering Army Engineering UniversityNanjing 210007 Department of Test Control High-tech InstituteQingzhou 262500

Under low signal-to-noise ratio(SNR)and burst noise conditions,the speech enhancement effect of existing deep learning network models is not *** contrast,humans can exploit the long-term correlation of speech to form an integrated perception of different speech ***,describing the long-term dependencies of speech can help improve the enhancement performance under low SNR and burst noise *** by this feature,a time domain end-to-end monaural speech enhancement model TU-net that fuses the multi-head self-attention mechanism and U-net deep network is *** TU-net model adopts the codec layer structure of U-net to achieve multi-scale feature *** introduces the dual-path Transformer module using the multi-head self-attention mechanism to calculate the speech mask and better model long-term *** TU-net model is trained with a weighted sum loss function in the time,time-frequency,and perceptual *** experiments are carried out and the results show that with maintaining relatively fewer network model parameters,TU-net outperforms other similar monaural enhancement network models in several evaluation metrics such as perceptual evaluation of speech quality(PESQ),short-time objective intelligibility(STOI)and SNR gain under low SNR and burst noise conditions.

关键词： network speech noise

Elevated CO_(2) increases shoot growth but not root growth and C:N:P stoichiometry of Suaeda aralocaspica plants

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Journal of Arid Land 2021年第11期13卷 1155-1162页

作者： WANG Lei fan Lianlian JIANG Li TIAN changyan State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Research Center for Ecology and Environment of Central Asia Chinese Academy of SciencesUrumqi 830011China

The purpose of the current study was to investigate the eco-physiological responses,in terms of growth and C:N:P stoichiometry of plants cultured from dimorphic seeds of a single-cell C4 annual Suaeda aralocaspica(Bunge)Freitag and Schütze under elevated CO_(2).A climatic chamber experiment was conducted to examine the effects of ambient(720μg/L)and CO_(2)-enriched(1440μg/L)treatments on these responses in *** at vegetative and reproductive stages in *** showed that elevated CO_(2) significantly increased shoot dry weight,but decreased N:P ratio at both growth *** grown from dimorphic seeds did not exhibit significant differences in growth and C:N:P stoichiometric *** transition from vegetation to reproductive stage significantly increased shoot:root ratio,N and P contents,but decreased C:N,C:P and N:P ratios,and did not affect shoot dry ***,our results indicate that the changes in N:P and C:N ratios between ambient and elevated CO_(2) are mainly caused by the decrease of N content under elevated CO_(2).These results provide an insight into nutritional metabolism of single-cell C4 plants under climate change.

关键词： biomass CO_(2)elevation C:N:P stoichiometry seed heteromorphism Suaeda aralocaspica

Comparison of enhancement techniques based on neural networks for attenuated voice signal captured by flexible vibration sensors on throats

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Nanotechnology and Precision Engineering 2022年第1期5卷 1-11页

作者： Shenghan Gao changyan Zheng Yicong Zhao Ziyue Wu Jiao Li Xian Huang School of Precision Instruments and Opto-Electronics Engineering Tianjin University92 Weijin RoadTianjin 300072China High-Tech Institute Fan Gong-Ting South Street on the 12thQingzhou 262550China

Wearable flexible sensors attached on the neck have been developed to measure the vibration of vocal cords during ***,highfrequency attenuation caused by the frequency response of the flexible sensors and absorption of high-frequency sound by the skin are obstacles to the practical application of these sensors in speech capture based on bone *** this paper,speech enhancement techniques for enhancing the intelligibility of sensor signals are developed and *** kinds of speech enhancement algorithms based on a fully connected neural network(FCNN),a long short-term memory(LSTM),a bidirectional long short-term memory(BLSTM),and a convolutional-recurrent neural network(CRNN)are adopted to enhance the sensor signals,and their performance after deployment on four kinds of edge and cloud platforms is also *** results show that the BLSTM performs best in improving speech quality,but is poorest with regard to hardware *** improves short-time objective intelligibility(STOI)by 0.18 to nearly 0.80,which corresponds to a good intelligibility level,but it introduces latency as well as being a large *** CRNN,which improves STOI to about 0.75,ranks second among the four neural *** is also the only model that is able to achieves real-time processing with all four hardware platforms,demonstrating its great potential for deployment on mobile *** the best of our knowledge,this is one of the first trials to systematically and specifically develop processing techniques for bone-conduction speed signals captured by flexible *** results demonstrate the possibility of realizing a wearable lightweight speech collection system based on flexible vibration sensors and real-time speech enhancement to compensate for high-frequency attenuation.

关键词： Flexible electronics Vibration sensor Neural network Speech enhancement Deep learning