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Resveratrol prevents hypoxia-induced retinal ganglion cell death related with ErbB2

International Journal of Ophthalmology(English edition) 2022年第3期15卷 394-400页

作者： Hyemin Seong Joo Yeon Jeong Jinhyun Ryu Juyeong Park Yong‑Seop Han Hyun-Kyung Cho Seong Jae Kim Jong Moon Park Sang Soo kang Seong Wook Seo Department of Ophthalmology Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Ophthalmology Gyeongsang National University Changwon HospitalGyeongsang National UniversityCollege of MedicineChangwon 51472Republic of Korea

AIM: To confirm the changes in proteins related with hypoxia-induced retinal cell death and to assess the effects of resveratrol(Res).METHODS: The therapeutic effect of Res was verified using an ischemic/reperfusion(I/R) model in vivo and a hypoxia modelin retinal ganglion cells(RGCs) in *** of RGCs were confirmed by TUNEL *** expression was confirmed by Western blotting and *** addition, flow cytometric analysis was used to confirm the response in the cell unit to obtain more accurate ***: ErbB2 expression and apoptosis in the ganglion cell layer(GCL) increased after I/R *** of Res rescued I/R-induced ganglion cell death, downregulated apoptosis and ErbB2 protein expression in the *** subsequent in vitro models, Res affects apoptosis by regulating the phosphorylation and expression of mouse double minute 2 homolog(MDM2), along with those of *** results suggest that Res reverses GCL-specific apoptosis via downregulation of ErbB2 in ischemic ***: In light of Res favorable properties, it should be evaluated in the treatment of RGC death and related retinal disease characterized by ErbB2 and MDM2 ***, Res is appropriate therapeutic agent for treating ischemic injury-related eye diseases by targeting the expression of ErbB2 and MDM2.

关键词： ischemia/reperfusion injury hypoxia retinal ganglion cell resveratrol ErbB2

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Antibiofilm and antithrombotic hydrogel coating based on superhydrophilic zwitterionic carboxymethyl chitosan for blood-contacting devices

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Bioactive Materials 2024年第4期34卷 112-124页

作者： Dong Uk Lee Mukhammad Kayumov Junghun Park Se Kye Park Yeongkwon kang Yejin Ahn Woojin Kim Seung Hwa Yoo Jun-Kyu Park Bong-Gi Kim Yong Suk Oh In-Seok Jeong Dong Yun Choi Biomedical Manufacturing Technology Center Korea Institute of Industrial TechnologyYeongcheon38822Republic of Korea Department of Thoracic and Cardiovascular Surgery Chonnam National University Hospital and Medical SchoolGwangju61469Republic of Korea Research Institute of Advanced Materials Seoul National UniversitySeoul08826Republic of Korea Department of Organic and Nano System Engineering Konkuk UniversitySeoul05029Republic of Korea Department of Quantum System Engineering Jeonbuk National UniversityJeonju-si54896Republic of Korea IMT Inc. Gwangju61086Republic of Korea Department of Mechanical Engineering Changwon National UniversityChangwon51140Republic of Korea

Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections,thrombosis,and intimal lesions caused by surface ***,achieving effective prevention of both bloodstream-associated infections and thrombosis poses a challenge due to the conflicting nature of antibacterial and antithrombotic activities,specifically regarding electrostatic *** study introduced a novel biocompatible hydrogel of sodium alginate and zwitterionic carboxymethyl chitosan(ZW@CMC)with antibacterial and antithrombotic activities for use in *** ZW@CMC hydrogel demonstrates a superhydrophilic surface and good hygroscopic properties,which facilitate the formation of a stable hydration layer with low *** zwitterionic-functionalized CMC incorporates an additional negative sulfone group and increased negative charge density in the carboxyl *** augmentation enhances electrostatic repulsion and facilitates the formation of hydration *** leads to exceptional prevention of blood clotting factor adhesion and inhibition of biofilm ***,the ZW@CMC hydrogel exhibited biocompatibility with tests of in vitro cytotoxicity,hemolysis,and catheter ***,in vivo tests of antithrombotic and systemic inflammation models with catheterization indicated that ZW@CMC has significant advantages for practical applications in cardiovascular-related and sepsis *** study opens a new avenue for the development of chitosan-based multifunctional hydrogel for applications in blood-contacting devices.

关键词： Zwitterionic Hydrogel Blood-clotting Antimicrobial Sepsis

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Enhanced thermoelectric properties of NbCoSn half-Heuslers through in-situ nanocrystallization of amorphous precursors during the consolidation process

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Journal of Materials Science & Technology 2023年第34期165卷 39-48页

作者： Chanwon Jung Kyuseon Jang Hail Park Jeongin Jang Hanhwi Jang Byungchul kang Kitae Park Siyuan Zhang Ruben Bueno Villoro SuDong Park Ho Jin Ryu Yeon Sik Jung Min-Wook Oh Christina Scheu Seong-Hoon Yi Pyuck-Pa Choi Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237Germany Electrical Materials Research Division Energy Conversion Research CenterKorea Electrotechnology Research Institute(KERI)Changwon 51543Republic of Korea Department of Materials Science and Metallurgical Engineering Kyungpook National University80 DaehakroDaegu 41566Republic of Korea Department of Nuclear and Quantum Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Materials Science and Engineering Hanbat National University125 Dongseodae-roYuseong-guDaejeon 34158Republic of Korea

Tailoring nanostructures is a general approach used to obtain enhanced thermoelectric properties for halfHeusler compounds because the wide areas of grain and phase boundaries could be scattering centers that lower lattice thermal ***,a common fabrication method based on the sintering of crystalline precursors crushed from as-cast alloy ingots has limitations in obtaining a homogeneous microstructure without microsized impurity phases,owing to residual elemental segregation from *** this study,we used amorphous NbCoSn alloys as a precursor for the sintered specimen to obtain a homogeneous NbCoSn bulk specimen without microsized impurity phases and segregation,which led to the enhanced Seebeck coefficient due to the high purity of the half-Heusler phase after ***,superplasticity originating from amorphous features enabled the powders to be largely deformed during the sintering process,even at a low sintering temperature(953 K).This resulted in less oxidation at both,the grain boundary and the interior,as the O diffusion pathway was blocked during the sintering *** a result,the NbCoSn0.95Sb0.05 specimen using an amorphous precursor exhibited an enhanced zT of 0.7,due to the increase in the power factor and a decrease in lattice thermal conductivity compared to the specimen using a crystalline precursor.

关键词： Half-Heusler compounds Amorphous Superplasticity Segregation Atom probe tomography

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Dry Sliding Friction and Wear Properties and Wear Mechanism of SiC_P/Al Composites

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Journal of Wuhan University of Technology(Materials Science) 2009年第S1期24卷 24-28页

作者：金云学 Provincial Key Llaboratory of Advanced Welding Technology Jiangsu University of Science & Technology

Dry sliding friction and wear properties of A356/SiC composites against AISI D2 were analyzed by means of SEM,XRD and *** indicated that the wear rate of A356/SiC increased with increase of the applied *** wear took place under lower load,transferring to severe wear at the load heavier than 400 *** mixed layer(MML) formed on worn surface during dry sliding friction process,whose thickness became deeper with increasing *** formed easily in MML and spread transversely,resulting in peeling *** wear mechanism of the composite is that oxidation wear mechanism was dominant under low load,with the formation of tiny powdery *** the load enhanced,peeling wear was primary due to laminar debris detached from the MML,including oxidation and adhesive wear at the same time,with the load at 350-450 N,adhesive wear with irregular debris and peeling wear were predominant.

关键词： A356/SiC dry friction wear mechanism wear property

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Overview of Modeling Strength Evolution during Friction Stir Welding

Overview of Modeling Strength Evolution during Friction Stir...

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第五届国际材料与热加工物理模拟及数值模拟学术会议

作者： Jaehyung Cho Hyung-Wuk Kim Suk-Bong kang Korea Institute of Materials Science 66 Sangnam Changwon Kyungnam South Korea 641-010 Korea Institute of Materials Science 66 Sangnam Changwon Kyungnam South Korea 641-010 Korea Institute of Materials Science 66 Sangnam Changwon Kyungnam South Korea 641-010

Using two-dimensional Eulerian formulations coupling viscoplastic flow and heat transfer, the behaviors of aluminum alloys and stainless steel during FSW were overviewed. The plastic behaviors of the materials are complicated and the flow stresses are depending on deformation rate, temperature and deformation histories. Constitutive equations considering both strain hardening from accumulation of crystal defects and softening from recovery or recrystallization were used to model the materials. Strain hardening is incorporated with a strength that evolves with deformation rate and temperature along streamlines in the flow field. Strength evolutions have a Voce-like saturation limit because of the severe plastic deformation during FSW process. The model equations for kinematic and temperature were solved using the standard finite element method. The evolution equation for the strength is integrated along streamlines. The strength and temperature distribution vary with process conditions and constitutive equations. Stainless steel and AA6061 have different strengthening mechanisms. Modified constitutive equations were applied to reflect microstructural features of each material.

关键词： Friction stir weld Eulerian formulation Hardness Aluminum alloys Stainless steel

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基于STL模型的双面数控渐进成形干涉检查与修正

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中国机械工程 2019年第23期30卷 2890-2897页

作者：朱虎肖冬选姜在宽沈阳航空航天大学机电工程学院沈阳110136 庆南大学机械自动化工学部昌原51767

针对双面数控渐进成形中工具头与板材之间容易发生干涉的问题,提出了基于STL模型的工具头与板材干涉检查与修正方法。对于主工具头,采用等距面生成无干涉的成形轨迹,以避免干涉;对于副工具头,将干涉类型分为工具头与板材非成形特征区的... 详细信息

针对双面数控渐进成形中工具头与板材之间容易发生干涉的问题,提出了基于STL模型的工具头与板材干涉检查与修正方法。对于主工具头,采用等距面生成无干涉的成形轨迹,以避免干涉;对于副工具头,将干涉类型分为工具头与板材非成形特征区的干涉和工具头与板材成形特征区的干涉两种类型,并通过判断副工具头刀位点与支撑面的位置关系来确定是否发生干涉。算法应用实例和成形实验结果表明,所提出的算法能够避免干涉,进而生成无干涉的工具头运动轨迹。

关键词：双面数控渐进成形干涉检查干涉修正 STL模型

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基于背板的双面数控渐进成形方法

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计算机集成制造系统 2019年第1期25卷 90-102页

作者：朱虎肖冬选姜在宽沈阳航空航天大学机电工程学院辽宁沈阳110136 庆南大学机械自动化工学部韩国昌原51767

为了解决双面数控渐进成形中板材件无支撑悬空区域存在变形的问题,提出一种背板辅助的双面数控渐进成形方法。该方法以背板对板材的支撑作用,抑制板材件非成形区的非理想变形,进而提高成形质量。研究了面向复杂板材件基于背板的双面数... 详细信息

为了解决双面数控渐进成形中板材件无支撑悬空区域存在变形的问题,提出一种背板辅助的双面数控渐进成形方法。该方法以背板对板材的支撑作用,抑制板材件非成形区的非理想变形,进而提高成形质量。研究了面向复杂板材件基于背板的双面数控渐进成形策略和对于一个给定待成形板材件标准模板库模型自动生成所需背板计算机辅助设计模型的算法。该算法根据板材件类型的不同,通过提取待成形板材件标准模板库模型的特征轮廓,采用顶点偏置方法生成出背板计算机辅助设计模型,并采用数值模拟和实际成形实验对所提背板辅助双面数控渐进成形方法进行了验证和评估。有限元分析和实验结果表明,双面数控渐进成形中背板的使用能够有效提高成形件的成形质量,具有可行性和可应用性。

关键词：板材成形双面数控渐进成形背板成形质量

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Transferable,highly crystalline covellite membrane for multifunctional thermoelectric systems

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InfoMat 2024年第11期6卷 66-80页

作者： Myungwoo Choi Geonhee Lee Yea-Lee Lee Hyejeong Lee Jin-Hoon Yang Hanhwi Jang Hyeonseok Han MinSoung kang Seonggwang Yoo A-Rang Jang Yong Suk Oh Inkyu Park Min-Wook Oh Hosun Shin Seokwoo Jeon Jeong-O Lee Donghwi Cho Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea Thin Film Materials Research Center Korea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Chemical Data-Driven Research Center Korea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Division of Chemical and Material Metrology Korea Research Institute of Standards and ScienceDaejeonRepublic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Therapeutics&Biotechnology Division Drug Discovery Platform Research CenterKorea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Querry Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIllinoisUSA Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonanRepublic of Korea Department of Mechanical Engineering Changwon National UniversityChangwonRepublic of Korea Department of Materials Science and Engineering Hanbat National UniversityDaejeonRepublic of Korea Advanced Materials and Chemical Engineering University of Science and TechnologyDaejeonRepublic of Korea

Emerging freestanding membrane technologies,especially using inorganic thermoelectric materials,demonstrate the potential for advanced thermoelectric ***,using rare and toxic elements during material processing must be ***,we present a scalable method for synthesizing highly crystalline CuS membranes for thermoelectric *** sulfurizing crystalline Cu,we produce a highly percolated and easily transferable network of submicron CuS *** CuS membrane effectively separates thermal and electrical properties to achieve a power factor of 0.50 mW m^(-1) K^(-2) and thermal conductivity of 0.37 W m^(-1) K^(-1) at 650 K(estimated value).This yields a record-high dimensionless figure-of-merit of 0.91 at 650 K(estimated value)for ***,integrating 12 CuS devices into a module resulted in a power generation of4μW atΔT of 40 K despite using a straightforward configuration with only p-type ***,based on the temperature-dependent electrical characteristics of CuS,we develop a wearable temperature sensor with antibacterial properties.

关键词： copper sulfide flexible thermoelectric generator multifunctional thermoelectric systems sulfurization thermoelectric membrane

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Damage Detection of Composite Plates Using Finite Element Analysis Based on Structural Health Monitoring

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材料科学与工程（中英文B版） 2011年第1期1卷 14-21页

作者： Kyoung-Tak kang Heoung-Jae Chun Jin Ah Lee Joon-Hyung Byun Moon-Kwang Um Sang-Kwan Lee Byung-SunKim School of Mechanical Engineering Yonsei University 262 Seongsanno Seodaemun-Gu Seoul 120-749 Korea Korea Institute of Materials Science 66 Sangnam-Dong Changwon Kyungnam 641-010 Korea

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A Study on the Improvement of Dynamic Characteristics in Interior Permanent Magnet Motor by Rotor Shape Design

A Study on the Improvement of Dynamic Characteristics in Int...

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11th International Conference on Electrical Machines and Systems

作者： Byung-Chae Yun Kwang-Kyu Han Dong-Yeup Lee Gyu-Hong kang Ki-Bong Jang Heung-Kyo Shin Gyu-Tak Kim Dept. of Electrical Engineering Changwon National UnivGyeongnam641-773Korea GemTech Co. LtdGyeongnam641-847Korea Dept. of Electrical Engineering Kyeongsang National UnivGyeongnam660-701Korea

＜正＞This paper presents the improvement of dynamic characteristics in Interior Permanent Magnet（IPM） type BLDC motor with *** notch is applied on the surface of the rotor to reduce the cogging torque and to improve dynamic *** current,inductance and torque of initial model and optimal model are analyzed by *** validity of improved dynamic characteristics is confirmed.

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