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Epigenetics: An emerging player in gastric cancer

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World Journal of Gastroenterology 2014年第21期20卷 6433-6447页

作者： changwon kang Ji-Joon Song Jaeok Lee Mi Young Kim Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 305-701South Korea

Cancers,like other diseases,arise from gene mutations and/or altered gene expression,which eventually cause dysregulation of numerous proteins and noncoding *** in gene expression,i.e.,upregulation of oncogenes and/or downregulation of tumor suppressor genes,can be generated not only by genetic and environmental factors but also by epigenetic factors,which are inheritable but nongenetic modifications of cellular chromosome *** of the factors that contribute to individual cancers is a prerequisite to a full understanding of cancer mechanisms and the development of customized cancer *** search for genetic and environmental factors has a long history in cancer research,but epigenetic factors only recently began to be associated with cancer formation,progression,and *** alterations of chromatin include DNA methylation and histone modifications,which can affect gene-expression *** studies have revealed diverse mechanisms by which chromatin modifiers,including writers,erasers and readers of the aforementioned modifications,contribute to the formation and progression of ***,functional RNAs,such as microRNAs and long noncoding RNAs,have also been identified as key players in these *** review highlights recent findings concerning the epigenetic alterations associated with cancers,especially gastric cancer.

关键词： Gastric cancer Epigenetics DNA methylation Histone modification Gene expression

Evaluation of the k-nearest neighbor method for forecasting the influent characteristics of wastewater treatment plant

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Frontiers of Environmental Science & Engineering 2016年第2期10卷 299-310页

作者： Minsoo KIM Yejin KIM Hyosoo KIM Wenhua PIAO changwon KIM Department of Civil and Environmental Engineering Pusan National University Busan 609-735 Republic of Korea Department of Civil and Environmental Engineering Catholic University of Pusan Busan 609-757 Republic of Korea EnvironSoft Co. Ltd. #511 Industry-University Co.Bld. Pusan Nationai University Busan 609-735 Republic of Korea

The k-nearest neighbor （k-NN） method was evaluated to predict the influent flow rate and four water qualities, namely chemical oxygen demand （COD）, suspended solid （SS）, total nitrogen （T-N） and total phosphorus （T-P） at a wastewater treatment plant （WWTP）. The search range and approach for determining the number of nearest neighbors （NNs） under dry and wet weather conditions were initially optimized based on the root mean square error （RMSE）. The optimum search range for considering data size was one year. The square root-based （SR） approach was superior to the distance factor-based （DF） approach in determining the appropriate number of NNs. However, the results for both approaches varied slightly depending on the water quality and the weather conditions. The influent flow rate was accurately predicted within one standard deviation of measured values. Influent water qualities were well predicted with the mean absolute percentage error （MAPE） under both wet and dry weather conditions. For the seven-day prediction, the difference in predictive accuracy was less than 5% in dry weather conditions and slightly worse in wet weather conditions. Overall, the k-NN method was verified to be useful for predicting WWTP influent characteristics.

关键词： influent wastewater prediction data-drivenmodel k-nearest neighbor method (k-NN)

Significant enhancement of photoresponsive characteristics and mobility of MoS2-based transistors through hybridization with perovskite CsPbBr3 quantum dots

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Nano Research 2019年第2期12卷 405-412页

作者： Taeho Noh Heung Seob Shin changwon Seo Jun Young Kim Jongwon Youn Jeongyong Kim Kwang-Sup Lee Jinsoo Joo Department of Physics Korea University Seoul 02841 Republic of Korea Department of Advanced Materials and Chemical Engineering Hannatn University Daejeon 34430 Republic of Korea Department of Energy Science Sungkyunkwan University Suwon 16419 Republic of Korea

Inorganic perovskite CsPbBr3 quantum dots (QDs) are potential nanoscale photosensitizers;moreover,two-dimensional (2-D) molybdenum disulfide (MoS2) has been intensively studied for application in the active layers of optoelectronic *** this study,heterostructures of 2D-monolayered MoS2 with zero-dimensional functionalized CsPbBr3 QDs were prepared,and their nanoscale optical characteristics were *** effect of n-type doping on the MoS2 monolayer after hybridization with perovskite CsPbBr3 QDs was observed using laser confocal microscope photoluminescenca (PL) and Raman ***-effect transistors (FETs) using MoS2 and the MoS2-CsPbBr3 QDs hybrid were also fabricated,and their electrical and photoresponsive characteristics were investigated in terms of the charge transfer *** the MoS2-CsPbBr3 QDs-based FETs,the field effect mobility and photoresponsivity upon light irradiation were enhanced by ~ 4 times and a dramatic ~ 17 times,respectively,compared to the FET prepared without the parovskite QDs and without light *** is noteworthy that the photoresponsivity of the MoS-2-CsPbBr3 QDs-based FETs significantly increased with increasing light power,which is completely contrary to the behavior observed in previous studies of MoS2-based *** increased mobility and significant enhancement of the photoresponsivity can be attributed to the n-type doping effect and efficient energy transfer from CsPbBr3 QDs to *** results indicate that the optoelectronic characteristics of MoS2-based FETs can be significantly improved through hybridization with photosensitive parovskite CsPbBr3 QDs.

关键词： MoS2 perovskite quantum dot transistor photoresponsivity mobility charge transfer

Fabrication, microstructure and properties of SiCp/Cu heat sink materials

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Rare Metals 2006年第z2期25卷 232-236页

作者： kang Suk-bong Korea Institute of Machinery and Materials 66 Sangnam-dong Changwon 641-010 Korea

Cu-coated powder was fabricated by electroless plating process, and the composition and morphology of coated powder were studied. Moreover, Cu-30, 40, 50 vol.%SiCp heat sink materials were fabricated by hot pressing using coated and uncoated powder. And the microstructure and thermophysical properties of the heat sink materials were also studied. The results show that SiCp particles distribute uniformly in heat sink materials and the interface between SiCp particles and Cu matrix is clear and well bonded. On the condition of same volume fraction of SiCp, the thermal conductivity of the material using coated powder is larger than that of the material using uncoated powder. Under experiment conditions, the thermal conductivity and coefficient of thermal expansion of Cu-30 vol.%SiCp heat sink material is 236.2 W·m-1·K-1 and 9.9×10-6/K (30-200 ℃) respectively. It provides important reference data for future experiments.

关键词： heat sink material electroless copper plating coefficient of thermal expansion thermal conductivity

DEVELOPMENT　OF　BRAIDED－PULTRUSION　PROCESS　AND　STRUCTURE－PROPERTY　RELATIONSHIPS　FOR　TUBULAR　COMPOSITES

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Acta Metallurgica Sinica(English Letters) 1996年第6期9卷 555-564页

作者： J.H. Byun S.-K.Lee and B.S. Kim (Korea Institute of Machinery and Materials, P.O. Box 41, changwon, Korea Korea Inst of Machinery and Materials Changwon South Korea

In order to realize the potential of composite materials, it is imperative to develop a manufacturing process, to understand the microstructures, and to assess the structural performance of the composite. The braided-pultrusion process, which combines the pultrusion process with the braiding technology, has been developed by utilizing a novel resin impregnation device. The goal of the development is to achieve both costeffectiveness and performance of the composite. The tubular composites of diameter 5.3 mm have been produced using Kevlar 49 fiber and polyester resin. In order to assess the mechanical performance of the composites, an analytical method for predicting the elastic constants has been developed. The analysis includes the geometric model of a unit cell, coordinate transformation, and averaging of stiffness and compliance constants of the constituent materials. The analytic predictions compared favorably with experimental results.

关键词： braided pultrusion impregnation structural performance

THE INFLUENCES OF Zn CONTENT AND COOLING RATE ON ASCAST MICROSTRUCTURE IN Al75% Mg ALLOYS

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Acta Metallurgica Sinica(English Letters) 1999年第4期12卷 521-527页

作者： Q.Wu1)and S.B.kang2) 1) Department of Material Science and Engineering, Nanjing University of Science and Technology , Nanjing,210014 ,China 2) Department of Material Engineering ,Korea Institute of Mechanics and Materials,changwon , Korea

Thesolidification processof Al 7 5% Mg Zn alloys wasstudiedin *** Zn contentand cooling rate werechanged andtheirinfluenceson as cast microstructure were measured by different methods. The solute segregation during nonequilibrium solidification process wascalculated byternary Scheilequation which wasin good agreement with experimentresulte.

关键词： aluminum alloy as cast microstructure nonequilibrium solidification

Effects of Additional Elements on Microstructure and Precipitation Behaviour in Rapidly Solidified Al-Ti Base Alloys

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Journal of Materials Science & Technology 1996年第3期12卷 195-198页

作者： Won-Wook Park Chul-Jin Choi and Bong-Sun You (Dept. of Materials Processing, Korea Institute of Machinery and Metals, 66 Sangnam-Dong,changwon, Kyungnam, Korea 641-010)(To whom correspondence should be addressed) Dept. of Materials Processing Korea Institute of Machinery and Metals Changwon Kytmgnam 641-010 66 Sangnam-Dong South Korea

Rapidly solidified Al-Ti base alloys were prepared by melt spinning at the cooling rate about 107 K/s. The melt-spun ribbons were used to observe the dricrostructures after heat *** the supersaturated Al-Tl-Si alloy, age hardening occurred after 1 h anneal in the temperature range of 4000~500℃, which seems to be attributed to the precipitation of metastable Ll2- (Al,Si)3Ti phase. However. the microhardness was relatively low because of the low v/o and the insufflcient stability of precipitates. Thus. Cr was added to Al-Ti-Si alloys in order to stabilize the microstructures and to increase the v/o of precipitate5. As a result. the alIoys containing Cr were evaluated to possess the improved properties at the service temperature.

关键词： Ti Base Al Effects of Additional Elements on Microstructure and Precipitation Behaviour in Rapidly Solidified Al-Ti Base Alloys

Microstructure comparison of ZK60 alloy under casting,twin roll casting and hot compression

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Transactions of Nonferrous Metals Society of China 2010年第5期20卷 763-768页

作者：王守仁王敏 kang Suk-bong CHO Jae-hyung School of Mechanical Engineering University of Ji'nan School of Materials Science and Engineering Shandong University Korea Institute of Materials Science 66 Sangnam-dongChangwon 641010Korea

The microstructures of ZK60 alloy under conventional direct as-casting (DC),twin roll casting (TRC) and twin roll casting followed by hot compression (TRC-HC) were analyzed by optical morphology (OM),electron backscatter diffraction (EBSD) and X-ray diffraction (XRD).The deformation condition of hot compression is 350 ℃,0.1 s?*** microstructural evolution under TRC-HC deformation followed by annealing at different temperatures and time was *** results show that TRC provides more modified microstructure compared with *** are found in TRC processing;dynamic recrystallization (DRX),shear bands and twins are found in TRC-HC.A short annealing time has little effect on hardness,while during a long time annealing,it is found that low annealing temperatures increase the micro-hardness and high temperature decreases it.

关键词： microstructural evolution anneal dynamic recrystallization static recrystallization twin-roll casting hot compression magnesium alloy ZK60

Review on Fabrication Methods of in situ Metal Matrix Composites

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Journal of Materials Science & Technology 2000年第6期16卷 619-626页

作者： ChunXiang CUI Yutian SHEN Fanbin MENG Seuk Bong kang School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China Korea Institute of Machinery&Materials P.O.Box(Changwon)41Kyungsangnam-doKorea

This paper deals with a series of novel processing techniques based on the in situ production of metal matrix composites (MMCs). In situ techniques involve a chemical reaction resulting in the formation of a very fine and thermodynamically stable reinforcing ceramic phase within a metal matrix. As a result, this provides thermodynamic compatibility at the matrix-reinforcement interface. The reinforcement surfaces are also likely to be free of contamination and, therefore, a stronger matrix-dispersion bond can be achieved. Some of these technologies including DIMOX^? XD, PRIMEX^? reactive gas infiltration, high-temperature self-propagating synthesis (SHS), and liquid-solid, or solid-gas-liquid reactions as well as plasma in situ MMCs are expressed in this paper.

关键词： Powder metallurgy