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Signal Transduction and Targeted Therapy 2024年第6期9卷 2362-2390页

作者： Yao Zong Hao Li Peng Liao long Chen Yao Pan Yongqiang Zheng changqing Zhang Delin Liu Minghao Zheng Junjie Gao Centre for Orthopaedic Research Medical SchoolThe University of Western AustraliaNedlandsWA 6009Australia Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Institute of Microsurgery on Extremities and Department of Orthopedic SurgeryShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Sixth People’s Hospital Fujian No.16Luoshan SectionJinguang RoadLuoshan StreetJinjiang CityQuanzhouFujianChina

Mitochondria,with their intricate networks of functions and information processing,are pivotal in both health regulation and disease ***,mitochondrial dysfunctions are identified in many common pathologies,including cardiovascular diseases,neurodegeneration,metabolic syndrome,and ***,the multifaceted nature and elusive phenotypic threshold of mitochondrial dysfunction complicate our understanding of their contributions to ***,these complexities do not prevent mitochondria from being among the most important therapeutic *** recent years,strategies targeting mitochondrial dysfunction have continuously emerged and transitioned to clinical *** intervention such as using healthy mitochondria to replenish or replace damaged mitochondria,has shown promise in preclinical trials of various *** components,including mtDNA,mitochondria-located microRNA,and associated proteins can be potential therapeutic agents to augment mitochondrial function in immunometabolic diseases and tissue ***,we review current knowledge of mitochondrial pathophysiology in concrete examples of common *** also summarize current strategies to treat mitochondrial dysfunction from the perspective of dietary supplements and targeted therapies,as well as the clinical translational situation of related pharmacology ***,this review discusses the innovations and potential applications of mitochondrial transplantation as an advanced and promising treatment.

关键词： dysfunction injuries replace

Collision-avoidance strategy for a spinning electrodynamic tether system

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Astrodynamics 2024年第2期8卷 247-259页

作者： Linxiao Li Aijun Li Hongshi Lu changqing Wang Yuriy Mikhailovich Zabolotnov Yong Guo School of Automation Northwestern Polytechnical UniversityXi’an 710129China Institute of IT and Cybernatics Samara National Research UniversitySamara 443086Russia

Spinning electrodynamic tether systems(SEDTs)have promising potential for the active removal of space debris,the construction of observation platforms,and the formation of artificial ***,owing to the survivability problem of long tethers,designing collision-avoidance strategies for SEDTs with space debris is an urgent *** study focuses on the design of collision-avoidance strategies for SEDTs with an electrodynamic force(Ampere force).The relative distance between the debris and the SEDT is first derived,and then two collision-avoidance strategies are proposed according to the two different *** debris collides closer to a lighter subsatellite,a stationary avoidance strategy is proposed to change the spatial position of the subsatellite by adjusting only the angular motion of the tether,which maintains the original orbit of the *** debris collides closer to a heavier main spacecraft,a comprehensive avoidance strategy is proposed to change the spatial position of the SEDT by slightly modifying the orbital height and changing the tether angular motion *** numerical results illustrate that the proposed strategies promptly avoid potential collisions of an SEDT with space debris without significant changes in the orbital parameters of the SEDT.

关键词： spinning electrodynamic tether systems(SEDTs) collision analysis collision avoidance

基于蓝海战略的禽肉制品营销竞争策略分析——以河南华英集团为例

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新疆农垦经济 2008年第4期 12-15,24页

作者：龙长青徐锋华中农业大学经济管理学院湖北武汉430070

本文运用蓝海战略理论,以河南华英禽业集团为例,分析了禽肉制品企业在激烈的竞争环境中,如何进行产品价值创新,运用"删除——减少——增加——创造"四步操作框架,讨论了如何进行战略制定及实施策略,最后得出对我国企业参与国际市场竞争... 详细信息

本文运用蓝海战略理论,以河南华英禽业集团为例,分析了禽肉制品企业在激烈的竞争环境中,如何进行产品价值创新,运用"删除——减少——增加——创造"四步操作框架,讨论了如何进行战略制定及实施策略,最后得出对我国企业参与国际市场竞争的启示与建议。

关键词：蓝海战略禽肉制品价值创新四步操作框架价值曲线

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

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Signal Transduction and Targeted Therapy 2024年第1期9卷 326-337页

作者： You Zhai Yicong Du Guanzhang Li Mingchen Yu Huimin Hu changqing Pan Di Wang Zhongfang Shi Xu Yan Xuesong Li Tao Jiang Wei Zhang Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingPR China Department of Urology Peking University First HospitalInstitute of UrologyPeking UniversityNational Urological Cancer CenterBeijingPR China Department of Pathophysiology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China China National Clinical Research Center for Neurological Diseases BeijingPR China Center of Brain Tumor Beijing Institute for Brain DisordersBeijingPR China Research Unit of Accurate Diagnosis Treatmentand Translational Medicine of Brain TumorsChinese Academy of Medical SciencesBeijingPR China Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA) BeijingPR China

Chimeric antigen receptor(CAR)T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid *** instances of rapid tumor remissions have been observed in animal models and clinical trials,tumor relapses occur with multiple therapeutic resistance ***,while the mechanisms underlying the long-term therapeutic resistance are well-known,short-term adaptation remains less ***,more views shed light on short-term adaptation and hold that it provides an opportunity window for long-term *** this study,we explore a previously unreported mechanism in which tumor cells employ trogocytosis to acquire CAR molecules from CAR-T cells,a reversal of previously documented *** mechanism results in the depletion of CAR molecules and subsequent CAR-T cell dysfunction,also leading to short-term antigen loss and antigen *** type of intercellular communication is independent of CAR downstream signaling,CAR-T cell condition,target antigen,and tumor cell ***,it is mainly dependent on antigen density and CAR sensitivity,and is associated with tumor cell cholesterol *** mitigation of this trogocytosis-induced CAR molecule transfer can be achieved by adaptively administering CAR-T cells with antigen density-individualized CAR ***,our study reveals a dynamic process of CAR molecule transfer and refining the framework of clinical CAR-T therapy for solid tumors.

关键词： Together instance depletion

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明尼苏达多相人格调查表的因子分析研究

心理学报 1989年第3期21卷 266-273页

作者：邹义壮赵传绎姜长青北京迴龙观医院北京安定医院

本文介绍了我们用因子分析的方法,对MMPI在北京地区两大精神病院和部分正常人中进行的研究,证明了MMPI在精神科临床和不同性别、不同文化程度的正常人中具有十分近似的因子结构,具有良好的结构效度。本研究得到的因子结构与美国等国家... 详细信息

本文介绍了我们用因子分析的方法,对MMPI在北京地区两大精神病院和部分正常人中进行的研究,证明了MMPI在精神科临床和不同性别、不同文化程度的正常人中具有十分近似的因子结构,具有良好的结构效度。本研究得到的因子结构与美国等国家报道的因子结构十分近似,提示MMPI可以对不同文化的民族和国家的人们具有的一些共同的人格维度进行有效的测量。最后用因子分析的结果建立了六个人格因子量表,方便了MMPI的解释工作。

关键词：因子分析 MMPI 明尼苏达多相人格调查表正常人邹义壮因素分析外向临床量表

带有混合时滞的惯性神经网络系统的反同步控制

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中南民族大学学报（自然科学版） 2020年第3期39卷 321-326页

作者：张国东龙常青中南民族大学数学与统计学学院武汉430074

研究了一类带有混合时滞的惯性神经网络系统的反同步控制问题.利用合适的变量替换,将二阶时滞惯性神经网络微分方程转化为一阶时滞微分方程组.借助Lyapunov稳定性理论、反馈控制理论及一些不等式技巧,获得了确保惯性神经网络驱动-响应... 详细信息

研究了一类带有混合时滞的惯性神经网络系统的反同步控制问题.利用合适的变量替换,将二阶时滞惯性神经网络微分方程转化为一阶时滞微分方程组.借助Lyapunov稳定性理论、反馈控制理论及一些不等式技巧,获得了确保惯性神经网络驱动-响应系统之间反同步的几个充分条件.给出数值仿真例子验证所得结果.

关键词：神经网络混合时滞 Lyapunov稳定性理论反同步控制

Contemporary Asymmetric Genetic Introgression Between Two Pelophylax Species in Shanghai

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Asian Herpetological Research 2024年第1期15卷 1-11页

作者： Xu WEI Wenli LIU Gang WANG Rui MA Meiling HUANG Jiaxin ZHENG Tingwei DONG changqing YUAN Shunqi BO Xiao YUAN Ben LI Shuo MA Qu YUE Youzhong DING Zhenghuan WANG School of Life Sciences East China Normal UniversityShanghai 200241China Shanghai Landscaping and City Appearance Administrative Bureau Shanghai 200041China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration East China Normal UniversityShanghai 200241China Yangtze Delta Estuarine Wetland Ecosystem Observation and Research Station Ministry of Education&Shanghai Science and Technology CommitteeShanghai 202162China

Human disturbances are considered to break reproduction barriers among *** increases in hybridization events have been reported among a large number of taxonomic groups in anthropogenic environments,providing novel insights into species evolution mechanisms and conservation management in the *** Eastern Golden Frog(Pelophylax plancyi)and BlackSpotted Frog(***)are two sympatric anuran species with a long history of mitochondrial genome introgression in highly urbanized continental East ***,there is only limited understanding of the pattern of their contemporary hybridization and factors influencing their interspecific relationship under anthropogenic ***,interspecific hybridization between *** and *** at the population level was investigated in *** except two haplotypes obtained from both species in Shanghai were mixed together,and located in the introgression clade,implying multiple ancient mitochondrial introgression events occurred in the populations of our study *** genetic introgression was detected by microsatellite markers,with 0.7%of *** and 14.6%of *** identified as contemporary admixed *** with the trend of population density,higher genetic diversity of neutral microsatellite loci was found in the more abundant ***;however,variation in mitochondrial(Cyt-b)and nuclear(POMC)genes was higher in relatively rare *** population density of *** and number of water patches within local habitats were significantly positively correlated with both occurrences and proportions of admixed individuals in the populations of *** and *** the prevalent transformation of habitats in urbanized areas,these results imply that a high population density in isolated artificially altered habitats is likely to increase interspecific ***,population monitoring and improveme

关键词： anthropogenic disturbances interspecific hybridization Pelophylax species abundance urban landscape urbanization

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汽车全生命周期碳排放研究与分析

汽车工艺与材料 2024年第7期 1-8页

作者：龙苏华魏长庆奇瑞汽车股份有限公司芜湖241000

为研究供应链对汽车全生命周期碳排放的影响,通过中国工业碳排放信息系统收集供应链碳排放数据,并对某款车型全生命周期碳排放进行研究与核算分析,发现原材料生产、零件生产及整车使用阶段等上下游供应链碳排放是整车生命周期碳排放的... 详细信息

为研究供应链对汽车全生命周期碳排放的影响,通过中国工业碳排放信息系统收集供应链碳排放数据,并对某款车型全生命周期碳排放进行研究与核算分析,发现原材料生产、零件生产及整车使用阶段等上下游供应链碳排放是整车生命周期碳排放的主要来源,并提出供应链碳排放管理的建议。

关键词：生命周期碳排放供应链 CICES 系统

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前板块构造与大陆起源研究进展及关键科学问题

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科学通报 2024年第12期69卷 1572-1585页

作者：龙晓平赵国春翟明国郭敬辉初航彭澎张少兵尹常青西北大学地质学系大陆动力学国家重点实验室西安710069 香港大学地球科学系中国香港中国科学院地质与地球物理研究所岩石圈国家重点实验室北京100029 中国地质调查局天津地质调查中心天津300170 中国科学技术大学地球和空间科学学院中国科学院壳幔物质与环境重点实验室合肥230026 中山大学地球科学与工程学院珠海510275

本文总结了现阶段前板块构造与大陆起源研究的三大重要进展:(1)提出了地幔柱构造、重力凹沉构造和热管构造的前板块构造模式;(2)揭示了非板块构造与板块构造的标志;(3)发现了地球早期层圈演化地质记录.但是,现有的前板块构造并不能完美... 详细信息

本文总结了现阶段前板块构造与大陆起源研究的三大重要进展:(1)提出了地幔柱构造、重力凹沉构造和热管构造的前板块构造模式;(2)揭示了非板块构造与板块构造的标志;(3)发现了地球早期层圈演化地质记录.但是,现有的前板块构造并不能完美解释太古宙大陆的起源,板块构造在解释大陆起源与演化方面也遇到重大挑战.此外,阐述了我国开展前板块构造与大陆起源研究的必要性、研究优势及风险,并凝练了目前前板块构造与大陆起源研究的关键科学问题:(1)地球是先有陆还是先有板块构造;(2)海陆的形成是否同步;(3)冥古宙陆壳和英云闪长岩-奥长花岗岩-花岗闪长岩(tonalite-trondhjemite-granodiorite,TTG)的起源.基于学科发展,提出动力学热模拟和比较行星学在前板块构造与大陆起源研究中的重要性.在此基础上,认为未来5~10年前板块构造与大陆起源的研究重点领域为:(1)大陆的起源及其对早期地球环境和生命的影响;(2)前板块构造样式及其形成机制;(3)太古宙的构造热体制及热演化;(4)前板块构造与类地行星演化.

关键词：大陆起源板块构造前板块构造比较行星学动力学热模拟