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Chinese Medical Journal 2023年第8期136卷 1001-1003页

作者： Minjuan Li Dantong Shao Jiachen Zhou Jianhua Gu Zhiyuan Fan Junjie Qin Xinqing Li changqing hao Wenqiang Wei National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Guangzhou Institute of Pediatrics Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouGuangdong 510180China Department of Epidemiology and Biostatistics School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Promegene Institute ShenzhenGuangdong 518038China Department of Endoscopy Cancer Institute/Hospital of LinzhouLinzhouHenan 456550China

To the Editor:Esophageal cancer(EC)ranks ninth and fifth among the leading cause of global cancer-related morbidity and mortality,respectively.[1]Esophageal squamous cell carcinoma(ESCC)is the predominant histologic subtype of EC in China.Population screening effectively decreases the morbidity and mortality of ESCC,highlighting the necessity of early detection and early diagnosis.

关键词： mortality squamous esophageal

DNA image cytometry test for primary screening of esophageal cancer: a population-based multi-center study in high-risk areas in China

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Chinese Journal of Cancer Research 2016年第4期28卷 404-412页

作者： Meng Wang changqing hao Qing Ma Guohui Song Shanrui Ma Deli Zhao Lin Zhao Xinqing Li Wenqiang Wei Department of Cancer Epidemiology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Endoscopy Linzhou Cancer Hospital Department of Epidemiology Cixian Cancer Hospital Department of Cancer Center Feicheng People Hospital Medical Record Room Xuanwu Hosital

Objective： To evaluate the feasibility of DNA image cytometry （DNA-ICM） as a primary screening method for esophageal squamous cell cancer （ESCC）. Methods： A total of 5,382 local residents aged 40-69 years from three high-risk areas in China （Linzhou in Henan province, Feicheng in Shandong province and Cixian in Hebei province） from 2008 to 2011 were recruited in this population-based screening study. And 2,526 subjects declined to receive endoscopic biopsy examination with Lugol＇s iodine staining, while 9 and 815 subjects were excluded from liquid-based cytology and DNA-ICM test respectively due to slide quality. Finally, 2,856, 5,373 and 4,567 subjects were enrolled in the analysis for endoscopic biopsy examination, liquid-based cytology and DNA-ICM test, respectively. Sensitivity （SE）, specificity （SP）, negative predictive values （NPV） and positive predictive values （PPV） as well as their 95% confidence intervals （95% CI） for DNA-ICM, liquid-based cytology and the combination of the two methods were calculated. Receiver operating characteristic （ROC） curves were applied to determine the cutoff point of DNA-ICM for esophageal cancer. Results： DNA-ICM results were significantly correlative with esophageal cancer and precancer lesions （X2= 18.016, P〈0.001）. The cutoff points were 5,802, 5,803 and 8,002 based on dissimilar pathological types of low grade intraepithelial neoplasia （LGIN）, high grade intraepithelial neoplasia （HGIN）, and ESCC, respectively, and 5,803 was chosen in this study considering the SE and SP. The SE, SP, PPV, NPV of DNA-ICM test （cutoff point 5,803） combined with liquid-based cytology [threshold atypical squamous cells of undetermined significance （ASCUS）] were separately 72.1% （95% CI： 70.3%-73.9%）, 43.3% （95% CI. 41.3%-45.3%）, 22.8% （95% CI： 21.1%-24.5%） and 87.0% （95% CI： 85.7%-88.3%） for LGIN, 85.7% （95% CI： 84.3%-87.1%）, 41.3% （95% CI： 39.3%-43.3%）, 4.6% （95% CI： 3.8%-5.4%） and 98.9% （95% CI： 98.5%-99.3%） for HGIN, and 96.0% （95% CI： 95.2%-96.8%）, 40.8% （95% CI： 38.8%-42.8%）, 1.7% （95%

关键词： DNA image cytometry esophageal cancer cutoff point

Efficacy of endoscopic treatment on patients with severe dysplasia/carcinoma in situ of esophageal squamous cell carcinoma: A prospective cohort study

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Chinese Journal of Cancer Research 2019年第2期31卷 357-365页

作者： Meng Wang changqing hao Shuanghua Xie Shanrui Ma Qing Ma Rongshou Zheng Ru Chen Xinqing Li Wenqiang Wei Office of Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endoscopy Linzhou Cancer Hospital

Objective: To explore the natural history of severe dysplasia/carcinoma in situ(SD/CIS) patients and to evaluate the efficacy of endoscopic treatment to SD/CIS patients.Methods: Between January 2005 and December 2009, a population-based prospective screening program on esophageal squamous cell carcinoma(ESCC) was performed in Linzhou, China, with endoscopic screening plus iodine staining. All the eligible histologically confirmed SD/CIS patients were followed up through the door-todoor follow-up and local cancer registry. The endpoint was diagnosed as ESCC or the December 31 st, 2016.Kaplan-Meier survival analysis and Log-rank test were used to compare the survival rates among treated and untreated patients.Results: A total of 175 SD/CIS patients were enrolled and grouped by whether they received endoscopic treatment. Eleven-year cumulative incidence rates for untreated and treated SD/CIS patients were 10.7% [95%confidence interval(95% CI): 6.9-16.1] and 3.2%(95% CI: 1.4-7.0), respectively. The ESCC incidence free survival rate, and all-cause incidence and mortality free survival rates were all significantly higher in the treated patients vs. untreated patients(P=0.043, P=0.008 and P=0.015, respectively). The ESCC mortality free survival rate showed no significant differences between the two groups(P=0.847).Conclusions: The cumulative incidence rate of SD/CIS patients to ESCC was much lower than previously reported. The Kaplan-Meier survival analysis showed that endoscopic treatment could increase the ESCC and allcause disease-free survival rates of SD/CIS patients significantly.

关键词： Endoscopy esophageal squamous cell carcinoma precancerous lesions management mass screening

Food-Borne Poisoning Accident from Amanitin Toxin in Wild Mushrooms—Xingtai City,Hebei Province,China,2023

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China CDC weekly 2024年第3期6卷 56-59页

作者： Baopu Lv Liang Liu hao Xiao Qingbing Meng Rui Zhang Yaqing An Yingli Jin Yu Ma Hengbo Gao Yongkai Li Qian He Yutao Zhang changqing Liu Xiaoyan Luo Xiaomin Xu Fenshuang Zheng Yingping Tian Hongshun Zhang Dongqi Yao Emergency Department The Second Hospital of Hebei Medical UniversityShijiazhuang CityHebei ProvinceChina National Institute of Occupational Health and Poison Control Chinese Centre for Disease Control and PreventionBeijingChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Emergency Department The Affiliated Hospital of Yunnan UniversityKunming CityYunnan ProvinceChina

What is already known about this topic?Fatal poisonings caused by wild mushrooms containing amanita toxins pose a significant threat in the southern regions of China.These toxins primarily induce gastrointestinal symptoms initially,which are then followed by potentially life-threatening acute liver damage.What is added by this report?This report contributes to the existing knowledge on these cases of poisoning by documenting the second occurrences in Hebei Province and the first occurrences in Xingtai City.Five individuals reported consuming wild mushrooms from the same origin,and laboratory tests confirmed the presence ofα-amanitin in their blood samples.What are the implications for public health practice?This underscores the risk associated with the collection and consumption of amanita toxin-containing mushrooms in Hebei.It is important to note that the identification of toxic and non-toxic mushrooms should not solely rely on personal experience or appearance.

关键词： Hebei consuming initially

铁路货车轮毂对轴承压装力-位移曲线的影响研究

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机械与电子 2024年第5期42卷 76-80页

作者：魏常庆张皓国能铁路装备有限责任公司肃宁车辆维修分公司河北沧州062350

为保障铁路货车行驶安全,实现对铁路货车轮对磨耗状况的预测,研究铁路货车轮毂对轴承压装力-位移曲线的影响。首先以轮毂轴承内圈与车轴轴颈配合为基础,从力学角度分析轮毂对轴承压装过程,获取轴承压装力-位移间的标准曲线,并以此为基础... 详细信息

为保障铁路货车行驶安全,实现对铁路货车轮对磨耗状况的预测,研究铁路货车轮毂对轴承压装力-位移曲线的影响。首先以轮毂轴承内圈与车轴轴颈配合为基础,从力学角度分析轮毂对轴承压装过程,获取轴承压装力-位移间的标准曲线,并以此为基础,依照广义胡克理论计算轮毂对轴承压装力值。然后构建基于最小二乘支持向量机的预测模型,以轴承压装力值与车轮直径等参数为输入向量,以铁路货车轮对磨耗为输出变量,利用量子粒子群算法优化预测模型参数,通过参数编码、确定适应度参数等过程提升预测模型求解效率与精度。最后利用实验证明所提方法的先进性。实验结果表明,该方法可获取研究对象压装力-位移曲线,通过校正可获取满足轴承设计标准的压装力理论结果,以此为基础可准确预测车轮对的磨耗状况。

关键词：铁路货车轮毂轴承压装力-位移磨耗状况胡克理论

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气基竖炉直接还原数值模拟分析

钢铁 2024年第1期59卷 41-48页

作者：白晨晨师学峰王明阳于浩胡长庆韩涛华北理工大学冶金与能源学院河北唐山063210

针对气基竖炉直接还原过程无法直接观察还原反应运行程度的难点,基于三界面未反应核模型,在忽略模型球团内部温度及假设球团还原反应的热效应完全发生在固相的条件下,建立了气基竖炉直接还原模型,对铁氧化物价态转变进行了数值模拟和验... 详细信息

针对气基竖炉直接还原过程无法直接观察还原反应运行程度的难点,基于三界面未反应核模型,在忽略模型球团内部温度及假设球团还原反应的热效应完全发生在固相的条件下,建立了气基竖炉直接还原模型,对铁氧化物价态转变进行了数值模拟和验证。结果表明,由于所建立的气固模型包含3个界面,随着铁氧化物的逐级还原,每个界面的反应半径最终趋于0,而还原反应速率随着竖炉深度的增加呈现出先升高后降低的趋势。球团在竖炉内下降到3 m深度时,出现半径为15 mm的FeO反应界面,此时球团还原率约为28%。随着球团继续在竖炉内下行约2 m到达5 m的深度时,Fe_(3)O_(4)的界面半径减小为0,此时铁氧化物完全转变成了浮氏体形态,球团还原率约为34%。通过改变不同的工艺参数进行模拟可以发现,还原球团金属化率和还原率随着气体温度的升高而增大。当气体温度以50℃、还原气体流量以5040 m^(3)/h梯度增大时,其对应的球团金属化率分别增大8%和4%左右。相比之下,球团金属化率受下料速度的影响远超过气体温度和还原气体流量,具体表现为,当下料速度增大0.02 t/h时,金属化率降低约0.07%。而当球团粒度减小时,金属化率会表现增大的趋势,球团粒度减小1 mm,球团金属化率增大2.23%。

关键词：气基竖炉气基法直接还原数值模拟还原率金属化率

基于大规模筛查队列的食管癌及癌前病变真实世界研究

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中华肿瘤防治杂志 2023年第23期30卷 1401-1406页

作者：陈茹李琰琰郝长青宋国慧华召来李军魏文强国家癌症中心·国家肿瘤临床医学研究中心·中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室北京100021 肥城市人民医院肿瘤防治中心山东肥城271600 林州市肿瘤医院内镜科河南林州456550 磁县肿瘤防治研究所·磁县肿瘤医院流行病学研究室河北邯郸056500 扬中市人民医院肿瘤防治研究所江苏扬中212200 盐亭县肿瘤医院癌防办公室四川盐亭621600

目的了解食管癌高发区人群筛查现状,为食管癌筛查方案优化提供真实世界证据。方法依托河北省磁县、河南省林州市、山东省肥城市、四川省盐亭县和江苏省扬中市食管癌筛查人群构建多中心队列,选取2005-2012年所有受邀参与内镜筛查的40~69... 详细信息

目的了解食管癌高发区人群筛查现状,为食管癌筛查方案优化提供真实世界证据。方法依托河北省磁县、河南省林州市、山东省肥城市、四川省盐亭县和江苏省扬中市食管癌筛查人群构建多中心队列,选取2005-2012年所有受邀参与内镜筛查的40~69岁、无肿瘤史的常住居民为研究对象。通过筛查依从性、基线检出率、危险因素、进展风险等多个指标探讨食管癌筛查的起始年龄、筛查间隔等问题。结果2005-2012年共有284476人受邀参加筛查,其中100880人参与了内镜检查,筛查依从性为35.46%。女性依从性(38.95%)高于男性(31.95%);50~59岁人群依从性最高(39.26%),40~49岁依从性最低(31.61%);肥城市依从性最高(55.63%),扬中市依从性最低(27.74%),性别、年龄和地区依从性差异有统计学意义,均P<0.001。在基线筛查人群中,低级别上皮内瘤变、高级别上皮内瘤变和食管癌分别检出8011例、960例和369例,检出率分别为7.94%、0.95%和0.37%。男性、高龄、吸烟等是食管癌和癌前病变共同的危险因素,均P<0.001。中位随访12.15年后,低级别和高级别上皮内瘤变患者进展为食管癌的风险分别是正常人群的5.00倍(HR=5.00,95%CI:4.37~5.72)和26.41倍(HR=26.41,95%CI:22.54~30.94),发生食管癌死亡的风险分别是正常人群的3.37倍(HR=3.37,95%CI:2.77~4.10)和17.85倍(HR=17.85,95%CI:14.32~22.26)。低级别上皮内瘤变患者的食管癌发病率随着随访时间延长不断升高,死亡率在随访3年后缓慢上升,随访5年后加速上升。结论提高食管癌筛查的起始年龄可以降低筛查负担并提高筛查的依从性和检出率。筛查方案的优化应结合危险因素制定个体化的筛查方案,并根据病理诊断制定合理的治疗和监测方案。

关键词：食管癌癌前病变检出率吸烟进展风险

A semi-analytical model for coupled flow in stress-sensitive multi-scale shale reservoirs with fractal characteristics

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Petroleum Science 2024年第1期21卷 327-342页

作者： Qian Zhang Wen-Dong Wang Yu-Liang Su Wei Chen Zheng-Dong Lei Lei Li Yong-Mao hao Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Oil Development Branch Changqing Oilfield CompanyPetroChinaQingyang745708GansuChina PetroChina Research Institute of Petroleum Exploration&Development Beijing100083China

A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes due to stress sensitivity, which plays a crucial role in controlling pressure propagation and oil flow. This paper proposes a multi-scale coupled flow mathematical model of matrix nanopores, induced fractures, and hydraulic fractures. In this model, the micro-scale effects of shale oil flow in fractal nanopores, fractal induced fracture network, and stress sensitivity of multi-scale media are considered. We solved the model iteratively using Pedrosa transform, semi-analytic Segmented Bessel function, Laplace transform. The results of this model exhibit good agreement with the numerical solution and field production data, confirming the high accuracy of the model. As well, the influence of stress sensitivity on permeability, pressure and production is analyzed. It is shown that the permeability and production decrease significantly when induced fractures are weakly supported. Closed induced fractures can inhibit interporosity flow in the stimulated reservoir volume (SRV). It has been shown in sensitivity analysis that hydraulic fractures are beneficial to early production, and induced fractures in SRV are beneficial to middle production. The model can characterize multi-scale flow characteristics of shale oil, providing theoretical guidance for rapid productivity evaluation.

关键词： Multi-scale coupled flow Stress sensitivity Shale oil Micro-scale effect Fractal theory

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乳液型环氧固化剂的制备与性能研究

涂料工业 2024年第7期54卷 53-59页

作者：黄清华张豪李永康申亮付长清江西科技师范大学化学化工学院涂料与高分子系南昌330013 江西省水性涂料工程研究中心南昌330013

为制备稳定性良好及高耐性的乳液型环氧固化剂,以三乙烯四胺、聚乙二醇二缩水甘油醚、环氧树脂E51、邻甲苯缩水甘油醚为原料合成了一种非离子反应型乳化剂(NIRE);以二乙烯三胺或间苯二甲胺、环氧树脂E20、苯基缩水甘油醚为原料合成了改... 详细信息

为制备稳定性良好及高耐性的乳液型环氧固化剂,以三乙烯四胺、聚乙二醇二缩水甘油醚、环氧树脂E51、邻甲苯缩水甘油醚为原料合成了一种非离子反应型乳化剂(NIRE);以二乙烯三胺或间苯二甲胺、环氧树脂E20、苯基缩水甘油醚为原料合成了改性胺作为被乳化物(ES)。利用NIRE与ES之间的疏水性差异,通过相反转法制得乳液型环氧固化剂(WCA),并考察了WCA固化的水性双组分环氧底漆的应用性能。采用红外光谱表征了NIRE、ES的结构;探究了制备NIRE的最佳反应条件;并研究了NIRE用量、乳化温度、剪切速度对WCA性能的影响;以及ES结构中胺的种类及封端率对WCA应用性能的影响。结果表明:当NIRE质量为ES的25%,乳化温度为60℃,剪切速率为2 000 r/min时,可制得粒径小、稳定性良好的WCA,由其制备的水性双组分环氧底漆具有优异的附着力、耐水性和耐盐雾性。

关键词：反应型乳化剂乳液型固化剂漆膜性能双组分水性环氧底漆

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检察机关提起公益诉讼制度研究

辽宁公安司法管理干部学院学报 2017年第3期 21-24页

作者：郝长青锦州市人民检察院辽宁锦州121013

检察机关提起公益诉讼制度,是检察机关法律监督职能的拓展,目前这一制度正处于试点时期。检察机关提起公益诉讼的基本原理是宪政精神、检察监督和风险社会;诉讼程序上应遵循普遍性和特殊性、独立性和附带性、衔接性和转换性规律。检察... 详细信息

检察机关提起公益诉讼制度,是检察机关法律监督职能的拓展,目前这一制度正处于试点时期。检察机关提起公益诉讼的基本原理是宪政精神、检察监督和风险社会;诉讼程序上应遵循普遍性和特殊性、独立性和附带性、衔接性和转换性规律。检察机关应当结合诉讼领域、案件线索、前置程序和办案效果,从主体、程序和实体三个方面对提起公益诉讼进行制度构建。

关键词：公益诉讼检察监督原理规律制度构建