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Nanomedicine-based treatment:An emerging therapeutical strategy for pulmonary hypertension

Nano Research 2023年第5期16卷 7007-7029页

作者： Shuya Wang Qiaohui Chen Tianjiao Zhao Kelong Ai changping hu Department of Pharmacology Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410078China hunan Provincial Key Laboratory of Cardiovascular Research Changsha 410078China

Pulmonary hypertension(PH)can cause breathing difficulty,a rapid decline of exercise capacity,heart failure,eventually death of the patients.The latest epidemiological study demonstrates that PH has a much higher incidence than previously thought.PH is still a highly fatal disease due to the many disadvantages of the current drugs,such as short half-life,lack of targeting,potent side effects.The PH pathological features offer great opportunities for nanomedicines for PH.Recently,emerging nanomedicines demonstrated great advantages in the therapeutic effect of PH by enhancing the accumulation of drugs in PH lesion,optimizing drug efficacy,minimizing drug side effects.However,this promising field of cross-cutting research is far from being widely explored due to the huge professional barriers.To solve this problem,we provide a comprehensive review for the latest progresses of nanomedicines in the treatment of PH.Firstly,we systematical summarized the PH pathological features and the current clinical drug treatment of PH.The advantages of nanomedicines are also deeply discussed in the treatment of PH.Subsequently,we focused on the research progresses of nanomedicines in PH through three aspects:advanced nano-drug delivery system for traditional drugs and new target drugs,gene therapy-based nanomedicines,other nanomedicines for the treatment of PH.Finally,we also discussed the prospects and challenges for the clinical application of nanomedicines in PH,provided directions for the research and development of nanomedicines for PH treatment in the future.

关键词： pulmonary hypertension nanomedicines enhanced penetration and retention effects polymer liposome

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数智背景下的信息交互与服务发展

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情报理论与实践 2024年第4期47卷 1-9页

作者：胡昌平邓胜利武汉大学信息管理学院湖北武汉430072

[目的/意义]随着数字智能技术的应用拓展,面向用户的智能交互、多模态信息融合和数字空间活动的延伸,对数字信息资源组织、面向交互认知的描述和深层次服务的开展提出了新的要求。如何有效解决数字智能背景下信息交互与服务的深层次发... 详细信息

[目的/意义]随着数字智能技术的应用拓展,面向用户的智能交互、多模态信息融合和数字空间活动的延伸,对数字信息资源组织、面向交互认知的描述和深层次服务的开展提出了新的要求。如何有效解决数字智能背景下信息交互与服务的深层次发展问题成为亟待探讨的议题。[方法/过程]文章在分析数字智能环境形成及其对信息交互与服务影响的基础上,研究面向用户的智能交互与体验设计,以及基于智能交互的生成式人工智能的发展与安全保障。[结果/结论]在面向用户的信息服务组织中,应立足于数字智能环境的形成及其影响,寻求与智能环境相适应的服务组织模式和数字智能驱动下的服务组织方式。数字服务中以用户为中心的智能交互,在于充分理解用户的意图,融合用户视觉、听觉等交互通道,为智能化服务开展提供支持。同时针对快速发展的生成式人工智能,既要应对其带来的安全威胁,也要正确合理地确保生成式人工智能安全落地,保障生成式人工智能系统的安全。

关键词：数字智能信息服务智能交互与体验生成式人工智能

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新文科背景下服务设计理论在动画专业教学中的应用与实践——以“三维动画制作流程”课程为例

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当代教育理论与实践 2024年第2期16卷 56-62页

作者：胡畅平湘潭大学艺术学院湖南湘潭411105

强调学科交叉、跨界融合的新文科建设,带来了人文社会科学全新改革思路。以“三维动画制作流程”课程为例,探讨服务设计理念与动画制作相关课程融合的教学模型,从设计思维学习、跨学科能力拓展、项目化教学实践等维度,推进新文科背景下... 详细信息

强调学科交叉、跨界融合的新文科建设,带来了人文社会科学全新改革思路。以“三维动画制作流程”课程为例,探讨服务设计理念与动画制作相关课程融合的教学模型,从设计思维学习、跨学科能力拓展、项目化教学实践等维度,推进新文科背景下动画专业人才培养创新发展。在此基础上,提出动画学科跨界融合的教学改革应打破专业壁垒,激活学生的学习驱动力,实施差异化培养,提升学生的就业竞争力,推动创新性转化,以更好地服务社会需求。

关键词：新文科服务设计动画专业教学三维动画制作流程

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An analysis of user interactive learning behavior in academic library information commons in China

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Journal of Library Science in China 2014年 99-116页

作者： changping hu Yuan hu School of Information Management Wuhan University

This study explores the influencing factors of user interactive learning behavior in academic library information commons,by extending the original Technology Acceptance Model.The hypothesized relationships were tested via structural equation modeling,combining the specific context of academic library information commons.The results show that:a) Perceived usefulness,perceived ease of use,and perceived encouragement are the direct influencing factors;b) Perceived ease of use and perceived encouragement can directly affect perceived usefulness;c) User characteristic,social identity,service content affect user interactive learning behavior via perceived encouragement and perceived ease of use;d) Service ability can affect user interactive learning behavior via perceived encouragement.

关键词： Information commons User interactive learning Influencing factors Empirical study Academic libraries

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Factors influencing user adoption of location based service:From the expanded TAM perspective

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Chinese Journal of Library and Information Science 2014年第2期7卷 15-30页

作者： Yuan hu changping hu Jin hu School of Information Management Wuhan University Center for Studies of Information Resources School of Information Management.Wuhan University huangpi Branch of State Administration of Taxation

Purpose:This study intends to examine the factors influencing user adoption of location based service(LBS).Design/methodology/approach:This paper develops the research model for user adoption of LBS with the technology acceptance model(TAM) as the theoretical foundation.Using a questionnaire and sampling method,empirical data was collected from 386 participants.Structured equation modeling was used to test the validity of the proposed model.Findings:The results show that I) perceived ease of use.perceived usefulness and perceived playfulness were direct determinants of behavioral intention,and perceived ease of use has the greatest impact of the three;2) emergency,ubiquity,technology maturity and social trust all have positive and significant impacts on perceived ease of use;3) emergency and social trust significantly influence perceived usefulness positively:4) individualization and social impact significantly affect perceived playfulness positively.Research limitations:Subjects were from China’s mainland,which limits the generalizability of the research findings.The interaction effects of age,gender and user experience were not included.Practical implications:This study offers LBS operators,marketers and application developers insights into the way to attract more users by increasing perceived usefulness,ease of use and playfulness of LBS.Originality/value:Location based service is still a relatively new concept and there were few theoretical and empirical studies that examine user adoption of the serv ice.This study contributes to existing LBS adoption studies by modifying and extending TAM and meanwhile the empirical study will help the research community gain a deeper understanding of the factors affecting user adoption of LBS.

关键词： Location based service(LBS) User adoption Structured equation modeling(SEM) Empirical study

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A study on service quality evaluation of digital libraries in China based on tetra-class model

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Chinese Journal of Library and Information Science 2013年第2期6卷 14-32页

作者： changping hu Weiwei YAN Yuan hu Center for Studies of Information Resources Wuhan University

Purpose: This study intends to evaluate the service quality of academic digital libraries(DLs)in China. By utilizing tetra-class model which concentrates on categorizing services according to their contributions to user satisfaction, this paper attempts to visually categorize the specific DL service elements to reveal their present performances, and then further explain the categorizing variations among different groups of users to discover the user preference.Design/methodology/approach: This paper carries out a survey to evaluate user experience on 27 typical DL services summarized from our investigations of representative Chinese university DLs. Based on the five-point Likert-type scale evaluation, the users’ attitudes toward specific service element are divided into negative and positive dimensions. Afterwards,a correspondence analysis is applied to calculate the contributions to satisfaction and dissatisfaction of each service element based on tetra-class model. As a result, the DL service elements of Chinese academic libraries are classified into four categories(i.e. Basic, Secondary,Plus, and Key). Finally, we compared the categorizing variations.Findings: The results show that the DL service elements of Chinese academic libraries are all distributed in Basic and Key services regarding information retrieval and informationorganizing; 80% of the interaction services elements are Plus services, while 50% of the Secondary services are information-providing services. The results also reveal that service categorization is obviously influenced by the users’ education background, especially their disciplines. Furthermore, the users who are older, more highly-educated, or studying in higher reputation universities are more likely to evaluate DL services as either critical or useless.Research limitations: Tetra-class model cannot reveal the interplay among the DL service elements. In addition, the user segmentation in our studies is limited to the sample structure.Practical implications: This empirical study focuse

关键词： Digital library(DL) Tetra-class model User satisfaction User preference User characteristic Service categorization

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苍山洱海国家级自然保护区土地利用格局

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大理大学学报 2024年第6期9卷 24-30页

作者：胡昌平姜健发王有兵李亚楠王生云南省林业调查规划院大理分院云南大理671000

目的:了解云南苍山洱海国家级自然保护区(以下简称“保护区”)土地利用结构及特征,掌握土地利用的景观格局,为保护区整合优化及后期管理提供指导。方法:以相关调查数据为基础,基于GIS技术,对保护区土地利用现状、景观格局及矛盾冲突进... 详细信息

目的:了解云南苍山洱海国家级自然保护区(以下简称“保护区”)土地利用结构及特征,掌握土地利用的景观格局,为保护区整合优化及后期管理提供指导。方法:以相关调查数据为基础,基于GIS技术,对保护区土地利用现状、景观格局及矛盾冲突进行分析。结果:苍山片区以林地和草地为主(面积占比96.43%),洱海片区以水体为主(面积占比98.02%);研究区域林地、水域和草地景观形状较为规整,景观破碎度较低,受人为干扰较少;保护区的景观多样性较丰富,但分布不均;保护区各类矛盾冲突图斑面积占保护区总面积的2.44%,矛盾冲突地块主要分布于缓冲区和实验区,以耕地和集体人工商品林为主,采矿用地、城镇建成区和村庄对保护区的影响程度最大。结论:保护区土地结构较为合理,苍山片区管理上要以森林防火、生物多样性保护、地质遗迹保护为主;洱海片区要以湿地保护,特别是水体质量维护和提升,以及水生动植物保护为主。

关键词：土地利用景观格局矛盾冲突苍山洱海国家级自然保护区

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苍山洱海国家级自然保护区森林资源动态

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大理大学学报 2024年第6期9卷 31-37页

作者：李亚楠王生王有兵姜健发胡昌平云南省林业调查规划院大理分院云南大理671000

目的:了解云南苍山洱海国家级自然保护区(以下简称“保护区”)森林资源近20年的动态变化特征,为保护区编制经营管理方案提供指导。方法:以2005、2015年森林资源调查矢量数据、2021年森林、草原、湿地监测数据、第三次全国土地调查数据... 详细信息

目的:了解云南苍山洱海国家级自然保护区(以下简称“保护区”)森林资源近20年的动态变化特征,为保护区编制经营管理方案提供指导。方法:以2005、2015年森林资源调查矢量数据、2021年森林、草原、湿地监测数据、第三次全国土地调查数据为基础数据,基于GIS技术,分析保护区森林资源动态。结果:保护区土地利用类型中,有林地面积最大,并逐年增加;林地中,3个调查年度均以有林地和灌木林地为主,面积占保护区总面积的60.82%以上;保护区森林覆盖率2005—2015年间逐年增加,2015—2021年间增加值逐步趋于稳定;蓄积量以有林地蓄积为主,并逐年增加;乔木林地面积和蓄积量以栎类、云南松、华山松和苍山冷杉为主,且逐年增加;乔木林地中幼龄林、中龄林、近熟林和成熟林比重相对均衡,过熟林面积较少;各年度郁闭度等级均以中为主,且郁闭度等级为中和密的乔木林地面积和蓄积量均逐年增加。结论:保护区森林质量和生态防护功能逐年提高,后期森林资源管理以增加栎类等阔叶林为主。

关键词：森林资源动态分析森林质量苍山洱海国家级自然保护区

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Role of LOX-1 in pulmonary vascular remodeling in rats with hypoxia induced pulmonary arterial hypertension and the underlying mechanisms

Role of LOX-1 in pulmonary vascular remodeling in rats with ...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： Weifang ZHANG changping hu 中南大学 Department of Pharmacology School of Pharmaceutical SciencesCentral South University

Aim:To investigate the role of lectin-like oxidized low-density lipoprotein receptor-1（LOX-1）in pulmonary vascular remodeling in rats with hypoxia-induced pulmonary arterial hypertension（PAH）and the underlying mechanisms.Methods:SD rats were maintained under hypoxia（10%O2）for 3 weeks to induce PAH.The right ventricular systolic pressure（RVSP）,the mean pulmonary arterial pressure（m PAP）were monitored.Excised lungs were fixed to observe pulmonary vascular remodeling.Rat pulmonary arterial smooth muscle cells（PASMCs）were stimulated by 3%O2 to induce cell proliferation.Theexpression of LOX-1,p Elk,MRTF-A,SRF,c-fos was analyzed.Results:Exposure of rats to hypoxia for 3weeks induced PAH,as shown as by an increase in RVSP,m PAP and vascular hypertrophy.The expression of LOX-1,p Elk,SRF,c-fos was significantly increased while MRTF-A is decreased in pulmonary artery in hypoxia-induced PAH rats and in hypoxia-treated PASMCs.Anti-LOX-1 antibody and LOX-1 si RNA significantly inhibited hypoxia-induced proliferation of PASMCs,and reversed the increased expression of p Elk,SRF and c-fos as well as the decreased MRTF-A expression in hypoxia-treated PASMCs.Conclusion:LOX-1 is a novel regulator of hypoxia-induced proliferation of PASMCs via p Elk/MRTF-A/SRF/c-fos pathway,which may contribute to pulmonary vascular remodeling in rats with hypoxia-induced PAH.

关键词： pulmonary arterial hypertension pulmonary vascular remodeling lectin-like oxidized low density lipoprotein receptor-1

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云计算环境下国家数字学术资源信息安全协同治理框架研究--基于信息生态视角

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图书情报工作 2022年第8期66卷 55-62页

作者：仇蓉蓉胡昌平西安邮电大学经济与管理学院西安710061 武汉大学信息管理学院武汉430072

[目的/意义]结合信息生态理论和现代化治理理论,重构云计算环境下国家数字学术资源信息安全协同治理框架,以期对其信息安全进行有效治理。[方法/过程]在分析信息生态与国家数字学术资源信息安全协同治理关联关系的基础上,构建信息生态... 详细信息

[目的/意义]结合信息生态理论和现代化治理理论,重构云计算环境下国家数字学术资源信息安全协同治理框架,以期对其信息安全进行有效治理。[方法/过程]在分析信息生态与国家数字学术资源信息安全协同治理关联关系的基础上,构建信息生态视角下国家数字学术资源信息安全协同治理框架,并分析其构成要素间的协同关系。同时,基于信息生态视角分析云计算环境下国家数字学术资源信息安全协同治理的治理对象、治理主体、治理环境及各要素内部的协同治理机制。[结果/结论]厘清云计算环境下国家数字学术资源信息安全协同治理信息生态系统中的主客体及其协同治理机制,为实现云计算环境下国家数字学术资源信息安全协同治理提供参考。

关键词：云计算信息安全协同治理信息生态数字学术资源

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