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CD30L/CD30 is critical for maintenance of IL-17A-producing gd T cells bearing Vγ6 in mucosa-associated tissues in mice

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CD30L/CD30 is critical for maintenance of IL-17A-producing g...

第九届全国免疫学学术大会

作者： Xun Sun changlong lu Department of Immunology China Medical University

CD30 ligand(CD30L,CD153),a member of the TNF superfamily,and its receptor CD30 are important for differentiation and activation of CD4Th17 *** the present report,we demonstrate that the IL-17A-producing gd T cells normally developed in the fetal thymus,whereas Vγl-Vγ4-γδ T cells expressed Vγ6 gene transcript,selectively

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RNA sensors:Recent progress on studying of RLRs family

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RNA sensors:Recent progress on studying of RLRs family

第十一届全国免疫学学术大会

作者： Zhai Jingbo lu changlong Brucellosis institute Inner Mongolia Uni.for the Nationalities Dept.of Immunol.China Med.Uni.

The innate nonspecific immunity is one of the first and most important lines of defense against viral infection. Toll-like receptors(TLRs) and retinoic acid-inducible gene I(RIG-I)-like receptors(RLRs) are two main receptor families detecting viral nucleic acid. So far, three RLR family members were well characterized: RIG-I, MDA5 and LGP2. RLR constitute a family of cytoplasmic helicases, which recognized intracellular single-stranded and double-stranded RNA that is introduced to cytosol during viral infection and replication. In this work we review the current knowledge about the pattern recognition and signaling mechanisms of RIG-I and MDA5 and their signaling pathways for the activation of type I interferons and pro-inflammatory cytokines synthesis.

关键词： RNA sensors RLRs Signaling pathway

RNA sensors:Recent progress on studying of Protein Kinase PKR

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RNA sensors:Recent progress on studying of Protein Kinase PK...

第十一届全国免疫学学术大会

作者： Zhai Jingbo lu changlong Brucellosis institute Inner Mongolia Uni.for the Nationalities Dept.of Immunol.China Med.Uni.

PKR is a serine/threonine kinase that phosphorylates the α-subunit of eukaryotic translation initiation factor 2α(eIF2α) and autophosphorylated. PKR binds viral ds RNA and inhibits translation, which results in a decrease in total cellular and viral protein synthesis, thereby effectively reducing viral replication through PKR/e IF-2αpathway. In addition, PKR has a role in signal transduction and transcriptional control through activation of the inhibitor of IκB(inhibitor of NF-κB)/NF-κB(nuclear factor κB) pathway. There is a relationship between tumor growth and PKR activity, PKR is considered a target for cancer therapy. PKR is a crucial determinant of the host defensemechanism, acting at various levels and sensing whether thecell lives or dies. Emerging studies will provide further insightsinto the mode of PKR action, as well as its potential utility asan antiviral and antitumor effector molecule.

关键词： RNA sensors Protein kinase PKR PKR/eIF-2α pathway Target of cancer therapy

CD226 as a Genetic Adjuvant to Enhance Immune Efficacy Induced by Ag85A DNA Vaccination

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CD226 as a Genetic Adjuvant to Enhance Immune Efficacy Induc...

第十六届中国科协年会——分13感染、免疫和疫苗论坛

作者： Yan LI Xun SUN changlong lu Department of Immunology China Medical University Department of Immunology and Microbiology Liaoning College of Health Vocational Technology

Antigen-85A(Ag85A)is one of the major proteins secreted by Mycobacterium *** studies on animal models have shown that vaccination with the recombinant Ag85A-DNA or Ag85A protein induces powerful immune ***,these vaccines cannot induce sufficient protective immune response in the systemic ***226,a member of the immunoglobulin superfamily,is mainly expressed on NK cells,T cells,monocytes and platelets,and can be served as a co-stimulator that contributes to multiple innate and adaptive immune ***-CSF is an effective genetic adjuvant that increases Ag85A immunogenicity to enhance the activity of cytotoxic T lymphocytes(CTLs)in mice immunized with recombinant pRSC-Ag85A-GM-CSF plasmid ***,there has been no study showing that either CD226 protein or DNA has been used as an adjuvant for vaccine *** aim of this study was to develop a novel Ag85A DNA vaccine with CD226 as the genetic adjuvant to increase the immune efficacy of *** vaccination with pcDNA3.1-Ag85A-CD226 DNA induced potent immune responses in ***226 was an effective genetic adjuvant that improved the immune efficacy of Ag85A and enhanced the activity of CTLs and NK cells in *** results suggest that CD226 is an effective adjuvant to enhance the immune efficacy of *** findings provide a new strategy for the development of a DNA vaccine co-expressing Ag85A and CD226 against tuberculosis and tumors.

关键词： Ag85A,CD226,genetic adjuvant,DNA vaccine

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甘肃李子金矿选矿工艺流程改造

现代矿业 2021年第6期37卷 238-240,258页

作者：陆长龙长春黄金设计院有限公司吉林省长春市130012

为解决甘肃李子金矿选矿厂设备老化、产品设计不合理问题,进而提高企业的经济效益和社会效益,对选矿工艺进行了优化改造。1 a的生产实践表明,改造后的工艺流程稳定可靠,适应性强,可为企业可持续发展、经济效益和社会效益提高创造条件;... 详细信息

为解决甘肃李子金矿选矿厂设备老化、产品设计不合理问题,进而提高企业的经济效益和社会效益,对选矿工艺进行了优化改造。1 a的生产实践表明,改造后的工艺流程稳定可靠,适应性强,可为企业可持续发展、经济效益和社会效益提高创造条件;优化改造后各项工艺指标均达到设计要求,金回收率提高约2个百分点,每年为企业增加销售收入300余万元;该项改造为国内其他小型含金多金属矿山的工艺流程优化提供了借鉴。

关键词：高金多金属矿石工艺流程优化改造 GF型浮选机软管泵铜铅金精矿

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连续梁桥施工中混凝土质量控制分析

现代工程科技 2023年第5期2卷 19-22页

作者：卢昌龙淮南市重点工程建设管理中心安徽淮南232000

市政桥梁是城市建设的重要组成部分,为有效控制市政连续梁桥大体积混凝土浇筑的质量问题,结合淮南市淮上淮河大桥工程Ⅲ标段(40+70+50)m连续梁桥在梁板、桥墩和承台结构的混凝土现场浇筑工程实践,以及以往出现问题的总结和分析,发现质... 详细信息

市政桥梁是城市建设的重要组成部分,为有效控制市政连续梁桥大体积混凝土浇筑的质量问题,结合淮南市淮上淮河大桥工程Ⅲ标段(40+70+50)m连续梁桥在梁板、桥墩和承台结构的混凝土现场浇筑工程实践,以及以往出现问题的总结和分析,发现质量控制的关键在于浇注工艺的具体细节把控和养护阶段的温度及湿度的调控。最终通过严格把控施工工艺和布置结构内部冷水降温循环系统,把降温管在桥墩结构中水平分为8块,竖向分为6层布置,避免了出现温度裂缝和结构面的蜂窝等现象,达到较好的质量效果。该方法可为类似市政桥梁工程施工中大体积混凝土现场浇筑质量控制提供技术参考。

关键词：市政桥梁工程连续梁现浇施工混凝土质量控制

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江西金山金矿选矿工艺流程改造

现代矿业 2021年第3期37卷 132-134页

作者：陆长龙长春黄金设计院有限公司吉林省长春市130012

江西金山金矿原矿来源多样,矿石性质多变,为了实现矿产资源的高效利用,提升选矿厂的处理能力,改善生产操作条件并降低维护成本,对选矿工艺流程进行了优化改造。选矿厂改造后,取得了良好的技术经济指标,提升了企业竞争力,也为国内其他类... 详细信息

江西金山金矿原矿来源多样,矿石性质多变,为了实现矿产资源的高效利用,提升选矿厂的处理能力,改善生产操作条件并降低维护成本,对选矿工艺流程进行了优化改造。选矿厂改造后,取得了良好的技术经济指标,提升了企业竞争力,也为国内其他类似矿山的建设提供了宝贵经验。

关键词：流程改造三段二闭路破碎顽石返回尼尔森重选

中小城市综合管廊施工技术探讨——以淮南市为例

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现代工程科技 2022年第10期1卷 16-19页

作者：卢昌龙淮南市重点工程建设管理中心安徽淮南232000

为适应现代城镇化的建设需求,城市地下综合管廊的施工技术应朝着现代化、多元化、智能化的方向迈进。以淮南市中兴路综合管廊建设项目为典型代表,通过城市地下管廊施工流程的综合分析,从施工工艺流程、施工安全和资源调度等方面总结中... 详细信息

为适应现代城镇化的建设需求,城市地下综合管廊的施工技术应朝着现代化、多元化、智能化的方向迈进。以淮南市中兴路综合管廊建设项目为典型代表,通过城市地下管廊施工流程的综合分析,从施工工艺流程、施工安全和资源调度等方面总结中小城市地下管廊施工技术应用措施和具体问题解决方案。

关键词：综合管廊中小城市市政工程城镇化建设应用技术

Enhanced therapeutic effect for murine colon carcinoma through Colon 26/Ag85A-CD226 tumor cell vaccine in BALB/c mice

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Enhanced therapeutic effect for murine colon carcinoma throu...

第九届全国免疫学学术大会

作者： Yan Li Jingbo Zhai Fangli Yang Lixuan Sang Junfeng Zhu Dan Yue Shengjun Li Xun Sun changlong lu Department of Immunology China medical university

Objective:To examine the effects of Colon 26/Ag85A-CD226 tumor cell vaccine on colon carcinoma in ***:The recombinant pcDNA3.1-Ag85A-CD226 was constructed and stable transfected into the Colon 26 *** BALB/c mice were subcutaneously inoculated with Colon 26 cells and after three days,mice were immunized three times with Colon 26 cells,Colon 26/pcDNA3.1 cells,Colon 26/CD226 cells,Colon 26/Ag85A cells,or Colon 26/Ag85A-CD226 cells,which were inactivated by mitomycin C,at weekly intervals,*** immunotherapeutic effects by the tumor vaccines were evaluated by measuring the size of tumor and observing the survival of tumor-bearing mice,histopathological analysis and immunohistochemistry of CD4 or CD8 and TUNEL expression in tumor *** activities of NK cells and the tumor-specific cytotoxicity of CTL and The number of tumor-specific CD4and CD8T cells secreting IFN-γin spleen and MLNs were detected by ***:The survival rate of mice vaccinated with Colon 26/Ag85A-CD226 tumor cell vaccine was significantly increased,and the tumor volume and weight were the smallest in mice vaccinated with Colon 26/Ag85A-CD226 cell *** results of Massive necrosis in tumor tissues mice vaccinated with Colon 26/Ag85A-CD226 cell vaccine were *** expression and the infiltration of CD4or CD8T cell were increased in the Colon 26/Ag85A-CD226tumor cell vaccine treated mice as compared with that in other tumor cell vaccine treated *** activity of NK cell or CTL cytotoxicity in spleen of mice immunized with the Colon 26/Ag85A-CD226 tumor cell vaccine was significantly higher than other groups *** number of CD4IFN-γor CD8IFN-γT cells was significantly increased in spleen and MLN of mice immunized with the Colon 26/Ag85A-CD226 tumor cell vaccine as compared with that in other groups ***:The Colon 26/Ag85A-CD226 tumor cells vaccine treatment could protect mice from Colon Carcinoma through enhancing the antitumor immune respons

关键词： lon carcinoma Ag85A CD226 tumor cell vaccine