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Embryonic skeleton development and neonatal learning and memory ability of rats anesthetized with pentobarbital sodium: Differences of administration occasion and time

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Neural Regeneration Research 2006年第9期1卷 844-846页

作者： changling peng yuhua zhu ankang hu xiaorong zhu Experimental Animal Center Xuzhou Medical CollegeXuzhou 221002 Jiangsu Province China Experimental Animal CenterXuzhou Medical CollegeXuzhou 221002 Jiangsu Province China Experimental Animal CenterXuzhou Medical CollegeXuzhou 221002 Jiangsu Province China Experimental Animal CenterXuzhou Medical CollegeXuzhou 221002 Jiangsu Province China

BACKGROUND: Generally speaking, anesthesia is often used in gravid body and it has been already proved that many kind of medicine can result in malformation. OBJECTIVE: To explore embryonic skeleton development and neonatal learning and memory of rats anesthetized with pentobarbital sodium in gravid rats. DESIGN: A randomized control trial. SETTING: Laboratory Animal Center of Xuzhou Medical College. MATERIALS: A total of 80 adult female SD rats, of clean grade and weighing 220-240 g, were selected in this study. The main reagents were detailed as follows: pentobarbital sodium (Shanghai Xingzhi Chemical Plant, batch number: 921019); MG-2 maze test apparatus (Zhangjiagang Biomedical Instrument Factory); somatotype microscope (Beijing Taike Instrument Co., Ltd.). METHODS: ① A total of 160 SD rats of half males and females were selected in this study. All rats were copulated. The day that the plug was checked out in the vagina next day was looked as the first day of pregnancy. Gravid rats were divided randomly into four groups, including early anesthesia group, second anesthesia group, late anesthesia group and control group with 20 in each group. Rats in the early anesthesia group were injected with 25 mg/kg soluble pentobarbitone on the 7th day of pregnancy for once; rats in the second anesthesia group were anesthetized with 25 mg/kg soluble pentobarbitone on the 7th and the 14th days of pregnancy for once; rats in the late anesthesia group were anesthetized with 25 mg/kg soluble pentobarbitone on the 14th day of pregnancy for once; rats in the control group did not treat with anything. The time of anesthetizing was controlled in 3 to 4 hours and ether was absorbed while the time was not enough. ② Half of each group was sacrificed on day 20th of pregnancy and the fetus was taken out to be stained with alizarin red S. After stained, the fetal skeleton was examined. The learning and memorizing of one-month rats that were given birth by the rest gravid rats were tested

关键词： Embryonic skeleton development and neonatal learning and memory ability of rats anesthetized with pentobarbital sodium Differences of administration occasion and time

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有氧运动对2型糖尿病小鼠血糖及血清胰岛素影响的研究

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徐州医学院学报 2012年第1期32卷 51-53页

作者：朱裕华彭长凌胡安康朱孝荣徐州医学院实验动物中心江苏徐州221002

目的探讨不同有氧运动方式对2型糖尿病小鼠血糖和血清胰岛素的影响.方法将40只C57BL/6J小鼠分为4组：正常组（A组）,糖尿病游泳1组（B组）,糖尿病游泳2组（C组）,糖尿病非运动组（D组）,每组10只.高脂饲料饲养小鼠4周,B组、C组和D组... 详细信息

目的探讨不同有氧运动方式对2型糖尿病小鼠血糖和血清胰岛素的影响.方法将40只C57BL/6J小鼠分为4组：正常组（A组）,糖尿病游泳1组（B组）,糖尿病游泳2组（C组）,糖尿病非运动组（D组）,每组10只.高脂饲料饲养小鼠4周,B组、C组和D组小鼠一次性腹腔注射链脲佐菌素（STZ）,获得糖尿病模型小鼠.B组每日游泳1次,连续游泳90min;C组每日游泳2次,每次45min;B组、C组游泳时间为6周,A组和D组不做游泳运动.血糖仪检测血糖浓度,碘[125I]胰岛素放射免疫分析血清胰岛素的变化.结果 C组血糖浓度明显低于B组和D组[（14.64±2.69）mmol/L,（19.22±3.28）mmol/L,（27.35±2.88）mmol/L,P〈0.05];C组血清胰岛素明显低于D组[（36.95±14.66）mU/L,（55.24±18.42） mU/L,P〈0.05].结论每日2次各45 min的有氧运动对改善2型糖尿病小鼠血糖及胰岛素水平具有一定疗效.

关键词： 2型糖尿病有氧运动血糖胰岛素小鼠

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