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异位妊娠腹腔镜输卵管切除术对患者血清性激素和AMH水平的影响

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系统医学 2024年第1期9卷 161-164页

作者：李长玲平邑县人民医院妇产科山东临沂273000

目的分析异位妊娠腹腔镜输卵管切除术对患者血清性激素和抗穆勒管激素水平(Anti-Müllerian Hormone,AMH)的影响。方法选择2019年1月—2022年1月在平邑县人民医院接受治疗的50例异位妊娠患者为研究对象,通过随机数表法分为观察组和对照... 详细信息

目的分析异位妊娠腹腔镜输卵管切除术对患者血清性激素和抗穆勒管激素水平(Anti-Müllerian Hormone,AMH)的影响。方法选择2019年1月—2022年1月在平邑县人民医院接受治疗的50例异位妊娠患者为研究对象,通过随机数表法分为观察组和对照组,各25例。观察组行异位妊娠腹腔镜输卵管切除术,对照组行输卵管开窗术。比较两组相关手术指标及术后血清性激素水平和AMH水平。结果观察组住院时间为(5.39±1.63)d、手术时间为(45.65±10.23)min,均短于对照组的(7.54±1.76)d、(52.96±11.65)min,差异有统计意义(t=4.481、2.357,P均licle Stimulating Hormone,FSH)、LH、雌二醇(17β-estradiol,E2)、AMH水平比较,差异无统计学意义(P均>0.05),观察组术后1个月FSH、LH、E2水平及术后3个月FSH、E2水平均高于对照组,差异有统计学意义(P均<0.05)。结论异位妊娠腹腔镜输卵管切除术,对于改善患者病症有明显效果,且可最大限度保留患者的生育能力。

关键词：血清性激素抗穆勒管激素水平异位妊娠腹腔镜输卵管切除术

SolidEarth： a new Digital Earth system for the modeling and visualization of the whole Earth space

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Frontiers of Earth Science 2014年第4期8卷 524-539页

作者： liangfeng ZHU Jianzhong SUN changling li Bing ZHANG Key Laboratory of Geographic Information Science for Ministry of Education East China Normal University Shanghai 200241 China Center for Earth System Science Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201203 China School of Environmental Science and Spatial Informatics China University of Mining and Technology Xuzhou 221008 China College of Geomatics Engineering Nanjing University of Technology Nanjing 211816 China.

Although many of the first-generation Digital Earth systems have proven to be quite useful for the modeling and visualization of geospatial objects relevant to the Earth＇s surface and near-surface, they were not designed for the purpose of modeling and application in geological or atmospheric space. There is a pressing need for a new Digital Earth system that can process geospatial information with full dimensionality. In this paper, we present a new Digital Earth system, termed SolidEarth, as an alternative virtual globe for the modeling and visualization of the whole Earth space including its surface, interior, and exterior space. SolidEarth consists of four functional components： modeling in geographical space, modeling in geological space, modeling in atmo- spheric space, and, integrated visualization and analysis. SolidEarth has a comprehensive treatment to the third spatial dimension and a series of sophisticated 3D spatial analysis functions. Therefore, it is well-suited to the volumetric representation and visual analysis of the inner/ outer spheres in Earth space. SolidEarth can be used in a number of fields such as geoscience research and education, the construction of Digital Earth applications, and other professional practices of Earth science.

关键词： Digital Earth Earth space full dimensionality,visualization

Identification of potential interdisciplinary cooperative topics based on co-word network:Taking liS and computer science as an example

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Data Science and Informetrics 2022年第3期2卷 64-81页

作者： changling li Guoyang Rong Kun Luan Xinxin Wang lixu Shen Qingqing Fan Institute of Information Management Shandong University of TechnologyZiboChina

[Purpose/significance]Interdisciplinary knowledge fusion plays a key role in promoting the development of interdisciplinary integration and providing new ideas for interdisciplinary cooperative research.This study sets out to identify potential interdisciplinary cooperative topics between library and Information Science(liS)and Computer Science.[Method/Process]We built an interdisciplinary co-word network to identify potential interdisciplinary cooperative topics by closed and opened irrelevant knowledge discovery methods.We also constructed the topic interdisciplinary cooperation potential index(TICPI)to calculate the interdisciplinary cooperation potential of the topic and found the best contact path of the cooperation topic by constructing the practicable value(PV)of the contact patch.[Result/Conclusion]The experimental data suggested that both methods can identify the same potential interdisciplinary cooperative topics,such as knowledge service&matrix decomposition,online comments&social media processing,academic text&generative adversarial network,network public opinion&smart home.Exploiting the cooperation potential of these topics can help the knowledge fusion between disciplines.

关键词： Interdisciplinary cooperative topics Interdisciplinary research Irrelevant knowledge discovery library and Information Science Computer Science

水生动物医学研究生综合实验设计及教学模式改革

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实验室研究与探索 2024年第5期43卷 225-229页

作者：于非非李俊辉李长玲谢妙梁海鹰广东海洋大学水产学院广东湛江524088 广东海洋大学水产科学与技术国家级实验教学示范中心(广东海洋大学) 广东湛江524088

设计水生动物医学综合实验,对一批患病珍珠龙趸石斑鱼Hybridized Grouper(Epinephelus fuscoguttatus♀×E.lanceolatus♂)的养殖水体理化因子、生物因子以及鱼体病原体进行检测。分析病鱼体血清指标及组织的病理变化,总结珍珠龙趸石斑... 详细信息

设计水生动物医学综合实验,对一批患病珍珠龙趸石斑鱼Hybridized Grouper(Epinephelus fuscoguttatus♀×E.lanceolatus♂)的养殖水体理化因子、生物因子以及鱼体病原体进行检测。分析病鱼体血清指标及组织的病理变化,总结珍珠龙趸石斑鱼患病的原因,并通过查阅文献给出解决方案。通过设计综合型、实践型、创新型的水生动物医学综合实验,并在实验教学中采用虚拟仿真、经典案例微视频、联用数字标本库的新型混合教学方式,以多元化的考核方式进行考核,提高了学生的学习兴趣、创新能力和实践科研能力。

关键词：水生动物医学实验教学改革综合实验

基于学科势能的跨学科知识来源识别——以图书情报学为例

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图书情报工作 2024年第9期68卷 89-97页

作者：徐卫杰李长玲王浩荣国阳范晴晴高峰山东理工大学信息管理学院淄博255049 武汉大学信息管理学院武汉430072 南京农业大学信息管理学院南京210095 山东理工大学淄博发展研究院淄博255049

[目的/意义]在我国加快构建中国特色哲学社会科学学科体系、学术体系、话语体系的背景下,探究目标学科主要的知识来源学科,对促进其与其他学科交叉融合,加速其知识理论体系完善具有重要意义。[方法/过程]跨学科引文网络中的知识流动类... 详细信息

[目的/意义]在我国加快构建中国特色哲学社会科学学科体系、学术体系、话语体系的背景下,探究目标学科主要的知识来源学科,对促进其与其他学科交叉融合,加速其知识理论体系完善具有重要意义。[方法/过程]跨学科引文网络中的知识流动类似于理想流体的流动——由势能高处向低处流动,促进低势能学科的势能增加。引用物理学中的重力势能定理,从引用质量指数和学科地位高度指数两方面构建学科势能模型。以图书情报学为例,计算2012—2016年和2017—2021年两个时间段图书情报学引用跨学科文献所拥有的学科势能及势能差。根据学科势能和势能差的大小,识别图书情报学主要知识来源学科,并探讨知识输入程度的变化趋势。[结果/结论]实证研究发现:管理科学与工程、计算机科学与技术一直是图书情报学主要的知识来源学科;新闻传播学、教育学、应用与理论经济学对图书情报学的知识输入呈增长趋势;自然科学各学科对图书情报学的知识输入相对较少。

关键词：学科势能跨学科知识流动知识来源图书情报学

正交分解跨学科推动力识别学科对外输出热点——以图书情报学为例

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图书情报工作 2024年第7期68卷 69-78页

作者：王浩李长玲高峰徐卫杰荣国阳范晴晴山东理工大学信息管理学院淄博255049 山东理工大学淄博发展研究院淄博255049 武汉大学信息管理学院武汉430072 南京农业大学信息管理学院南京210095

[目的/意义]识别学科对外输出热点,有利于分析学科交叉发展现状及趋势,把握学科影响力的提升方向。[方法/过程]目标学科文献跨学科被引,可以推动其他学科知识、文献的创新与产生,形成“跨学科推动力”。但跨学科推动力的大小不完全等同... 详细信息

[目的/意义]识别学科对外输出热点,有利于分析学科交叉发展现状及趋势,把握学科影响力的提升方向。[方法/过程]目标学科文献跨学科被引,可以推动其他学科知识、文献的创新与产生,形成“跨学科推动力”。但跨学科推动力的大小不完全等同于被引数量,尤其与引用/被引双方知识的相关性有关。因此,本文引入物理学中的正交分解法,构建目标学科知识跨学科推动力综合模型,从知识跨学科输出强度、广度、加速度、相关度等方面识别目标学科对外输出热点。[结果/结论]以图书情报学2017—2022年数据为例进行实证研究,识别结果表明模型具有可行性、有效性;同时依据一定分类原则将该学科知识对外输出热点划分为前沿、稳定、衰退3种类型,社会关注热点、学科交叉知识、专业核心知识分别属于以上类型。同时,综合分析发现图书情报学对外输出热点集中在交叉领域的信息管理与分析相关知识,但专业核心知识对外输出能力不足。

关键词：热点识别跨学科知识输出正交分解法跨学科推动力

A phase 3,double-blind,randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapynaı¨ve patients with mCRPC in China,Malaysia,Thailand and Russia

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Asian Journal of Urology 2017年第2期4卷 75-85页

作者： Dingwei Ye Yiran Huang Fangjian Zhou Keji Xie Vsevolod Matveev changling li Boris Alexeev Ye Tian Mingxing Qiu Hanzhong li Tie Zhou Peter De Porre Margaret Yu Vahid Naini Hongchuan liang Zhuli Wu Yinghao Sun Department of Urology Fudan University Shanghai Cancer CenterShanghaiChina Department of Urology Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhouGuangdongChina Guangzhou First Municipal People’s Hospital GuangzhouGuangdongChina Department of Urology Russian Academy of Medical SciencesMoscowRussia Department of Urology Cancer Institute(Hospital)Peking Union Medical College and Chinese Academy of Medical SciencesBeijingChina Department of Oncology Moscow Oncology Research InstituteMoscowRussia Department of Stomatology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Urology Sichuan Academy of Medical Science&Sichuan Provincial People’s HospitalChengduSichuanChina Department of Oncology Peking Union Medical College HospitalBeijingChina Department of Urology Changhai HospitalSecond Military Medical UniversityShanghaiChina Department of Oncology Janssen Research&DevelopmentBeerseBelgium Department of Medical Oncology Janssen Research&DevelopmentSan DiegoCAUSA Department of Urology Janssen Research&DevelopmentBeijingChina

Objective:This double-blind,placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate+prednisone(abiraterone)to prednisone alone in chemotherapy-naı¨ve,asymptomatic or mildly symptomatic metastatic castrationresistant prostate cancer(mCRPC)patients from China,Malaysia,Thailand and Russia.Methods:Adult chemotherapy-naı¨ve patients with confirmed prostate adenocarcinoma,Eastern Cooperative Oncology Group(ECOG)performance status(PS)grade 0e1,ongoing androgen deprivation(serum testosteroneline characteristics were balanced.At clinical cut-off(median follow-up time:3.9 months),80% patients received treatment(abiraterone:n Z 138,prednisone:n Z 112).Median time to PSA progression was not reached with abiraterone versus 3.8 months for prednisone,attaining 58%reduction in PSA progression risk(HR=0.418;plikely to achieve radiographic response than prednisonetreated patients(22.9%vs.4.8%,p=0.0369).Median survival was not reached.Most common(≥10% abiraterone vs.prednisone-treated)adverse events:bone pain(7%vs.14%),pain in extremity(6%vs.12%),arthralgia(10%vs.8%),back pain(7%vs.11%),and hypertension(15%vs.14%).Conclusion:Interim analysis confirmed favorable benefit-to-risk ratio of abiraterone in chemotherapy-naı¨ve men with mCRPC,consistent with global study,thus supporting use of abiraterone in this patient population.

关键词： Abiraterone Chemotherapy-naı¨ve Metastatic castrationresistant prostate cancer Prostate specific antigen Prednisone

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中药防治糖尿病视网膜神经病变研究进展

辽宁中医杂志 2024年第5期51卷 206-210页

作者：怀宝赓李昌玲宋民怀宝莎曹英娟刘德山山东中医药大学山东济南250014 山东大学齐鲁医院山东济南250012

糖尿病视网膜病变一直以眼底微血管病变为主要临床特征,其研究热点与治疗靶点也多集中在微血管方向。近年研究发现视网膜神经病变也在糖尿病视网膜病变的发生发展中扮演了重要角色。中药对糖尿病视网膜病变的治疗运用已久,疗效确切,中... 详细信息

糖尿病视网膜病变一直以眼底微血管病变为主要临床特征,其研究热点与治疗靶点也多集中在微血管方向。近年研究发现视网膜神经病变也在糖尿病视网膜病变的发生发展中扮演了重要角色。中药对糖尿病视网膜病变的治疗运用已久,疗效确切,中药多靶点、多层次的作用机制对防治糖尿病视网膜神经病变也具有独特优势。文章通过对防治糖尿病视网膜神经病变的中药及机制研究进展进行综述,为临床运用中药防治糖尿病视网膜神经病变提供参考。

关键词：糖尿病视网膜病变神经元中药机制研究

Research on identification of potential knowledge growth points in information science

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Data Science and Informetrics 2021年第2期1卷 79-99页

作者： changling li Guoyang Rong Yanxin Pai Dehui Du Lu Xu Qingqing Fan Fuzhong Xiang Institute of Information Management Shandong University of TechnologyZiboChina

The scientific system’s complexity makes it impossible to solve social problems by a single discipline independently,and interdisciplinary knowledge cooperation and innovation become an indispensable research mode of modern science.Identifying the potential interdisciplinary knowledge association is the key to promoting interdisciplinary cooperation.In this paper,based on analyzing the growth points of science,"knowledge growth point"is defined as the growth point of science that produces new knowledge,and its fundamental attributes and evaluation indexes have been analyzed.In contrast,the"interdisciplinary knowledge growth point"is defined as the introduction of related interdisciplinary concepts,theories,techniques,and methods,to conduct integrated research of key knowledge points of active disciplines,to generate growth point of innovative knowledge,and analyze its related research status.The identification of"potential interdisciplinary knowledge growth points"is helpful to promote knowledge innovation.Therefore,it is intended to analyze the identification methods of the generation of key knowledge nodes of the element of disciplines and interdisciplinary related knowledge,and explore quantitative and qualitative consultation to identify potential interdisciplinary knowledge growth points.

关键词： Knowledge Growth Point Potential Interdisciplinary Knowledge Growth Points Identification Methods