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STRAP binds to and promotes the repair of N1-methyldeoxyadenosine in DNA

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Chinese Chemical Letters 2024年第3期35卷 204-207页

作者： Meijuan zhou Qian Liu Mengting Pan Ying Yang Xiaoxia Dai changjun You State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical BiologyMolecular Science and Biomedicine LaboratoryCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

N1-methyladenosine(m1A)is an important RNA modification that functions in various biological processes by interacting with cellular ***,the binding proteins of N1-methyldeoxyadenosine(1mdA)in DNA remain largely ***,we employed a quantitative proteomics strategy to identify the potential binding proteins of 1mdA in human *** results revealed that serine–threonine kinase receptor-associated protein(STRAP)can bind to 1mdA-carrying *** further demonstrated that STRAP participates in alkylating agent-induced DNA damage response and can promote the repair of 1mdA embedded in ***,we investigated the effects of STRAP on 1mdA-induced perturbation in transcription using a shuttle vector-and next-generation sequencing-based assay,and found that STRAP is involved in the transcriptional bypass of 1mdA in human ***,our study revealed STRAP as a novel 1mdA-binding protein in human cells and provided new insight into the biological implications of STRAP and 1mdA modification in human diseases.

关键词： N1-methyldeoxyadenosine 1mdA-binding protein STRAP DNA repair Transcription

Design and simulation of ex-range gliding wing of high altitude air-launched autonomous underwater vehicles based on SIMULINK

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Chinese Journal of Aeronautics 2013年第2期26卷 319-325页

作者： Pan changjun Guo Yingqing School of Power and Energy Northwestern Polytechnical University

High altitude air-launched autonomous underwater vehicle （AL-AUV） is a new anti-submarine field, which is designed on the Lockheed Martin＇s high altitude anti-submarine warfare weapons concept （HAAWC） and conducts the basic aerodynamic feasibility in a series of wind tunnel trials. The AL-AUV is composed of a traditional torpedo-like AUV, an additional ex-range gliding wings unit and a descending parachute unit. In order to accurately and conveniently investigate the dynamic and static characteristic of high altitude AL-AUV, a simulation platform is established based on MATLAB/SIMULINK and an AUV 6DOF （Degree of Freedom） dynamic model. Executing the simulation platform for different wing＇s parameters and initial fixing angle, a set of AUV gliding data is generated. Analyzing the recorded simulation result, the velocity and pitch characteristics of AL-AUV deployed at varying wing areas and initial setting angle, the optimal wing area is selected for specific AUV model. Then the comparative simulations of AL-AUV with the selected wings are completed, which simulate the AUV gliding through idealized windless air environment and gliding with Dryden wind influence. The result indicates that the method of wing design and simulation with the simulation platform based on SIMULINK is accurately effective and suitable to be widely employed.

关键词： Autonomous underwater vehicles Air launch Design Simulation Wings

A perspective on Petri Net learning

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Frontiers of Computer Science 2023年第6期17卷 1-3页

作者： Hongda QI changjun JIANG Key Laboratory of Embedded System and Service Computing(Ministry of Education) Tongji UniversityShanghai 201804China National(Province-Ministry Joint)Collaborative Innovation Center for Financial Network Security Tongji UniversityShanghai 201804China

Petri Nets(PNs)are used for modeling and analyzing discreteevent systems,such as communication protocols,trafficsystems,human-computer interaction,and fault ***’state space explosion problem means that the state spaceof PNs grows exponentially with PNs’*** thefundamental reachability problem is still an NP-Hard problemin *** has been proved that the equivalence problem forthe reachability sets of arbitrary PNs is undecidable except forsome subclass of PNs[1].That is,the reachability problem ofarbitrary PNs cannot be solved ***,there is noefficient and accurate algorithm to solve the problem.10172In recent years,with the emergence of big data and thedevelopment of computing hardware,a series ofbreakthroughs have been achieved in machine learning,suchas AlphaGo,AlphaFold,and ChatGPT[2−4].As a data-drivenapproach,machine learning can learn potential mappingrelationships between inputs and outputs from large-scaledata.

关键词： breakthrough hardware learning

Endocrine role of bone in the regulation of energy metabolism

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Bone Research 2021年第4期9卷 425-443页

作者： Ruoyu zhou Qiaoyue Guo Ye Xiao Qi Guo Yan Huang changjun Li Xianghang Luo Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunanChina

Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic ***,an increasing number of studies have characterized the significance of bone as an endocrine organ,suggesting that bone-derived factors regulate local bone metabolism and metabolic *** addition,these factors can regulate global energy homeostasis by altering insulin sensitivity,feeding behavior,and adipocyte *** findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis,treatment,and prevention of metabolic diseases such as osteoporosis,obesity,and diabetes *** this review,we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research.

关键词： metabolism homeostasis prevention

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大庆地区非耕地棚室食用菌生产技术规程

黑龙江农业科学 2024年第5期 125-128页

作者：刘冰刘德福冯鹏周长军孙兴容吴耀坤黑龙江省农业科学院大庆分院黑龙江大庆163316 昭通学院云南昭通657000

为提高大庆地区非耕地棚室发展食用菌产业的经济效益,保证菌菇产品的安全性,避免其生产过程不规范,缺乏标准化生产技术规程等问题。通过广泛地进行生产调研,查阅、收集有关食用菌的生产情况和技术资料,深入合作社和种植大户调查生产工... 详细信息

为提高大庆地区非耕地棚室发展食用菌产业的经济效益,保证菌菇产品的安全性,避免其生产过程不规范,缺乏标准化生产技术规程等问题。通过广泛地进行生产调研,查阅、收集有关食用菌的生产情况和技术资料,深入合作社和种植大户调查生产工艺、流程。同时,收集具有代表性的非耕地棚室食用菌样品进行分析检验,获得实测数据,确定了非耕地棚室食用菌的生产过程和栽培工艺。规范了非耕地棚室食用菌生产技术规程的术语和定义、菇场要求、栽培工艺、栽培管理、病虫害防治、采收、保鲜和贮藏的相关标准,从而促进大庆地区非耕地棚室食用菌生产实现标准化、规范化,实现菌种生产、技术培训、加工包装、市场销售的良性发展。

关键词：非耕地棚室食用菌技术规程

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Effect of Mg on Microstructure and Growth Kinetics of Zn-22.3Al-1.1Si Coating

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Journal of Wuhan University of Technology(Materials Science) 2019年第2期34卷 373-382页

作者：涂浩 WEI Dasheng zhou Shengjie LIU Ya WU changjun WANG Jianhua 苏旭平 Jiangsu Key Laboratory of Materials Surface Science and Technology Changzhou University Jiangsu Collaborative Innovation Center of Photovolatic Science and Engineering Changzhou University

The effects of Mg on the microstructure and growth kinetics of the hot-dip Zn-22.3 Al-1.1 Si-x Mg(x = 0, 0.2, 0.4, and 0.6) coatings were investigated in detail. Scanning electron microscopy with energy dispersive spectroscopy and X-ray diffraction studies revealed the presence of η-Zn, α-Al, Zn/Al eutectoid,(Si), Al/Si eutectic, and Zn/Al/Mg_2 Zn11 ternary eutectic on the top surface of these Mg-containing coatings. Especially, a small amount of MgZn2 phase appears in top surface of Zn-22.3 Al-1.1 Si-0.6 Mg coating. Five phases are found in the alloy layers, i e, Fe_2 Al_5, FeAl_3, τ_(5C), τ_(5H), and τ_1. The addition of 0.2% Mg can delay the emergence of FeAl_3 phase. When the Mg content is more than 0.2%, the outer layers of coating change from τ_(5C) to τ_(5H) phase. The growth of the inhibition layer is diffusion controlled for various Mg content baths. Mg improves the corrosion resistance of the Mg-containing coatings, and the Zn-22.3 Al-1.1 Si-0.6 Mg coating possesses the highest protective properties.

关键词： Mg microstructure growth kinetics inhibition layer diffusion

Synthesis of Asymmetrical Monobenzo-Substituted Cobalt Thioporphyrazines and Their Biomimetic Catalytic Property

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Chinese Journal of Chemistry 2016年第10期34卷 1013-1020页

作者： Peng zhou Juanjuan Jin Bingguang Zhang changjun Yang Zehui Zhang Zhe Li Kejian Deng Key Laboratory of Catalysis and Material Sciences of the State Ethnic Affairs Commission & Ministry of Education College of Chemistry and Material Sciences South-Central University for Nationalities Wuhan Hubei 430074 China

Two novel monobenzo porphyrazines bearing nitro and methoxyl respectively on fused benzene ring were suc- cessfully synthesized. Also, an asymmetrical porphyrazine with one butylthio branch at the pyrrolic p-position sub- stituted by hydrogen atom was successfully isolated in the course of synthesis of symmetric octakis（butylthio） porphyrazine. Their corresponding cobalt complexes were subsequently obtained and characterized. Their catalytic ability was assessed by aerobic oxidation of benzoin, showing the highest benzil yield of 95.2% for 60 min. A pos- sible mechanism was also presented from the in-situ UV-Vis spectra, in which a novel and characteristic absorption peak of metal-oxo was observed. At the same time, similar results of the extended oxidation of benzyl alcohol also confirmed the reactive mechanism.

关键词： cobalt thioporphyrazines monobenzo-substituted derivatives aerobic oxidation of benzoin to benzil,In-situ UV-Vis spectra mechanism of biomimetic catalysis

Rolling optimization algorithm based on collision window for single machine scheduling problem

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Journal of Systems Engineering and Electronics 2005年第4期16卷 816-822页

作者： Wang changjun Xi Yugeng Dept. of Automation Shanghai Jiaotong Univ. Shanghai 200030 P. R. China

Focusing on the single machine scheduling problem which minimizes the total completion time in the presence of dynamic job arrivals, a rolling optimization scheduling algorithm is proposed based on the analysis of the character and structure of scheduling. An optimal scheduling strategy in collision window is presented. Performance evaluation of this algorithm is given. Simulation indicates that the proposed algorithm is better than other common heuristic algorithms on both the total performance and stability.

关键词： single machine scheduling rolling scheduling performance analysis heuristic algorithm.

Tail behavior of supremum of a random walk when Cramer＇s condition fails

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Frontiers of Mathematics in China 2014年第2期9卷 431-453页

作者： changjun YU Yuebao WANG School of Mathematical Sciences Soochow University Suzhou 215006 China School of Sciences Nantong University Nantong 226019 China

We investigate tail behavior of the supremum of a random walk in the case that Cramer＇s condition fails, namely, the intermediate case and the heavy-tailed ease. When the integrated distribution of the increment of the random walk belongs to the intersection of exponential distribution class and O-subexponential distribution class, under some other suitable conditions, we obtain some asymptotic estimates for the tail probability of the supremum and prove that the distribution of the supremum also belongs to the same distribution class. The obtained results generalize some corresponding results of N. Veraverbeke. Finally, these results are applied to renewal risk model, and asymptotic estimates for the ruin probability are presented.

关键词： Random walk supremum exponential distribution class O-subexponential distribution class closure property asymptotic estimate ruin probability