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Association of erythropoietin gene rs576236 polymorphism and risk of adrenal tumors in a Chinese population

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The Journal of Biomedical Research 2014年第6期28卷 456-461页

作者： Chao Zhang Zhongxing Li Qiang Cao Chao Qin Hongzhou Cai Hai Zhou Jian Qian Xiaobing Ju changjun yin Department of Urology The First Affiliated Hospital of Nanjing Medical University Department of Urology Zhenjiang Second People's Hospital

Erythropoietin（EPO） is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue *** objective of the present study was to determine if the EPO rs576236 polymorphism was associated with the risk of adrenal *** genotyped the EPO rs576236 polymorphism in a case-control study of 288 adrenal tumor patients and 456 cancer-free controls by using the TaqMan method,and assessed the association between the polymorphism and the adrenal tumor risk by logistic ***,95%confidence interval（CI） was used to assess the genetic association between the polymorphism and the risk of adrenal *** with the TT genotype,the TC genotype had a significantly increased risk of adrenal tumor[adjusted odds ratio（OR） = 1.24,95%CI = 1.12-2.22].Furthermore a significantly increased risk of adrenal tumor was found in the combined variant genotypes TC＋CC compared with the TT genotype（adjusted OR = 1.17,95%CI = 1.12-2.21）.Our present study suggests that the rs576236 polymorphism of EPO confers susceptibility to adrenal tumor in the Chinese population.

关键词： polymorphism genetic susceptibility erythropoietin adrenal tumor

心肌缺血再灌注损伤中心肌免疫细胞单细胞图谱绘制及具有心肌保护效应的Ym-1hi中性粒细胞的鉴定

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Science Bulletin 2024年第7期69卷 949-967页

作者：董亚兰康真玉张子力张永强周海锋刘艳飞帅欣欣李君仪殷梁青青王埙埙马彦范恒 Feng Jiang 林志豪丁从珠金渊真 Alexey Sarapultsev 李芳菲张戈谢天尹长军程翔罗珊珊刘玥胡德胜 Department of Integrated Traditional Chinese and Western Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210008China National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChinese Academy of Chinese Medical SciencesBeijing 100091China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of International Education Tianjin University of Traditional Chinese MedicineTianjin 300193China Institute of Neuroscience School of MedicineXiamen UniversityXiamen 361102China School of Traditional Chinese Medicine Xiamen University MalaysiaSepang 43900Malaysia School of Medical Biology South Ural State UniversityChelyabinsk 620049Russia Shum Yiu Foon Sum Bik Chuen Memorial Centre for Cancer and Inflammation Research(CCIR) School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Institute of Integrated Bioinfomedicine and Translational Science School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Division of Vascular Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-UniversityMunich 80336Germany Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China China-Russia Medical Research Center for Stress Immunology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Myocardial ischemia–reperfusion injury(MIRI)is a major hindrance to the success of cardiac reperfusion *** increased neutrophil infiltration is a hallmark of MIRI,the subtypes and alterations of neutrophils in this process remain ***,we performed single-cell sequencing of cardiac CD45^(+)cells isolated from the murine myocardium subjected to MIRI at six-time *** identified diverse types of infiltrating immune cells and their dynamic changes during *** neutrophils showed the most immediate response and largest changes and featured with functionally heterogeneous subpopulations,including Ccl3^(hi)Neu and Ym-1^(hi)Neu,which were increased at 6 h and 1 d after reperfusion,***-1^(hi)Neu selectively expressed genes with protective effects and was,therefore,identified as a novel specific type of cardiac cell in the injured *** analysis indicated that neutrophils and their subtypes orchestrated subsequent immune responses in the cardiac tissues,especially instructing the response of *** abundance of Ym-1^(hi)Neu was closely correlated with the therapeutic efficacy of MIRI when neutrophils were specifically targeted by anti-Lymphocyte antigen 6 complex locus G6D(Ly6G)or anti-Intercellular cell adhesion molecule-1(ICAM-1)neutralizing *** addition,a neutrophil subtype with the same phenotype as Ym-1^(hi)Neu was detected in clinical samples and correlated with ***-1 inhibition exacerbated myocardial injury,whereas Ym-1 supplementation significantly ameliorated injury in MIRI mice,which was attributed to the tilt of Ym-1 on the polarization of macrophages toward the repair phenotype in myocardial ***,our findings reveal the antiinflammatory phenotype of Ym-1^(hi)Neu and highlight its critical role in myocardial protection during the early stages of MIRI.

关键词： Myocardial ischemia-reperfusion injury Neutrophil Ym-1 Cardiac immune response Single-cell sequencing

Radiofrequency ablation versus partial nephrectomy for the treatment of clinical stage 1 renal masses： a systematic review and meta-analysis

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Chinese Medical Journal 2014年第13期127卷 2497-2503页

作者： Wang Shangqian Qin Chao Peng Zhihang Cao Qiang Li Pu Shao Pengfei Ju Xiaobing Meng Xiaoxin Lu Qiang Li Jie Wang Meilin Zhang Zhengdong Gu Min Zhang Wei yin changjun Department of Urology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China Department of Epidemiology and Biostatistics Department of Molecular and Genetic Toxicology School of Public Health Nanjing Medical UniversityNanjing Jiangsu 210029 China

Background Over the past two decades,the clinical presentation of renal masses has evolved,where the rising incidence of small renal masses （SRMs） and concomitant minimal invasive treatments have led to noteworthy changes in paradigm of kidney *** study was to perform a proportional meta-analysis of observational studies on perioperative complications and oncological outcomes of partial nephrectomy （PN） and radiofrequency ablation （RFA）.Methods The US National Library of Medicine＇s life science database （Medline） and the Web of Science were exhaustly searched before August 1,*** stage 1 SRMs that were treated with PN or RFA were included,and perioperative complications and oncological outcomes of a total of 9 565 patients were *** Patients who underwent RFA were significantly older （P ＜0.001）.In the subanalysis of stage T1 tumors,the major complication rate of PN was greater than that of RFA （laparoscopic partial nephrectomy （LPN）/robotic partial nephrectomy （RPN）：7.2％,open partial nephrectomy （OPN）：7.9％,RFA：3.1％,both P ＜0.001）.Minor complications occurred more frequently after RFA （RFA：13.8％,LPN/RPN：7.5％,OPN：9.5％,both P ＜0.001）.By multivariate analysis,the relative risks for minor complications of RFA,compared with LPN and OPN,were 1.7-fold and 1.5-fold greater （both P ＜0.01）,*** treated with RFA had a greater local progression rate than those treated by PN （RFA：4.6％,LPN/RPN：1.2％,OPN：1.9％,both P ＜0.001）.By multivariate analysis,the local tumor progression for RFA versus LPN/RPN and OPN were 4.5-fold and 3.1-fold greater,respectively （both P ＜0.001）.Conclusions The current data illustrate that both PN and RFA are viable strategies for the treatment of *** with PN,RFA showed a greater risk of local tumor progression but a lower major complication rate,which is considered better for poor *** is with no doubt the golden treatment for SRMs,and LPN has been widely accepted as the first option for nephro

关键词： meta-analysis partial nephrectomy radiofrequency ablation complication oncological outcomes

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强降雨条件下非饱和粉土雨水渗透规律研究

铁道科学与工程学报 2021年第1期18卷 81-86页

作者：印长俊龙勇齐湘潭大学土木工程与力学学院湖南湘潭411105 岩土力学与工程安全湖南省重点实验室湖南湘潭411105

由雨水渗透规律计算得到的雨水渗透体积是判断非饱和土粉土强度受降雨扰动的主要参数。提供一种强降雨条件下非饱和粉土雨水渗透规律的计算方法,可以根据降雨条件与土体性质预测非饱和粉土在降雨渗透过程中雨水渗透率随时间的变化规律... 详细信息

由雨水渗透规律计算得到的雨水渗透体积是判断非饱和土粉土强度受降雨扰动的主要参数。提供一种强降雨条件下非饱和粉土雨水渗透规律的计算方法,可以根据降雨条件与土体性质预测非饱和粉土在降雨渗透过程中雨水渗透率随时间的变化规律。该方法通过扩展已有非饱和土渗透模型建立降雨渗透计算模型。在经典Green-Ampt模型基础上,根据土体含水量的不同和在降雨过程中出现顺序,依次将土体进行分层。采用毛细渗透公式与达西定律对降雨渗透过程分阶段进行计算,得到降雨渗透过程中雨水渗透率随时间的变化规律。与实验实测数据的对比表明,理论计算值与实验实测数据基本吻合,能较好的预测雨水渗透率变化规律。

关键词：非饱和粉土强降雨条件雨水渗透规律

基于杆系单元法的基坑三排桩支护结构简化计算方法

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建筑结构 2023年第S1期53卷 2883-2890页

作者：谭天憧印长俊湘潭大学土木工程学院湘潭411105

三排桩作为一种新型支护结构,相较一般的支护形式具有较大的侧向刚度以及抗倾覆能力,因此在一些安全要求较高的基坑工程中已有应用,但因其缺乏系统的计算方法和理论研究,给工程设计和建设带来了一定的困扰。以双排桩中常用的桩土相互作... 详细信息

三排桩作为一种新型支护结构,相较一般的支护形式具有较大的侧向刚度以及抗倾覆能力,因此在一些安全要求较高的基坑工程中已有应用,但因其缺乏系统的计算方法和理论研究,给工程设计和建设带来了一定的困扰。以双排桩中常用的桩土相互作用模型和土压力分配模型为切入点,结合现行技术规程,通过对三排桩的结构受力机理进行探讨分析,分别建立了三种针对三排桩的平面杆系有限元模型,结合具体的算例,对这三种模型的合理性加以验证,研究了不同模型下三排桩支护结构的内力与变形规律,并对这三种模型的适用范围进行了探讨,同时在规程模型和桁架模型两种桩土相互作用模型的基础上,研究了桩间土压缩性能对支护结构内力及其变形的影响,旨在为基坑三排桩的工程应用提供一定的参考。

关键词：三排桩基坑杆系单元法内力与变形压缩性能

Clinical study of maglignancy in renal allograft recipients

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Clinical study of maglignancy in renal allograft recipients

Laparoscopic partial nephrectomy with segmental renal artery clamping

2012中国器官移植大会

作者： pei lu,qiang lv,ruoyun tan,changjun yin,wei zhang,min gu 江苏省人民医院

【Objectives】To study the incidence,type and treatment of neoplasms in renal transplantation recipients.【Methods】A retrospective analysis was made on 1401 patients who received renal allographts from 1978 to 201 1 and anti-rejectiontreatmentforatleast6months.【Result】1401 recipients,17(1.21%)developed malignancies.12 patients were living longer than 1 year,and 5 patients died in 1 year incuding 2 cases of transplanted renal carcinoma,1 case of hepatocellular carcinoma,1 case of transplanted

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Laparoscopic partial nephrectomy with segmental renal artery...

第十七届全国泌尿外科学术会议

作者： Pengfei Shao,changjun yin,Xiaoxin Meng,Xiaobin Ju, Jie Li,Zhengquan Xu urology department

Purpose Laparoscopic partial nephrectomy is indicated in Tla kidney *** common procedure is performed through clamping the main renal artery with the warm ischmic time limited in *** study the feasibility of laparosco...

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注浆微型钢管桩抗弯性能研究

应用力学学报 2023年第5期40卷 1125-1132页

作者：印长俊易丹萍龚家兴湘潭大学土木工程与力学学院湘潭411105 湘潭大学岩土力学与工程安全湖南省重点实验室湘潭411105

为探讨注浆微型钢管桩的抗弯性能,对不同钢管管径、壁厚以及砂浆强度的12根试件,采用正交试验方案进行纯弯曲试验,基于试验结果提出极限抗弯承载力表达式,并采用有限元软件ANSYS建立模型进行验证。结果表明:注浆微型钢管桩的弯曲全过程... 详细信息

为探讨注浆微型钢管桩的抗弯性能,对不同钢管管径、壁厚以及砂浆强度的12根试件,采用正交试验方案进行纯弯曲试验,基于试验结果提出极限抗弯承载力表达式,并采用有限元软件ANSYS建立模型进行验证。结果表明:注浆微型钢管桩的弯曲全过程可分为3个阶段,即,弹性阶段、弹塑性阶段和强化阶段;对注浆微型钢管极限荷载敏感性大小为,钢管管径>钢管壁厚>砂浆强度等级;不同规程计算的极限抗弯承载力与试验差异较大,本研究所提出的注浆微型钢管桩极限抗弯承载力表达式与试验结果吻合较好,钢管的抗弯承载力约占注浆微型钢管桩总抗弯承载力的78%,管内砂浆约占22%;有限元模拟结果显示,管内砂浆对微型钢管桩的抗弯性能有较大的提升,验证了所提出的注浆微型钢管桩抗弯承载力表达式的正确性。

关键词：正交试验微型钢管桩砂浆强度等级有限元分析

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强化管理创新加快推进林业科技发展

国家林业局管理干部学院学报 2013年第4期12卷 49-52页

作者：尹昌君中国林业科学研究院北京100091

科技管理创新,就是通过在管理理念、管理方法、管理手段、管理体制等方面的改革与创新,促进科技工作的发展。科技管理创新与科技创新之间是辩证关系。强化林业科技管理创新有其必要性。建议在有效整合资源,建立协同创新机制,深化林业科... 详细信息

科技管理创新,就是通过在管理理念、管理方法、管理手段、管理体制等方面的改革与创新,促进科技工作的发展。科技管理创新与科技创新之间是辩证关系。强化林业科技管理创新有其必要性。建议在有效整合资源,建立协同创新机制,深化林业科研院所改革,努力营造科研人员潜心研究的政策环境,建立稳定的投入与适度竞争相协调的林业科研立项新机制,完善林业科研评价机制等方面加强林业科技管理创新。

关键词：科技创新科技管理创新