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TCT结合HR-HPV基因检测对宫颈病变的诊断及HPV基因型与TCT结果、病理分型的关系

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分析仪器 2022年第4期 87-92页

作者：吴杉牛振楠孟常娟路萌成云云邢台市第三医院健康体检中心邢台054000 邢台市第三医院内镜室邢台054000 邢台市第三医院病理科邢台054000

目的:探讨TCT结合HR-HPV基因检测对宫颈病变的诊断及HPV基因型与TCT结果、病理分型的关系。方法:选取2019年1月~2020年10月行宫颈病变的426例,均采用宫颈脱落细胞液基细胞学检查(TCT)和高危型人体乳头瘤病毒(HR-HPV)基因型检测,观察HPV... 详细信息

目的:探讨TCT结合HR-HPV基因检测对宫颈病变的诊断及HPV基因型与TCT结果、病理分型的关系。方法:选取2019年1月~2020年10月行宫颈病变的426例,均采用宫颈脱落细胞液基细胞学检查(TCT)和高危型人体乳头瘤病毒(HR-HPV)基因型检测,观察HPV基因型与年龄,TCT结果及病理分型的相关性;相比于HPV16或HPV18^(+),HPV16^(+)及HPV18亚型感染率在不同病例分级(CNⅠ、CNⅡ、CNⅢ、SCC)中明显升高(P65岁组HR-HPVS阳性率升高(P65岁组L-HPV阳性率降低(P65岁组HR-HPV阳性率均升高(P0.05);而HPV阴性率比较差异无统计学意义(P>0.05);TCT检查宫颈病变级别的增高,病理阳性率随之增加(P<0.05);提示随着宫颈病变病理级别增加,高危型HPV感染率呈上升趋势(P<0.05);TCT+HR-HPV检测的阴性预测值均高于单独的TCT和HR-HPV检测;TCT+HR-HPV检测敏感度及特异度均高于单独的TCT和HR-HPV检测,将两方法联合的检测敏感度及特异度均明显升高;以16、18、31、35、39、45、51、58、68、73及82分型,进行相关性分析,其中16、18、31、58、73及82密切相关。结论:宫颈病变的诊断中联合采用TCT、HR-HPV基因检测,能尽早发现宫颈病变,进而有助于预防宫颈癌,对宫颈病变的诊断具有重要意义,诊断灵敏度明显高于单独检测,值得在临床上推广和应用。

关键词： TCT HR-HPV 宫颈病变 HPV 诊断病理分型

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan Wen Zhigang Tao Hai Pu Tianci Deng Yaoyao meng Qingbin meng Hongwen Jing Bo meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

miR-214通过调控Notch1信号对口咽鳞状细胞癌细胞株增殖、侵袭及凋亡的作用机制研究

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中华细胞与干细胞杂志（电子版） 2019年第6期9卷 345-350页

作者：刘少斌刘子宸孟嫦娟张翠丽河北邢台医学高等专科学校人体解剖学教研室 0540001 河北邢台市第三医院病理科 054000 河北邢台医学高等专科学校应用数学 0540001

目的研究miR-214通过调控Notch1信号对口咽鳞状细胞癌(OSCC)细胞株增殖、侵袭及凋亡的作用机制。方法在ATCC细胞库购买OSCC细胞株,分为3组:抑制组(IN组)、模拟组(SI组)及对照组(CO组)。通过Western blot法、qRT-PCR法、TUNEL法、侵袭实... 详细信息

目的研究miR-214通过调控Notch1信号对口咽鳞状细胞癌(OSCC)细胞株增殖、侵袭及凋亡的作用机制。方法在ATCC细胞库购买OSCC细胞株,分为3组:抑制组(IN组)、模拟组(SI组)及对照组(CO组)。通过Western blot法、qRT-PCR法、TUNEL法、侵袭实验及CCK-8法分析3组癌细胞中Notch1的蛋白、mRNA表达水平、细胞凋亡、迁移及增殖能力的差异性,三组间比较采用单因素方差分析,组间两两比较采用LSD-t检验。结果IN、SI、CO组细胞内miR-214mRNA表达量分别为1.15±0.26,3.34±0.89,2.08±0.67,SI组分别与IN组、CO组比较,差异具有统计学意义(t=5.281,P=0.002;t=2.529,P=0.045);SI组、IN组的Notch1-UTR表达分别为0.42±0.11、0.86±0.09,差异具有统计学意义(t=5.362,P=0.006);IN、SI、CO组的OSCC细胞凋亡率分别为(0.78±0.10)、(0.32±0.06)、(0.56±0.12),IN组分别与CO组、SI组比较,差异具有统计学意义(t=3.149,P=0.020;t=8.823,P<0.001);IN、SI、CO组癌细胞的增殖率分别为(0.65±0.05)、(1.26±0.06)、(1.89±0.04),IN组与SI组、IN组与CO组比较,差异具有统计学意义(t=11.056,P<0.001;t=27.394,P<0.001),CO组与SI组比较,差异具有统计学意义(t=12.365,P<0.001);IN、SI、CO组癌细胞侵袭率分别为(0.13±0.02)、(0.89±0.13)、(0.48±0.11),SI组与CO组、SI组与IN组比较,差异具有统计学意义(t=4.176,P=0.006;t=10.147,P<0.001);IN、SI、CO组的Notch1蛋白含量分别为:2.38±1.34、0.94±0.23、1.76±0.67,SI组与CO组、SI组与IN组比较,差异具有统计学意义(t=2.588,P=0.041;t=2.368,P=0.056);IN、SI、CO组的Notch1 mRNA表达量分别为4.26±1.06、1.45±0.38、2.46±0.87,IN组与CO组、IN组与SI组比较,差异具有统计学意义(t=2.935,P=0.026;t=5.583,P=0.001)。结论miR-214可能与OSCC细胞株增殖呈负相关,在细胞中miR-214含量升高,可能抑制Notch1信号通路表达,从而促进癌细胞增长、侵袭,抑制癌细胞凋亡。

关键词： miR-214 Notch1 口咽鳞状细胞癌

Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network parameter prediction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan meng Zheng Wang Ruisong Zhu Ruijie Liu Jiang Ma Lina Hu Weihua Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lake Materials Laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkable superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work, a low-frequency active force modulation system is employed to apply a stable, precise, and real-time feedback stress field for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy based on back-propagation(BP) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

Smart Cellulose‑Based Janus Fabrics with Switchable Liquid Transportation for Personal Moisture and Thermal Management

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianfeng Xi Yanling Lou Liucheng meng Chao Deng Youlu Chu Zhaoyang Xu Huining Xiao Weibing Wu Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human ***,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a ***,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/*** cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability *** fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too *** addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

关键词： Directional water transport Cotton fabric Anti-gravity directional liquid transportation Janus wettability

Joint Probabilistic Scheduling and Resource Allocation for Wireless Networked Control Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 258-260页

作者： meng Zheng Lei Zhang Wei Liang IEEE the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences the University of Chinese Academy of Sciences

Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI Ke XIE meng XIA Huarong CHENG Anyu LIU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency