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Protecting against different subtypes of influenza viruses:a nanoparticle approach

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1982-1983页

作者： changhua yi Yongxiang yi Junwei Li Pradeep Kumar Sacitharan Department of Infectious Diseases The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Public Health and Therapy Center of Nanjing 211113 NanjingChina Department of General Surgery The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina College of Veterinary Medicine Qingdao Agricultural University266109 QingdaoChina The Institute of Ageing and Chronic Disease University of LiverpoolLiverpool L78TXUK Department of Biological Sciences Xi’an Jiaotong-Liverpool University#111 Ren’ai RoadSuzhou Industrial Park215123 SuzhouJiangsu ProvinceChina

A recent article by Wang et *** synthesized new nanoparticles consisting of cyclic guanosine monophosphate–adenosine monophosphate(cGAMP),which were administered alongside vaccines,to successfully deliver into the lungs of animals leading to protection against different subtypes of influenza infection without inflammatory side effects.

关键词： nanoparticle approach guanosine

Targeting IL-22 and IL-22R protects against experimental osteoarthritis

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Cellular & Molecular Immunology 2021年第5期18卷 1329-1331页

作者： changhua yi Yongxiang yi Jie Wei Qingwen Jin Junwei Li Pradeep Kumar Sacitharan Department of Infectious Diseases The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina College of Medical Laboratory Shaoyang UniversityShaoYang422000Hunan ProvinceChina Department of General Surgery The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Department of Neurology The Sir Run Run HospitalNanjing Medical University#109 Longmian AvenueJiangning DistrictNanjingJiangsu ProvinceChina College of Veterinary Medicine Qingdao Agricultural University266109QingdaoChina The Institute of Ageing and Chronic Disease University of LiverpoolLiverpoolL78TXUK Department of Biological Sciences Xi’an Jiaotong-Liverpool University#111 Ren’ai RoadSuzhou Industrial ParkSuzhou215123Jiangsu ProvinceChina

Osteoarthritis(OA)is characterized by cartilage degradation,pain,and synovitis.1 Joint inflammation driven by cytokines has been demonstrated to cause cartilage degradation and pain.2 However,approaches to neutralize cytokines,such as IL-1 and TNF-α,known to be involved in OA have shown poor clinical efficacy.3 There is an unmet clinical need to find better anti-inflammatory and pain targets for OA therapy and to elucidate the role of other cytokines in OA *** studies have shown that IL-22 and its receptor IL-22R play central roles in inflammation and diseases such as psoriasis,ulcerative colitis,graft-versus-host disease,certain infections and tumors,as well as in liver and pancreas damage.4,5 The role of IL-22/IL-22R and the potential for therapeutic targeting of both proteins in OA remain largely unknown,which we sought to investigate.

关键词： inflammation clinical pain

Adiponectin exacerbates influenza infection in elderly individuals via IL-18

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2095-2097页

作者： Youzhu Jiang changhua yi Yongxiang yi Qingwen Jin Angray SKang Junwei Li Pradeep Kumar Sacitharan Department of Neurology The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Department of Infectious Diseases The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Public Health and Therapy Center of Nanjing Nanjing 211113China Department of General Surgery The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Department of Neurology The Sir Run Run HospitalNanjing Medical University#109 Longmian AvenueJiangning DistrictNanjingJiangsu ProvinceChina Centre for Oral Immunobiology and Regenerative Medicine Institute of DentistryBarts and the London School of Medicine and DentistryQueen Mary University of LondonLondon E12ATUK College of Veterinary Medicine Qingdao Agricultural UniversityQingdao 266109China The Institute of Ageing and Chronic Disease University of LiverpoolLiverpool L78TXUK Xi’an Jiaotong-Liverpool University Department of Biological Sciences#111 Ren’ai RoadSuzhou Industrial ParkSuzhouJiangsu Province 215123P.R.China

Dear Editor,Influenza affects humans of all ages;however,elderly people have increased susceptibility to infections and are especially predisposed to complications.1 A number of global efforts have increased influenza vaccination administration in elderly people to reduce complications,particularly when seasonal influenza infections peak.2 To date,much is known about how influenza infection and host immunity interact during pathogenesis,which has led to a number of vaccines.3,4 However,the impact of influenza vaccines in older people is modest.2 Hence,the underlying pathophysiological mechanisms responsible for the worsening of influenza infection in old age are still elusive.

关键词： influenza infection immunity

Impact of inactivated COVID-19 vaccines on viral shedding in B.1.617.2(Delta)variant-infected patients

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Science China(Life Sciences) 2022年第12期65卷 2556-2559页

作者： Zhiliang Hu yi yin Kai Wang Miaomiao Xu Chengyuan Ding Yan Song changhua yi Junwei Li Yongxiang yi Zhihang Peng Nanjing Infectious Disease Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003 China Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166 China School of Public Health Nanjing Medical UniversityNanjing 211166China The First Affiliated Hospital of Nanjing Medical University Nanjing 210029China

Dear Editor,The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2)has waged a global pandemic. As of April 15, 2022, more than 500 million cases of COVID-19 had been reported, with more than 6 million deaths. The ultimate arsenal to fight against this pandemic is highly effective vaccines (Bok et al.,2021;Sadarangani et al., 2021).

关键词： vaccines acute

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An unusual COVID-19 case with over four months of viral shedding in the presence of low neutralizing antibodies: a case report

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The Journal of Biomedical Research 2020年第6期34卷 470-474页

作者： Wei Chen Zhiliang Hu changhua yi Yun Chi Qingfang Xiong Chee Wah Tan Yongxiang yi Lin-Fa Wang Clinical Research Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjingJiangsu 210003China Nanjing infectious Disease Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjingJiangsu 210003China Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore 169857Singapore

The ongoing coronavirus disease 2019(COVID-19)pandemic is a global public health crisis,causing social and economic disasters in many *** China,two-consecutive negative results of nucleic acid tests for SARS-CoV-2 from the respiratory samples are required to end the quarantine of COVID-19 ***,clinicians face a dilemma in case of patients with long-term viral *** report described an unusual COVID-19 case who had persistent viral RNA positivity for more than 4 months after initial illness in the presence of low neutralizing antibodies,but without prolonged clinical *** anti-viral drug treatments had no impact and there was no evidence of *** the patient was self-quarantined at home,no infection occurred to the three family members living with her for 15 to 19 *** viral culture in BSL-3 laboratory on the 102nd day after symptom onset was *** the 129th day on,8 continuous nucleic acid tests of sputum samples showed negative *** patient was discharged on 137th days since symptom *** conclusion,viral RNA shedding in the sputum of the COVID-19 patient may last over 4 *** no evidence shows the existence of infectious virus,two-consecutive negative nucleic acid tests may not be the prerequisite for ending quarantine of COVID-19 patients with prolonged viral shedding.

关键词： COVID-19 SARS-CoV-2 viral shedding neutralizing antibodies quarantine

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地球物理勘探测量技术发展综述

物探装备 2015年第3期25卷 146-148,204页

作者：易昌华东方地球物理公司装备服务处河北涿州072750

陆上传统测量的地位受到挑战,点位获取模式以及数据处理功能都发生了变化,把握好时机做好革命性的转变;海上传统导航得到进一步延伸,基于信息化的船队管理、复杂的计算以及质控手段,使得传统测量员逐渐转变为指挥员、数据处理员和质控员... 详细信息

陆上传统测量的地位受到挑战,点位获取模式以及数据处理功能都发生了变化,把握好时机做好革命性的转变;海上传统导航得到进一步延伸,基于信息化的船队管理、复杂的计算以及质控手段,使得传统测量员逐渐转变为指挥员、数据处理员和质控员;地理信息获取和处理技术是陆上传统测量转变的方向,因此应提前做好进一步的技术储备,完善数据采集、数据处理、数据管理和数据应用全流程技术。

关键词：物探测量挑战转变综述

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高校校园网前端技术的研究与探索

价值工程 2010年第2期29卷 193-194页

作者：易昌华上海理工大学上海200093 上海海洋大学上海201306

随着网站前端技术的迅速发展,为数不少的高校校园网也逐渐进行了对其站点的改造,踏出了从Table架构到DIV+CSS架构的脚步,但是技术水平比较参差不齐。本文对现有的前端技术进行分析,结合高校自身发展情况,对这一系列问题进行一些研究与... 详细信息

随着网站前端技术的迅速发展,为数不少的高校校园网也逐渐进行了对其站点的改造,踏出了从Table架构到DIV+CSS架构的脚步,但是技术水平比较参差不齐。本文对现有的前端技术进行分析,结合高校自身发展情况,对这一系列问题进行一些研究与探索。

关键词：前端技术校园网 JavaScript DIV+CSS Web2.0

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定位技术的几个前沿问题

物探装备 2007年第3期17卷 163-166页

作者：易昌华东方地球物理公司装备事业部河北涿州072751

定位技术主要包括定位设备和定位信号服务。软件接收机具备小型化和灵活性等一系列优点,代表了未来GPS接收机的方向。网格化GNSS是一种在新一代互联网技术基础上提出的全新理念的定位服务,是空间定位服务的大趋势。

关键词：软件接收机网格化 GNSS

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang changhua Wang Chung Hsien Wu Jiwen Jiang Fei Long Liyuan Han Qifeng Han yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination