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Oncology Research 2021年第6期29卷 401-409页

作者： HUALIANG LV changchun lai WENQU ZHAO YIBO SONG Department of Pulmonary and Critical Care Medicine Maoming People’s HospitalMaomingChina Department of Clinical Laboratory Maoming People’s HospitalMaomingChina Department of Pulmonary and Critical Care Medicine Nanfang Hospital Affiliated to Southern Medical UniversityGuangzhouChina

It has been certiﬁed that GABPB1-AS1 is aberrantly expressed and plays as a vital role in some kinds of ***,its expression pattern and functions in non-small cell lung cancer(NSCLC)are still largely *** study aims to assess GABPB1-AS1 expression and biological roles in *** expression of GABPB1-AS1 was detected in NSCLC specimens and adjacent normal ***8 and Transwell assays were performed to evaluate the effects of GABPB1-AS1 on NSCLC cell proliferation,migration and *** tools and luciferase reporter assays were applied to predict and verify GABPB1-AS1’s direct *** results revealed that GABPB1-AS1 is sharply reduced in NSCLC specimens and cell ***8 assays indicated that overexpression of GABPB1-AS1 dramatically reduced NSCLC cell growth,and Transwell assays proved that NSCLC cell migration and invasion were distinctly inhibited by *** of the mechanism uncovered that miRNA-566(miR-566)/F-box protein 47(FBXO47)is directly targeted by GABPB1-AS1 in *** study demonstrated that GABPB1-AS1 inhibited NSCLC cell proliferation,migration and invasion by targeting miR-566/FBXO47.

关键词： GABPB1-AS1 NSCLC Progression miRNA-566 FBXO47

Power Flow Analytical Solutions and Multi-dimensional Voltage Stability Boundaries Based on Multivariate Quotient-difference Method

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1168-1178页

作者： Chengxi Liu Qiupin lai School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Hubei Engineering and Technology Research Center for AC/DC Intelligent Distribution Network Wuhan 430072China IEEE

This paper proposes a novel Multivariate Quotient-Difference(MQD)method to obtain the approximate analytical solution for AC power flow ***,in the online environment,the power flow solutions covering different operating conditions can be directly obtained by plugging values into multiple symbolic variables,such that the power injections and consumptions of selected buses or areas can be independently *** method first derives a power flow solution through a Multivariate Power Series(MPS).Next,the MQD method is applied to transform the obtained MPS to a Multivariate Pad´e Approximants(MPA)to expand the Radius of Convergence(ROC),so that the accuracy of the derived analytical solution can be significantly *** addition,the hypersurface of the voltage stability boundary can be identified by an analytical formula obtained from the coefficients of *** direct method for power flow solutions and voltage stability boundaries is fast for many online applications,since such analytical solutions can be derived offline and evaluated online by only plugging values into the symbolic variables according to the actual operating *** proposed method is validated in detail on New England 39-bus and IEEE 118-bus systems with independent load variations in multi-regions.

关键词： Analytical power flow solution multivariate power series multivariate Padéapproximants multivariate quotient-difference multi-dimensional voltage stability boundary

Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

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Virologica Sinica 2023年第2期38卷 233-243页

作者： Pei Yu Zijian Liu Zhuoqi Zhu Jiaqing Yang Min Deng Mingxiao Chen changchun lai Weiya Kong Shilong Xiong Li Wan Weikang Mai Lu Chen Yu Lei Shahzad Akbar Khan Jianfeng Ruan An Kang Xuguang Guo Qiang Zhou Wenrui Li Zheng Chen Yuemei Liang Pingchao Li Lei Zhang Tianxing Ji Clinical Laboratory Medicine Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China State Key Laboratories of Respiratory Diseases Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory DiseaseGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou510535China Clinical Laboratory Medicine Department Dongguan Ninth People's HospitalDongguan523016China State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510120China Clinical Laboratory Medicine Department Maoming People's HospitalMaoming525000China Laboratory of Pathology Department of PathobiologyUniversity of Poonch Rawalakot Azad Kashmir Pakistan 12350Pakistan Hospital Infection-Control Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China Medical Examination Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China Department of Clinical Laboratory Medicine The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510140China Kidney Transplant Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China Department of Organ Transplantation The Third Affiliated Hospital of Sun Yat-sen University510630China Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases KingMed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou511436China

Homologous booster,heterologous booster,and Omicron variants breakthrough infection(OBI)could improve the humoral immunity against Omicron *** concerning about memory B cells(MBCs)and T cells immunity against Omicron variants,features of long-term immunity,after booster and OBI,needs to be ***,comparative analysis demonstrate antibody and T cell immunity against ancestral strain,Delta and Omicron variants in Omicron breakthrough infected patients(OBIPs)are comparable to that in Ad5-nCoV boosted healthy volunteers(HVs),higher than that in inactivated vaccine(InV)boosted ***,memory B cells(MBCs)immunity against Omicron variants was highest in OBIPs,followed by Ad5-nCoV boosted and InV boosted *** and Ad5-nCoV boosted HVs have higher classical MBCs and activated MBCs,and lower naïve MBCs and atypical MBCs relative to both vaccine boosted ***,these data indicate Omicron breakthrough infection elicit higher MBCs and T cells against SARS-CoV-2 especially Omicron variants relative to homologous InV booster and heterologous Ad5-nCoV booster.

关键词： Inactivated vaccine booster Ad5-nCoV booster Omicron variants breakthrough infection Memory immunity Binding antibody

Preface to the Special Issue:Additive Manufacturing—Expanding Production Horizon

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 1-2页

作者： lai-Chang Zhang Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

Additive manufacturing(AM),commonly known as 3D printing,has become a transformative technology that has a profound impact on various industrial *** encompasses a set of techniques for building objects layer by layer from digital *** conventional subtractive manufacturing methods that involve removing material from large blocks,AM adds material incrementally,providing unprecedented design flexibility and efficiency.

关键词： removing printing Expanding

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我国教师网络培训质量影响因素的元分析

远程教育杂志 2022年第4期40卷 82-91页

作者：王国光李金赖长春东莞理工学院教育学院广东东莞523808 天津大学教育学院天津300072 四川省教育评估院四川成都610200

网络培训现已被广泛应用于我国教师培训中,但质量却并未完全达到预期。目前,已有较多研究关注到培训质量的影响因素,但研究结果并不一致。在采用元分析的方法对已有21项研究进行综合量化分析后发现:从整体上看,网络培训具有普适的工具... 详细信息

网络培训现已被广泛应用于我国教师培训中,但质量却并未完全达到预期。目前,已有较多研究关注到培训质量的影响因素,但研究结果并不一致。在采用元分析的方法对已有21项研究进行综合量化分析后发现:从整体上看,网络培训具有普适的工具性价值,其质量不受学员背景信息影响;网络培训暂未发挥出信息技术的最佳优势。从培训方式上看,在集中培训时,学员的个人因素是实现网络培训质量增量的因素;在自主学习时,培训的固定设计是保障网络培训基本质量的因素;而混合培训受到集中培训与自主学习的双重影响。从调查地区看,东部地区教师需要交流互促,西部地区教师需要情感支持与专业引领,中部地区教师需要课程资源供给。基于此,对我国今后的教师网络培训提出三方面建议:着眼于信息技术优势的充分发挥,推动培训功能的结构性优化;整合保障型因素与增量型因素,推进网络培训的“参与式革命”;基于不同地域的差异性特征,推行网络培训模式的供给侧改革。

关键词：教师培训网络培训元分析影响因素培训质量

Remote sensing image encryption algorithm utilizing 2D Logistic memristive hyperchaotic map and SHA-512

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Science China(Technological Sciences) 2024年第5期67卷 1553-1566页

作者： lai Qiang LIU Yuan YANG Liang School of Electrical and Automation Engineering East China Jiaotong UniversityNanchang330013China

The two-dimensional Logistic memristive hyperchaotic map(2D-LMHM)and the secure hash SHA-512 are the foundations of the unique remote sensing image encryption algorithm(RS-IEA)suggested in this *** proposed map is formed from the improved Logistic map and the memristor,which has wide phase space and hyperchaotic range and is exceptionally excellent to be utilized in specific *** proposed image algorithm uses the permutation-assignment-diffusion *** generates two position matrices in a progressive manner to achieve an efficient random exchange of pixel positions,assignment is carried through on the image pixels of the permutated image to entirely remove the original image information,strengthening the relationship between permutation and diffusion,and loop diffusion in two different directions can use subtle changes of pixels to affect the whole *** random key and plain-image SHA-512 hash values are used to produce an additional key,which is then utilized to figure out the permutation parameters and the initial value of a chaotic *** experimental results with the average NPCR=99.6094%(NPCR:number of pixels change rate),average UACI=33.4638%(UACI:unified average changing intensity),100%pass rate of the targets in the test set,the average correlation coefficient is 0.00075,and the local information entropy is 7.9025,which shows that the algorithm is able to defend against a variety of illegal attacks and provide more trustworthy protection than some of the existing state-of-the-art algorithms.

关键词： chaos memristive hyperchaotic map remote sensing SHA-512 image encryption RS-IEA

Supercoiled DNA Minicircles under Double-strand Breaks

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Chinese Journal of Polymer Science 2024年第9期42卷 1353-1359,I0007页

作者： Ye-Peng Qiao Chun-lai Ren National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China

Understanding how supercoiled DNA releases intramolecular stress is essential for its functional ***,the molecular mechanism underlying the relaxation process remains insufficiently *** we employed MD simulations based on the oxDNA2 model to investigate the relaxation process of a 336-base pair supercoiled minicircular DNA under double-strand breaks with two fixed *** simulations show that the conformational changes in the DNA occur continuously,with intramolecular stress release happening abruptly only when the DNA chain traverses the breakage *** relaxation process is influenced not only by the separation distance between the fixed ends but also their ***,we observe an inhibitory effect on the relaxation characterized by small angles,where short terminal loops impede DNA conformational adjustments,preserving the supercoiled *** findings elucidate the intricate interplay between DNA conformational change,DNA motion and intramolecular stress release,shedding light on the mechanisms governing the relaxation of supercoiled DNA at the molecular level.

关键词： Supercoiled DNA DNA minicircle DNA relaxation oxDNA model MD simulation

First Digit Distributions of Gamma-Ray Bursts

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Research in Astronomy and Astrophysics 2024年第5期24卷 70-75页

作者： Hou-Yu lai Jun-Jie Wei Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China

The occurrence of the first significant digits from real world sources is usually not equally distributed,but is consistent with a logarithmic distribution instead,known as Benford’s *** this work,we perform a comprehensive investigation on the first digit distributions of the duration,fluence,and energy flux of gamma-ray bursts (GRBs) for the first *** a complete GRB sample detected by the Fermi satellite,we find that the first digits of the duration and fluence adhere to Benford’s ***,the energy flux shows a significant departure from this law,which may be due to the fact that a considerable part of the energy flux measurements is restricted by lack of spectral *** on the conventional duration classification scheme,we also check if the durations and fluences of long and short GRBs (with duration T_(90)>2 s and T_(90)≤2 s,respectively) obey Benford’s *** find that the fluences of both long and short GRBs still agree with the Benford distribution,but their durations do not follow Benford’s *** results hint that the long–short GRB classification scheme does not directly represent the intrinsic physical classification scheme.

关键词： (stars:)gamma-ray burst general-methods statistical-astronomical databases miscellaneous

Mechanical Performance of Bio-inspired Bidirectional Corrugated Sandwich Pressure Shell Under External Hydrostatic Pressure

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China Ocean Engineering 2024年第2期38卷 297-312页

作者： ZHANG Yi CHEN Yue YUN lai LIANG Xu Ocean College Zhejiang UniversityZhoushan 316000China Hainan Institute Zhejiang UniversitySanya 572000China

This paper aims to enhance the compression capacity of underwater cylindrical shells by adopting the corrugated sandwich structure of *** cuttlebone suffers uniaxial external compression,while underwater cylindrical shells are in a biaxial compressive stress *** suit the biaxial compressive stress state,a novel bidirectional corrugated sandwich structure is proposed to improve the bearing capacity of cylindrical *** static and buckling analysis for the sandwich shell and the unstiffened cylindrical shell with the same volume-weight ratio are studied by numerical *** is indicated that the proposed sandwich shell can effectively reduce the ratio between circumferential and axial stress from 2 to 1.25 and improve the critical buckling load by about 1.63 *** simulation shows that optimizing and adjusting the structural parameters could significantly improve the advantage of the sandwich ***,the hydrostatic pressure tests for shell models fabricated by 3D printing are carried *** to the experimental results,the overall failure position of the sandwich shell is at the center part of the sandwich *** has been found the average critical load of the proposed sandwich shell models exceeds two times that of the unstiffened shell ***,the proposed bio-inspired bidirectional corrugated sandwich structure can significantly enhance the pressure resistance capability of cylindrical shells.

关键词： bio-inspiration bidirectional corrugation sandwich shell external pressure buckling

Recorded recurrent deep reinforcement learning guidance laws for intercepting endoatmospheric maneuvering missiles

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Defence Technology（防务技术） 2024年第1期31卷 457-470页

作者： Xiaoqi Qiu Peng lai Changsheng Gao Wuxing Jing Department of Aerospace Engineering Harbin Institute of TechnologyHarbin150001China Shanghai Electro-Mechanical Engineering Institute Shanghai Academy of Spaceflight TechnologyShanghai201100China

This work proposes a recorded recurrent twin delayed deep deterministic(RRTD3)policy gradient algorithm to solve the challenge of constructing guidance laws for intercepting endoatmospheric maneuvering missiles with uncertainties and observation *** attack-defense engagement scenario is modeled as a partially observable Markov decision process(POMDP).Given the benefits of recurrent neural networks(RNNs)in processing sequence information,an RNN layer is incorporated into the agent’s policy network to alleviate the bottleneck of traditional deep reinforcement learning methods while dealing with *** measurements from the interceptor’s seeker during each guidance cycle are combined into one sequence as the input to the policy network since the detection frequency of an interceptor is usually higher than its guidance *** training,the hidden states of the RNN layer in the policy network are recorded to overcome the partially observable problem that this RNN layer causes inside the *** training curves show that the proposed RRTD3 successfully enhances data efficiency,training speed,and training *** test results confirm the advantages of the RRTD3-based guidance laws over some conventional guidance laws.

关键词： Endoatmospheric interception Missile guidance Reinforcement learning Markov decision process Recurrent neural networks