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西宁地区男男性行为人群艾滋病高危行为综合干预效果研究

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医学动物防制 2018年第11期34卷 1032-1035页

作者：陶宜新赵长成高晓宇何淑珍李云章西宁市疾病预防控制中心青海810007

目的对西宁地区近10年男男性行为人群艾滋病高危行为综合干预效果进行评估分析,评价干预效果,为今后调整干预策略提供科学依据。方法西宁地区2008年基线调查545名男男性行为者和实施艾滋病高危行为综合干预后2017年调查了347名男男性行... 详细信息

目的对西宁地区近10年男男性行为人群艾滋病高危行为综合干预效果进行评估分析,评价干预效果,为今后调整干预策略提供科学依据。方法西宁地区2008年基线调查545名男男性行为者和实施艾滋病高危行为综合干预后2017年调查了347名男男性行为者,比较分析通过综合干预后其知识、行为及HIV、HCV和梅毒感染率变化情况。结果综合干预后男男性行为人群艾滋病防治知识知晓率从2008年的51.93%上升到2017年的93.08%(χ~2=164.87,P<0.01),最近一年接受预防艾滋病干预服务比例上升至92.22%(χ~2=6.34,P<0.05),近6个月与同性发生肛交性行为的比例下降至88.18%(χ~2=52.06,P<0.01),近6个月与同性发生肛交性行为时每次都用安全套的比例上升至41.18%(χ~2=20.14,P<0.01),近6个月与异性发生性行为的比例下降至25.94%(χ~2=54.99,P<0.01),HIV感染率由2008年的4.59%上升至2017年的17.58%(χ~2=41.08,P<0.01),丙肝感染率由2008年的6.61%下降至2017年的0.86%(χ~2=16.71,P<0.01),梅毒感染率从2008年的8.62%下降至2017年的6.05%(χ~2=50.92,P<0.01),差异均有统计学意义。结论在男男性行为人群中开展艾滋病防控工作有着明显的社会效益,开展持续有效的艾滋病高危行为综合干预、减少男男性行为传播仍是目前艾滋病防控工作的重点和难点。

关键词：男男性行为者艾滋病高危行为干预效果

Detecting SARS-CoV-2 BA.2,BA.4,and BA.5 Variants Utilizing a Robust RT-RPA-CRISPR/Cas12a-Based Method-China,2023

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China CDC weekly 2023年第26期5卷 584-591页

作者： Meihui Luo Yang Pan Yaqing He Ruhan A changcheng Wu Baoying Huang Roujian Lu Li zhao Bo Peng Fei Ye Huijuan Wang Yuda Chen Zhen Li Daitao Zhang Wenling Wang Wenjie Tan MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChina CDCBeijingChina Beijing Center for Disease Prevention and Control BeijingChina Microbiology Laboratory Shenzhen Center for Disease Control and PreventionShenzhen CityGuangdong ProvinceChina School of Public Health Baotou Medical CollegeBaotou CityInner Mongolia Autonomous RegionChina Collaborative Innovation Centre for Regenerative Medicine and Medical BioResourse Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityGuangxi Zhuang Autonomous RegionChina

Introduction:Since 2019,numerous variants of concern for severe acute respiratory syndrome virus 2(SARS-CoV-2)have emerged,leading to significant *** development of novel,highly accurate,and rapid detection techniques for these new SARSCoV-2 variants remains a primary focus in the ongoing efforts to control and prevent the coronavirus disease 2019(COVID-19)***:Reverse transcription-recombinase polymerase amplification combined with the clustered regularly interspaced short palindromic repeatsassociated protein 12a(CRISPR/Cas12a)system was used to validate the detection of the Omicron BA.2,BA.4,and BA.5 variants of ***:Our results demonstrate that the CRISPR/Cas12a assay is capable of effectively detecting the SARS-CoV-2 BA.2,BA.4,and BA.5 variants with a limit of detection of 10,1,and 10 copies/μL,***,our assay successfully differentiated the three SARS-CoV-2 Omicron strains from one ***,we evaluated 46 SARS-CoV-2 positive clinical samples consisting of BA.2(n=20),BA.4(n=6),and BA.5(n=20)variants,and the sensitivity of our assay ranged from 90%to 100%,while the specificity was 100%.Discussion:This research presents a swift and reliable CRISPR-based method that may be employed to track the emergence of novel SARS-CoV-2 variants.

关键词： CRISPR/Cas limit specificity

Modeling and analytic optimization of dynamic comfort for wheelchair robots undergoing random roads

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第5期9卷 162-173页

作者： Leilei zhao Yuewei Yu changcheng Zhou Xiaohan Li Fuxing Yang School of Automation Beijing University of Posts and Telecommunications BeijingP.R.China School of Transportation and Vehicle Engineering Shandong University of Technology ZiboP.R.China

To make a rapid comfort assessment and a reasonable dynamic parameters choice of wheelchair robots,this paper proposes a dynamic comfort coefficientκand analytically optimizes the cushion ***,a traveling vibration model of the occupantwheelchair system for wheelchair robots running on random roads was ***,the analytic formula of the occupant RMS(root mean square)acceleration was ***,the dynamic coefficientκwas proposed and its influence laws were ***,the cushion system optimal damping ratio was calculated based onκ.The results show that theκvalue is only determined by the parameters of the occupant-wheelchair *** smaller theκvalue is,the better the dynamic comfort is for wheelchair robots running on random *** minimizingκ,the occupant-wheelchair system can achieve a statistically optimal dynamic comfort effect.

关键词： Wheelchair robots simulation evaluation comfort coefficient optimization.

The First Imported Case of Monkeypox in the Mainland of China—Chongqing Municipality,China,September 16,2022

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China CDC weekly 2022年第38期4卷 853-854页

作者： Hua zhao Wenling Wang Li zhao Sheng Ye Jingdong Song Roujian Lu Hua Zong changcheng Wu Wei Huang Baoying Huang Yao Deng Ruhan A Wujuan Xie Li Qi Wenbo Xu Hua Ling Wenjie Tan Chongqing Municipal Center for Disease Control and Prevention Chongqing MunicipalityChina Chongqing Municipal Key Laboratory for High Pathogenic Microbes Chongqing MunicipalityChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing MunicipalityChina Nan’an Center for Disease Control and Prevention Nan’an DistrictChongqing MunicipalityChina.&Joint first authors

Monkeypox is a zoonotic viral disease caused by the monkeypox virus(MPXV),and historically,all outbreaks have been linked to Africa;however,monkeypox has been posing an alarming challenge to the world in 2022(1)as approximately 60,000 cases have been reported in more than 100 nations and regions worldwide(2).Currently,many cases of monkeypox were identified in many nonendemic countries outside of Central and West Africa,and human-to-human transmission has occurred frequently,especially among men who have sex with men(MSM)presenting new clinical symptoms similar to syphilis and other sexually transmitted infections(3).

关键词： Chongqing clinical outside

Analytical simulation of dynamic characteristics of seat system with nonlinear suspension considering friction effects

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第6期11卷 185-200页

作者： Leilei zhao Yuewei Yu changcheng Zhou Xiaohan Li Dehui Huang School of Transportation and Vehicle Engineering Shandong University of Technology 12 Zhangzhou road Zibo 255049P.R.China FAW Jiefang Qingdao Auto Co. Ltd.Qingdao 266043P.R.China

The friction inevitably exists in the nonlinear suspension system for *** affects dynamic characteristics of the seat with the nonlinear suspension *** of the influences of the friction on the seat vibration responses is helpful to improve ***,it is also an important part of promoting the industrialization application of the nonlinear suspension system for *** order to verify the influences,a model of the seat with the nonlinear suspension system considering friction effects was established by combining *** on the model,by using the harmonic balance method,the analytical formulas of the seat frequency-domain vibration response considering friction effects were deduced,and the influences of the friction on the frequency response characteristics of the system were simulated and ***,the influences of the friction on the time-domain response characteristics were *** results show that the existence of the friction can help to reduce the vibration in the peak region and to increase the system stability,however,it is not conducive to the improvement of the seat comfort under random road conditions.

关键词： Seat comfort vibration friction

青海省2015-2018年哨点监测吸毒人群高危行为及HIV梅毒感染情况分析

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中国艾滋病性病 2020年第5期26卷 522-525页

作者：董世存王卫军祁林邢永杰赵长成蒲文权樊明李积平孙玉兰石燕马永成青海省疾病预防控制中心西宁810001 格尔木市疾病预防控制中心青海海西870000 西宁市疾病预防控制中心西宁810001 民和县疾病预防控制中心青海海东820003

目的了解青海省吸毒人群艾滋病病毒(HIV)和梅毒感染情况及高危行为情况,为下一步制定干预措施提供科学依据。方法收集青海省2015-2018年吸毒人群哨点监测资料,分析人口学特征、行为学特征及HIV和梅毒感染状况。结果共调查5 059人,其中55... 详细信息

目的了解青海省吸毒人群艾滋病病毒(HIV)和梅毒感染情况及高危行为情况,为下一步制定干预措施提供科学依据。方法收集青海省2015-2018年吸毒人群哨点监测资料,分析人口学特征、行为学特征及HIV和梅毒感染状况。结果共调查5 059人,其中55.39%(2 802人)单纯吸食海洛因,30.74%(1 555人)单纯吸食冰毒者,吸食海洛因和冰毒等多种毒品者占7.47%(378人);24.02%有注射吸毒史,40.78%最近一次发生性行为时使用了安全套,18.15%最近一年发生过商业性行为,最近一次商业性行为时安全套使用比例为30.78%,HIV抗体阳性率为0.12%,梅毒抗体阳性率为5.34%,2015-2018年梅毒抗体阳性率分别为7.13%、5.62%、4.32%、3.87%,差异有统计学意义(χ~2趋势=16.25,P <0.01)。结论青海省吸毒人群不安全性行为较普遍,梅毒抗体阳性率较高,在继续加强传统毒品滥用者预防干预的同时,应注重对新型毒品滥用人群的有效干预。

关键词：吸毒人群艾滋病梅毒哨点监测

抗结核分枝杆菌多表位融合抗原IgG抗体检测最佳临界值的建立和初步应用

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检验医学 2018年第10期33卷 899-902页

作者：戚应杰石玉如刘婷岳莉赵长城王云马筱玲安徽省立医院感染病院检验科安徽合肥230022 安徽省立医院安徽合肥230022

目的建立抗结核分枝杆菌多表位融合抗原IgG抗体(MTB-Ab)检测的最佳临界值,评价该项目对肺结核的诊断性能。方法采用酶联免疫吸附试验(ELISA)检测62例活动性肺结核患者、58例非活动性肺结核患者和168名体检健康者(正常对照组)血清MTB-Ab... 详细信息

目的建立抗结核分枝杆菌多表位融合抗原IgG抗体(MTB-Ab)检测的最佳临界值,评价该项目对肺结核的诊断性能。方法采用酶联免疫吸附试验(ELISA)检测62例活动性肺结核患者、58例非活动性肺结核患者和168名体检健康者(正常对照组)血清MTB-Ab,采用受试者工作特征(ROC)曲线确定最佳临界值并将其设为Cut-off值指数(COI),分别评价试剂盒推荐的Cut-off值和最佳COI值对肺结核和活动性肺结核的诊断性能。结果以正常对照组为对照,MTB-Ab诊断肺结核的最佳COI值(COI_1)为0.90,此时敏感性为92.5%,显著高于试剂盒Cut-off值(0.18)的敏感性(86.7%)(P0.05)。以非活动性肺结核组为对照,MTB-Ab诊断活动性肺结核的最佳COI值(COI_2)为3.65,其敏感性、特异性、约登指数、阳性似然比、阳性预测值、阴性预测值均低于COI_1(P<0.05),而阴性似然比高于COI_1(P<0.05)。结论以正常对照者为对照得出的最佳COI值(COI_1)作为判断限,可以提高MTB-Ab诊断肺结核的敏感性。以非活动性肺结核患者为对照得出的最佳COI值(COI_2)作为判断限,MTB-Ab鉴别诊断活动性与非活动性肺结核的性能均明显下降。

关键词：酶联免疫吸附试验结核抗体诊断性能

First Imported Case of SARS-CoV-2 Omicron Subvariant BA.4-Guangdong Province,China,May 4,2022

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China CDC weekly 2022年第40期4卷 902-903页

作者： Qianfang Guo changcheng Wu Aiping Deng Jingtao Liang Xiang zhao Ruhan A Jiajun Liu Fangzhu Ouyang Jing Xu Shen Huang Yang Song Lirong Zou Xiaoling Deng Kai Nie Baisheng Li Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Foshan Center for Disease Control and Prevention Foshan CityGuangdong ProvinceChina

On April 29,2022,a flight arrived at Baiyun International Airport,Guangzhou City,Guangdong Province,and departed from Amsterdam Schiphol Airport,*** the first test of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid at the Baiyun International Airport,all passengers were admitted to a quarantine hotel for a routine 14-day medical *** April 30,one of the passengers(a 20-year-old Chinese female)was reported positive for coronavirus disease 2019(COVID-19),and then a nasopharyngeal swab sample was immediately retested on May 1 and reported positive.

关键词： admitted Guangdong routine

坐姿人体与车辆-轨道系统的垂向耦合作用机理

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机械工程学报 2022年第16期58卷 290-300页

作者：于曰伟赵雷雷周长城山东理工大学交通与车辆工程学院淄博255000

为了探明车辆-轨道系统垂向振动与坐姿人体垂向振动之间的相互耦合作用影响,将人体视为依附于车厢地板的4自由度系统,在考虑车体弹性振动的基础上,建立了坐姿人体-车辆-轨道垂向耦合动力学模型,并利用实车线路运行试验对模型的正确性进... 详细信息

为了探明车辆-轨道系统垂向振动与坐姿人体垂向振动之间的相互耦合作用影响,将人体视为依附于车厢地板的4自由度系统,在考虑车体弹性振动的基础上,建立了坐姿人体-车辆-轨道垂向耦合动力学模型,并利用实车线路运行试验对模型的正确性进行了验证。在此基础上,以车辆-轨道垂向统一模型、坐姿人体垂向振动模型和坐姿人体-车辆-轨道垂向耦合动力学模型为参考,分析了坐姿人体垂向振动对车辆-轨道系统垂向随机振动响应特征的影响、坐姿人体与车辆-轨道系统垂向耦合振动效应对坐姿人体垂向振动特性的影响,以及坐姿人体-车辆-轨道垂向耦合作用下的人体振动响应特性。研究成果为轨道车辆的乘坐舒适性分析及动力学性能优化提供了有效的模型参考和理论依据。

关键词：轨道车辆人车耦合动力学建模耦合特性影响分析