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重载电磁轴承的牵引力和温升特性

轴承 2024年第7期 138-144页

作者：王路遥张福海孟晋张微赵长城核电运行研究(上海)有限公司上海200125 江苏核电有限公司江苏连云港222044

针对大型立式泵轴向电磁轴承在短期运行出现的绕组温升过高问题,采用磁-热耦合数值计算方法分析了气隙、电流和冷却通道对电磁轴承牵引力和散热性能的影响,结果表明:电磁轴承牵引力的最佳电流区间为12~20 A,在此区间牵引力与电流呈正相... 详细信息

针对大型立式泵轴向电磁轴承在短期运行出现的绕组温升过高问题,采用磁-热耦合数值计算方法分析了气隙、电流和冷却通道对电磁轴承牵引力和散热性能的影响,结果表明:电磁轴承牵引力的最佳电流区间为12~20 A,在此区间牵引力与电流呈正相关,牵引力与气隙呈负相关;冷却通道会降低电磁轴承的牵引力,降幅随冷却通道流量的增加而增大;铁芯上开设冷却通道能有效改善绕组的散热条件,冷却通道流量越大,绕组温度越低。

关键词：滑动轴承磁力轴承冷却通道牵引力散热数值分析

非法证据排除的规范原理新论以“制裁—救济”为分析框架

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中外法学 2023年第1期35卷 241-259页

作者：赵常成中国人民大学法学院

非法证据排除规则存在“制裁”与“救济”两种规范原理,这一分歧在我国并未得到认真对待。制裁原理以司法正洁与威慑违法作为证据排除的正当依据,具有国家本位、义务本位、违法者本位的基本特征。目前我国主流观点将证据排除理解为“程... 详细信息

非法证据排除规则存在“制裁”与“救济”两种规范原理,这一分歧在我国并未得到认真对待。制裁原理以司法正洁与威慑违法作为证据排除的正当依据,具有国家本位、义务本位、违法者本位的基本特征。目前我国主流观点将证据排除理解为“程序性制裁”,支持制裁原理下的非法证据排除规则,由此导致证据排除的存在意义难题、范围失控难题、裁量模糊难题等理论与实践问题。与之相对,救济原理引入矫正正义作为正当依据,主张证据排除是“程序性救济”,其目的在于恢复原状,具有个人本位、权利本位、受害者本位的基本特征。与制裁原理相比,救济原理可以为我国证据排除的存在意义、范围限制、裁量标准等提供更为妥当的解释。虽然如此,单一救济原理下的证据排除同样存在其缺陷。基于原理协同的立场,以制裁原理补充并修正部分解释结论,对我国非法证据排除规则而言更具积极意义。

关键词：排除规则非法证据裁量排除程序性制裁程序性救济

The Metabolic Profiling of Chinese Yam Fermented by Saccharomyces boulardii and the Biological Activities of its Ethanol Extract in Vitro

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Food Science and Human Wellness 2023年

作者： Xue Li Yiwen Shao Limin Hao Qiaozhen Kang Xiaolong Wang Jiaqing Zhu changcheng zhao Yanling Shi Jike Lu Juanjuan Yi Food Laboratory of Zhongyuan Zhengzhou University 3. Systems Engineering Institute Academy of Military Sciences (AMS) 4. Henan Yinfeng Biological Engineering Technology Co. Ltd. School of Life Sciences Zhengzhou University

Chinese yam (Dioscorea opposita Thunb.)， as one of the medicinal and edible homologous plants， is rich in various nutrients and functional factors. In this study， Chinese yam fermented by Saccharomyces boulardii was performed to investigate its bioactive components and metabolic profile. And then， the main bioactive components and biological activities of fermented Chinese yam ethanol extract (FCYE) were evaluated. Results showed that there were 49 up-regulated metabolites and 52 down-regulated metabolites in fermented Chinese yam compared to unfermented Chinese yam. Besides， corresponding metabolic pathways analysis initially revealed that the distribution of bioactive substances was concentrated on alcohol-soluble small molecular substances. Ulteriorly， the total polyphenol content and the total flavonoid content in FCYE were significantly increased， and the corresponding antioxidant and immunomodulatory activities in vitro were also significantly enhanced. Our study provided a new reference for the comprehensive utilization of Chinese yam and it also laid a theoretical foundation for the development and application of natural probiotic-fermented products.

关键词：

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

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National Science Review 2020年第6期7卷 998-1002页

作者： Yonggang Zhou Binqing Fu Xiaohu Zheng Dongsheng Wang changcheng zhao Yingjie Qi Rui Sun Zhigang Tian Xiaoling Xu Haiming Wei Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Science and Medical Center University of Science and Technology of China Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Science and Medical Center University of Science and Technology ofChina

Pathogenic human coronavirus infections, such as severe acute respiratory syndrome Co V (SARS-Co V) and Middle East respiratory syndrome Co V(MERS-Co V), cause high morbidity and mortality [1,2]. Recently, a severe pn... 详细信息

关键词： ACUTE RESPIRATORY SYNDROME CLINICAL CHARACTERISTICS CORONAVIRUS DISEASE LYMPHOCYTE SUBSETS DISTRESS-SYNDROME EXPRESSION BIOLOGY DRIVES

Association between QRS voltages and amyloid burden in patients with cardiac amyloidosis

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Chinese Medical Journal 2024年第3期137卷 365-367页

作者： Jing-Hui Li changcheng Li Yucong Zheng Kai Yang Yan Huang Huixin Zhang Xianmei Li Xiuyu Chen Linlin Dai Tian Lan Yang Sun Minjie Lu Shihua zhao Department of Magnetic Resonance Imaging Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Radiology Taian City Central Hospital(The Affiliated Taian City Central Hospital of Qingdao University)Tai’anShandong 271099China Department of Radiology Tsinghua University HospitalTsinghua UniversityBeijing 100084China Department of Radiology The Fifth People’s Hospital of Huai’anHuai’anJiangsu 223001China Department of Radiology Geriatric Hospital of Nanjing Medical UniversityNanjingJiangsu 210000China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Pathology Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

To the Editor:Cardiac amyloidosis(CA)is an infiltrative cardiomyopathy characterized by extracellular deposition of misfolded insoluble amyloid fibrils.^([1])Electrocardiography(ECG)is an essential diagnostic test characterized by low QRS voltages in CA,observed in 20–74%of patients.^([2])Cipriani et al^([3])reported that low QRS voltages could independently predict cardiovascular *** the mechanisms underlying low QRS voltages in CA remain unclear.

关键词： amyloid patients death.

Characterization of whole genomes from recently emerging Mpox cases in several regions of China,2023

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Science China(Life Sciences) 2024年第5期67卷 1079-1081页

作者： changcheng Wu Lunbiao Cui Yang Pan Ziquan Lv Mingxiao Yao Wenling Wang Fei Ye Weibang Huo Li zhao Baoying Huang Fengcai Zhu Roujian Lu Yao Deng Quanyi Wang Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China NHC Key Laboratory of Enteric Pathogenic Microbiology Jiangsu Provincial Medical Key Laboratory of Pathogenic Microbiology in Emerging Major Infectious DiseasesJiangsu Provincial Center for Disease Control and PreventionNanjing 210009China Beijing Center for Disease Prevention and Control Beijing 100013China Central Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518055China Shandong Center for Disease Control and Prevention Jinan 250014China

Dear Editor,Mpox(formerly known as monkeypox)is a zoonotic disease caused by infection with the monkeypox virus(MPXV).Mpox cases have been sporadic over the past few decades,with outbreaks occurring in only a limited ... 详细信息

关键词： cases primarily imported

刑事证明标准的经济分析?--与桑本谦、戴昕教授商榷

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甘肃政法大学学报 2022年第4期 28-42页

作者：赵常成中国人民大学法学院

经济分析方法的融入对于证据法学有所助益,然而当其被应用于刑事证明标准时,应当对此保持警惕.刑事证明标准的经济分析以“清晰界定证明标准”为出发点,摒弃了发现真相的道德义务,转向社会福利最大化的政策目标,简称“社会福利论”.这... 详细信息

经济分析方法的融入对于证据法学有所助益,然而当其被应用于刑事证明标准时,应当对此保持警惕.刑事证明标准的经济分析以“清晰界定证明标准”为出发点,摒弃了发现真相的道德义务,转向社会福利最大化的政策目标,简称“社会福利论”.这一理论以“冤纵比”为立论前提、以预期效用模型为基本结构、以威慑效用为核心要素,将证明标准的界定与判断改造为福利权衡问题.社会福利论不仅存在内部的结构性缺陷,同时面临来自实体法与程序法等外部的正当性质疑,因而并非可取的理论立场.解释刑事证明标准的应然路径不在于经济分析,而是在坚持客观证明标准的基础上,将最佳解释推理的证明方法与“案件事实清楚,证据确实充分”的证明标准相融合.

关键词：证明标准证明方法经济分析社会福利道德义务

Genomic Surveillance for SARS-CoV-2 Variants: Dominance of XBB Replacement — China, January–June 2023

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China CDC weekly 2024年第15期6卷 324-331页

作者： Yenan Feng Qiudong Su Lili Li Xiaozhou He Peihua Niu Xiaojuan Guo Xiang zhao Jing Tang Zhiyuan Jia Ji Wang changcheng Wu Baicheng Xia Zhixiao Chen Yuchao Wu Jing Yang Songqi Chen Cao Chen Shiwen Wang Xiaoping Dong National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina NHC Key Laboratory of Medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:In the first half of 2023,a global shift was observed towards the predominance of XBB *** faced a significant epidemic between late 2022 and early 2023 due to Omicron subvariants BA.5.2 and *** study aims to depict the evolving variant distribution among provincial-level administrative divisions(PLADs)in China and explore the factors driving the predominance of XBB ***:Sequences from local and imported coronavirus disease 2019(COVID-19)cases recorded between January 1 and June 30,2023,were *** study analyzed the changing distribution of viral variants and assessed how the prior dominance of specific variants,XBB subvariants,and imported cases influenced the prevalence of the XBB replacement ***:A total of 56,486 sequences were obtained from local cases,and 8,669 sequences were from imported *** in April,there was a shift in the prevalence of XBB from imported to local cases,with varying dominance among *** PLADs previously high in BF.7,the rise of XBB was delayed.A positive correlation was found between XBB proportions in imported cases from January to March and local cases in *** distribution pattern of XBB subvariants differed between local and imported cases within the same *** significant differences were noted in the replacement rates of XBB ***:The timing of XBB dominance differed among various PLADs in China in the first half of 2023,correlating closely with the prevalence of XBB variants among imported cases.

关键词： dominance imported distribution

Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing

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Virologica Sinica 2024年第1期39卷 134-143页

作者： changcheng Wu Ruhan A Sheng Ye Fei Ye Weibang Huo Roujian Lu Yue Tang Jianwei Yang Xuehong Meng Yun Tang Shuang Chen Li zhao Baoying Huang Zhongxian Zhang Yuda Chen Dongfang Li Wenling Wang Ke-jia Shan Jian Lu Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing100052China Chongqing Municipal Key Laboratory for High Pathogenic Microbes Chongqing Center for Disease Control and PreventionChongqing400042China MGI BGI-ShenzhenShenzhen518083China Thermo Fisher Scientific Beijing100013China School of Public Health Baotou Medical CollegeBaotou014030China BGI PathoGenesis Pharmaceutical Technology Shenzhen518000China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing100871China College of Life Sciences University of Chinese Academy of SciencesBeijing100049China

The monkeypox virus(MPXV)has triggered a current outbreak *** sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and *** is a significant challenge but necessary to optimize the strategy and application of rapid full-length genome identification and to track variations of MPXV in clinical specimens with low viral loads,as it is one of the DNA viruses with the largest genome and the most AT-biased,and has a significant number of tandem *** we evaluated the performance of metagenomic and amplicon sequencing techniques,and three sequencing platforms in MPXV genome sequencing based on multiple clinical specimens of five mpox cases in Chinese *** rapidly identified the full-length genome of MPXV with the assembly of accurate tandem repeats in multiple clinical *** sequencing enables cost-effective and rapid sequencing of clinical specimens to obtain high-quality MPXV ***-generation sequencing facilitates the assembly of the terminal tandem repeat regions in the monkeypox virus genome and corrects a common misassembly in published ***,several intra-host single nucleotide variations were identified in the first imported mpox *** study offers an evaluation of various strategies aimed at identifying the complete genome of MPXV in clinical *** findings of this study will significantly enhance the surveillance of MPXV.

关键词： Monkeypox virus(MPXV) Metagenomic Next generation sequencing Amplicon Third-generation sequencing