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Two ligands for a GPCR,proton vs lysolipid

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Acta Pharmacologica Sinica 2005年第12期26卷 1435-1441页

作者： Dong-soon im Laboratory of Pharmacology and Research Institute of Drug Development College of Pharmacy Pusan National University Busan 609-735 Republic of Korea

Recently,two different chemicals have been matched as ligands with the same G-protein-coupled receptor(GPCR).Double-pairing of OGR 1 family GPCRs with pro-ton and lysolipid raises several ***,whether both are the real ligandsfor the ***,whether modulation ofa GPCR by two chemicals could ***,one of the chemicals is ***-sensing not only is a newaction mode of GPCR activation,but also it could be generalized in other *** this review,I’d like to summarize the issue and discuss questions with pharma-cological criteria.

关键词： lysolipid proton G-protein-coupled receptor sphingosylphosphorylcholine lysophosphatidylcholine psychosine

Non-point source analysis of a railway bridge area using statistical method:Case study of a concrete road-bed

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Journal of Environmental Sciences 2014年第6期26卷 1321-1324页

作者： Kyungik Gil Jiyeol im Department of Civil Engineering Seoul National University of Science and TechnologyNowon-gu Seoul 139-743 Korea School of Civil Environmental and Architectural Engineering Korea University Anam-Dong 5gaSeongbuk-Gu Seoul 163-701 Korea

In an effort to protect the quality of the water system, interest in non-point source pollution is increasing. Recently, studies of non-point sources pollution are continuing in relation to various land- use areas, but such studies have not been fully conducted in railway facility sites. Using monitoring data of railway bridge area with concrete road-bed, the runoff characteristics, pollutant unit loads, and first flush criteria were assessed. Railway bridge area with concrete road-bed typically show the first flush effect, and the pollutant unit load was determined to be higher than other public facilities areas. Further, the first flush criteria show an effective rainfall amount of 7 mm. In other words, from the runoff of railway facilities, considerable amounts of non-point source pollutants are occurred, indicating the need to create best management practices which are adequate for railway facility sites.

关键词： non-point source pollution railway concrete road-bed first flush criteria first flush effect

Epidemiological Aspects of Obesity, Overweight and Cardiovascular Risk Factors at Associes in Semi-Urban Areas (Case of Sébikotane)

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Food and Nutrition Sciences 2024年第5期15卷 390-400页

作者： Djiby Sow Nafy Ndiaye Mouhamed Yakham Leye Maty Diagne Camara Michel Assane Ndour Mouhamed Dieng Houleye Saou Ndiouga Fall Boundia Djiba Demba Diédhiou im Diallo Anna Sarr Mbaye Maimouna Ndour Abdoulaye Leye Clinique Mé dicale II Centre Hospitalier Abass Ndao Universit&#233 Cheikh Anta Diop de Dakar Dakar Senegal Pikine Department of Internal Medicine and Endocrinology Cheikh Anta Diop University Dakar Senegal Department of Public Health Cheikh Anta Diop University Dakar Senegal

Introduction: Obesity and overweight are a public health problem. The general objective was to determine the epidemiological aspects of obesity, overweight and associated risk factors in a semi-urban environment. Patients and Methods: This was a cross-sectional, descriptive study conducted on November 28 and 29, 2023 in Sébikotane. It focused on volunteers for screening for chronic non-communicable diseases. Epidemiological and clinical data were evaluated. Results: One hundred and twenty-nine cases of obesity were recorded (28%). Two hundred and eighty-two cases were overweight or obese (61.3%). The mean age was 49.55 years, with a standard deviation of 12.41 years. The age group [40 - 49 years] was the most representative, with 85 cases (30.1%), and the majority were female, with 264 cases (93.6%). Primary education was the most common, with 75 cases (46.3%). Grade 1 obesity concerned ninety-seven cases (75.2%), and diabetes was present in thirty cases (23%). Hypertension was present in ninety-five cases (33.7%). Obesity was more marked in the age group [40 - 49 years] with 45 cases (36%). Conclusion: Obesity and overweight are a major cause of morbidity and mortality. The development and implementation of a prevention and management program is essential.

关键词： Obesity Overweight Risk Factors Sébikotane Senegal

improved rate-distortion optimized video coding using non-integer bit estimation and multiple Lambda search

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Frontiers of Computer Science 2016年第1期10卷 157-166页

作者： Sio Kei im Mohammad Mahdi GHANDI MPI-QMUL Information Systems Research Centre Macao Polytechnic Institute Macao China Department of Electronic Systems Engineering University of Essex Colchestey CO4 3SQ UK

Many modern video encoders use the Lagrangian rate-distortion optimization （RDO） algorithm for mode deci- sions during the compression procedure. For each encoding stage, this approach involves minimizing a cost, which is a function of rate, distortion and a multiplier called Lambda. This paper proposes to improve the RDO process by applying two modifications. The first modification is to increase the ac- curacy of rate estimation, which is achieved by computing a non-integer number of bits for arithmetic coding of the syntax elements. This leads to a more accurate cost computation and therefore a better mode decision. The second modification is to search and adjust the value of Lambda based on the char- acteristics of each coding stage. For the encoder used, this paper proposes to search multiple values of Lambda for the intra-4x4 mode decision. Moreover, a simple shift in Lambda value is proposed for motion estimation. Each of these modi- fications offers a certain gain in RDO performance, and, when all are combined, an average bit-rate saving of up to 7.0% can be achieved for the H.264/AVC codec while the same concept is applicable to the H.265/HEVC codec as well. The extra added complexity is contained to a certain level, and is also adjustable according to the processing resources available.

关键词： rate distortion optimization Lambda adjust-ment non-integer bit estimation H.264/AVC H265/HEVCvideo coding

Key-Value Store Coupled with an Operating System for Storing Large-Scale Values

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Computers, Materials & Continua 2022年第11期73卷 3333-3350页

作者： Jeonghwan im Hyuk-Yoon Kwon Graduate School of Data Science Seoul National University of Science and TechnologySeoulKorea Department of Industrial Engineering Graduate School of Data ScienceResearch Center for Electrical and Information ScienceSeoul National University of Science and TechnologySeoulKorea

The key-value store can provide flexibility of data types because it does not need to specify the data types to be stored in advance and can store any types of data as the value of the key-value *** types of studies have been conducted to improve the performance of the key-value store while maintaining its ***,the research efforts storing the large-scale values such as multimedia data files(e.g.,images or videos)in the key-value store were *** this study,we propose a new key-value store,WR-Store++aiming to store the large-scale values ***,it provides a new design of separating data and index by working with the built-in data structure of the Windows operating system and the file *** utilization of the built-in data structure of the Windows operating system achieves the efficiency of the key-value store and that of the file system extends the limited space of the storage *** also present chunk-based memory management and parallel processing of WR-Store++to further improve its performance in the GET *** the experiments,we show that WR-Store++can store at least 32.74 times larger datasets than the existing baseline key-value store,WR-Store,which has the limitation in storing large-scale data ***,in terms of processing efficiency,we show that WR-Store++outperforms not only WR-Store but also the other state-ofthe-art key-value stores,LevelDB,RocksDB,and BerkeleyDB,for individual key-value operations and mixed workloads.

关键词： Key-value stores large-scale values chunk-based memory management parallel processing

Two-dimensional physical habitat modeling of effects of habitat structures on urban stream restoration

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Water Science and Engineering 2011年第4期4卷 386-395页

作者： Dongkyun im Hyeongsik KANG Water Infrastructure Division Samsung C & T Corporation Seoul 1321-20 Korea Division of Water and Environment Korea Environment Institute Seoul 122-706 Korea

River corridors, even if highly modified or degraded, still provide important habitats for numerous biological species, and carry high aesthetic and economic values. One of the keys to urban stream restoration is recovery and maintenance of ecological flows sufficient to sustain aquatic ecosystems. In this study, the Hongje Stream in the Seoul metropolitan area of Korea was selected for evaluating a physically-based habitat with and without habitat structures. The potential value of the aquatic habitat was evaluated by a weighted usable area （WUA） using River2D, a two-dimensional hydraulic model. The habitat suitability for Zacco platypus in the Hongje Stream was simulated with and without habitat structures. The computed WUA values for the boulder, spur dike, and riffle increased by about 2%, 7%, and 131%, respectively, after their construction. Also, the three habitat structures, especially the riffle, can contribute to increasing hydraulic heterogeneity and enhancing habitat diversity.

关键词： stream restoration physical habitat River2D weighted usable area

A Lightweight Certificate-Based Aggregate Signature Scheme Providing Key Insulation

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Computers, Materials & Continua 2021年第11期69卷 1747-1764页

作者： Yong-Woon Hwang im-Yeong Lee Department of Software Convergence in Soonchunhyang University Asan-si31538Korea

Recently,with the advancement of Information and Communications Technology(ICT),Internet of Things(IoT)has been connected to the cloud and used in industrial sectors,medical environments,and smart ***,if data is transmitted in plain text when collecting data in an IoTcloud environment,it can be exposed to various security threats such as replay attacks and data ***,digital signatures are *** integrity is ensured when a user(or a device)transmits data using a *** addition,the concept of data aggregation is important to efficiently collect data transmitted from multiple users(or a devices)in an industrial IoT ***,signatures based on pairing during aggregation compromise efficiency as the number of signatories *** signature methods(e.g.,identity-based and certificateless cryptography)have been *** methods pose key escrow and key distribution *** order to solve these problems,the use of aggregate signatures in certificate-based cryptography is being studied,and studies to satisfy the prevention of forgery of signatures and other security problems are being *** this paper,we propose a new lightweight signature scheme that uses a certificate-based aggregate signature and can generate and verify signed messages from IoT devices in an IoT-cloud *** this proposed method,by providing key insulation,security threats that occur when keys are exposed due to physical attacks such as side channels can be *** can be applied to create an environment in which data is collected safely and efficiently in IoT-cloud is environments.

关键词： Internet of things certificate-based aggregate signature key insulation cloud lightweight physical attack

Intravenous morphine self-administration alters accumbal microRNA profiles in the mouse brain

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Neural Regeneration Research 2018年第1期13卷 77-85页

作者： Juhwan Kim Heh-In im Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University Gwangju South Korea Center for Neuroscience Korea Institute of Science and Technology (KIST) Seoul South Korea Convergence Research Center for Diagnosis Treatment and Care System of Dementia Korea Institute of Science and Technology (KIST) Seoul South Korea Division of Biomedical Science & Technology KIST School Korea University of Science and Technology Seoul South Korea

A significant amount of evidence indicates that microRNAs （miRNAs） play an important role in drug addiction. The nucleus accumbens （NAc） is a critical part of the brain’s reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have examined the expression of miRNAs and their functional roles in the NAc under conditions of morphine addiction. In this study, mice were intravenously infused with morphine （0.01, 0.03, 0.3, 1 and 3 mg/kg/infusion） and showed inverted U-shaped response. After morphine self-administration, NAc was used to analyze the functional networks of altered miRNAs and their putative target mRNAs in the NAc following intravenous self-administration of morphine. We utilized several bioinformatics tools, including Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway mapping and CyTargetLinker. We found that 62 miRNAs were altered and exhibited differential expression patterns. The putative targets were related to diverse regulatory functions, such as neurogenesis, neurodegeneration, and synaptic plasticity, as well as the pharmacological effects of morphine （receptor internalization/endocytosis）. The present findings provide novel insights into the regulatory mechanisms of accumbal molecules under conditions of morphine addiction and identify several novel biomarkers associated with morphine addiction.

关键词： nerve regeneration nucleus accumbens microRNA morphine self-administration bioinformatics neural regeneration

Time-domain channel estimator based on cyclic correlationfor OFDM systems with guard interval

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The Journal of China Universities of Posts and Telecommunications 2008年第2期15卷 26-31页

作者： im Se-bin CHOI Hyung-jin Communication Research Center Harbin Institute of Technology

Channel impulse response （CIR） can be estimated on the basis of cyclic correlation in time-domain for orthogonal frequency division multiplexing （OFDM） systems, This article proposes a generalized channel estimation method to reduce the estimation error by taking the average of different CIRs. Channel impulse responses are derived according to the different starting points of cyclic correlation. In addition, an effective CIR length estimation algorithm is also presented. The whole proposed methods are more effective to OFDM systems, especialiy to those with longer cyclic prefix. The analysis and the simulation results verify that the mean square error performance is 4-5 dB better than the conventional schemes under the same conditions.

关键词： CIR OFDM channel estimation mean squareerror (MSE)