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Journal of Environmental Sciences 2022年第5期34卷 363-373页

作者： Xi Li chang Wen Chen Liu Shiyun Lu Zhongbing Xu Qiue yang zhi Chen Hanpeng Liao Shungui Zhou Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China

The global dissemination of antibiotic resistance genes(ARGs),especially via plasmid-mediated horizontal transfer,is becoming a pervasive health *** our previous study found that herbicides can accelerate the horizontal gene transfer(HGT)of ARGs in soil bacteria,the underlying mechanisms by which herbicides promote the HGT of ARGs across and within bacterial genera are still ***,the underlying mechanism associ-ated with herbicide-promoted HGT was analyzed by detecting intracellular reactive oxygen species(ROS)production,extracellular polymeric substance composition,cell membrane integrity and proton motive force combined with genome-wide RNA *** to herbicides induced a series of the above bacterial responses to promote HGT except for the ROS response,including compact cell-to-cell contact by enhancing pilus-encoded gene expression and decreasing cell surface charge,increasing cell membrane permeability,and enhancing the proton motive force,providing additional power for DNA *** study provides a mechanistic understanding of the risk of bacterial resistance spread promoted by herbicides,which elucidates a new perspective on nonantibiotic agrochemical acceleration of the HGT of ARGs.

关键词： Herbicides Horizontal gene transfer Conjugation transfer Antibiotic resistance genes Cell membrane permeability

Model-Based Adaptive Predictive Control with Visual Servo of a Rotary Crane System

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Journal of Electronic Science and Technology 2018年第2期16卷 169-174页

作者： zhi-Ren Tsai Yau-Zen chang Department of Computer Science and Information Engineering Asia UniversityTaichung 41354 Department of Mechanical Engineering Chang Gung UniversityTaoyuan 33302 with the Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 41354 Department of Neurosurgery Chang Gung Memorial HospitalChiayi 61363

This paper investigated the implementation of an adaptive predictive controller using nonlinear dynamic echo state neural （ESN） model for a rotary crane system by the visual servo method. The control sequences within the control horizon were described using cubic spline interpolation to enlarge the predictive horizon. Verification of the proposed scheme in the face of exogenous disturbances and modeling error with inaccurate string length was demonstrated by both simulations and experiments.

关键词： Adaptive predictive controller echo state neural(ESN) model exogenous disturbances modeling error rotary crane

Enhancing Design of Visual-Servo Delayed System

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Journal of Electronic Science and Technology 2018年第3期16卷 232-240页

作者： zhi-Ren Tsai Yau-Zen chang the Department of Computer Science and Information Engineering Asia University the Department of Medical Research China Medical University Hospital China Medical University the Department of Mechanical Engineering Chang Gung University the Department of Neurosurgery Chang Gung Memorial Hospital

A robust adaptive predictor is proposed to solve the time-varying and delay control problem of an overhead crane system with a stereo-vision servo. The predictor is based on the use of a recurrent neural network(RNN) with tapped delays, and is used to supply the real-time signal of the swing angle. There are two types of discrete-time controllers under investigation, i.e., the proportional-integral-derivative(PID) controller and the sliding controller. Firstly, a design principle of the neural predictor is developed to guarantee the convergence of its swing angle estimation. Then, an improved version of the particle swarm optimization algorithm, the parallel particle swarm optimization(PPSO) method is used to optimize the control parameters of these two types of controllers. Finally, a homemade overhead crane system equipped with the Kinect sensor for the visual servo is used to verify the proposed scheme. Experimental results demonstrate the effectiveness of the approach, which also show the parameter convergence in the predictor.

关键词： Parallel particle swarm optimization robust adaptive predictor stereo-vision servo time-varying delay

A boryl-migratory semipinacol rearrangement

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Science China Chemistry 2022年第4期65卷 746-752页

作者： Dong-Hang Tan zhi-Hao Chen Ling yang chang-Ting Li Fang-Hai Tu Qingjiang Li Honggen Wang Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China

The semipinacol rearrangement is one of the classic yet useful synthetic tools in organic ***,semipinacol rearrangements involving heteroatom-migration are *** herein is a boryl-migratory semipinacol rearrangement of α-hydroxyallylboronates and α-hydroxypropargylboronates triggered by diverse halogen-,oxygen-,sulfur-and seleniumcontaining *** protocol leads to a mild and facile access to organoborons bearing valuable *** σ(C-B)hyperconjugation is believed to be the key factor that leads to the observed exclusive chemoselectivity and enhanced *** utilities of the formed products were demonstrated.

关键词： 1,2-boryl migration hyperconjugation iterative cross-coupling organoborons semipinacol rearrangement sp3-B tetrasubstituted alkene

In vitro degradation and cytocompatibility of a low temperature in-situ grown self-healing Mg-Al LDH coating on MAO-coated magnesium alloy AZ31

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Bioactive Materials 2020年第2期5卷 364-376页

作者： chang-yang Li Ling Gao Xiao-Li Fan Rong-chang Zeng Dong-Chu Chen Ke-Qian zhi Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao266590China Department of Oral and Maxillofacial Surgery The Affiliated Hospital of Qingdao UniversityQingdaoShandong266555China Key Lab of Oral Clinical Medicine The Affiliated Hospital of Qingdao UniversityQingdaoShandong266555China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China School of Materials Science and Energy Engineering Foshan UniversityFoshan528000China

Basically,Mg–Al layered double hydroxide(LDH)coatings are prepared on the surface of micro-arc oxidation(MAO)coated magnesium(Mg)alloys at a high temperature or a low pH *** scenario leads to the growth rate of LDH coating inferior to the dissolution rate of the MAO *** in turn results in limited corrosion resistance of the composite *** this study,a Mg–Al LDH coating on MAO-coated Mg alloy AZ31 is prepared through a water bath with a higher pH(13.76)at a lower temperature(60℃).FE-SEM,EDS,XRD,XPS,and FT-IR are applied to analyze the surface morphology,chemical compositions,and growth *** polarization,electrochemical impedance spectroscopy(EIS)and hydrogen evolution tests are employed to evaluate the corrosion resistance of the *** results disclose that the MAO coating is completely covered by the nanosheet-structured LDH coating with a thickness of approximately 3.8μ*** corrosion current density of the MAO-LDH composite coating is decreased four orders of magnitude in comparison to its substrate;the presence of a wide passivation region in anodic polarization branch demonstrates its strong self-healing ability,indicating the hybrid coating possesses excellent corrosion *** formation mechanism of the LDH coating on the MAO-coated Mg alloy is ***,the cytocompatibility is assessed via an indirect extraction test for MC3T3-E1 pre-osteoblasts,which indicates an acceptable cytocompatibility of osteoblasts for the composite coating.

关键词： Magnesium alloy Micro-arc oxidation Layered double hydroxide Corrosion resistance Cytocompatibility

Intermediate phase-assisted growth of CsPbBr_(3) for high performance of carbon-based perovskite solar cells

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Rare Metals 2024年第5期43卷 2222-2229页

作者： Bo-Yan Liu He-Ming yang Yu-Dong Zuo zhi-Hao Tao Jun-Chun Li Ya-Jing chang Guo-Qing Tong yang Jiang School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei 230037China

CsPbBr_(3)inorganic perovskites have been regarded as the promising materials in the field of photo-voltaics because of the high tolerance against *** high energy barrier of phase transition from lead bromide(PbBr_(2))to CsPbBr_(3)perovskite and low solubility of perovskite in organic solvent impede the further improvement of device performance in terms of CsPbBr_(3)solar ***,an intermediate phase-assisted growth of CsPbBr_(3)perovskite was proposed by introducing tetraphenylphosphonium bromide(TPPB)as *** TPPB is expected to react with PbBr_(2)in organic solvent to form an intermediate phase of[***]-PbBr_(2),which not only effectively improves the crystallinity of PbBr2 crystals,but also greatly reduces the phase transition energy barrier,leading to uniform and compact CsPbBr_(3)perovskite films with large grain size and high *** combination with carbon electrode,the CsPbBr_(3)solar cells yield a champion device performance of 9.57%in comparison of pristine CsPbBr_(3)solar cells showing a low efficiency of 8.17%.Furthermore,the intermediate phaseassisted growth of CsPbBr_(3)-based solar cells displays an outstanding storage over720 h.

关键词： CsPbBr_(3) Perovskite solar cells Carbon electrode Hole transport layer free Intermediate phase

Chimeric antigen receptor-engineered T-cell therapy for liver cancer

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 301-309页

作者： yang Chen chang-Yong E zhi-Wen Gong Shui Liu Zhen-Xiao Wang Yong-Sheng yang Xue-Wen Zhang Department of Hepatobiliary and Pancreas Surgery the Second Hospital of Jilin University Department of Hepatobiliary and Pancreatic Surgery China-Japan Union Hospital of Jilin University

Background: Chimeric antigen receptor-engineered T-cell(CAR-T) therapy is a newly developed immunotherapy used in the treatment of cancers. Because CAR-T therapy has shown great success in treating CD19-positive hematological malignancies, its application has been explored in the treatment of solid tumors, such as liver cancer. In this review, we discuss the immune characteristics of liver cancer, the obstacles encountered during the application of CAR-T therapy, and preclinical and clinical progress in the use of CAR-T therapy in patients with liver *** sources: The data on CAR-T therapy related to liver cancers were collected by searching Pub Med and the Web of Science databases prior to December 2017 with the keywords "chimeric antigen receptor","CAR-T", "liver cancer", "hepatocellular carcinoma", and "solid tumor". Additional articles were identified by manual search of references found in the primary articles. The data for clinical trials were collected by searching Clinical ***: The liver has a tolerogenic nature in the intrahepatic milieu and its tumor microenvironment significantly affects tumor progression. The obstacles that reduce the efficacy of CAR-T therapy in solid tumors include a lack of specific tumor antigens, limited trafficking and penetration of CAR-T cells to tumor sites, and an immunosuppressive tumor microenvironment. To overcome these obstacles, several strategies have emerged. In addition, several strategies have been developed to manage the side effects of CAR-T, including enhancing the selectivity of CARs and controlling CAR-T activity. To date, no clinical trials of CAR-T therapy against HCC have been completed. However, preclinical studies in vitro and in vivo have shown potent antitumor efficacy. Glypican-3, mucin-1, epithelial cell adhesion molecule, carcinoembryonic antigen, and other targets are currently being ***: The application of CAR-T therapy for liver cancer is just beginning to be expl

关键词： Liver cancer Chimeric antigen receptor-engineered T-cell therapy Immunotherapy Tumor-associated antigen

Ruyi Zhenbao Pills for Patients with Motor and Sensory Dysfunction after Stroke: A Double-Blinded, Randomized Placebo-Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2022年第10期28卷 872-878页

作者： LING Shan-shan PAN Rui-huan ZHAN Le-chang LI Mei yang zhi-jing yang Hao-dong CHEN Hong-xia Department of Rehabilitation The Second Afﬁliated HospitalGuangzhou University of Chinese MedicineGuangzhou(510120)China The Second Institute of Clinical Medicine Guangzhou University of Chinese MedicineGuangzhou(510120)China

Objective: To evaluate the efficacy and safety of Tibetan medicine Ruyi Zhenbao Pills(RZPs) in the treatment of patients with motor and sensory dysfunction after stroke. Methods: A total of 120 convalescent stroke patients hospitalized in the Rehabilitation Department of Guangdong Provincial Hospital of Chinese Medicine from June 2017 to December 2019 were enrolled in this trial. Patients were assigned to control(60 cases) and research(60 cases) groups by computer random assignment. All patients received internal treatment and modern rehabilitation training. On this basis, the research group was given oral RZPs for 4 weeks, while the control group was given oral placebo. The primary outcome was motor function of the affected side evaluated by simplified FuglMeyer Motion Assessment Scale(FMA-M). The secondary outcomes included sensory function, activity of daily living(ADL), quality of life, balance function, and pain, which were assessed by Fugl-Meyer Sensory Assessment Scale(FMA-S), Modified Barthel Index(MBI), Special Scale of the Quality of Life(SS-QOL), Berg Balance Scale(BBS), and Visual Analogue Scale(VAS), respectively. All of the assessments were performed before treatment, and 4 and 8 weeks after treatment. Vital signs, liver and kidney functions, routine blood test, blood coagulation profile, and routine urinalysis of patients were monitored. Results: After 4-week treatment, the FMA-M, BBS and FMA-S scores in the research group significantly increased compared with the control group(P0.05). Moreover, after treatment, there was no significant difference in vital signs, liver and kidney functions, blood coagulation function, blood routine and urinalysis between the 2 groups(P>0.05). Conclusion: RZPs improved limb motor, balance, and sensor

关键词： Ruyi Zhenbao Pills post-stroke motor dysfunction sensory dysfunction Tibetan medicine randomized controlled trial

Grain yield,nitrogen use efficiency and physiological performance of indica/japonica hybrid rice in response to various nitrogen rates

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Journal of Integrative Agriculture 2023年第1期22卷 63-79页

作者： ZHOU Qun YUAN Rui ZHANG Wei-yang GU Jun-fei LIU Li-jun ZHANG Hao WANG zhi-qin yang Jian-chang Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology/Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops College of AgricultureYangzhou UniversityYangzhou 225009P.R.China

Utilizing the heterosis of indica/japonica hybrid rice(IJHR)is an effective way to further increase rice grain *** application of nitrogen(N)fertilizer plays a very important role in using the heterosis of IJHR to achieve its great yield ***,the responses of the grain yield and N utilization of IJHR to N application rates and the underlying physiological mechanism remain *** purpose of this study was to clarify these *** rice cultivars currently used in rice production,an IJHR cultivar Yongyou 2640(YY2640),a japonica cultivar Lianjing 7(LJ-7)and an indica cultivar yangdao 6(YD-6),were grown in the field with six N rates(0,100,200,300,400,and 500 kg ha^(-1))in 2018 and *** results showed that with the increase in N application rates,the grain yield of each test cultivar increased at first and then decreased,and the highest grain yield was at the N rate of 400 kg ha^(-1)for YY2640,with a grain yield of 13.4 t ha^(-1),and at 300 kg ha^(-1)for LJ-7 and YD-6,with grain yields of 9.4–10.6 t ha^(-1).The grain yield and N use efficiency(NUE)of YY2640 were higher than those of LJ-7 or YD-6 at the same N rate,especially at the higher N *** compared with LJ-7 or YD-6,YY2640 exhibited better physiological traits,including greater root oxidation activity and leaf photosynthetic rate,higher cytokinin content in the roots and leaves,and more remobilization of assimilates from the stem to the grain during grain *** results suggest that IJHR could attain both higher grain yield and higher NUE than inbred rice at either low or high N application *** shoot and root traits of the IJHR contribute to its higher grain yield and NUE,and a higher content of cytokinins in the IJHR plants plays a vital role in their responses to N application rates and also benefits other physiological processes.

关键词： indica/japonica hybrid rice grain yield nitrogen use efficiency cytokinins non-structural carbohydrate root activity

Deciphering the morpho–physiological traits for high yield potential in nitrogen efficient varieties(NEVs):A japonica rice case study

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Journal of Integrative Agriculture 2022年第4期21卷 947-963页

作者： ZHU Kuan-yu YAN Jia-qian SHEN Yong ZHANG Wei-yang XU Yun-ji WANG zhi-qin yang Jian-chang Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology/Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Yangzhou UniversityYangzhou 225009P.R.China Joint International Research Laboratory of Agriculture and Agri-product Safety Ministry of EducationYangzhou UniversityYangzhou 225009P.R.China

The use of nitrogen(N)-efficient rice(Oryza sativa L.) varieties could reduce excessive N input without sacrificing yields. However, the plant traits associated with N-efficient rice varieties have not been fully defined or comprehensively explored. Here, three japonica N-efficient varieties(NEVs) and three japonica N-inefficient varieties(NIVs) of rice were grown in a paddy field under N omission(0 N, 0 kg N ha^(-1)) and normal N(NN, 180 or 200 kg N ha^(-1)) treatments. Results showed that NEVs exhibited higher grain yield and nitrogen use efficiency(NUE) than NIVs under both treatments, due to improved sink size and filled-grains percentage in the former which had higher root oxidation activity and greater root dry weight, root length and root diameter at panicle initiation(PI), as well as higher spikelet-leaf ratio and more productive tillers during the grain-filling stage. Compared with NIVs, NEVs also exhibited enhanced N translocation and dry matter accumulation after heading and improved flag leaf morpho-physiological traits, including greater leaf thickness and specific leaf weight and higher contents of ribulose^(-1),5-bisphosphate carboxylase/oxygenase, chlorophyll, nitrogen, and soluble sugars, leading to better photosynthetic performance. Additionally, NEVs had a better canopy structure, as reflected by a higher ratio of the extinction coefficient for effective leaf N to the light extinction coefficient, leading to enhanced canopy photosynthesis and dry matter accumulation. These improved agronomic and physiological traits were positively and significantly correlated with grain yield and internal NUE, which could be used to select and breed N-efficient rice varieties.

关键词： rice N-efficient varieties nitrogen use efficiency root morpho–physiological traits nitrogen translocation leaf morphology canopy structure