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Identification and Interaction Analysis of Key Genes and MicroRNAs in Systemic Sclerosis by Bioinformatics Approaches

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Current Medical Science 2019年第4期39卷 645-652页

作者： Yan-hong SUN Meng XIE Shi-di WU Jing ZHANG chang-zheng huang Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Dermatology Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Dermatology General Hospital of the Central Theater Command of the People's Liberation ArmyWuhan 430070China

Systemic sclerosis (SSc) is a highly heterogeneous autoimmune disease with a high mortality ***,the cellular and molecular mechanisms of SSc remain ***,we identified the key hub genes and microRNAs (miRNAs) that modulate the occurrence and development of *** downloaded the microarray dataset GSE95065 from the Gene Expression Omnibus (GEO) database and then analyzed the data by using *** Database for Annotation,Visualization and Integrated Discovery (DAVID) was used for functional pathway enrichment analyses of differentially expressed genes (DEGs),and Cytoscape software was used to generate the protein-protein interaction (PPI) *** addition,OmicsNet was used to predict the miRNAs for the hub genes of *** a result,783 DEGs were identified,of which 770 genes (142 up-regulated genes and 628 down-regulated genes) were matched to the genes in SSc skin *** Ontology (GO) analyses by DAVID indicated that the up-regulated genes were mainly involved in immune response,and the down-regulated genes were greatly enriched in glycinergic synaptic *** the PPI network,22 nodes were selected as key genes,including several members of the chemokine ***,after uploading these key genes to the OmicsNet tool,we found that hsa-miR-26b-5p might target CXCL9 and ***,we demonstrated that the hsa-miR-26b-5p inhibitor might inhibit fibrosis in TGF-β-activated fibroblasts,which would be a promising target for SSc therapy.

关键词： systemic sclerosis bioinformatics analysis CXCL9 CXCL13 hsa-miR-26b-5p

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Aneurysmal Fibrous Histiocytoma:Clinicopathology Analysis of 30 Cases of a Rare Variant of Cutaneous Fibrohistiocytoma

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Current Medical Science 2019年第1期39卷 134-137页

作者： Amelia Nabatanzi Musa Male Xiao-ying QU Yan-qiu LI Xie MENG Wu-shi DI chang-zheng huang Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Dermatology No.457 Airforce HospitaU Wuhan 430012China Department of Dermatology Zhongshan Hospital Wuhan 430030China

Aneurysmal fibrous histiocytoma is often clinically *** this study,we put forward an insight on how to help diagnose this disease clinically.A retrospective chart review was performed on all patients diagnosed with aneuiysmal fibrous histiocytoma from 2007 to 2017 in the Department of Dermatology,Union Hospital,China,and all clinical data were collected from the hospital *** a total of 418 patients diagnosed with cutaneous fibrous histiocytoma,only 30 patients were confirmed to have aneurysmal fibrous histiocytoma out of which only 2 patients were clinically diagnosed with aneurysmal fibrous *** remaining 28 patients were diagnosed with various types of vascular tumors although pathology classified them as having aneurysmal fibrous *** the 30 patients,9 were male and 21 were *** were following age groups:13-19(mean 16,n=4),20-29(mean 26.25,n=8),30-39(mean 33,n=7),40-49(mean 44,n=4),50-59(mean 56.75,n=4)5 60 and above(mean 61,n=3).Tumors were present on the head,neck,back,waist,hips and upper and lower *** complete excision,there was no recurrence and no ***,lesions showed the typical pseudoangiomatoid spaces without endothelial lining and infiltration of fibrohistiocytes in hemosiderotic *** was suggested that although the prognosis of aneurysmal fibrous histiocytoma is good,accurate diagnosis is paramount to avoid clinical misdiagnosis and subsequent complications.

关键词： aneurysmal fibrous histiocytoma cutaneous fibrous histiocytoma

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Pathogen Analysis of Superficial Mucocutaneous Mycosis in a Tertiary A-level Hospital from 2007 to 2018

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Current Medical Science 2022年第2期42卷 434-438页

作者： Ting WU Shi-di WU Ling-yun ZHANG Hai-hua YE Ye-hong MAO Xin LIAN Juan TAO chang-zheng huang Jing-si ZENG Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective This study aimed to analyze the fungal species of pathogens isolated from patients with superficial mucocutaneous mycosis from May 2007 to December *** A retrospective analysis was carried out to determine the pathogenic fungi isolated from patients with superficial fungal infections in the Medical Mycology Clinical Laboratory,Department of Dermatology and Venereology,Union Hospital,from May 2007 to December *** A total of 7639 strains were obtained,belonging to 21 genera and 36 *** mainly consisted of Candida(3707/7639,48.53%)and dermatophytes(3594/7639,47.05%).The specimens were skin scales,nail shavings,secretions on the nail grooves,broken or diseased hair and dandruff,secretions or pseudomembrane of the external genitalia,and the oral mucosa.A total of 7300 patients were enrolled in this study,including 3301 males and 3999 females aged 2 months to 92 years old with a median age of 46.04 years old except for 633 patients whose ages were *** strains of different species were isolated from each of 339 patients at different body *** most frequent species were Trichophyton rubrum complex(2906/7639,38.04%),Candida albicans(2619/7639,34.28%),and unclassified Candida *** were mostly isolated from glabrous skin(2138/3594,59.49%),with *** complex being the predominant *** strains were most commonly isolated from mucosal sites(1979/3707,53.39%),and *** was the most prevalent causative *** The main distribution of pathogenic fungal species isolated from patients with superficial mycosis from 2007 to 2018 in Wuhan,Hubei province and the surrounding areas was that Candida slightly outnumbered *** all of the isolated strains,*** complex was the most abundant.

关键词： superficial mycosis dermatophyte Candida

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Increased Cthrcl Activates Normal Fibroblasts and Suppresses Keloid Fibroblasts by Inhibiting TGF-β/Smad Signal Pathway and Modulating YAP Subcellular Location

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Current Medical Science 2018年第5期38卷 894-902页

作者： Meng-jie ZHAO Si-yuan CHEN Xiao-ying QU Bilal Abdul-fattah Ting LAI Meng XIE Shi-di WU You-wen ZHOU chang-zheng huang Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Dermatology the 457th Airforce HospitalWuhan 430015China Department of Dermatology and Skin Science Vancouver Coastal Health Research InstituteUniversity of British ColumbiaVancouverBC V5Z 1L8Canada

Keloid may induce severe impairment of life quality for the patients,although keloid is a cutaneous benign *** triple helix repeat containing protein 1 (Cthrc1) was identified as a novel gene that was originally found in adventitial fibroblasts after arterial *** address the role of Cthrcl in keloid,the expression level of Cthrcl was assessed in normal skin and keloid tissue,as well as in normal fibroblasts (NFs)and keloid fibroblasts (KFs)by using quantitative PCR,Western blotting and immunohistochemical *** results showed that Cthrcl was increased in keloid tissue and KFs as compared with normal skin and ***,CCK8 and Transwell assays found the cellular proliferation and migration of KFs were increased as compared with ***,to verify the function of Cthrcl in NFs and ***,we increased Cthrcl expression by transfecting lentivirns (LV) vectors *** cellular proliferation and migration,collagen synthesis and the influence on TGF-β and YAP signaling were *** cellular proliferation and migration were increased in NFs-Cthrcl as compared with ***,YAP expression and nuclear-location was increased in *** the contrary,when Cthrcl was overexpressed in KFs,the cellular migration was suppressed and YAP expression was reduced and transferred to cytoplasm in KFs-Cthrcl as compared with *** the expression level of collagen I was decreased and pSmad2/3 nucleus transfer was suppressed in both NFs-Cthrc1 and KFs-Cthrc1 by using Western blotting and *** Cthrcl activated NFs by promoting YAP nucleus translocation,whereas suppressed KFs by inhibiting YAP nucleus *** Cthrcl decreased collagen I in both NFs and KFs by inhibiting TGF-β/Smad *** conclusion,Cthrcl may play a role in the pathogenesis of keloid by inhibiting collagen synthesis and fibroblasts migration via suppressing TGF-β/Smad pathway and YAP nucleus translocation.

关键词： keloid Collagen triple helix repeat containing protein 1 TGF-β YAP

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Local Panatrophy Associated with Pain： A Rare Variant o Local Panatrophy or a New Entity？

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Chinese Medical Journal 2017年第20期130卷 2515-2516页

作者： Di-Qing Luo chang-zheng huang Wei Shi Zhuo Wang Ding-Yang He Department of Dermatology The Eastern Hospital of The First Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510700 China Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China Department of Dermatology Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Pathology The Eastern Hospital of The First Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510700 China

To the Editor： Local panatrophy, first described by Gower in 1903 and also called panatrophy of Gowers, is an exceptionally rare disorder characterized by asymptomatic atrophy of the overlying skin as well as partial or total loss of subcutaneous tissue, and may involve the underlying muscles and bones,Herein, we reported a case with such a condition associated with severe pain.

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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： zheng Liu Chunhua Pan Hao huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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Seborrheic keratosis mimicking basal cell carcinoma under dermoscopy:a case report

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Chinese Medical Journal 2020年第17期133卷 2139-2140页

作者： Yao-Ying Gao Xiang-Jie An Jing Yang chang-zheng huang Juan Tao Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Engineering Research Center for Skin Repair and Theranostics WuhanHubei 430022China

To the Editor:Seborrheic keratosis(SK)is one of the most common benign skin tumors in *** to the wide variation in its clinical features,however,and particularly when both its manifestations and dermoscopic findings of its lesion are atypical,it may be challenging to differentiate SK lesions from other benign or malignant skin tumors.[1,2]We here report a case of SK of an adenoid type that initially imitated pigmented basal cell carcinoma(BCC)upon dermoscopy.

关键词： clinical carcinoma kerato

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Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao LIU Rui zheng Liang DENG Jiahui ZHANG Wenzheng HUO Jinlu huang Li Shanghai Marine Diesel Engine Research Institute National Key Laboratory of Marine Engine Science and Technology Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong University

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm) and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC) with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT) imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： atomization dual-orifice nozzle nozzle structure spray flame asymmetry

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Bowen’s Disease on the Left Fifth Finger Successfully Treated with Photodynamic Therapy: A Case Report

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International Journal of Dermatology and Venereology 2022年第1期5卷 56-58页

作者： Wei-Hong Wu Maher Al-Muriesh Xiao-Hong Deng chang-zheng huang Department of Dermatology China Resources and WISCO General HospitalWuhanHubei 430080China Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Introduction:Bowen’s disease is a squamous cell carcinoma in *** is more common on the head and neck,less common on the nail units in which it usually involves the second to fourth fingers of both ***,we report a case of Bowen’s disease involving the left fifth finger of a 78-year-old Chinese *** presentation:The patient was treated with nine sessions of topical 5-aminolevulinic acid-photodynamic therapy(5-ALA-PDT),with a one-week interval between *** 5-ALA cream was applied to the lesion and the region surrounding its marginal diameter by 0.5 *** 3-4 hours,the lesion was irradiated with 635±10 nm red light at an intensity of 80mw/cm2 for *** excellent result with a topical 5-ALA-PDT was ***:PDT involves the application of a combination of a photosensitizing drug and light to cause selective damage to the target *** is more appropriate than surgical excision for lesions located in sites with poor healing ***:PDT appears to be effective,safe and has a better cosmetic outcome in the treatment of Bowen’s disease of the finger unit.

关键词： Bowen’s disease treatment photodynamic therapy

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo zheng Yu-Tao zheng Yi-Wei Dong Liping huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

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