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Fifteen acute retrobulbar optic neuritis associated with COVID-19:A case report and review of literature

World Journal of Clinical Cases 2024年第21期12卷 4827-4835页

作者： Rong-Rong Li Bao-Ming Zhang Su-Ran Rong Huan Li Peng-Fei Shi yun-chang wang Hebei Provincial Key Laboratory of Ophthalmology Hebei Provincial Clinical Research Center for Eye DiseasesHebei Eye HospitalXingtai 054001Hebei ProvinceChina

BACKGROUND A subtype of the Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is suggested to be responsible for the outbreak in Northern China since the quarantine was lifted in December *** coronavirus disease 2019 virus is primarily responsible for the development of respiratory illnesses,however,it can present a plethora of symptoms affecting a myriad of body *** virus has been theorized to be linked to demyelinating lesions of the peripheral and central nervous system including transverse myelitis and acute retrobulbar optic neuritis(ARON).For example,magnetic resonance imaging(MRI)of the orbit and brain showed enlargement of the retrobulbar intraorbital segments of the optic nerve with high T2 signal,and no abnormalities were seen in the brain *** this case series,we analyzed the connection between SARSCoV-2 infection and the onset of *** SUMMARY Fifteen patients,and a teenage boy who did not have any pre-existing ocular or demyelinating diseases suddenly experienced a loss of vision after SARS-CoV-2 *** patients expressed a central scotoma and a fever as the primary *** results of the fundus photography were found to be ***,the automated perimetry and MRI scans showed evidence of some typical *** of the 15 patients diagnosed with ARON after SARS-CoV-2 infection,only one individual tested positive for the aquaporin-4 *** Direct viral invasion of the central nervous system and an immune-related process are the two primary causes of SARS-CoV-2-related ARON.

关键词： SARS-CoV-2 COVID-19 Acute retrobulbar optic neuritis Central scotoma Li RR et al.ARON associated with COVID-19

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A new naphthoquinoneimine derivative from the marine algal-derived endophytic fungus Aspergillus niger EN-13

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Chinese Chemical Letters 2007年第8期18卷 951-953页

作者： Yi Zhang Xiao Ming Li chang yun wang Bin Gui wang Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Key Laboratory of Marine Drugs Ministry of Education Institute of Marine Drugs Ocean University of China Qingdao 266003 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Cultivation of an endophytic fungus Aspergillus niger EN-13 that was isolated from the inner tissue of the marine brown alga Colpomenia sinuosa resulted in the characterization of a new naphthoquinoneimine derivative, namely, 5,7-dihydroxy-2-[1-（4- methoxy-6-oxo-6H-pyran-2-yl）-2-phenylethylamino]-[ 1,4]naphthoquinone. The structure of the new compound was established on the basis of various NMR spectroscopic analyses including 2D NMR techniques, El-MS, and HR-ESI-MS. This compound displayed moderate antifungal activity.

关键词： Colpomenia sinuosa Endophytic fungus Aspergillus niger Naphthoquinoneimine 5,7-Dihydroxy-2-[1-(4-methoxy-6-oxo-6H-pyran-2-yl)-2-phenylethylamino]-[ 1,4]naphthoquinone

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Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application

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Marine Life Science & Technology 2019年第1期1卷 60-94页

作者： Lu Liu Yao-Yao Zheng chang-Lun Shao chang-yun wang Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Single-Cell Center CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy GeneticsQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China

Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive moleculeswith diverse structures. In recent years, we initiated a program to investigate the diversity of the secondary metabolites frommarine invertebrates and their symbiotic microorganisms collected from the South China Sea. In this review, representativecases are summarized focusing on molecular diversity, mining, and application of natural products from these marineorganisms. To provide a comprehensive introduction to the field of marine natural products, we highlight typical moleculesincluding their structures, chemical synthesis, bioactivities and mechanisms, structure-activity relationships as well as biogenesis. The mining of marine-derived microorganisms to produce novel secondary metabolites is also discussed through theOSMAC strategy and via partial chemical epigenetic modification. A broad prospectus has revealed a plethora of bioactivenatural products with novel structures from marine organisms, especially from soft corals, gorgonians, sponges, and theirsymbiotic fungi and bacteria.

关键词： Marine invertebrates Symbiotic microorganisms Marine natural products Molecular diversity Bioactivities Marine drugs

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The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms(1987-2020)

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Marine Life Science & Technology 2021年第4期3卷 488-518页

作者： Yang Hai Mei-Yan Wei chang-yun wang Yu-Cheng Gu chang-Lun Shao Key Laboratory of Marine Drugs School of Medicine and PharmacyThe Ministry of Education of ChinaOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Syngenta Jealott’s Hill International Research Centre BracknellBerkshire RG426EYUK

Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug *** unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor,antibiotic,anti-inflammatory and antiviral *** reviewed all the 484 sulfur-containing natural products(non-sulfated)isolated from marine microorganisms,of which 59.9%are thioethers,29.8%are thiazole/thiazoline-containing compounds and 10.3%are sulfoxides,sulfones,thioesters and many others.A selection of 133 compounds was further discussed on their structure-activity relationships,mechanisms of action,biosynthesis,and *** is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987,when the first one was reported,to December 2020.

关键词： Sulfur-containing natural products Marine microorganisms Molecular diversity Bioactivities Marine drugs

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Effect of liquid surface depression size on discharge characteristics and chemical distribution in the plasma-liquid anode system

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Plasma Science and Technology 2024年第9期26卷 17-31页

作者： yun LING Dong DAI Jiaxin chang Buang wang School of Electric Power South China University of TechnologyGuangzhou 510641People’s Republic of China University of Richmond Richmond 23173United States of America

Atmospheric pressure plasma-liquid interactions exist in a variety of applications,including wastewater treatment,wound sterilization,and *** practice,the phenomenon of liquid surface depression will inevitably *** applied gas will cause a depression on the liquid surface,which will undoubtedly affect the plasma generation and further affect the application ***,the effect of liquid surface deformation on the plasma is still *** this work,numerical models are developed to reveal the mechanism of liquid surface depressions affecting plasma discharge characteristics and the consequential distribution of plasma species,and further study the influence of liquid surface depressions of different sizes generated by different helium flow rates on the *** show that the liquid surface deformation changes the initial spatial electric field,resulting in the rearrangement of electrons on the liquid *** charges deposited on the liquid surface further increase the degree of distortion of the electric ***,the electric field and electron distribution affected by the liquid surface depression significantly influence the generation and distribution of active species,which determines the practical effectiveness of the relevant *** work explores the phenomenon of liquid surface depression,which has been neglected in previous related work,and contributes to further understanding of plasma-liquid interactions,providing better theoretical guidance for related applications and technologies.

关键词： plasma-liquid interaction deformation of the liquid surface liquid anode species fluxes

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Cardiopulmonary bypass induced microcirculatory injury of the small bowel in rats

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World Journal of Gastroenterology 2009年第25期15卷 3166-3172页

作者： Guo-Hua Dong chang-Tian wang yun Li Biao Xu Jian-Jun Qian Hai-Wei Wu Hua Jing Department of Cardiothoracic Surgery Jinling Hospital Clinical Medicine School of Nanjing University Nanjing 210002 Jiangsu Province China

AIM： To investigate microvascular injury quantitatively in the small bowel with respect to cardiopulmonary bypass （CPB） and related mechanisms. METHODS： In 10 male SD rats, normothermic CPB was established and continued with a flow rate of 100-150 mL/kg per minute for 60 min, while another 10 sham-operated animals served as controls. An approximate 10-cm loop of the terminal ileum was exteriorized for observation by means of intravital fluorescence microscopy. The small bowel microcirculatory network including arterioles, capillaries, and collecting venules was observed prior to CPB, CPB 30 min, CPB 60 min, post-CPB 60 min and post-CPB 120 rain. The intestinal capillary perfusion, microvascular permeability and leukocyte adherence were also measured. RESULTS： The systemic hemodynamics remained stable throughout the experiment in both groups. In CPB animals, significant arteriolar vasoconstriction, blood velocity reduction and functional capillary density diminution were found. As concomitances, exaggerated albumin extravasation and increased leukocyte accumulation were also noted. These changes were more pronounced and there were no signs of restitution at the end of the observation period. CONCLUSION： CPB induces significant microcirculatory injury of the small bowel in rats. The major underlying mechanisms are blood flow redistribution and generalized inflammatory response associated with CPB.

关键词： Cardiopulmonary bypass Functional capillary density Intestinal microcirculation Intravital microscopy

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Targeted isolation of antitubercular cycloheptapeptides and an unusual pyrroloindoline-containing new analog,asperpyrroindotide A,using LC–MS/MS-based molecular networking

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Marine Life Science & Technology 2023年第1期5卷 85-93页

作者： Yi-Qian Han Qun Zhang Wei-Feng Xu Yang Hai Rong Chao Cui-Fang wang Xue-Mei Hou Mei-Yan Wei Yu-Cheng Gu chang-yun wang chang-Lun Shao Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Syngenta Jealott’s Hill International Research Centre BracknellBerkshire RG426EYUK Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Further insights on the secondary metabolites of a soft coral-derived fungus Aspergillus versicolor under the guidance of MS/MS-based molecular networking led to the isolation of seven known cycloheptapeptides,namely,asperversiamides A–C(1–3)and asperheptatides A–D(4–7)and an unusual pyrroloindoline-containing new cycloheptapeptide,asperpyrroindotide A(8).The structure of 8 was elucidated by comprehensive spectroscopic data analysis,and its absolute configuration was determined by advanced Marfey’s *** semisynthetic transformation of 1 into 8 was successfully achieved and the reaction conditions were ***,a series of new derivatives(10−19)of asperversiamide A(1)was semi-synthesized and their anti-tubercular activities were evaluated against Mycobacterium tuberculosis *** preliminary structure−activity relationships revealed that the serine hydroxy groups and the tryptophan residue are important to the activity.

关键词： Marine natural product MS/MS-based molecular networking Cycloheptapeptides Semi-synthesis Anti-tubercular activity

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A combined strategy for the overproduction of complex ergot alkaloid agroclavine

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Synthetic and Systems Biotechnology 2022年第4期7卷 1126-1132页

作者： Zhi-Pu Yu Chunyan An Yongpeng Yao chang-yun wang Zhoutong Sun Chengsen Cui Ling Liu Shu-Shan Gao Key Laboratory of Marine Drugs The Ministry of Education of ChinaInstitute of Evolution&Marine BiodiversitySchool of Medicine and PharmacyOcean University of ChinaQingdao266003PR China Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin300308PR China Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and TechnologyQingdao266003PR China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing100101PR China Beijing Institute for Drug Control NMPA Key Laboratory for Research and Evaluation of Generic DrugsBeijing Key Laboratory of Analysis and Evaluation on Chinese MedicineBeijing102206PR China National Technology Innovation Center of Synthetic Biology Tianjin300308PR China

Microbial cell factories(MCFs)and cell-free systems(CFSs)are generally considered as two unrelated approaches for the biosynthesis of *** the current study,two systems were combined together for the overproduction of agroclavine(AC),a structurally complex ergot *** whole biosynthetic pathway for AC was split into the early pathway and the late pathway at the point of the FAD-linked oxidoreductase EasE,which was reconstituted in an MCF(Aspergillus nidulans)and a four-enzyme CFS,*** final titer of AC of this combined system is 1209 mg/L,which is the highest one that has been reported so far,to the best of our *** development of such a combined route could potentially avoid the limitations of both MCF and CFS systems,and boost the production of complex ergot alkaloids with polycyclic ring systems.

关键词： Microbial cell factories Cell-free systems Overproduction Agroclavine Ergot alkaloids

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Artemordins A-S, Cadinane-Type Sesquiterpenoid Dimers from Artemisia ordosica and Their Antihepatoma Activities

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Chinese Journal of Chemistry 2024年第13期42卷 1493-1508页

作者： Yuan wang Tian-Ze Li yun-Bao Ma chang-An Geng Yong-Cui wang Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Nineteen new cadinane-involving sesquiterpenoid dimers,artemordins A-S(1-—19),together with 13 known SDs(20-32)were isolated from Artemisia *** structures and absolute configurations were established by comprehensive spectral analyses,X-ray single crystal diffraction,theoretical ECD,and NMR ***,artemordins A-F(1—6)were the first examples of two cadinane units constructed by unprecedented C-3−C-15′or C-3−C-13′single bond with an oxido-rearranged 6/5/6/6 fused ring system;artemordins G-K(7-11)were biogenetically connected by[4+2]cycloaddition reaction and artemordins G-J(7-10)possessed a novel 5/6/6/6/6/6/5-heptacyclic fused ring *** L-S(12-19)were formed by esterification,which involved three different types of *** assay suggested that the most active compounds,artemordins B and H(2 and 8),exhibited inhibitory activities on three hepatoma cell lines with IC50 values of 26.9 and 25.1μmol/L(HepG2),29.5 and 18.3μmol/L(Huh7),19.7 and 15.7μmol/L(SK-Hep-1).

关键词： Artemisia ordosica Artemordins A-s Cadinane-type sesquiterpenoid dimers Antihepatoma activities Terpenoids Natural products Cytotoxicity

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High-Performance Liquid Chromatography Fingerprint of Marine Traditional Chinese Medicine Haliotidis

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 446-452页

作者： Qing Zhao Shu-Yue Song Meng-Qi Zhang Xin Li Yang Liu chang-yun wang Key Laboratory of Marine Drugs The Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaLaboratory for Marine Drugs and BioproductsQingdao National Laboratory for Marine Science and TechnologyQingdaoChina Insect Biotechnology Justus Liebig University GiessenGiessenGermany

Objective: Haliotidis, the dried muscle of abalone, has long been used as a marine traditional Chinese medicine(TCM) due to its high medicinal and nutritive values, whereas few reports contributed to its quality control. This study aimed to establish the high-performance liquid chromatography(HPLC) fingerprints of Haliotidis. Materials and Methods: The HPLC fingerprints of Haliotidis, the manufacturing products of dried muscle of abalone, were analyzed by reverse-phase HPLC, using a YMC HPLC C18 column(250 mm × 4.6 mm, 5 μm).The gradient elution mode was applied with mobile phase starting from 5% acetonitrile and 0.1% phosphoric acid aqueous solution to 100%acetonitrile in 70 min at a flow rate of 1.0 mL/min. The detection wavelength was set at 190 nm. Results: Through compared the HPLC fingerprint chromatograms of 14 batches of Haliotidis, 25 peaks were assigned as the characteristic common peaks, of which one index component L-phenylalanine was identified by comparison with its standard substance. The established HPLC fingerprint analysis method of Haliotidis was validated with good precision, repeatability, and stability. Based on the above study, a reference HPLC fingerprint chromatogram of Haliotidis was proposed. Conclusions: It is the first time to establish the HPLC fingerprint chromatogram of TCM Haliotidis, which could contribute to the establishment of its quality control system.

关键词： Marine traditional Chinese medicine Haliotidis HPLC fingerprint quality control

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