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Journal of Magnesium and Alloys 2022年第6期10卷 1672-1679页

作者： Joo-Hee Kang Jiwon park Kyung Song chang-Seok Oh Oleg Shchyglo Ingo Steinbach Korea Institute of Materials Science Changwon 51508Republic of Korea Interdisciplinary Centre for Advanced Materials Simulation Ruhr-University Bochum44801 BochumGermany

In this study the partially divorced eutectic microstructure ofα-Mg andβ-Mg17Al12was investigated by electron backscatter diffraction,transmission electron microscopy,and phase-field modeling in hypoeutectic Mg-Al *** orientation relationships between the individual eutecticαgrains,eutecticβphase,and primaryαgrains were *** the amount of eutectic morphology is primarily determined by the Al content,the in-depth microstructure analyses and the phase-field simulation suggest non-interactive nucleation and growth of eutecticαphase in theβphase grown on the interdendritic primaryα***,phase-field simulations showed a preferred nucleation sequence where theβphase nucleates first and subsequently triggers the nucleation of eutecticαphase at the movingβphase solidification front,which supports the microstructural analysis results.

关键词： Mg-Al alloy Partially divorced eutectic Solidification Electron backscatter diffraction Phase-Field modeling

Fabrication of High-Density Out-of-Plane Microneedle Arrays with Various Heights and Diverse Cross-Sectional Shapes

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Nano-Micro Letters 2022年第2期14卷 60-78页

作者： Hyeonhee Roh Young Jun Yoon Jin soo park Dong-Hyun Kang Seung Min Kwak Byung Chul Lee Maesoon Im Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792South Korea Division of Electrical Engineering College of EngineeringKorea UniversitySeoul 02841South Korea Micro/Nano Fabrication Center KISTSeoul 02792South Korea Division of Bio‑Medical Science&Technology KIST SchoolUniversity of Science&Technology(UST)Seoul 02792South Korea

Out-of-plane microneedle structures are widely used in various applications such as transcutaneous drug delivery and neural signal recording for brain machine *** work presents a novel but simple method to fabricate high-density silicon(Si)microneedle arrays with various heights and diverse cross-sectional shapes depending on photomask pattern *** proposed fabrication method is composed of a single photolithography and two subsequent deep reactive ion etching(DRIE)***,a photoresist layer was patterned on a Si substrate to define areas to be etched,which will eventually determine the final location and shape of each individual ***,the 1st DRIE step created deep trenches with a highly anisotropic etching of the Si ***,the photoresist was removed for more isotropic etching;the 2nd DRIE isolated and sharpened microneedles from the predefined trench *** on diverse photomask designs,the 2nd DRIE formed arrays of microneedles that have various height distributions,as well as diverse cross-sectional shapes across the *** these simple steps,high-aspect ratio microneedles were created in the high density of up to 625 microneedles mm^(-2)on a Si *** tests showed a small force as low as~172μN/microneedle is required for microneedle arrays to penetrate the dura mater of a mouse *** demonstrate a feasibility of drug delivery application,we also implemented silk microneedle arrays using molding *** fabrication method of the present study is expected to be broadly applicable to create microneedle structures for drug delivery,neuroprosthetic devices,and so on.

关键词： Microneedle Various heights Cross-sectional shapes Isotropic etch Deep reactive ion etching

MXene ink hosting zinc anode for high performance aqueous zinc metal batteries

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Journal of Energy Chemistry 2023年第1期76卷 187-194,I0005页

作者： Jae Min park Milan Jana Sang Ha Baek Taehun Kang Peixun Xiong Jeong Hee park Jun soo Kim Ali Shayesteh Zeraati Mikhail Shekhirev Paul V.Braun Yury Gogotsi Ho Seok park School of Chemical Engineering Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746Republic of Korea Department of Chemical and Petroleum Engineering University of Calgary2500 University Dr NWCalgary T2N 1N4Canada Department of Materials Science and Engineering Materials Research LaboratoryBeckman Institute for Advanced Science and TechnologyUniversity of Ilinois at Urbana-ChampaignUrbanaIL61801USA A.J.Drexel Nanomaterials Institute and Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA 19104USA SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University 2066SeoburoJangan-guSuwon 440-746Republic of Korea

Despite the safety,low cost,and high theoretical capacity(820 mA h g^(-1))of Zn metal anodes,the practical application of aqueous Zn metal batteries remains a critical challenge due to the Zn dendrite growth,corrosion,and hydrogen evolution ***,we demonstrate the MXene ink hosting Zn metal anodes(MX@Zn)for high-performance and patternable Zn metal full *** as-designed MX@Zn electrode is more facile and reversible than bare Zn and CC@Zn,as verified by better cyclic stability and lower overpotentials of symmetric cells with the plating capacity of 0.05 mA h cm^(-2)at 0.1 m A cm^(-2)and of 1 m A h cm^(-2)at 1 m A cm^(-2).The MX@Zn|MnO_(2)full cells deliver a high specific capacity of 281.9 m A h g^(-1),91.5%of the theoretical capacity,achieving 50%capacity retention from 60 mA g^(-1)to 300 mA g^(-1)and 79.7%of initial capacity after 200 ***,the patterned devices based on the MX@Zn electrode achieve high energy and power densities of 348.57 Wh kg^(-1)and 1556 W kg^(-1),respectively,along with a capacity retention of 64%and Coulombic efficiency of 99%over 500 *** high performance of MX@Zn is attributed to the high electrical conductivity and hydrophilicity of MXene and rapid ion diffusion through the 3D interconnected porous channels.

关键词： MXene ink Zinc anode Metal batteries Patterning Electrodeposition

Congenital stapes suprastructure fixation presenting with fluctuating auditory symptoms:A case report

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World Journal of Clinical Cases 2023年第1期11卷 249-254页

作者： Sun Choi Seok Hyun park Ji Su Kim Jiwon chang Department of Otolaryngology-Head and Neck Surgery Kangnam Sacred Heart HospitalHallym University College of MedicineSeoul 07441South Korea

BACKGROUND Stapes ankylosis is a rare cause of conductive hearing loss,and stapes suprastructure fixation is extremely rare with fewer than 30 reported *** usually visit the clinic with non-progressive conductive hearing loss that typically began in the early years of *** SUMMARY Herein,we report a case of a 37-year-old female with an isolated stapedial suprastructure *** patient presented with unusual fluctuating auditory symptoms of tinnitus,ear fullness and mixed hearing ***-operative temporal bone computed tomography findings and operative findings revealed an isolated stapedial suprastructure fixation with monopod stapes caused by elongated pyramidal *** hearing threshold recovered completely,and fluctuating auditory symptoms disappeared after the *** This is the first report of stapedial suprastructure fixation with fluctuating auditory *** results are expected with surgical treatment.

关键词： Isolated stapes ankylosis Stapes suprastructure fixation Elongated pyramidal eminence Stapes monopod Fluctuating auditory symptoms Exploratory tympanotomy Case report

Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice,an AD model

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Translational Neurodegeneration 2022年第1期11卷 31-45页

作者： Chanho Kong Eun-Jeong Yang Jaewoo Shin Junwon park Si-Hyun Kim Seong-Wook park Won Seok chang chang-Han Lee Hyunju Kim Hye-Sun Kim Jin Woo chang Department of Neurosurgery Yonsei University College of Medicine50 Yonsei-RoSeodaemun-GuSeoulRepublic of Korea Department of Pharmacology College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Neuroscience Research Center College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Department of Biomedical Sciences College of MedicineSeoul National University103 DaehakroJongro-GuSeoulRepublic of Korea Bundang Hospital Seoul National University College of MedicineBundang-GuSungnamRepublic of Korea.

Background:Aducanumab(Adu),which is a human IgG1 monoclonal antibody that targets oligomer and fibril forms of beta-amyloid,has been reported to reduce amyloid pathology and improve impaired cognition after administration of a high dose(10 mg/kg)of the drug in Alzheimer’s disease(AD)clinical *** purpose of this study was to investigate the effects of a lower dose of Adu(3 mg/kg)with enhanced delivery via focused ultrasound(FUS)in an AD mouse ***:The FUS with microbubbles opened the blood-brain barrier(BBB)of the hippocampus for the delivery of *** combined therapy of FUS and Adu was performed three times in total and each treatment was performed biweekly.Y-maze test,Brdu labeling,and immunohistochemical experimental methods were employed in this *** addition,RNA sequencing and ingenuity pathway analysis were employed to investigate gene expression profiles in the hippocampi of experimental ***:The FUS-mediated BBB opening markedly increased the delivery of Adu into the brain by approximately 8.1 times in the *** combined treatment induced significantly less cognitive decline and decreased the level of amyloid plaques in the hippocampi of the 5×FAD mice compared with Adu or FUS *** treatment with FUS and Adu activated phagocytic microglia and increased the number of astrocytes associated with amyloid plaques in the hippocampi of 5×FAD ***,RNA sequencing identified that 4 enriched canonical pathways including phagosome formation,neuroinflammation signaling,CREB signaling and reelin signaling were altered in the hippocami of 5×FAD mice receiving the combined ***:In conclusion,the enhanced delivery of a low dose of Adu(3 mg/kg)via FUS decreases amyloid deposits and attenuates cognitive function ***-mediated BBB opening increases adult hippocampal neurogenesis as well as drug *** present an AD treatment strategy through the synergistic effect of the combined therapy of

关键词： Aducanumab Alzheimer’s disease Focused ultrasound Transcriptome profiling

A new strengthening mechanism driven by disruptive shear and solute segregation during warm rolling in 1.4 GPa class 12.5 wt% Al added-FeMnC ultra-lightweight steel

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Journal of Materials Science & Technology 2023年第26期157卷 174-188页

作者： Chiwon Kim Hyun-Uk Hong Joonoh Moon Bong Ho Lee Seong-Jun park chang-Hoon Lee Department of Materials Convergence and System Engineering Changwon National University 20 Changwondaehak-roChangwonGyeongnam 51140Republic of Korea Advanced Analysis Team Daegu Gyeongbuk Institute of Science and Technology 333 Technojungang-daeroDaegu42988Republic of Korea Ferrous Alloy Department Korea Institute of Materials Science 797 ChangwondaeroChangwonGyeongnam 51508Republic of Korea

Novel strengthening of Fe-29.1Mn-12.5Al-1.35C-4.95Cr steel achieved by warm rolling was *** solution-treated steel consisted of aγ-matrix containing nano-sizedκ-carbide((Fe,Mn)_(3) AlC)and elongated prior ferrite,which was transformed into FeAl-type B2 and Fe_(3) Al-type D0_(3) *** solution-treated steel exhibited poor strain hardening owing to glide softening associated withκ-carbide shearing by ***,after warm rolling with a reduction ratio of 30%at 300℃,the yield and tensile strengths significantly increased from 917 to 1300 MPa and 1025 to 1419 MPa,*** tensile test conducted at 300℃to simulate warm rolling exhibited serrated flows,indicating dy-namic strain aging(DSA).Atom probe tomography exhibited that the C atoms inκ-carbide were swept away along the slip direction by disruptive shear during rolling at 300℃.The swept C atoms along the slip direction interacted strongly with dislocations at 300℃,with repeated pinning and breakaway of dislocations from the C *** contributed to significant strengthening owing to the formation of a solute-rich atmosphere after warm *** results of the tensile tests at 300℃indicated that the de-gree of strengthening was proportional to the pre-strain *** strength of 1.4 GPa can be achieved with good ductility(17%elongation)by warm *** novel warm-rolling strengthening method ex-pedites the potential application of Fe-29.1Mn-12.5Al-1.35C-4.95Cr as a 1.4 GPa class ultra-lightweight steel.

关键词： FeMnAlC Cr addition κ-carbide Dynamic strain aging Strengthening

Ni, Co-double hydroxide wire structures with controllable voids for electrodes of energy-storage devices

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Journal of Materials Science & Technology 2020年第20期52卷 126-135页

作者： Jin Kyu Kim chang soo Lee Jae Hun Lee Jung Tae park Jong Hak Kim Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Chemical Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Republic of Korea

We re port the facile synthesis of Ni,Co-double hydroxide wire(NCHW)-based electrodes directly grown on a conductive substrate via a hydrothermal *** NCHW nanostructures were grown on Ni foam,and the growth was controlled using different compositions of solvents(ethanol and water).With increasing volume ratio of ethanol to water,the density of the wires decreased,and the spatial voids between the wires *** formation of large empty spaces improved the electrochemical performance because the exposure of a large surface area of the structure to the electrolyte resulted in a large number of active sites and facile electrolyte penetration into the *** different NCHW structures were ascribed to the pivotal role of the solvent in the urea hydrolysis;the solvent triggered the formation of hydroxides during the hydrothermal *** electrochemical performance of the NCHW electrodes was investigated via galvanostatic charge/discha rge tests,cyclic voltammetry,and electrochemical impedance *** highest specific capacitance was 1694.7 m F/cm^2 at 2 mA/cm^2,with excellent capacitance retention of 81.5% after 5000 *** superior electrochemical performance of the NCHW electrodes is attributed to the large number of active sites and facile electrolyte diffusion into the structure,due to the well-organized structure with an optimized density of nanowires and large voids between the wires.

关键词： Ni,Co-double hydroxide Nanowire Electrode Energy-storage device Supercapacitor

Surgical excision of a large retroperitoneal lymphangioma: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11561-11566页

作者： John Hee park Donghyoun Lee Young Hee Maeng Won-Bae chang Department of Surgery Samsung Medical CenterSeoul 06351South Korea Department of Surgery Jeju National University HospitalJeju-si 63241JejudoSouth Korea Department of Pathology Jeju National University Medical CenterJeju-si 63241Jeju-doSouth Korea Department of Surgery Jeju National University Medical CenterJeju-si 63241Jeju-doSouth Korea

BACKGROUND Lymphangiomas are rare benign tumors most commonly found in children under 2 years of age;adult cases are extremely *** lymphangiomas represent less than 1%of all *** of their benign nature and possibility of spontaneous resolution,lymphangiomas are sometimes left untreated for long periods of ***,if they grow large enough to compress surrounding structures,retroperitoneal lymphangiomas may cause symptoms such as abdominal pain,nausea or *** report a case of a rapidly growing retroperitoneal lymphangioma in an adult,treated with complete surgical *** SUMMARY A 60-year-old female who was diagnosed with an intra-abdominal cystic mass(11 cm×9.5 cm)seven years ago presented to our hospital with symptoms of early satiety,nausea,and intermittent abdominal *** tomography(CT)scan confirmed interval enlargement to a 24 cm×22 cm-sized huge left retroperitoneal mass,causing left hydronephrosis by external *** was done via long midline *** to severe adhesion between the aorta and the medial border of the mass,the cyst was intentionally opened for fluid aspiration and size *** suture closure of the opening,we proceeded carefully with *** showed light yellowish serous *** mass was excised completely,and the pathology was consistent with cystic *** post-operative period was uneventful,and the patient was discharged without ***-up CT scan one month after surgery confirmed complete removal of the mass and decreased left *** Excision of the huge retroperitoneal cystic mass resulted in relief of the patient’s symptoms,originally caused by external compression,and also ruled out the possibility of malignancy.

关键词： Retroperitoneum Lymphangioma Hydronephrosis Case report

Orthotic approach to prevention and management of diabetic foot:A narrative review

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World Journal of Diabetes 2022年第11期13卷 912-920页

作者： Min Cheol chang Yoo Jin Choo In Sik park Myung Woo park Du Hwan Kim Rehabilitation Medicine Yeungnam UniversityDaegu 42415South Korea Korean Podiatry and Pedorthics Institute Goyang 10442South Korea Physical Medicine and Rehabilitation Chung-Ang UniversitySeoul 06973South Korea

Diabetic foot is a common complication affecting more than one-fifth of patients with *** not treated in time,it may lead to diabetic foot ulcers or Charcot *** the management of diabetic foot,shoe modifications and orthoses can be used to reduce pressure on the affected foot or provide the foot with increased *** addition,the shoe modifications and orthotic devices can relieve patient discomfort during *** shoe modifications include changing the insole material,modifying the heel height,adding a steel shank or rocker sole,and using in-depth ***,a walking brace or ankle-foot orthosis can be used to reduce the pressure on the affected *** purpose of this narrative review was to provide a reference guide to support clinicians in prescribing shoe modifications and foot orthoses to treat diabetic foot ulcers and Charcot arthropathy.

关键词： Diabetic foot Foot ulcers Charcot arthropathy Shoes Foot orthosis

快速原位杂交技术在感染性病原体诊断中的应用

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华西医科大学学报 2000年第2期31卷 269-271页

作者：刘明陈灼怀庞青平梁传余朴彰洙深圳市人民医院耳鼻咽喉科深圳518020 深圳市人民医院病理科华西医科大学附属第一医院耳鼻咽喉科韩国全南大学校病院病理科

快速原位杂交技术是一种近年才发展起来的检测常现病理标本中有无感染原存在的非常有效的工具，与现在普遍采用的原位杂交技术相比具有更强的核酸定位能力。作者采用该项新技术，用非同位素标记的寡聚核苷酸探针以及毛细虹吸技术完成常... 详细信息

快速原位杂交技术是一种近年才发展起来的检测常现病理标本中有无感染原存在的非常有效的工具，与现在普遍采用的原位杂交技术相比具有更强的核酸定位能力。作者采用该项新技术，用非同位素标记的寡聚核苷酸探针以及毛细虹吸技术完成常规福尔马林固定、石蜡包理病理标本中感染原的检测。结果显示，使用这种快速原位杂交技术能在1小时内完成鼻咽癌组织和非鼻咽癌鼻咽部组织中的爱泼斯坦-巴尔病毒和宫颈组织中的人类乳头状瘤病毒的检测，且染色清晰，定位准确，效果满意，可广泛应用于临床病理实验室的日常检测工作以及感染性病原体相关疾病的研究。

关键词：快速原位杂交感染性病原体诊断病理标本