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Exosomes as promising frontier approaches in future cancer therapy

World Journal of Gastrointestinal Oncology 2025年第1期17卷 28-33页

作者： Fatt-Yang Chew Chin-Hung Tsai Kuang-Hsi chang Yu-Kang chang Ruey-Hwang Chou Yi-Jui liu Department of Medical Imaging China Medical University HospitalTaichung 404TaiwanChina Department of Radiology School of MedicineChina Medical UniversityTaichung 404TaiwanChina Department of Cancer Center Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Department of Chest Medicine Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402TaiwanChina Department of Medical Research Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Center for General Education China Medical UniversityTaichung 404TaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoli 356TaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoli 356TaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichung 404TaiwanChina Center for Molecular Medicine China Medical University HospitalTaichung 404TaiwanChina Department of Medical Laboratory and Biotechnology Asia UniversityTaichung 413TaiwanChina Department of Automatic Control Engineering Feng Chia UniversityTaichung 407TaiwanChina

In this editorial,we will discuss the article by Tang et al published in the recent issue of the World Journal of Gastrointestinal *** explored an innovative approach to enhancing gemcitabine(GEM)delivery and efficacy using human bone marrow mesenchymal stem cells(HU-BMSCs)-derived *** manufacture of GEM-loaded HU-BMSCs-derived exosomes(Exo-GEM)has been *** Tang et al’s study demonstrated that Exo-GEM exhibits enhanced cytotoxicity and apoptosis-inducing effects compared to free GEM,highlighting the potential of exosome-based drug delivery systems as a more effective and targeted approach to chemotherapy in pancreatic *** in vivo studies are required to confirm the safety and effectiveness of Exo-GEM before it can be considered for clinical use.

关键词： Mesenchymal stem cells Exosomes Gemcitabine Pancreatic cancer Apoptosis

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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue Li Cui chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

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地源热泵地埋管随机热阻及可靠性分析

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武汉理工大学学报 2010年第3期32卷 70-72,82页

作者：管昌生刘卓栋陈绪义武汉理工大学土木工程与建筑学院武汉430070

分析了地源热泵地埋管周围岩土热阻的随机性,研究了岩土随机热阻及负荷对地源热泵地埋管换热性能的影响。基于热阻随机分析,提出了地源热泵地埋管的可靠性设计方法,得出了可靠度计算公式。结合工程实例进行计算,并与确定性设计方法进行... 详细信息

分析了地源热泵地埋管周围岩土热阻的随机性,研究了岩土随机热阻及负荷对地源热泵地埋管换热性能的影响。基于热阻随机分析,提出了地源热泵地埋管的可靠性设计方法,得出了可靠度计算公式。结合工程实例进行计算,并与确定性设计方法进行了对比分析。计算结果表明,岩土热阻的变异性对地源热泵地埋管的设计影响较大,可靠性理论对地源热泵地埋管的随机传热性能研究有重要意义。

关键词：岩土热阻随机性地源热泵地埋管可靠性设计

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摇摆运动下大空间内气泡浮升运动研究

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江苏科技大学学报（自然科学版） 2016年第6期30卷 538-541,564页

作者：何莉蔺常勇马畅李湦刘单武汉第二船舶设计研究所辐射防护与核技术应用研究中心武汉430205

气泡的浮升运动在除氧器和鼓泡塔饱和池式沸腾换热设备中非常常见.摇摆运动是一种最为常见的海洋条件,由于附加惯性力的存在,摇摆运动会对气泡的浮升运动产生一定的影响.文中对大容积内摇摆运动下的气泡浮升运动进行了理论分析,建立了... 详细信息

气泡的浮升运动在除氧器和鼓泡塔饱和池式沸腾换热设备中非常常见.摇摆运动是一种最为常见的海洋条件,由于附加惯性力的存在,摇摆运动会对气泡的浮升运动产生一定的影响.文中对大容积内摇摆运动下的气泡浮升运动进行了理论分析,建立了摇摆运动下浮升运动气泡的受力模型,并根据该模型进行了数值计算.计算结果表明:摇摆运动下的气泡浮升运动与静止条件有很大的不同;气泡的运动轨迹、运动速度与摇摆运动的周期、振幅和初始相位有关;此外,系统的布置也会对气泡的浮升运动产生很大的影响.

关键词：气泡浮升运动海洋条件摇摆运动气泡受力

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中等卫生职业教育应推广医院信息系统的教学

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中国数字医学 2008年第2期3卷 76-77页

作者：赵昌伦贵州省毕节地区卫生学校

中等卫生职业教育对信息技术的教学要求与现实医院实践需要存在脱节的问题,尤其是对医院信息系统的教学内容缺少必要的强制性要求。因此,在中等卫生职业教育中适当推广医院信息系统的教学,可以促进培养目标与实际需要的联系,从而推动中... 详细信息

中等卫生职业教育对信息技术的教学要求与现实医院实践需要存在脱节的问题,尤其是对医院信息系统的教学内容缺少必要的强制性要求。因此,在中等卫生职业教育中适当推广医院信息系统的教学,可以促进培养目标与实际需要的联系,从而推动中等卫生职业教育的健康发展。

关键词：卫生职业教育医院信息系统信息技术中等教育

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Elevated C-reactive protein adds to the predictive value of low-density lipoprotein cholesterol for coronary artery disease severity

Elevated C-reactive protein adds to the predictive value of ...

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第十三次全国心血管病学术会议

作者： liu Hai-hang,ZHAO Dong,MA chang-sheng,liu Xiao-hui, L Qiang,QI Yue,LI Yan,REN Jie,liu Jing *Department of Epidemiology,Capital Medical University Beijing Anzhen Hospital,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China

Objective Prospective studies and clinical trials have shown that C-reactive protein(CRP) independent predicts the occurrence of cardiovascular events,even in individuals without *** thus aimed to illustrate the association of CRP levels with the severity of coronary artery stenosis documented by angiography in patients with lower LDL-C(LDL-C<3.37 mmol/L). Methods A total of 676 subjects who were submitted to angiography for suspected CAD in the Department of Cardiology,

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Influence of genetic variation on statin treatment in Han Chinese

Influence of genetic variation on statin treatment in Han Ch...

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第十三次全国心血管病学术会议

作者： QI Yue,liu Jing,MA chang-sheng,liu Xiao-hui,L Qiang, LI Yan,REN Jie,liu Hai-hang,ZHAO Dong *Department of Epidemiology,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Capital Medical University Beijing Anzhen Hospital,Beijing 100029,China

Objective Mounting clinical and epidemiological cvidence indicates that there are obvious inter-individual differences for statin efficacy in either long-term or short-term treatment,which undoubtedly leads to the inability to lower cardiovascular disease(CVD) risk among some *** therefore decided to assess the influence of genetic variation on statin efficacy in a Han Chinese CVD-high-risk population aiming to elucidate the inherited genetic underpinnings,which would further di-

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Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng Zhou Wei Yang Di Zhu Bi-Fei Wu Hai-Bin Shi sheng liu Wei-Zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee Cheng-Hui Lin Chi-Huan Wu Yung-Kuan Tsou Kai-Feng Sung sheng-Fu Wang Nai-Jen liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

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