检索结果-南通市图书馆

Chinese Medical Journal 2011年第11期124卷 1672-1677页

作者： ZENG Wei-jie SUN Yun-juan XIONG chang-ming gu qing HE Jian-guo Center for Diagnosis and Management of Pulmonary VascularDiseases Department of Cardiology Cardiovascular Institute andFuwai Hospital Chinese Academy of Medical Sciences & PekingUnion Medical College Beiiing 100037 China

Background An echocardiographic right/left ventricular end-diastolic diameter ratio （RV/LV ratio）〉0.9 is an independent predictor of poor prognosis in patients with acute pulmonary embolism. Right ventricular dilation is a common characteristic of both acute pulmonary embolism and idiopathic pulmonary arterial hypertension （IPAH）. However, the prognostic value of the RV/LV ratio in patients with IPAH is unknown. Methods Ninety-five consecutive patients with newly diagnosed IPAH were included, 17 were re-evaluated by echocardiography after 3-12 months of targeted therapy, Follow-up data were obtained by telephone interviews and review of the patients＇ records.

关键词： hypertension, pulmonary echocardiography right ventricular dilation prognosis

Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 297-309页

作者： chang gu guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang Lei Qian Xiaofei Hu Ting Zhang Chaoyu Xiang Yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line width3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

Trinuclear gold-catalyzed site-selective alkylation of peptides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期 249-256页

作者： qing-Yun Fang Chengyihan gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词：

同方期刊数据库

基于度量学习理论的马田系统改进及其应用研究

在线全文

学校读者我要写书评

暂无评论

管理工程学报 2025年第2期39卷 221-233页

作者：常志朋顾玉萍陈闻鹤安徽工业大学商学院安徽工业大学复杂系统多学科管理与控制安徽普通高校重点实验室安徽财经大学管理科学与工程学院南京理工大学经济管理学院

为提升马田系统的识别性能,本文利用度量学习理论对其进行改进。一是将传统协方差马氏距离改进为以度量矩阵为参变量的马氏距离函数,然后利用简单直接的KISSME度量学习算法估计一个最能反映数据间内在关系的度量矩阵,该度量矩阵可以使... 详细信息

为提升马田系统的识别性能,本文利用度量学习理论对其进行改进。一是将传统协方差马氏距离改进为以度量矩阵为参变量的马氏距离函数,然后利用简单直接的KISSME度量学习算法估计一个最能反映数据间内在关系的度量矩阵,该度量矩阵可以使同类样本更紧凑、非同类样本更分离,这有助于提升马田系统的识别性能。二是基于拉近同类样本、推远非同类样本的思想,定义一个新的特征子集评估函数代替田口方法中的信噪比,这有助于筛选出可以提高马田系统识别性能的特征。改进后的马田系统仍然保持了原理简单、易于操作的优势。本文选取6个UCI数据集进行验证,得出改进后的马田系统在Accuracy、Specificity、G-means和降维率等方面均明显优于传统马田系统的结论。最后,本文通过返贫识别验证了改进后马田系统的可行性和有效性。

关键词：马田系统度量学习 KISSME 返贫识别

同方期刊数据库

Excretion and detection of SARS coronavirus and its nucleic acid from digestive system

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第28期11卷 4390-4395页

作者： Xin-Wei Wang qing-Xin Kong Zhong Li Nong Song Min Jin chang-qing gu Jing Yin guo-Rong Ou Fu-Huan Chao Jun-Wen Li Jin-Song Li Bei Zhen Xiao-Ming Wu Wen-Jun Xiao Wei Wei Min-Nian Wang gui-Jie Wang Ting-Kai guo Xiu-Mei Zhu Wei Yao Jian-Feng Li Yao-Hui Qiu Huai-Huan Wu Chao Liu Tong-Yu Fang Tianjin Institute of Environment and Health Tianjin 300050 China Institute of Microbiology and Epidemiology Beijing 100072 China Xiao Tang Shan Hospital Beijing 102211 China Bin Yi 309 Hospital of PLA Beijing 100091 China Beijing Institute of Pharmacology and Toxicology Beijing 100850 China Beijing Institute of Basic Medicine Beijing 100850 China

AIM： To study whether severe acute respiratory syndrome coronavirus （SARS-CoV） could be excreted from digestive system.METHODS： Cell culture and semi-nested RT-PCR were used to detect SARS-CoV and its RNA from 21 stool and urine samples, and a kind of electropositive filter media particles was used to concentrate the virus in 10 sewage samples from two hospitals receiving SAILS patients in Beijing in China. RESULTS： It was demonstrated that there was no live SARS-CoV in all samples collected, but the RNA of SARS-CoV could be detected in seven stool samples from SARS patients with any one of the symptoms of fever, malaise, cough, or dyspnea, in 10 sewage samples before disinfection and 3 samples after disinfection from the two hospitals. The RNA could not be detected in urine and stool samples from patients recovered from SARS.CONCLUSION： Nucleic acid of SARS-CoV can be excreted through the stool of patients into sewage system, and the possibility of SARS-CoV transmitting through digestive system cannot be excluded.

关键词： Severe acute respiratory syndrome Nucleic acid Digestive system

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Time synchronization and ranging under unknown positions and velocities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2017年第2期60卷 271-281页

作者： gu XiaoBo chang qing XU Yong WANG Dun School of Electronic & Information Engineering Beihang University Space Star Technology Co. Ltd

The process to achieve time synchronization and ranging for a network of mobile nodes is raising a concern among researchers, and hence a variety of joint time synchronization and ranging algorithms have been proposed in recent years. However, few of them handle the case of all-node motion under unknown positions and velocities. This study addresses the problem of determining ranging and time synchronization for a group of nodes moving within a local area. First, we examined several models of clock discrepancy and synchronous two-way ranging. Based upon these models, we present a solution for time synchronization with known positions and velocities. Next, we propose a functional model that jointly estimates the clock skew, clock offset, and time of flight in the absence of a priori knowledge for a pair of mobile nodes. Then, we extend this model to a network-wide time synchronization scheme by way of a global least square estimator. We also discuss the advantages and disadvantages of our model compared to the existing algorithms, and we provide some applicable scenarios as well. Finally, we show that the simulation results verify the validity of our analysis.

关键词： time synchronization two-way ranging relative motion clock model joint estimation

上海浦东新区良性前列腺增生合并膀胱过度活动症的流行病学调查

在线全文

学校读者我要写书评

暂无评论

现代泌尿外科杂志 2017年第10期22卷 732-737页

作者：伊庆同龚旻胡巍陈楚红陈长青顾建军祝凤明上海市浦东医院复旦大学附属浦东医院泌尿外科上海201399

目的调查上海浦东新区≥50岁人群良性前列腺增生(BPH)合并膀胱过度活动症(OAB)的患病率、相关危险因素及其对患者生活质量的影响。方法运用描述性流行病学多阶段随机抽样方法,在上海浦东新区一般人群中抽取≥50岁BPH患者1 632名,对下尿... 详细信息

目的调查上海浦东新区≥50岁人群良性前列腺增生(BPH)合并膀胱过度活动症(OAB)的患病率、相关危险因素及其对患者生活质量的影响。方法运用描述性流行病学多阶段随机抽样方法,在上海浦东新区一般人群中抽取≥50岁BPH患者1 632名,对下尿路症状(LUTS)情况采用国际前列腺症状评分(IPSS)和生活质量评分(QoL)进行评估;应用国际勃起功能指数问卷-5(IIEF-5)记录患者的阴茎勃起功能情况;对合并OAB患者采用膀胱过度活动症症状评分(OABSS)和King健康问卷评分(KHQ)调查;评估BPH合并OAB对患者生活质量的影响。结果共获得有效问卷1 476份。BPH合并OAB的总患病率为39.6%,50岁~、60岁~、70岁~、80岁~及≥90岁年龄组的患病率分别为28.1%、34.2%、44.6%、48.2%、51.5%。年龄、前列腺体积及焦虑抑郁是BPH合并OAB的危险因素。随着年龄与前列腺体积的增加,BPH合并OAB患病率升高,患者LUTS加重,IPSS、QoL、OABSS、KHQ评分增加,IIEF-5评分下降。KHQ评分较高的项目有一般健康状况(26.9±7.4)分、排尿问题严重程度(29.6±8.2)分和睡眠/精力(32.5±8.3)分。结论浦东新区≥50岁人群BPH合并OAB患病率为39.6%,其患病率与年龄、前列腺体积及焦虑抑郁程度呈正相关;BPH可能是男性OAB的患病危险因素之一,而BPH合并OAB可严重影响患者生活质量。

关键词：良性前列腺增生膀胱过度活动症流行病学调查

BIVARIATE LAGRANGE-TYPE VECTOR VALUED RATIONAL INTERPOLANTS

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2002年第2期20卷 207-216页

作者： Chuan-qing gu Gong-qing Zhu Department of Mathematics Shanghai UniversityShanghai 200436China Department of Mathematics Hefei Polytechnic UniversityHefei 230009China

Focuses on a study that presented an axiomatic definition to bivariate vector valued rational interpolation on distinct plane interpolation points. Definition; Existence and uniqueness; Connection.

关键词： bivariate vector value rational interpolation determinantal formula

Transition-layer of coreerim structures andβ→a transformation in SiC ceramics

在线全文

学校读者我要写书评

暂无评论

Journal of Materiomics 2023年第2期9卷 299-309页

作者： qing-qing Shao Hui gu Materials Genome Institute School of Materials Science and EngineeringShanghai UniversityShanghai200444China

Similar to Si_(3)N_(4)ceramics,β→a phase transformation in SiC ceramics plays a key role in tailoring the microstructures thus optimizing related *** microstructures are dominated with the core erim structures by AlN-solution,and by EBSD analysis,a-lamellae were revealed as stacking-faults(SF)and twin-boundaries(TB)in b-grains,co-existing with the coreerim structures asα/β→α’/β’transformation by *** structural transformation can proceed much further by gas-pressuresintering than hot-pressing with only RE2O3 agents,while the latter retain a high-density of SF/TB in the metastable b-SiC *** high-angle secondary-electron imaging,nanoscale transition-layer(TL)was observed as an inter-phase to fully separate the core and rim,which is created by a transitory equilibrium in the solutionereprecipitation *** enrichment of AlN or RE in TL demonstrates their segregation to core surface until reaching the super-saturation and before the growth of *** higher AlN or RE solution and after sintering,a shear stress can develop from TL contour to drive the expansion of SF/TB in Martensitic transition,especially under an external isotropic *** combinations ofβ→a transformation,coreerim structures and viscous liquid-phase enable the comprehensive assessment of sintering-microstructure-property-performance relationship of SiC ceramics,as demonstrated for their creep behaviors and fracture toughness.

关键词： SiC ceramics Coreerim structures Transition-layer Martensitic transition Creep behaviors