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银杏苦内酯B对重症急性胰腺炎大鼠血浆细胞因子的影响

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世界华人消化杂志 2006年第22期14卷 2169-2173页

作者：邸瑶夏时海佟长青武警医学院生理教研室天津市300162 武警医学院附属医院消化内科胰腺中心天津市300162

目的:观察重症急性胰腺炎(SAP)大鼠血浆中TNF-α,血小板活化因子(PAF),IL-10, IL-12,sTNFR的水平变化及其银杏苦内酯B(BN52021)的影响.方法:实验选用Wistar♂大鼠45只,随机分成SAP模型组(SAP,n=15),BN52021治疗组(BN,n=15)和阴性对照组(NC,n=15)．前两组以50 g／L牛磺胆酸钠逆行注入主胰管制成SAP模型,NC组开腹后仅翻动十二指肠并触摸胰腺数次关腹．制模15 min后,SAP组经股静脉以5 mL／mg注射生理盐水;BN组以BN52021(5 mg／kg)代替生理盐水静注．制模后分别于1,6,12 h采血,应用ELISA技术测定血浆TNF-α,PAF,IL-10,IL-12和sTNFR水平．结果:SAP组,NC组和BN组大鼠血浆TNF-α和PAF水平相比,具有显著性差异,SAP组(746．2±374．1,82．5±35．4 ng／L)显著高于NC组(385．1±86．3．1．1±1．9 ng／L),BN组(503．7±177．9,39．9±29．9 ng／L)显著低于SAP组(P0．05)．结论:SAP大鼠促炎细胞因子和抗炎细胞因子均显著升高．BN52021能降低血浆促炎因子含量,提高IL-12和细胞因子拮抗剂sTNFR含量．

关键词：胰腺炎细胞因子银杏苦内酯B

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Gilbert综合征合并巨幼细胞贫血1例

中国现代医学杂志 2020年第1期30卷 127-128页

作者：康虹阳佟长青河北北方学院附属第一医院血液科

Gilbert综合征(Gilbert syndrome,GS)是一种先天性血清胆红素增高症,以黄疸为主要临床表现。同时合并巨幼细胞贫血非常少见,容易造成漏诊。将河北北方学院附属第一医院血液科收治的1例GS合并巨幼细胞贫血患者报道如下。1临床资料患者,男... 详细信息

Gilbert综合征(Gilbert syndrome,GS)是一种先天性血清胆红素增高症,以黄疸为主要临床表现。同时合并巨幼细胞贫血非常少见,容易造成漏诊。将河北北方学院附属第一医院血液科收治的1例GS合并巨幼细胞贫血患者报道如下。1临床资料患者,男性,27岁。因乏力、食欲不振1个月,皮肤巩膜黄染1周,于2018年7月19日入院。患者原于1个月前大量饮酒后出现乏力、食欲不振,未引起重视。1周前发现皮肤巩膜黄染,在当地医院查血常规:白细胞3.76×10^9/L,血红蛋白92 g/L,平均红细胞体积105.9 fl,血小板84×10^9/L,考虑为血液病至本院就诊,查血常规:白细胞3.55×10^9/L,血红蛋白87 g/L,平均红细胞体积104 fl,平均红细胞血红蛋白量38.3 pg,平均红细胞血红蛋白浓度369 g/L,血小板75×10^9/L,网织红细胞3.3%;生化指标:谷草转氨酶47 u/L,总胆红素79.43μmol/L,间接胆红素69.29μmol/L,乳酸脱氢酶2025 u/L,α-羟丁酸脱氢酶2315 u/L。

关键词：吉尔伯特综合征贫血病例报道

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-Xin Yang Bao-Xia Dong tong-Bu Lu Di-chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Effect of intermittent hypoxia and hypoxia combined with training on mitochondrial fusion and fission of skeletal muscles in rats

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Effect of intermittent hypoxia and hypoxia combined with tra...

时效工艺对Cu-Cr-Zr合金带材性能和析出动力学的影响

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Zi-Quan LIU~*,Hai BO,Hai-Sheng LI,Yao DI,Hai-Ying LI,chang-qing tong Department of Physiology and pathophysiology,Medical College of Chinese People''s Armed Police Force,Tianjin 300162,China

＜正＞Objective To observe changes in mitochondrial ultrastructure and function of skeletal muscles in rats after hypoxia and hypoxia combined with training,in order to understand the effects of proper training under hypoxia on skeletal *** The animal models under hypoxia and hypoxia combined with training were set up and then the changes in mitochondrial ultrastructure of the soleus muscles were observed by an electron *** the same time mitochondrial respiratory function was measured polarographically using a Clark-type oxygen *** expression of mitochondrial protein and mRNA which taking part in mitofusin and mitofision including Mfn2 and Fis1 were detected by Western-Blotting and *** The mitochondrial network,the respiratory control rate,the expression of gene and protein of Mfn2 and Fis1 in hypoxia combined with training are all increased than that in control group and under hypoxia *** respiratory of state 4,the respiratory control rate,the expression of the gene and protein of Fis1 under hypoxia group were all increased than that in control group,otherwise the respiratory of state 3 decreased than that in control *** Hypoxia combined with proper training can increase the network of mitochondria,which can improve the mitochondrial aero-bic-metaboliz ability and enhance their accustomization to hypoxia.

关键词： intermittent hypoxia training mitochondria fusion and fission function

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Transactions of Nonferrous Metals Society of China 2023年第8期33卷 2439-2448页

作者：杨海特王文委教王晨王健周建辉童长青陈俊锋汪炳叔福州大学材料科学与工程学院福州350108 福建紫金铜业有限公司龙岩364200 龙岩学院化学与材料学院龙岩364012

通过固溶−冷轧−时效工艺制备Cu−1.0Cr−0.1Zr合金带材,研究时效工艺对合金导电率、力学性能和微观结构的影响,并进行析出动力学分析。结果表明,Cu−1.0Cr−0.1Zr合金在430℃时效180 min后获得最佳综合性能,导电率为85.86%IACS,硬度为HV 176... 详细信息

通过固溶−冷轧−时效工艺制备Cu−1.0Cr−0.1Zr合金带材,研究时效工艺对合金导电率、力学性能和微观结构的影响,并进行析出动力学分析。结果表明,Cu−1.0Cr−0.1Zr合金在430℃时效180 min后获得最佳综合性能,导电率为85.86%IACS,硬度为HV 176.54,抗拉强度为552 MPa。对于在430℃时效的样品,当时效时间从30 min增加到180 min时,细小的fcc-Cr和Cu8Zr3析出相的尺寸从~5 nm长大到~8 nm,且析出相与铜基体的关系由共格转变为半共格。同时,还观察到bcc-Cr相的棒状和球状粗大颗粒(≥300 nm)。此外,建立合金在不同时效温度下的析出动力学方程,绘制等温转变TTT曲线,通过计算获得合金的析出激活能为65 kJ/mol。

关键词： Cu−Cr−Zr合金力学性能导电率析出相析出动力学

Reconstruction of the tongue with lateral arm free flap after hemiglossectomy.

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中国口腔颌面外科杂志 2008年第B5期6卷 198-198页

作者： Liao Gui-qing Su Yu-xiong Liu Hai-chao Li Jin Wan chang-qing Zhang tong-han Department of Oral and Maxillofacial Surgery Guanghua Schoolof Stomatology Sun Yat-sen University Guangzhou 510055China

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Modeling stochastic mortality with O-U type processes

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Applied Mathematics(A Journal of Chinese Universities) 2018年第1期33卷 48-58页

作者： ZHENG Jing tong chang-qing ZHANG Gui-jun College of Economics Hangzhou Dianzi University

Modeling log-mortality rates on O-U type processes and forecasting life expectancies are explored using U.S. data. In the classic Lee-Carter model of mortality, the time trend and the age-specific pattern of mortality over age group are linear, this is not the feature of mortality model. To avoid this disadvantage, O-U type processes will be used to model the log-mortality in this paper. In fact, this model is an AR(1) process, but with a nonlinear time drift *** on the mortality data of America from Human Mortality database(HMD), mortality projection consistently indicates a preference for mortality with O-U type processes over those with the classical Lee-Carter model. By means of this model, the low bounds of mortality rates at every age are given. Therefore, lengthening of maximum life expectancies span is estimated in this paper.

关键词： mortality stochastic forecasting O-U type process

A Mixed-finite Volume Element Coupled with the Method of Characteristic Fractional Step Difference for Simulating Transient Behavior of Semiconductor Device of Heat Conductor And Its Numerical Analysis

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Acta Mathematicae Applicatae Sinica 2017年第4期33卷 1053-1072页

作者： Yi-rang YUAN qing YANG chang-feng LI tong-jun SUN Institute of Mathematics Shandong University Jinan 250100 China School of Mathematical Sciences Shandong Normal University Jinan 250014 China School of Economics Shandong University Jinan 250100 China

The mathematical system is formulated by four partial differential equations combined with initial- boundary value conditions to describe transient behavior of three-dimensional semiconductor device with heat conduction. The first equation of an elliptic type is defined with respect to the electric potential, the successive two equations of convection dominated diffusion type are given to define the electron concentration and the hole concentration, and the fourth equation of heat conductor is for the temperature. The electric potential appears in the equations of electron concentration, hole concentration and the temperature in the formation of the intensity. A mass conservative numerical approximation of the electric potential is presented by using the mixed finite volume element, and the accuracy of computation of the electric intensity is improved one order. The method of characteristic fractional step difference is applied to discretize the other three equations, where the hyperbolic terms are approximated by a difference quotient in the characteristics and the diffusion terms are discretized by the method of fractional step difference. The computation of three-dimensional problem works efficiently by dividing it into three one-dimensional subproblems and every subproblem is solved by the method of speedup in parallel. Using a pair of different grids （coarse partition and refined partition）, piecewise threefold quadratic interpolation, variation theory, multiplicative commutation rule of differential operators, mathematical induction and priori estimates theory and special technique of differential equations, we derive an optimal second order estimate in L2-norm. This numerical method is valuable in the simulation of semiconductor device theoretically and actually, and gives a powerful tool to solve the international problem presented by J. Douglas, Jr.

关键词： transient behavior of three-dimensional semiconductor device numerical simulation mixed finitevolume element modified characteristic fractional step difference second order estimate in L2 norm