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Neurochemical features of endomorphin-2-containing neurons in the submucosal plexus of the rat colon

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World Journal of Gastroenterology 2015年第34期21卷 9936-9944页

作者： jun-Ping Li Ting Zhang chang-jun gao Zhen-Zhen Kou Xu-Wen Jiao Lian-Xiang Zhang Zhen-Yu Wu Zhong-Yi He Yun-Qing Li Department of Anatomy Histology and EmbryologyK.K. Leung Brain Research CentreThe Fourth Military Medical University Department of Anatomy Histology and EmbryologyNingxia Medical University Department of Anesthesiology Tangdu HospitalThe Fourth Military Medical University

AIM:To investigate the distribution and neurochemical phenotype of endomorphin-2(EM-2)-containing neurons in the submucosal plexus of the rat ***:The mid-colons between the right and left flexures were removed from rats,and transferred into Kreb's solution. For whole-mount preparations,the mucosal,outer longitudinal muscle and inner circularmuscle layers of the tissues were separated from the submucosal layer attached to the submucosal plexus. The whole-mount preparations from each rat mid-colon were mounted onto seven gelatin-coated glass slides,and processed for immunofluorescence histochemical double-staining of EM-2 with calcitonin gene-related peptide(CGRP),choline acetyltransferase(Ch AT),nitric oxide synthetase(NOS),neuron-specific enolase(NSE),substance P(SP) and vasoactive intestinal peptide(VIP). After staining,all the fluorescence-labeled sections were observed with a confocal laser scanning microscope. To estimate the extent of the co-localization of EM-2 with CGRP,Ch AT,NOS,NSE,SP and VIP,ganglia,which have a clear boundary and neuronal cell outline,were randomly selected from each specimen for this analysis. RESULTS:In the submucosal plexus of the mid-colon,many EM-2-immunoreactive(IR) and NSE-IR neuronal cell bodies were found in the submucosal plexus of the rat mid-colon. Approximately 6 ± 4.2 EM-2-IR neurons aggregated within each ganglion and a few EM-2-IR neurons were also found outside the ganglia. The EM-2-IR neurons were also immunopositive for Ch AT,SP,VIP or NOS. EM-2-IR nerve fibers coursed near Ch AT-IR neurons,and some of these fibers were even distributed around Ch AT-IR neuronal cell bodies. Some EM-2-IR neuronal cell bodies were surrounded by SP-IR nerve fibers,but many long processes connecting adjacent ganglia were negative for EM-2 immunostaining. Long VIP-IR processes with many branches coursed through the ganglia and surrounded the EM-2-IR neurons. The percentages of the EM-2-IR neurons that were also positive for Ch AT,S

关键词： Endomorphin-2 Submucosal plexus Enteric neuron Col

Entropy of Dilatonic Black Hole due to Arbitrary Spin Fields

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Chinese Journal of Astronomy and Astrophysics 2001年第4期1卷 357-364页

作者： You-Gen Shen and chang-jun gao (Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 Institute of Theoretical Physics, Chinese Academy of Scienc Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100080

Using the membrane model based on the brick-wall model, we calculate the free energy and entropy of dilatonic black hole due to arbitrary spin fields. The result shows that the entropy of scalar field and the entropy ... 详细信息

关键词： black hole physics - entropy - spin

Microcosm study on fate and dynamics of mangrove tannins during leaf litter leaching

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Ecological Processes 2023年第1期12卷 520-533页

作者： Hai-Chao Zhou Hui-Xing Kang Jian Wei chang-jun gao Muzammil Hussain Yi-Jian Fu Ming-Dang Li Feng-Lan Li Steven Jing-Liang Xu Fred Wang-Fat Lee Ming-Guo Jiang Yi-Bing Wang Xiao-Xia Chen Nora Fung-Yee Tam Tao Lang Greater Bay Area Coastal Mangrove Wetland Research&Development Centre MNR Key Laboratory for Geo-Environmental Monitoring of Great Bay AreaCollege of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060China Institute of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface Processes of Ministry of EducationPeking UniversityBeijing 100091China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China School of Science and Technology The Hong Kong Metropolitan UniversityKowloonHong Kong 999077SARChina Guangxi Key Laboratory for Polysaccharide Materials and Modifications School of Marine Sciences and BiotechnologyGuangxi Minzu UniversityNanning 530008China State Key Laboratory of Marine Pollution City University of Hong KongKowloonHong Kong 999077SARChina

Background Mangrove tannins can participate in wetland biogeochemical ***,their fate and dynamics during leaf litter leaching have yet to be elucidated in coastal aquatic *** By using a simulated microcosm experiment,changes in leaf litter mass and tannin compounds,including total phenolics(TP),extractable condensed tannins(ECT),and bound condensed tannins(BCT),were examined in the litters and leachates of four common mangrove species:Kandelia obovata(Ko),Aegiceras corniculatum(Ac),Sonneratia apetala(Sa),and Avicennia marina(Am).Results Leaching caused a notable decline in litter mass,TP,and ECT in the leaf litter of Ko,Ac,Sa,and Am,while BCT increased significantly in Ko and *** in foliar TP was higher than in leaf litter mass,and loss in foliar ECT was higher than in TP of Ko and Ac,but Sa showed the opposite *** temporal changes of TP and ECT concentrations in leachates followed a similar trend,with an initial increase followed by a *** dynamics in Ko and Ac leachates correlated with their TP concentrations,while in Sa leachate,the peak ECT occurred 72 h later than its TP *** leachate ECT concentrations were highest in Ac,followed by Ko,and significantly lower in *** peak TP and ECT proportions in leachates accounted for 9.2-23.9%and 7.7-9.4%of the total decreases in foliar TP and ECT,*** During the leaching process,tannins’fate was species-specific,while the dynamics were almost similar.

关键词： Mangrove tannins Leaf litter decomposition Leaching Total phenolics Condensed tannins

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Preliminary Design of a System for Picking up Audio-Signals From Bubble Detectors gao Si-ze1,NI Bang-fa,ZHANG Gui-ying,XIAO Cai-jin,LIU Cun-xiong, CHEN Zhe1,NIE Peng,LIU Chao1,ZHAO chang-jun (*** of Physics Science and Engineering Technology,Guang

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Preliminary Design of a System for Picking up Audio-Signals ...

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

作者： gao Si-ze NI Bang-fa ZHANG Gui-ying XIAO Cai-jin LIU Cun-xiong CHEN Zhe NIE Peng LIU Chao ZHAO chang-jun College of Physics Science and Engineering Technology Guangxi University

This system is designed to pick up sound signals from large volume,low-threshold energy, low-background superheated droplets bubble detectors.A sound-sensitive bubble detector is composed of a container filled with a mixture of superheated droplets and gel,a temperature and pressure control system,and an audio acquisition system attached on the outer surface of the *** superheated droplets are in a metastable and superheated state at ambient temperature and *** the outside

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Nano Research 2025年第1期18卷 653-674页

作者： Qian gao Lin Tang jun Zhan Yiyuan Xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao gao Xingzhao Zhang Dacheng Ma Chuanlei Zhu jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

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亚硝酸盐暴露致雄性小鼠生殖毒性的探讨

解剖学报 2017年第5期48卷 576-584页

作者：高艳王志新常成刘俊高晓群邓锦波郑州大学基础医学院人体解剖学系郑州450001 河南大学神经生物学研究所河南开封475004

目的探讨亚硝酸盐暴露对雄性小鼠生殖毒性的分子机制。方法 36只2月龄健康雄性小鼠,随机分为对照组(生理盐水)、低剂量组(60 mg/kg)和高剂量组(120 mg/kg),每组12只进行亚硝酸盐灌胃3个月,观察小鼠的生长状况,HE染色法观察睾丸组织病理... 详细信息

目的探讨亚硝酸盐暴露对雄性小鼠生殖毒性的分子机制。方法 36只2月龄健康雄性小鼠,随机分为对照组(生理盐水)、低剂量组(60 mg/kg)和高剂量组(120 mg/kg),每组12只进行亚硝酸盐灌胃3个月,观察小鼠的生长状况,HE染色法观察睾丸组织病理变化,免疫荧光和Western blotting方法分析检测睾丸组织细胞增殖与凋亡情况及DNA甲基化、组蛋白去乙酰化相关酶的表达情况。结果亚硝酸盐暴露组小鼠较对照组小鼠体重增加缓慢,睾丸指数降低(P<0.01),形态发生病理性改变;亚硝酸盐暴露组小鼠睾丸组织细胞增殖较对照组明显减少,细胞凋亡较对照组明显增加(P<0.01);同时DNA甲基化和组蛋白去乙酰化水平高于对照组(P<0.01),且均具有剂量依赖性。结论亚硝酸盐暴露通过抑制雄性小鼠生长发育及睾丸生精细胞增殖,诱导睾丸生精细胞凋亡,造成雄性生殖毒性;DNA甲基化及组蛋白去乙酰化水平升高,提示表观遗传学可能参与了亚硝酸盐暴露对雄性生殖系统的损伤过程及调控机制。

关键词：亚硝酸盐生殖毒性 DNA甲基化组蛋白去乙酰化免疫印迹法小鼠

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya gao Shuyue Li Cui chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

湘西李梅铅锌矿区外围地层碳酸盐岩地球化学特征及其意义

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矿物学报 2017年第4期37卷 427-433页

作者：张旭阳杨阳吕古贤薛长军高伟利苗强军长安大学地球科学与资源学院陕西西安710064 中国地质科学院地质力学研究所北京100081 中国地质大学(北京)地球科学与资源学院北京100083

为了探讨湘西李梅矿区碳酸盐岩沉积时期古环境的指示特征,对矿区外围下寒武统清虚洞组灰岩、白云岩和高台组纹层状白云岩进行了元素地球化学分析。结果表明:1)Sr与Ca O,Si、Al、K和Fe,Si、Al、K、V和Ti相互之间具有密切相关性,反映了清... 详细信息

为了探讨湘西李梅矿区碳酸盐岩沉积时期古环境的指示特征,对矿区外围下寒武统清虚洞组灰岩、白云岩和高台组纹层状白云岩进行了元素地球化学分析。结果表明:1)Sr与Ca O,Si、Al、K和Fe,Si、Al、K、V和Ti相互之间具有密切相关性,反映了清虚洞期到高台期碳酸盐岩沉积受陆源物质和成岩作用的影响有限。2)碳酸盐岩中∑REE含量较低,稀土元素分异程度较弱,轻稀土元素相对重稀土元素呈轻微富集特征,符合海相碳酸盐岩稀土含量较低的典型特征。3)研究区岩石学特征和元素地球化学特征所反映的沉积环境相一致性,对岩石地球化学特征的研究有益于古沉积环境恢复和古气候的判别与重建。岩石学和地球化学特征指示了研究区清虚洞期到高台期海相碳酸盐岩沉积环境为由潮湿到干旱的气候变化,古海水温为暖水环境,古海水介质为氧化条件的意义。

关键词：清虚洞组-高台组碳酸盐岩主、微量元素沉积环境湘西李梅矿区