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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo En Ning chang Liu yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Contrasting strategies of optimizing carrier concentration in bulk InSe for enhanced thermoelectric performance

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Rare Metals 2024年第9期43卷 4425-4432页

作者： Hao-Nan Shi Shu-Lin Bai yu-Ping Wang Li-Zhong Su Qian Cao Cheng chang Li-Dong Zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Huabei Cooling Device Co.Ltd. Hebei 065400China

Indium selenide(InSe),as a wide-bandgap semiconductor,has received extensive attention in the flexible electronics field in recent years due to its exceptional plasticity and promising thermoelectric ***,the low carrier concentration severely limits its thermoelectric performance *** this work,we conducted contrasting strategies that can be employed to increase the carrier concentration of InSe,including bandgap narrowing and heterovalent ***,the carrier concentration initially increases as a result of the reduced bandgap upon Te alloying and then slightly decreases due to the weak electronegativity of *** Br doping realizes high carrier concentration by pushing the Fermi level into the conduction bands and activating the multiple *** the other hand,both Te and Br obviously suppress the thermal conductivity due to the point defect *** contrast,Br doping realizes a higher thermoelectric performance with a maximum ZT of~0.13 at 773 K benefiting from the better optimization of carrier *** work elucidates the strategies for enhancing carrier concentration at anion sites and demonstrates the high efficiency of halogen doping in ***,the carrier concentration of InSe is promising to be further optimized,and future work should focus on employing approaches such as cation doping or secondphase compositing.

关键词： Thermoelectric InSe Carrier concentration Bandgap Heterovalent doping

Advanced nanofabrication for elastic inorganic aerogels

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Nano Research 2024年第10期17卷 8842-8862页

作者： Xiaota Cheng Xinyi chang Fan Wu Yalong Liao Kai Pan Hao Fong Jianyong yu Yi-Tao Liu Bin Ding Innovation Center for Textile Science and Technology College of TextilesDonghua UniversityShanghai 201620China Aerospace Institute of Advanced Material and Processing Technology Beijing 100074China College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China

Inorganic aerogels with low density,high porosity,large specific surface area,and superior mechanical properties are excellent candidate materials in fields such as thermal management,energy,catalysis,and biomedical applications.A comprehensive overview of existing elastic inorganic aerogels is provided,covering their structural units,preparation methods,mechanical performances,and ***,based on the constituent building blocks and microstructures,a detailed analysis of the mechanical properties and guidelines for elastic design of aerogels is *** with a succinct summary of prospective developmental direction,this review deliberates on the challenges and potential opportunities of elastic inorganic aerogels,with the intent of providing a versatile platform for designing new types of elastic inorganic aerogels for various applications.

关键词： inorganic aerogels compressive stretchable fabrication mechanical performances applications

Advancements in machine learning for material design and process optimization in the field of additive manufacturing

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China Foundry 2024年第2期21卷 101-115页

作者： Hao-ran Zhou Hao Yang Huai-qian Li Ying-chun Ma Sen yu Jian shi Jing-chang Cheng Peng Gao Bo yu Zhi-quan Miao Yan-peng Wei National Key Laboratory of Advanced Casting Technologies Shenyang Research Institute of Foundry Co.Ltd.CAMShenyang 110022China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory of Space Physics Beijing 100076China School of Materials Science and Engineering Nanyang Technological University639798Singapore

Additive manufacturing technology is highly regarded due to its advantages,such as high precision and the ability to address complex geometric ***,the development of additive manufacturing process is constrained by issues like unclear fundamental principles,complex experimental cycles,and high *** learning,as a novel artificial intelligence technology,has the potential to deeply engage in the development of additive manufacturing process,assisting engineers in learning and developing new *** paper provides a comprehensive overview of the research and applications of machine learning in the field of additive manufacturing,particularly in model design and process ***,it introduces the background and significance of machine learning-assisted design in additive manufacturing *** then further delves into the application of machine learning in additive manufacturing,focusing on model design and process ***,it concludes by summarizing and forecasting the development trends of machine learning technology in the field of additive manufacturing.

关键词： additive manufacturing machine learning material design process optimization intersection of disciplines embedded machine learning

Crossed renal ectopia with rectal cancer:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2122-2127页

作者： Zhen-Wei Tang Hui-Feng Yang Zhao-yu Wu chang-You Wang Department of General Surgery North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Crossed renal ectopia(CRE)occurs when one kidney crosses the midline from the primary side to the contralateral side while the ureter remains on the primary *** cancer,one of the most common malignant tumors of the digestive tract,refers to cancer from the dentate line to the rectosigmoid *** concurrent presentation of CRE alongside rectal cancer is an uncommon clinical *** SUMMARY Herein,we report a 69-year-old male patient with rectal cancer who was diagnosed with CRE via computed tomography during *** thorough preoperative evaluations,the patient underwent Dixon *** We performed laparoscopic radical resection of rectal cancer and adequate lymph node removal in a patient with CRE with no postoperative discomfort.

关键词： Rectal cancer Crossed renal ectopia Anatomy Laparoscopic surgery Case report

Preoperative blood markers and intra-abdominal infection after colorectal cancer resection

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 451-462页

作者： chang-Qing Liu Zhong-Bei yu Jin-Xian Gan Tian-Ming Mei Department of Gastrointestinal Anorectal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina

BACKGROUND Colorectal cancer(CRC)has one of the highest morbidity and mortality rates among digestive tract ***-abdominal infection(IAI)is a common postoperative complication that affects the clinical outcomes of patients with CRC and hinders their rehabilitation ***,the factors influencing abdominal infection after CRC surgery remain unclear;further,prediction models are rarely used to analyze preoperative laboratory indicators and postoperative *** To explore the predictive value of preoperative blood markers for IAI after radical resection of *** The data of 80 patients who underwent radical resection of CRC in the Anorectal Surgery Department of Suzhou Hospital affiliated with Anhui Medical University were *** patients were categorized into IAI(n=15)and non-IAI groups(n=65)based on whether IAI *** factors were compared;general data and laboratory indices of both groups were *** relationship between the indicators was ***,a nomogram prediction model was developed and evaluated;its utility and clinical applic-ability were *** The risk factors for IAI after radical resection of CRC were neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR),systemic immune-inflammation index(SII),and carcinoembryonic antigen(CEA)*** was correlated with PLR and SII(r=0.604,0.925,and 0.305,respectively),while PLR was correlated with SII(r=0.787).The nomogram prediction model demonstrated an area under the curve of 0.968[95%confidence interval(CI):0.948-0.988]in the training set(n=60)and 0.926(95%CI:0.906-0.980)in the validation set(n=20).The average absolute errors of the calibration curves for the training and validation sets were 0.032 and 0.048,respectively,indicating a good model *** decision curve analysis curves demonstrated high net income above the 5%threshold,indicating the clinical practicality of the *** The nomogram model constructed

关键词： Radical resection of colorectal cancer Inflammatory factors Intra-abdominal infection Predictive model Blood markers

Microstructure and mechanical properties of Co-28Cr-6Mo-0.22C investment castings by current solution treatment

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China Foundry 2024年第4期21卷 369-378页

作者： Ze-yu Dan Jun Liu Jian-lei Zhang Yan-hua Li yuan-xin Deng yun-hu Zhang chang-jiang Song Center for Advanced Solidification Technology School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Wuxi CastPro Precision Co. Ltd.Wuxi 214105JiangsuChina

This study examined the impact of current solution treatment on the microstructure and mechanical properties of the Co-28Cr-6Mo-0.22C alloy investment *** findings reveal that the current solution treatment significantly promotes the dissolution of carbides at a lower *** optimal conditions for solution treatment are determined as a solution temperature of 1,125°C and a holding time of 5.0 *** these parameters,the size and volume fraction of precipitated phases in the investment castings are measured as6.2μm and 1.1vol.%.The yield strength,ultimate tensile strength,and total elongation of the Co-28Cr-6Mo-0.22C investment castings are 535 MPa,760 MPa,and 12.6%,*** values exceed those obtained with the conventional solution treatment at 1,200°C for 4.0 *** findings suggest a phase transformation of M_(23)C_(6)→σ+C following the current solution treatment at 1,125°C for 5.0 *** comparison,the traditional solution treatment at 1,200°C for 4.0 h leads to the formation of M_(23)C_(6)and M_(6)C *** is noteworthy that the non-thermal effect of the current during the solution treatment modifies the free energy of both the matrix and precipitation *** modification lowers the phase transition temperature of the M_(23)C_(6)→σ+C reaction,thereby facilitating the dissolution of *** a result,the current solution treatment approach achieves carbide dissolution at a lower temperature and within a significantly shorter time when compared to the traditional solution treatment methods.

关键词： CoCrMo alloy investment castings current solution treatment microstructure mechanical property carbide

SMXL5 attenuates strigolactone signaling in Arabidopsis thaliana by inhibiting SMXL7 degradation

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Molecular Plant 2024年第4期17卷 631-647页

作者： Qingtian Li Haiyang yu Wenwen chang Sunhyun chang Michael Guzman Lionel Faure Eva-Sophie Wallner Heqin Yan Thomas Greb Lei Wang Ruifeng Yao David C.Nelson Department of Botany and Plant Sciences University of CaliforniaRiversideRiversideCA 2521USA Yazhouwan National Laboratory Sanya 572025China Hainan Seed Industry Laboratory Sanya 57205China State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental RegulationCollege of BiologyHunan UniversityChangsha 410082China Key Laboratory of Seed Innovation Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuangHebei 050021China University of Chinese Academy of Sciences Beijing 10004China School of the Sciences Biology DivisionTexas Woman’s UniversityDentonTX 76204USA Centre for Organismal Studies(COS) Heidelberg University6120 HeidelbergGermany

Hormone-activated proteolysis is a recurring theme of plant hormone signaling *** strigolactone signaling,the enzyme receptor DWARF14(D14)and an F-box protein,MORE AXILLARY GROWTH2(MAX2),mark SUPPRESSOR OF MAX21-LIKE(SMXL)family proteins SMXL6,SMXL7,and SMXL8 for rapid *** of these transcriptional corepressors initiates downstream growth *** homologous proteins SMXL3,SMXL4,and SMXL5,however,are resistant to MAX2-mediated *** discovered that the smxl4 smxl5 mutant has enhanced responses to ***5 attenuates strigolactone signaling by interfering with AtD14-SMXL7 ***5 interacts with AtD14 and SMXL7,providing two possible ways to inhibit SMXL7 ***5 function is partially dependent on an ethylene-responsive-element binding-factor-associated amphiphilic repression(EAR)motif,which typically mediates interactions with the TOPLESS family of transcriptional ***,we found that loss of the EAR motif reduces SMXL5-SMXL7 interactions and the attenuation of strigolactone signaling by *** hypothesize that integration of SMXL5 into heteromeric SMXL complexes reduces the susceptibility of SMXL6/7/8 proteins to strigolactone-activated degradation and that the EAR motif promotes the formation or stability of these *** mechanism may provide a way to spatially or temporally fine-tune strigolactone signaling through the regulation of SMXL5 expression or translation.

关键词： Arabidopsis typically inhibiting

Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu yu-Ya Wang Gui-Tao Huo Yan-Wei Yang Nan Xu Hong Wang Yong Wu yu-Fa Miao Rui Fu yu-Wei Zhao chang-Fa Fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

Metal-Free Electrochemical Trifluoromethylation of Imidazole-Fused Heterocycles with Trifluoromethyl Thianthrenium Triflate

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Chinese Journal of Chemistry 2024年第15期42卷 1679-1685页

作者： chang Ge Lipeng Qiao yuyang Zhang Kai Sun jangzhen An Mei Peng Xiaolan Chen Lingbo Qu Bing yu College of Chemistry Zhengzhou UniversityZhengzhouHenan 450001China National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass Nanjing Forestry UniversityNanjingJiangsu210037China School of Pharmacy Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

A novel and eco-friendly electrochemical activation of trifluoromethyl thianthrenium triflate(TT-CF_(3)^(+)OTf^(-))for trifluoromethylation of imidazole-fused heteroaromatic compounds was *** method involves the direct electrolysis of TT-CF_(3)^(+)OTf^(-)without the requirement of external oxidants or catalysts,aligning with the principles of green chemistry.A wide range of imidazole-fused heteroaromatic compounds including imidazo[1,2-a]pyridines and benzo[d]imidazo[2,1-b]thiazoles have been successfully trifluoromethylated using this technique,exhibiting excellent compatibility with various functional groups and a broad substrate ***,the method's applicability for one-pot sequential reactions enables the reduction of waste and resource consumption by eliminating the need for intermediate purification steps.

关键词： Trifluoromethylation Electrochemical Metal-free Imidazole-fused heterocycles Thianthrenium