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多西他赛联合阿帕替尼二线治疗进展期非小细胞肺癌的临床研究

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中国临床药理学杂志 2019年第22期35卷 2812-2814,2818页

作者：俞昌赫延边大学附属医院呼吸内科

目的观察多西他赛联合阿帕替尼二线治疗进展期非小细胞肺癌临床效果及对无进展生存期的影响。方法将76例进展期非小细胞肺癌患者随机分为试验组(n=38)和对照组(n=38)。对照组给予多西他赛60 mg·m^-2,每天1次,静脉滴注;试验组在对照组... 详细信息

目的观察多西他赛联合阿帕替尼二线治疗进展期非小细胞肺癌临床效果及对无进展生存期的影响。方法将76例进展期非小细胞肺癌患者随机分为试验组(n=38)和对照组(n=38)。对照组给予多西他赛60 mg·m^-2,每天1次,静脉滴注;试验组在对照组基础上给予阿帕替尼250 mg,每天1次,口服,21d为1个周期。化疗2个周期后,比较2组血清指标、疗效、无进展生存期和药物不良反应发生情况。结果治疗后,试验组客观缓解率(ORR)和疾病控制率(DCR)分别为18.42%和65.79%,对照组分别为10.53和47.37%,差异均无统计学意义(均P>0.05)。治疗后,试验组癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、血管内皮生长因子(VEGF)和基质金属蛋白酶9(MMP-9)分别为(8.58±1.32)μg·L^-1,(3.91±0.63)μg·L^-1,(291.53±31.34)ng·L^-1,(873.92±90.65)μg·L^-1,对照组分别为(13.19±2.47)μg·L^-1,(5.62±0.58)μg·L^-1,(493.16±42.48)ng·L^-1,(1245.68±120.59)μg·L^-1,差异均有统计学意义(均P<0.05)。试验组复发病例数10例,对照组复发为18例,2组无进展生存率差异有统计学意义(P<0.05)。治疗过程中,2组均出现恶心呕吐、口腔黏膜炎、血小板减少、血红蛋白减少,试验组口腔黏膜炎发生率为7.89%(3例/38例),显著低于对照组23.68%(9例/38例,P<0.05)。结论多西他赛联合阿帕替尼二线治疗进展期非小细胞肺癌近期疗效较好,可降低肿瘤标志物的表达,延长无进展生存期。

关键词：非小细胞肺癌多西他赛阿帕替尼无进展生存期癌胚抗原

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软件定义网络一致性协同更新算法

电子学报 2018年第10期46卷 2341-2346页

作者：于倡和兰巨龙胡宇翔国家数字交换系统工程技术研究中心河南郑州450002

为实现软件定义网络的一致性更新,本文提出一种协同利用分段路由、顺序更新、两步复制三种机制的更新算法.算法首先启用分段路由机制,尝试用现有路径规则拼接待更新数据流的最终路径,并根据最终路径是否能由现有规则拼接,将数据流分为... 详细信息

为实现软件定义网络的一致性更新,本文提出一种协同利用分段路由、顺序更新、两步复制三种机制的更新算法.算法首先启用分段路由机制,尝试用现有路径规则拼接待更新数据流的最终路径,并根据最终路径是否能由现有规则拼接,将数据流分为可拼接与不可拼接两种.对于可拼接流,分段路由可将最终路径信息封装入数据包包头,使得数据包能立即沿最终路径转发.对于不可拼接流,算法计算最长一致性更新序列,并按照此序列依次更新节点,最后利用两步复制机制来完成剩余未更新节点的更新.并且经实验验证,算法比之前研究提出的算法不仅消耗更少的三态内容寻址存储器的空间资源,并且有更好的适用性与稳定性.

关键词：一致性更新分段路由 OpenFlow

Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on lymphangiogenesis of gastric cancer in a nude mouse model

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Chinese Medical Journal 2008年第21期121卷 2167-2171页

作者： WANG Liang CAI Shi-rong ZHANG chang-hua he yu-long ZHAN Wen-hua WU Hui PENG Jian-jun Department of Gastroenteropancreatic Surgery First Affiliated Hospital Center of Gastric Cancer Sun Yat-sen University Guangzhou Guangdong 510080 China

Background Angiotensin-converting enzyme inhibitors （ACEI） and angiotensin II type 1 receptor blockers （ARB） can inhibit tumor growth by inhibition of angiogenesis. This study was designed to study the anticancer effects of ACEI and ARB on tumor growth and lymphangiogenesis in an implanted gastric cancer mouse model. Methods A model of gastric cancer was established by subcutaneously inoculating human gastric cancer cell line SGC-7901 into 60 nude mice. One week later, all mice were randomly divided into 5 groups. A control group received physiologic saline once daily for 21 days. Mice in the 4 treatment groups received one of the following agents by gavage once daily for 21 days： perindopril, 2 mg/kg; captopril, 5 mg/kg; Iosartan, 50 mg/kg; or valsartan, 40 mg/kg. Twenty-one days after treatment, all the mice were sacrificed and the tumors were removed. Tumor sections were processed, and immunohistochemical methods were used to observe the expressions of vascular endothelial growth factor C （VEGF-C）, matrix metalloproteinase 7 （MMP-7）, and lymphatic microvessel density （LMVD）. Results Tumor volume was significantly inhibited in all ACEI and ARB groups, compared with the control group （all P 〈0,01）. LMVD in the ACEI and ARB groups was also significantly lower than that of the control group （all P 〈0.01）. In the ACEI groups, the expressions of VEGF-C and MMP-7 were both significantly decreased, compared with the control group （all P 〈0.05）. In the ARB groups, expression of VEGF-C was significantly decreased compared with the control group （all P 〈0.05）. However, no significant difference was found in the expression of MMP-7 between ARB groups and the control group. Conclusion In a mouse model, ACEI and ARB might inhibit gastric cancer tumor growth by suppressing lymphangiogenesis.

关键词： stomach neoplasms angiotensin-converting enzyme inhibitor angiotensin Ⅱ type Ⅰ receptor blocker lymphangiogenesis

Fast track surgery accelerates the recovery of postoperative insulin sensitivity

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Chinese Medical Journal 2012年第18期125卷 3261-3265页

作者： YANG Dong-jie ZHANG Sheng he Wei-ling CheN Hua-yun CAI Shi-rong CheN Chuang-qi SONG Xin-ming CUI Ji MAJin-pingI ZHANG chang-hua he yu-long Department of Gastrointestinal-Pancreatic Surgery the FirstAffiliated Hospital of Sun Yat-Sen University Guangzhou China Guangdong 510080

Background Few clinical studies or randomized clinical trial results have reported the impact of fast track surgery on postoperative insulin sensitivity. This study aimed to investigate the effects of fast track surgery on postoperative insulin sensitivity in patients undergoing elective open colorectal resection. Methods Controlled, randomized clinical trial was conducted from November 2008 to January 2009 with one-month post-discharge follow-up. Seventy patients with colorectal carcinoma requiring colorectal resection were randomized into two groups： a fast track group （35 cases） and a conventional care group （35 cases）. All included patients received elective open colorectal resection with combined tracheal intubation and general anesthesia. Clinical parameters （complication rates, return of gastrointestinal function and postoperative length of stay）, stress index and insulin sensitivity were evaluated in both groups perioperatively. Results Sixty-two patients finally completed the study, 32 cases in the fast-track group and 30 cases in the conventional care group. Our findings revealed a significantly faster recovery of postoperative insulin sensitivity on postoperative day 7 in the fast-track group than that in the conventional care group. We also found a significantly shorter length of postoperative stay and a significantly faster return of gastrointestinal function in patients undergoing fast-track rehabilitation. Conclusion Fast track surgery accelerates the recovery of postoperative insulin sensitivity in elective surgery for colorectal carcinoma with a shorter length of postoperative hospital stay.

关键词： fast track surgery colorectal carcinoma, insulin sensitivity, clinical trial

低信噪比下相干信号的DOA估计的白噪声滤除方法

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信号处理 2012年第7期28卷 957-962页

作者：余昌和李建黎电子科技大学自动化工程学院成都611731

在波达方向估计中,"相干"和"信噪比"一直引人关注。相干会使多重信号分类等算法失效,究其原因就是信源协方差矩阵的秩亏缺。低信噪比使阵列协方差矩阵的主次特征值区分困难,造成信号和噪声的子空间划分错误。针对相干,人们往往都是从"... 详细信息

在波达方向估计中,"相干"和"信噪比"一直引人关注。相干会使多重信号分类等算法失效,究其原因就是信源协方差矩阵的秩亏缺。低信噪比使阵列协方差矩阵的主次特征值区分困难,造成信号和噪声的子空间划分错误。针对相干,人们往往都是从"解相干"的角度出发,通过各种手段使信源的协方差矩阵能够满秩,但并未对秩亏缺特性加以利用。基于此,本文给出了一种在低信噪比下对相干源的波达方向估计的噪声消除方法,在仅有加性白噪声的环境下,利用相干信号协方差矩阵不能满秩的特点,通过求解方程组,用求的值代替估计的协方差矩阵的相关对角元素(即对角加载处理),置换被噪声污染的对角元素,进而可以滤除掉白噪声的影响。仿真结果证实了方法的有效性。

关键词：相干信号波达方向估计白噪声滤除多重信号分类算法前后向空间平滑算法

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo En Ning chang Liu yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

基于文献报道中医古方治疗前列腺癌的用药分析

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中草药 2021年第18期52卷 5688-5696页

作者：吴威李楠于长禾张会永珠海科技学院广东珠海519041 辽宁中医药大学中医脏象理论及应用国家教育部重点实验室辽宁沈阳110847 北京中医药大学东直门医院北京100700 辽宁中医药大学附属医院辽宁沈阳110032

目的基于文献报道,回顾总结中医古方辨证治疗前列腺癌的临床应用情况,为进一步开展古方治疗前列腺癌现代临床应用及其药效学机制研究提供指导。方法通过中国全文期刊数据库(CNKI)、维普中文期刊服务平台、万方数据知识服务平台,将检索... 详细信息

目的基于文献报道,回顾总结中医古方辨证治疗前列腺癌的临床应用情况,为进一步开展古方治疗前列腺癌现代临床应用及其药效学机制研究提供指导。方法通过中国全文期刊数据库(CNKI)、维普中文期刊服务平台、万方数据知识服务平台,将检索时间限定为自建库到2020年7月4日,查阅中医或中西医结合运用古方辨证治疗前列腺癌的相关文献并追溯综述类文章,将涉及的古方与对应证型的名称规范化并按功能分类整理方剂,运用SPSS26.0软件对不同古方治疗前列腺癌的使用频数进行分析,运用Cytoscape软件对古方-功能类别-证型的复杂网络进行可视化分析。结果从3大数据库中共检索到中医古方治疗前列腺癌相关不重复文献共2025篇,依据研究目的共纳入医家经验38篇,病例报道14篇。证型规范后有34种,湿热蕴结证最常见,频率为10.7%,其次是肝肾阴虚证和瘀血内阻证,频率皆为8.4%,气血两虚证频率为7.6%。共得到古方64种,功能类别以补益剂、祛湿剂和理血剂为主,单个古方使用频率由高到低依次为六味地黄丸8.3%、八正散7.7%、知柏地黄丸5.9%、肾气丸4.1%、四君子汤4.1%等。古方-功能类别-证型的网络分析亦证实这一结论,六味地黄丸在网络中的关联程度最高,方剂对应的证型多为肝肾阴虚证、瘀血内阻证、湿热蕴结证等。结论通过对中医古方治疗前列腺癌的临床经验的梳理和总结可为古方治疗前列腺癌现代临床应用提供参考和指导,但其药效学机制仍需深入探究。

关键词：前列腺癌中医古方功能类别证型临床应用

Degradation of 1,1,2,2-tetrachloroethane by Mechanochemical Method

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Meteorological and Environmental Research 2011年第11期2卷 60-63页

作者： TANG Xiao-lin,MENG chang-yu,he Xing-cun,HUANG Zhi,CheN Meng-lin Guangxi Normal University,Guilin 541004,China

[Objective]We aimed to study the degradation of 1,1,2,2-tetrachloroethane by mechanochemical method.[Method] Nano-scale NiO particles were prepared by homogeneous precipitation method using nickel sulfate hexahydrate NiSO 4 ·6H 2 O as a raw material and ammonium carbonate (NH 4) 2 CO 3 as *** catalytic effect of NiO on the degradation of 1,1,2,2-tetrachloroethane has been investigated.[Result]The concentrations of chloride ion increased as the enhancement of initial concentrations of tetrachloroethane and amounts of catalyst,and the degradation efficiency of tetrachloroethane in water were influenced by the initial concentrations of tetrachloroethane,amounts of catalyst and so on.[Conclusion] This research could provide a novel method for the degradation of 1,1,2,2-tetrachloroethane as an organic pollutant.

关键词： NiO 1,1,2,2-tetrachloroethane Mechanical agitation Dechlorination China

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan he Weitai Chai Meng Tian Huali yu Xiaoxiao he Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan