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Interleukin-4 promotes microglial polarization toward a neuroprotective phenotype after retinal ischemia/reperfusion injury

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Neural Regeneration Research 2022年第12期17卷 2755-2760页

作者： Di Chen Cheng Peng Xu-Ming Ding Yue Wu chang-Juan Zeng li Xu Wen-Yi Guo Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiChina

Glaucoma results from irreversible loss of retinal ganglion cells(RGCs)through an unclear *** polarization and neuroinflammation play an important role in retinal *** study aimed to explore the function of microglial polarization during glaucoma progression and identify a strategy to alleviate retinal *** ischemia/reperfusion injury was induced in C57BL/6 *** a separate cohort of animals,interleukin(IL)-4(50 ng/mL,2μL per injection)or vehicle was intravitreally injected after retinal ischemia/reperfusion *** loss was assessed by counting cells that were positive for the RGC marker RNA binding protein,mRNA processing factor in retinal flat *** expression of classically activated(M1)and alternatively activated(M2)microglial markers were assessed by quantitative reverse transcription-polymerase chain reaction,immunofluorescence,and western *** results showed that progressive RGC loss was accompanied by a continuous decrease in M2 microglia during the late phase of the 28-day period after retinal ischemia/reperfusion ***-4 was undetectable in the retina at all time points,and intravitreal IL-4 administration markedly improved M2 microglial marker expression and ameliorated RGC loss in the late phase post-retinal ischemia/reperfusion *** summary,we observed that IL-4 treatment maintained a high number of M2 microglia after RIR and promoted RGC survival.

关键词： glaucoma hyper-intraocular pressure in vivo interleukin-4 intravitreal injection M2 microglia neurodegeneration neuroprotective effect retinal ganglion cell retinal ischemia-reperfusion

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有限域上两类线性码的构造

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河南师范大学学报（自然科学版） 2024年第3期52卷 98-105页

作者：李文婷衡子灵李晓茹长安大学理学院西安710064

利用定义集的方法构造了两类p元线性码,研究了它们的参数和重量分布.第一类线性码为三重极小码,可用于构造具有安全高效访问结构上的密钥共享方案.第二类线性码为二重线性码,且当p=3时为自正交射影码,可用于构造量子码和强正则图.

关键词：线性码自正交码极小码重量分布

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Hoxc13/β-catenin Correlation with Hair Follicle Activity in Cashmere Goat

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Journal of Integrative Agriculture 2012年第7期11卷 1159-1166页

作者： WU Jiang-hong ZHANG Yan-jun ZHANG Jia-xin chang Zi-li li Jin-quan YAN Zu-wei Husile ZHANG Wen-guang Key Laboratory of Animal Genetics Breeding and Reproduction Inner Mongolian Autonomous Region Hohhot 010018 P.R.China College of Animal Science Inner Mongolia Agricultural University Hohhot 010018 P.R.China College of Science Inner Mongolia Agricultural University Huhhot 010018 P.R.China

Seasonal hair follicle activity and fibre growth in some Cashmere-bearing goats （Caprus hircus） is a cyclic process that is well characterized morphologically but understood incompletely at the molecular level. As an initial step in discovering regulators in hair-follicle activity and cycling, we used qPCR to investigate 19 genes expression in Cashmere goat side skin from 12 mon. Many of these genes may be associated with the hair follicle development-relevant genes （HFDRGs） in the literature. Here we show that Hoxc13/β-catenin gene associated with the follicle activity. In addition, Hoxc13 was found to be expressed with an drastic increase between July and November for melatonin treatments. To further investigate the role of Hoxcl3 on HFDRGs, fibroblasts and keratinocytes from Cashmere goat skin were transfected with p-ECFP- Hoxc13. The result suggested that overexpression ofHoxcl3 gene decreased HFDRGs with negative role for hair follicle development and increase HFDRGs with positive role for hair follicle development in vitro. These findings provide data on the Hoxc13 expression profile of normal Cashmere goat skin and Cashmere goat skin with melatonin treatment, and demonstrate hair-follicle-activity dependent regulation of Hoxc13 expression.

关键词： Hoxcl3 β-catenin Cashmere goat hair follicle activity cycle

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基于遥感+GIS的山火检测及火势蔓延监控平台实现

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灾害学 2024年第1期39卷 51-56页

作者：杨知刘宇舜李闯张思航朱理宏刘彬刘畅张振威徐英辉中国电力科学研究院有限公司北京100010 国网安徽省电力有限公司电力科学研究院安徽合肥230601 安徽送变电工程有限公司安徽合肥230601

基于遥感与Web GIS技术,构建了山火检测及火势蔓延监控平台,主要包括多模型联合的火点检测、基于Rothermel模型的地表火蔓延模拟和基于粒子模拟的三维可视化等功能。系统在多源遥感数据的基础上,联合多项火点检测模型,实现高温异常点的... 详细信息

基于遥感与Web GIS技术,构建了山火检测及火势蔓延监控平台,主要包括多模型联合的火点检测、基于Rothermel模型的地表火蔓延模拟和基于粒子模拟的三维可视化等功能。系统在多源遥感数据的基础上,联合多项火点检测模型,实现高温异常点的定位,并模拟不同下垫面及气象等因子影响下的火势蔓延过程,进而建立直观的可视化模拟。文章以大同市森林火灾为例,验证系统的可行性,结果表明该系统能够有效检测火点并模拟预测火势蔓延情况,对于提高山区森林防灭火工作水平,减少人员伤亡和财产损失,保护生态环境提供技术支撑。

关键词：山火检测火势蔓延模拟遥感三维可视化

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MiR-21-5p-expressing bone marrow mesenchymal stem cells alleviate myocardial ischemia/reperfusion injury by regulating the circRNA_0031672/miR-21-5p/programmed cell death protein 4 pathway

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Journal of Geriatric Cardiology 2021年第12期18卷 1029-1043页

作者： Jing ZHANG chang-Jun LUO Xiao-Qi XIONG Jun li San-Hua TANG lin SUN Qiang SU Department of Cardiovascular Medicine Liuzhou Municipal Liutie Central HospitalLiuzhouChina Department of Clinical Laboratory Liuzhou Municipal Liutie Central HospitalLiuzhouChina Department of Cardiology Affiliated Hospital of Guilin Medical UniversityGuangxiChina

BACKGROUND For patients with coronary heart disease,reperfusion treatment strategies are often complicated by ischemia/reperfusion(I/R)injury(IRI),leading to serious organ damage and *** miR-21/programmed cell death protein 4(PDCD4)pathway is involved in the IRI of cardiomyocytes;however,the aberrant miR-21 expression remains ***,this study aimed to explore whether circRNA_0031672 downregulates miR-21-5p expression during I/R and to dete-rmine whether miR-21-5p-expressing bone marrow mesenchymal stem cells(BMSCs)reduce myocardial *** CircRNA_0031672,miR-21-5p,and PDCD4 expressions were evaluated in the I/R rat model and hypoxia/re-oxy-genation(H/R)-treated H9C2 *** interactions were subsequently investigated using luciferase reporter and RNA pull-down ***-like 3,a methyltransferase catalyzing N6-methyladenosine(m6A),was overexpressed in H9C2 cells to determine whether m6A modification influences miR-21-5p targeting *** stably expressing miR-21 were co-cultured with H9C2 cells to investigate the protective effect of BMSCs on H9C2 cells upon H/*** I/R downregulated miR-21-5p expression and upregulated circRNA_0031672 and PDCD4 ***_0031672 knockdown increased miR-21-5p expression,but repressed PDCD4 expression,indicating that circRNA_0031672 com-petitively bound to miR-21-5p and prevented it from targeting PDCD4 *** m6A modification regulated PDCD4 expres-sion,but had no effect on miR-21-5p targeting *** circRNA_0031672/miR-21-5p/PDCD4 axis regulated myocardial cells viability and apoptosis after H/R treatment;co-culture with miR-21-5p-expressing BMSCs restored miR-21-5p abundance in H9C2 cells and further reduced H9C2 cells apoptosis induced by H/*** We identified a novel circRNA_0031672/miR-21-5p/PDCD4 signaling pathway that mediates the apoptosis of cardiomyocytes and successfully alleviates IRI in myocardial cells by co-culture with miR-21-5p-expres

关键词： protective expressing injury

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Ni单原子负载氮掺杂多孔碳促进锂硫电池中的多硫化物转化

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Science China Materials 2024年第6期67卷 1938-1946页

作者：陈乐园孙焱焱常智柴思敏何琼潘安强 School of Materials Science and Engineering Central South UniversityChangsha 410083China School of Materials Science and Engineering Xinjiang UniversityUrumqi 830046China

由分散在氮掺杂碳载体上的原子级金属位点组成的单原子催化剂(M SAC@NC)因其具有最大的原子利用率、独特的物理化学性质和优异的催化活性,已成为li-S电池中的高性能电催化材料.本文采用物理吸附和热解相结合的方法,成功制备了一系列具... 详细信息

由分散在氮掺杂碳载体上的原子级金属位点组成的单原子催化剂(M SAC@NC)因其具有最大的原子利用率、独特的物理化学性质和优异的催化活性,已成为li-S电池中的高性能电催化材料.本文采用物理吸附和热解相结合的方法,成功制备了一系列具有相似结构和理化性质的M SAC@NC(M=Ni,Co,Fe).双球差校正高角环形暗场扫描透射电子显微镜和X射线吸收光谱表明成功形成了单原子金属位点.此外,对硫氧化还原反应的催化活性趋势为Ni SAC@NC>Co SAC@NC>Fe SAC@NC,其中Ni SAC@NC在0.5C下表现出1280.6mAh g^(-1)的最高容量,循环800次后,平均每圈容量衰减率仅为0.07%,具有优异的电池性能.

关键词： single-atomic catalyst electrocatalysis li-S battery

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Evodiamine inhibits high-fat diet-induced colitis-associated cancer in mice through regulating the gut microbiota

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Journal of Integrative Medicine 2021年第1期19卷 56-65页

作者： li-qing Zhu li Zhang Jia Zhang Guo-lin chang Gang liu Dan-dan Yu Xiao-min Yu Mi-sheng Zhao Bin Ye Department of Pathogenic Biology Chongqing Medical UniversityChongqing 400016China Research Center for Molecular Medicine and TumorChongqing Medical UniversityChongqing 400016China Department of Clinical LaboratoryThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325023Zhejiang ProvinceChina Department of PathophysiologyChongqing Medical UniversityChongqing 400016China Department of Clinical LaboratoryWenzhou People’s HospitalWenzhou 325023Zhejiang ProvinceChina Department of EmergencyUniversity-Town Hospital of Chongqing Medical UniversityChongqing 401331China

Objective:High-fat diet is one of the main risk factors that disrupt the balance of gut microbiota,which eventually will induce colorectal cancer(CRC).Evodiamine(EVO)is a wildly used multifunctional traditional Chinese medicine *** this study,we investigated the role of gut microbiota in high-fat dietpropelled CRC and the potential of EVO for CRC ***:Gut microbiota,serum D-lactic acid and endotoxin from 38 patients with colon cancer and 18 healthy subjects were detected by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay(EliSA).In addition,body mass index,phospho-signal transducer and activator of transcription 3(p-STAT3)expression in cancer tissues and paracancerous tissues were detected by immunohistochemistry.A mouse intestinal inflammatory tumor model was established by azomethane/sodium dextran sulfate,followed by treatment with EVO and 5-aminosalicylic acid(ASA).Gut microbiota and inflammatory factors were detected by quantitative polymerase chain reaction,while serum D-lactic acid and endotoxin were detected by ***,cell proliferation,cell apoptosis,and interleukin(IL)-6/STAT3/P65 pathway were evaluated by 5-ethynyl-20-deoxyuridine,terminal-deoxynucleotidyl transferase-mediated nick-end labeling,and Western blot ***:In patients with colon cancer,the numbers of Enterococcus faecalis and Escherichia coli were increased,while those of Bifidobacterium,Campylobacter and Lactobacillus were *** endotoxin and D-lactic acid levels and p-STAT3 levels were significantly *** the mouse model,both EVO and ASA inhibited tumor formation,decreased the proliferation of tumor cells,and induced apoptosis of tumor *** with the control group,the numbers of *** and *** were decreased,while Bifidobacterium,Campylobacter and Lactobacillus numbers were *** the EVO group,serum endotoxin and D-lactic acid levels and inflammatory factors were signifi

关键词： Evodiamine Gut microbiota Colitis-associated cancer Signal transducer and activator of transcription 3

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变暖背景下砾石换填对多年冻土区机场跑道下地温场的影响

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气候变化研究进展 2024年第3期20卷 291-303页

作者：王娇娇张虎金晓颖黄帅王宏伟王文辉詹涛周刚义车富强李艳李新宇何瑞霞张泽张圣嵘李国玉童长江王逊金会军东北林业大学土木与交通学院冻土研究所/教育部东北冻土地质系统与环境观测试验研究站哈尔滨150040 黑龙江省自然资源调查院大兴安岭漠河冻土与寒区环境野外科学观测研究站(自然资源部) 哈尔滨150036 中国科学院西北生态环境资源研究院甘肃遥感重点实验室和黑河遥感试验研究站兰州730000 国家林业和草原局重点国有林区森林资源监测中心加格达奇165100 中国科学院西北生态环境资源研究院冻土工程国家重点实验室兰州730000 哈尔滨工业大学土木工程学院哈尔滨150090

受气候变暖影响,东北北部地区冻融灾害频发,对寒区工程设施造成了重要影响。地基温度场的研究是分析与解决工程基础冻融灾害的重要手段。文中我们以漠河机场跑道为对象,通过有限单元法研究了洁净砾石换填对机场道基温度场的影响,并对运... 详细信息

受气候变暖影响,东北北部地区冻融灾害频发,对寒区工程设施造成了重要影响。地基温度场的研究是分析与解决工程基础冻融灾害的重要手段。文中我们以漠河机场跑道为对象,通过有限单元法研究了洁净砾石换填对机场道基温度场的影响,并对运行30年内道基温度场进行预测。结果表明,换填使季节最大冻结深度(MSF)增加,且换填对道基下MSF的水平影响范围在道面中心线两侧30 m左右。之后,通过比较不同换填深度(1.5(顶)~3.5(底)、1.5~4.5、1.5~5.5和1.5~6.5 m)的道基温度场变化,发现:换填底部深度达到4.5 m时,MSF变化的速率开始减小。最后,根据IPCC第六次评估报告(AR6)未来100年间不同气候变暖速率模型模拟研究了无换填与不同换填深度下的MSF可能变化。结果发现,到2100年,在SSP2-4.5情景下,未换填及不同换填深度的道基下MSF分别为1.63、1.86、1.84、1.84和1.84 m。因此,利用换填法来减少跑道冻融灾害时换填深度应至少达到4.5 m。同时,应加强漠河机场道基地表水与该跑道区地下水的防排水设施建设与维运。研究结果有助于进一步认识换填对多年冻土和活动层水热状态的影响,可为解决道基冻胀和融沉问题提供重要科学依据。

关键词：多年冻土机场跑道地温季节最大冻结深度(MSF) 数值模拟

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D-半乳糖对小鼠睾丸TM4支持细胞连接功能损伤及淫羊藿素的改善作用研究

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中国药理学通报 2024年第9期40卷 1634-1641页

作者：姚志丽赵海霞马小玉付国庆吴杰宋来新张长城三峡大学国家中医药管理局中药药理科研三级实验室湖北宜昌443002 三峡大学健康医学院湖北宜昌443002 三峡大学基础医学院湖北宜昌443002 三峡大学分析测试中心湖北宜昌443002 武汉市东西湖区人民医院湖北武汉430040

目的研究D-半乳糖(D-galactose,D-gal)对小鼠睾丸TM4支持细胞连接功能损伤以及淫羊藿素(icaritin,ICT)的改善作用机制。方法首先将TM4细胞分为正常对照组、不同浓度D-gal处理组,Western blot检测TM4细胞连接功能相关蛋白(ZO-1、Occludi... 详细信息

目的研究D-半乳糖(D-galactose,D-gal)对小鼠睾丸TM4支持细胞连接功能损伤以及淫羊藿素(icaritin,ICT)的改善作用机制。方法首先将TM4细胞分为正常对照组、不同浓度D-gal处理组,Western blot检测TM4细胞连接功能相关蛋白(ZO-1、Occludin、β-catenin和Cx43)以及ERα/FAK信号通路相关蛋白(ERα、FAK和pY397-FAK)表达水平的变化;随后MTT筛选ICT药物浓度,并将TM4细胞分为正常对照组、D-gal处理组、D-gal处理+不同浓度ICT组,Western blot检测上述蛋白表达水平变化;分子对接研究ERα与ICT之间的相互作用,并预测两者之间的亲和力;最后将TM4细胞分为正常对照组、D-gal处理组、ERα抑制剂组、D-gal+ICT组、ERα抑制剂+ICT组,Western blot检测上述蛋白表达水平的变化。结果D-gal可浓度依赖性下调连接功能相关蛋白(ZO-1、Occludin、β-catenin和Cx43)以及ERα/FAK信号通路相关蛋白(ERα、FAK和pY397-FAK)表达水平;给予ICT药物后,上述蛋白表达水平均明显上调;ERα和ICT分子对接结果显示,ERα的Asp351氨基酸残基与ICT之间形成2个距离为3.4Å和2.4Å的氢键,且两者之间的对接结合能小于-7 kcal·mol^(-1);ERα抑制剂处理TM4细胞后,上述蛋白表达水平均明显下调,给予ICT后,上述蛋白表达水平未有明显变化。结论D-gal可导致TM4细胞连接功能损伤,而ICT可改善其损伤,机制可能与上调ERα/FAK信号通路相关。

关键词： D-半乳糖 TM4细胞淫羊藿素雌激素受体α 黏着斑激酶连接功能

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Advanced carbon-based materials for Na,K,and Zn ion hybrid capacitors

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Rare Metals 2023年第3期42卷 719-739页

作者： Jian Zhou Hong-Yu Hu Hong-Qiang li Zhi-Peng Chen chang-Zhou Yuan Xiao-Jun He School of Chemistry and Chemical Engineering Anhui University of TechnologyMaanshan 243002China School of Material Science and Engineering University of JinanJinan250022China

Developing electrochemical energy storage devices with high energy and power densities,long cycling life,as well as low cost is of great *** metal-ion capacitors(MICs),commonly consisting of high energy battery-type anodes and high power capacitor-type cathodes,have become a trade-off between batteries and *** efforts have been devoted to searching for high-performance electrode materials due to poor rate capability of anodes,low capacity of cathodes,and interior sluggish kinetic *** materials with large surface area,good electrical conductivity and stability have been considered to be ideal candidates for electrodes of *** this review,the advanced carbon materials directly as cathodes and anodes of MICs are systematically ***,the key structural/chemical factors including the structure engineering,porous characteristics,and heteroatom incorporation for improving electrochemical performance of carbon materials are ***,the challenges and opportunities for future research on carbon materials in MICs are also proposed.

关键词： Metal-ion capacitor(MIC) Carbon materials Electrodes Structural/chemical factors Electrochemical performance

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