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Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study

World Journal of Pediatrics 2024年第11期20卷 1168-1178页

作者： Qiang Ma Ya-Qi Li Qing-Tang Meng Bo Yang Hai-Tao Zhang Hua Shi chang-you liu Tian-Chao Xiang Na Zhao Jia Rao Department of Nephrology Tai’an Maternal and Child Health HospitalTai’anChina Department of Nephrology Children’s Hospital of Fudan UniversityNational Children’s Medical Center399 Wanyuan RoadShanghaiChina Department of Obstetrics Tai’an Maternal and Child Health HospitalTai’anChina Department of Color Ultrasound Tai’an Maternal and Child Health HospitalTai’anChina Department of Neonatology Tai’an Maternal and Child Health HospitalTai’anChina Shanghai Kidney Development and Pediatric Kidney Disease Research Center ShanghaiChina Shanghai Key Lab of Birth Defect Children’s Hospital of Fudan UniversityShanghaiChina National Key Laboratory of Kidney Diseases BeijingChina

Background Congenital anomalies of the kidneys and urinary tract(CAKUT)are the most common cause of prenatally diagnosed developmental *** study aimed to assess the relationship between maternal diseases and CAKUT in *** This retrospective study enrolled all pregnant women registered from January 2020 to December 2022 at one medical *** information on maternal noncommunicable diseases,including obesity,hypertension,diabetes mellitus,kidney disease,hyperthyroidism,hypothyroidism,psychiatric disease,epilepsy,cancer,and autoimmune disease was *** on the records of ultrasound scanning during the third trimester,the diagnosis was classified as isolated urinary tract dilation(UTD)or kidney *** logistic regression was performed to establish models to predict antenatal *** Among the 19,656 pregnant women,perinatal ultrasound detected suspicious CAKUT in 114(5.8/1000)fetuses,comprising 89 cases with isolated UTD and 25 cases with kidney *** risk of antenatal CAKUT was increased in the fetuses of mothers who experienced gestational diabetes,thyroid dysfunction,neuropsychiatric disease,anemia,ovarian and uterine disorders.A prediction model for isolated UTD was developed utilizing four confounding factors,namely gestational diabetes,gestational hypertension,maternal thyroid dysfunction,and hepatic ***,a separate prediction model for kidney anomalies was established based on four distinct confounding factors,namely maternal thyroid dysfunction,gestational diabetes,disorders of ovarian/uterine,and kidney *** Isolated UTD and kidney anomalies were associated with different maternal *** results may inform the clinical management of pregnancy and highlight potential differences in the genesis of various subtypes of CAKUT.

关键词： Congenital anomalies of the kidney and urinary tract(CAKUT) Kidney anomalies Predictive model Risk factors Urinary tract dilation(UTD)

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Reply to“maternal health and fetal development:investigating the connection between maternal diseases and congenital anomalies of the kidneys and urinary tract”

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World Journal of Pediatrics 2024年第11期20卷 1198-1199页

作者： Qiang Ma Ya-Qi Li Qing-Tang Meng Bo Yang Hai-Tao Zhang Hua Shi chang-you liu Tian-Chao Xiang Na Zhao Jia Rao Department of Nephrology Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina

As Tang states,according to the theory of the fetal origins of health and disease,the mechanisms driving in utero programming as it relates to impaired organogenesis are being unraveled but remain complex[1].Maternal ... 详细信息

关键词： fetal impaired urinary

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Long-duration aqueous Zn-ion batteries achieved by dual-salt highly-concentrated electrolyte with low water activity

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Journal of Energy Chemistry 2025年第2期101卷 778-785页

作者： Lvzhang Jiang Lingbo Yao Gege Wang chang liu Xiaowei Chi Yu liu Shanghai Institute of Ceramics Chinese Academy of Sciences University of Chinese Academy of Sciences

Aqueous Zn-ion batteries have attracted much attention due to their unique high safety and low-cost ***,their practical applications are at a slow pace due to their short cycle life,which fundamentally results from the instability of the positive/negative electrode interface in the traditional dilute aqueous electrolytes with high water *** highly concentrated electrolyte（HCE）has been considered as an effective *** previous studies of single salt-based HCE（SSHCE）,herein,a new dual-salt HCE（15 m ZnCl2+10 m NH4NH2SO3DS-HCE） was proposed for the first ***-HCE was proven to simultaneously possess higher conductivity than traditional dilute electrolytes and ultralow water activity of SS-HCE by the regulation of dual high-concentration salts on the solvation structure,which renders the Zn‖Zn symmetric cell the record-long cycling life of 2200 h compared with those with SS-HCE（30 m ZnCl2,300 h） and other reported ***,the Zn‖NH4V4O10full cell with DS-HCE demonstrated impressed rate capability within a wide-range current densities from 0.1 to 10 A ***,at the high current density of 5 A g-1,the full cell shows almost100% capacity retention after 4000 cycles,which indicates the promising future of the DS-HCE system for long-duration aqueous Zn-ion batteries.

关键词： Ammonium vanadate Aqueous zinc battery Cycling stability Electrolyte

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Relation of abnormal gallbladder arterioles to gallbladder emptying in patients with gallstone and diabetes mellitus

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 275-278页

作者： Xiong Ding, Jian-Ping Gong, chang-you Lu, chang-An liu, Yu-Jun Shi and Gen-Wu Gao Chongqing, China Department of Hepatobiliary Surgery, Second Clinical College, Chongqing University of Medical Science, Chongqing 400010, China Department of Hepatobiliary Surgery Second Clinical College Chongqing University of Medical Science Chongqing 400010 China. dingpanda@***

BACKGROUND: Diabetes mellitus is thought to be related to gallstone formation in emptying the gallbladder. Diabe- tes mellitus may lead to many changes in microarterioles and micronerves; the aim of this study was to investigate the abnormality of arterioles in the gallbladder and its rela- tion to gallbladder hypomotility in patients with gallstone and diabetes mellitus. METHODS: Thirty patients with simple gallstones and 30 patients with gallstones and diabetes mellitus were analy- zed , and their gallbladder emptying function was measured with B ultrasound before operation. After operation, the arterioles of the gallbladder rinsed with periodic acid-schiff (PAS) reagent in photos were used for analysis of the tu- blar area and stereo system with the Beihang CM-2000B biological and medical photo system. RESULTS: In patients with gallstones and diabetes mellitus, the gallbladder emptying function was significantly im- paired, the area ratio of the arteriole wall to whole arte- rioles in cross section was significantly higher than that in patients with simple gallstones (0.81 ±0.09 vs. 0.58±0.15, P 0.05). CONCLUSION: In patients with diabetes mellitus, the se- dimentation of PAS positive material in the wall of arte- rioles leads to the stenosis of arterioles. It is probably con- tributive to hypomotility of the gallbladder.

关键词： gallstone diabetes mellitus arterioles gallbladder motility

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang liu Yu-Chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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Probing the special angle in twisted bilayer MoS_(2)via angle-dependent scanning tunneling microscopy studies

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 153-160页

作者： Xueying liu Shiying liu Yulong Xiao chang Xu Jiaxin Wu Kaihui Li Si-Yu Li Anlian Pan Key Laboratory for Micro-Nano Physics and Technology of Hunan Province Hunan Institute of Optoelectronic Integration and College of Materials Science and EngineeringHunan UniversityChangsha410082China School of Physics and Electronics Hunan Normal UniversityChangsha410081China

Twisted transition metal dichalcogenides(TMDs)homo-bilayers host unique quantum properties,which can be tuned by interlayer twist angleθ.However,the systematic evolution of their typical electronic properties with respect to the twist angleθ,which is crucial for identifying the“special angle”analogous to the“magic angle”of twisted bilayer graphene in correlation physics studies,remains incompletely ***,via scanning tunneling microscopy(STM)and spectroscopy(STS),we investigate the variation of the moirépotential,flat band,and layer polarization characteristics across a wide range of twist angleθin twisted bilayer MoS_(2)(TB-MoS_(2)).The moirépotential of the valence band exhibits a non-monotonic variation withθ,peaking at a maximum value up to 204 me Vatθ~1.7°.Concurrently,at the sameθ,the bandwidth of the flat band at theΓ_(V)point of the valence band attains its minimum,precisely signifying the“special angle”θ_(c)~1.7°in TB-MoS_(2).Interestingly,layer polarization in the moirésuperlattice is spatially visualized through the distribution of local density of states(LDOS)at the energies of bothΓ_(V)and K_(V)points of the valence band,where the polarization degree at theΓ_(V)point demonstrates a close dependency onθ.Our findings deepen understanding of twist-angle effect in TMDs,advancing both fundamental physics and practical application.

关键词： twisted bilayer MoS_(2) flat band moirépotential twist-angle dependence scanning tunneling microscopy

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Pyrrolic nitrogen coordinated Ni^(2+) dual-atom catalyst for boosting CO_(2) electroreduction

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Science China Chemistry 2025年第2期68卷 570-579页

作者： Zhi-Wei Chen Hong-Juan Wang chang liu Xiu-Li Lu Tong-Bu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Nitrogen-doped carbon materials have been widely used for the constructions of single-atom catalysts,while the effect of different species of doped nitrogen on the catalytic activity of CO_(2) electroreduction has rarely been *** we found that pyrrolic-N coordinated Ni2+catalysts display much higher electrocatalytic CO_(2)-to-CO activity and selectivity than the corresponding pyridinic-N coordinated low valent Ni^((0–+2))catalysts,and pyrrolic-N coordinated Ni2 dual-atoms catalyst of Ni2/N-CNTs exhibits the best electrocatalytic performance,with over 90%Faradaic efficiencies in a broad potentials from−0.6 to−1.2 V *** hydrogen electrode,as well as an outstanding CO specific current of 56.2 A/mgNi and high turnover frequency of 6.2×10^(4) h^(−1),over 7-times higher than those of pyridinic-N coordinated Ni *** results indicate the weak electron-donor nature of pyrrolic-N facilitates the generation of a reduced active site at low overpotential for boosting CO_(2) *** functional theory calculations reveal that the reaction free energy for the*COOH formation on pyrrolic-N coordinated Ni catalysts are lower than those on pyridinic-N coordinated Ni catalysts,and a H_(2)Oadsorbed Ni_(2)/N-CNTs displays the optimized reaction free energy for both*COOH formation and CO desorption,which derive the best catalytic performance.

关键词： dual-atom catalyst CO_(2) electroreduction synergistic catalysis pyrrolic-N pyridinic-N

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Paving the Way towards Green Development:Impact of the Belt and Road Initiative on Electrification in Participating Countries

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China & World Economy 2025年第1期33卷 36-63页

作者： Mao Zhou Jiahui Wu Xia Wang chang liu School of International Business Southwestern University of Finance and Economics(SWUFE)China School of International Business SWUFEChina School of Public Finance and Taxation SWUFEChina Institute of Western China Economic Research SWUFEChina

Electrification is crucial for achieving global net zero emissions and reducing energy poverty, particularly in developing countries involved in the Belt and Road Initiative (BRI). This study uses the difference-in-differences method to examine the BRI's impact on electrification levels in 118 countries from 2009 to 2020. Its findings indicate that the BRI increased electrification in BRI countries by approximately 1 percent compared with non-BRI countries. This increase was driven primarily by enhanced trade and investments, which facilitated imports of power equipment and supported China-backed power-plant projects. The BRI's impact was more pronounced in Maritime Silk Road countries, high-income nations, and those with favorable business environments. Although the BRI promoted both renewable and nonrenewable power equipment imports, it primarily favored nonrenewable infrastructure investments. Given China's expertise in clean energy, there remains untapped potential for the BRI to prioritize renewable energy integration, fostering a sustainable and low-carbon future.

关键词： Belt and Road Initiative electrification level power equipment import.power plant investment

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Effect of surface species on the alcohol-acid adsorption from FTS wastewater on graphene:A structure-capacity study

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Journal of Environmental Sciences 2025年第3期149卷 651-662页

作者： Xiao liu Xiaolong Zhang Chunyu Geng Qinglan Hao Jie chang Xin Hu Yongwang Li Botao Teng Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-utilization College of Chemical Engineering and Materials ScienceTianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer MaterialsCollege of ChemistryNankai UniversityTianjin 300071China National Energy Center for Coal to Liquids Synfuels China Co.Ltd.Beijing 101407China Institute of Sustainability of Chemical Energy and EnvironmentAgency for ScienceTechnology and Research627833Singapore Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Zhejiang Normal UniversityJinhua 321004China

Fischer-Tropsch synthesis(FTS)wastewater retaining low-carbon alcohols and acids are organic pollutants as a limiting factor for FTS *** this work,the structurecapacity relationships between alcohol-acid adsorption and surface species on graphene were reported,shedding light into their intricate *** graphene oxide(GO)and reduced graphene oxide(rGO)were synthesized via improved Hummers method with flake graphite(G).The physicochemical properties of samples were characterized via SEM,XRD,XPS,FT-IR,and *** alcohol-acid adsorption behaviors and adsorption quantities on G,GO,and rGO weremeasured via theoretical and *** was revealed that the presence of COOH,C=O and C–O species on graphene occupy the adsorption sites and increase the interactions of water with graphene,which are unfavorable for alcoholacid *** equilibrium adsorption quantities of alcohols and acids grow in pace with carbon *** monolayer adsorption occurs on graphene was verified viamodel *** has the highest FTS modeling wastewater adsorption quantity(110 mg/g)due to the reduction of oxygen *** novel findings provide a foundation for the alcoholacid wastewater treatment,as well as the design and development of high-performance carbon-based adsorbent materials.

关键词： Alcohol-acid adsorption Fischer-Tropsch synthesis wastewater Graphene Surface species Density functional theory

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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue Li Cui chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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