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A survey on the epidemiology of trauma and China trauma care training in subtropical regions of Hainan Province

Journal of Acute Disease 2018年第3期7卷 108-114页

作者： Jiang-Ling Yao chang-xi zhou Ji-Min Fu Jian Fu Yun-Tao Gu Zhu-Long Meng Lei Peng Zhong-Lin zhou Trauma Center The First Affiliated Hospital of Hainan Medical CollegeHainan Province 570102China Nanlou Respiratory Diseases Department PLA General Hospital28 Fuxing RoadBeijing 100853China Hainan Medical College No.3 Xueyuan RoadHaikouHainan Province 570102China

Objective: To investigate the epidemiology of trauma patients in subtropical areas of Hainan Province and the improvement of the level of trauma treatment in China trauma care training (CTCT). Methods: From 01-01-2015 to 01-01-2016, the epidemiological data of 2476 patients with trauma were collected. From 01-01-2016 to 01-01-2017, 105 professional doctors and nurses in emergency surgery took part in CTCT, and their knowledge were compared before and after training. Results: There were 1656 male and 820 female trauma patients with 1614 cases in the middle and young age and 478 cases were the elderly. In terms of occupational distribution, 736 peasants, 574 workers and 458 retirees were involved. In May, the number of patients was the highest 332. October to January was the high-incidence season of trauma. In 24 hours a day: 11:00-13:00, 18:00-19:00, 23:00-03:00 were the high incidence periods. Referred to trauma sites, 904 cases of trauma happened on roads, 540 cases in family and 370 cases in restaurants or entertainment facilities. Through CTCT, the scores of the theoretical examination, the assessment of the trauma treatment skills and the field test scores of the emergency surgery practitioners were better than before (P<0.05).The misdiagnosis rate of severe trauma patients decreased from 26.21% to 15.36% (P<0.05). The mortality rate of severe trauma patients decreased from 18.67% to 13.94% (P<0.05). Conclusions:Trauma epidemiology in Hainan is closely related to its special geographical environment, which provides a reference for the prevention and treatment of trauma in Hainan, and some information for the government to formulate corresponding laws and regulations, as well as emergency plans and other relevant strategies. CTCT training improves the level of theoretical knowledge and first aid skills of medical personnel involved in trauma treatment. Health departments and medical education departments may consider extending CTCT training and continuing educati

关键词： Epidemiology CTCT Training Trauma Subtropical

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu chang Lin xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu xiaoling Liu Biao Meng Tao Chen Yu Han Jun Wang Shibo xi Yu zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Activation energy

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Adaptive subcarrier allocation for MIMO-OFDMA wireless systems using Hungarian method

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Journal of Shanghai University(English Edition) 2009年第2期13卷 146-149页

作者：管张均李昊徐昌庆周希朗张唯炯 Department of Electronic Engineering School of ElectronicInformation and Electrical EngineeringShanghai Jiaotong UniversityShanghai 200240P.R.China

MIMO-OFDMA is a promising technique for future broadband wireless communication systems. In this paper, the problem of allocating subcarriers among different users to maximize the total capacity is addressed. The optimal solution can be obtained by Hungarian method is proved, using two utility matrices, i.e. the Frobenius-norm matrix and the determinant matrix. Simulation results show that the proposed algorithm can achieve higher capacity than the existing algorithms, and it is globally optimal and easy to be implemented.

关键词： MIMO-OFDMA subcarrier allocation Hungarian method

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循环加载与卸围压组合扰动下红砂岩损伤破裂与渗透特性

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岩土工程学报 2025年第1期47卷 48-56页

作者：姚玮俞缙周先齐常方强常旭厦门理工学院土木工程与建筑学院福建厦门361024 华侨大学福建省隧道与城市地下空间工程技术研究中心福建厦门361021

为探究深地工程开挖诱导岩体损伤破裂及渗透性演化规律,开展了同步测定波速与渗透率的循环加载与卸围压组合扰动三轴试验,研究了不同条件下红砂岩的损伤与渗透性演化规律。结果表明:①岩石在不同组合扰动阶段具有不同的应力应变曲线形态... 详细信息

为探究深地工程开挖诱导岩体损伤破裂及渗透性演化规律,开展了同步测定波速与渗透率的循环加载与卸围压组合扰动三轴试验,研究了不同条件下红砂岩的损伤与渗透性演化规律。结果表明:①岩石在不同组合扰动阶段具有不同的应力应变曲线形态,其末端形态取决于在何种扰动阶段破坏,初始应力比为决定组合扰动诱发岩石破坏难易的主要因素;②总峰值轴向应变随初始应力比增大而增大,其中组合扰动轴向应变占比始终较低,总峰值体积应变绝对值随初始应力比增大而先增大后减小,其中组合扰动体积应变占比较高;③在初始加载阶段,波速增大,渗透率降低,在组合扰动阶段,波速下降,渗透率增加,且损伤与体积应变近似呈线性关系,损伤与渗透率随扰动次数增加均呈先慢后快的增长趋势,且拐点分别近似在一条直线上;④岩石在组合扰动卸围压阶段破坏为单剪切破坏模式,在组合扰动循环加载阶段破坏为共轭剪切破坏模式;⑤双高(高初始应力比与高初始围压)条件将显著加剧岩体开挖失稳破坏风险。

关键词：深地工程组合扰动力学特性损伤渗透性

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雌激素对血管平滑肌细胞中c-fos和增殖细胞核抗原表达的影响

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解剖学杂志 2004年第5期27卷 468-471页

作者：唐燕陈锡昌周新华宋健武汉大学医学院人体解剖学教研室武汉430071

目的 :研究并比较雌激素和 /或血清对血管平滑肌细胞 (VSMC)中c fos和增殖细胞核抗原 (PCNA)表达的影响。方法 :分别在有或无他莫昔芬 (TAM) (雌激素受体ER拮抗剂 )预处理的情况下 ,采用免疫细胞化学和图像分析方法 ,研究雌二醇 (E2 )... 详细信息

目的 :研究并比较雌激素和 /或血清对血管平滑肌细胞 (VSMC)中c fos和增殖细胞核抗原 (PCNA)表达的影响。方法 :分别在有或无他莫昔芬 (TAM) (雌激素受体ER拮抗剂 )预处理的情况下 ,采用免疫细胞化学和图像分析方法 ,研究雌二醇 (E2 )和 /或新生小牛血清 (NCS)对传代大鼠VSMC中的c fos和PCNA蛋白表达的影响。结果 :E2 以及NCS均能上调细胞中c fos和PCNA蛋白的表达 ,TAM能阻断其效应。结论 :雌激素能促进传代VSMC增生。

关键词： c-fos 表达雌激素 VSMC 血管平滑肌细胞增殖细胞核抗原 PCNA蛋白传代免疫细胞化学介导

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浅谈汽车电子产品的特点与相关认证

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中国集成电路 2018年第4期27卷 76-80页

作者：周金成郭昌宏李习周天水华天科技股份有限公司甘肃天水741000

随着汽车电子市场的迅速发展,更多的电子电器企业计划进入汽车电子行业供应链。本文详细阐述了汽车电子产品的特点,AEC标准的主要内容,AEC-Q100的等级定义与验证流程、项目,TS 16949的基本内容。讨论了汽车电子与普通电子产品验证项目... 详细信息

随着汽车电子市场的迅速发展,更多的电子电器企业计划进入汽车电子行业供应链。本文详细阐述了汽车电子产品的特点,AEC标准的主要内容,AEC-Q100的等级定义与验证流程、项目,TS 16949的基本内容。讨论了汽车电子与普通电子产品验证项目的差异,标准与规范的运用。总结了汽车电子产品认证的核心内容与关键项目。

关键词：汽车电子认证 AEC-Q100标准 TS 16949规范

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An OWL-based WordNet lexical ontology

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第6期8卷 864-870页

作者： HUANG xiao-xi zhou chang-le School of Computer Science and Technology Zhejiang University Hangzhou 310027 China Center for the Study of Language and Cognition Zhejiang University Hangzhou 310028 China Institute of Artificial Intelligence Xiamen University Xiamen 361005 China

This paper discribes a data representation for WordNet 2.1 based on Web Ontology Language (OWL). The main components of WordNet database are transformed as classes in OWL, and the relations between synsets or lexcial words are transformed as OWL properties. Our conversion is based on the data file of WordNet instead of the Prolog database. This work can be used to enrich the work in progress of standard conversion of WordNet to the RDF/OWL representation at W3C.

关键词： WordNet Web Ontology Language (OWL) Semantic Web Ontology Natural Language Processing (NLP)

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大豆胰蛋白酶抑制剂对鲢丝氨酸蛋白酶的作用

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水产学报 2005年第4期29卷 502-506页

作者：蒋欣静王锡昌周常义翁凌曹敏杰集美大学生物工程学院上海水产大学食品学院集美大学生物工程学院福建厦门361021上海水产大学食品学院上海200090 福建厦门361021

研究了大豆胰蛋白酶抑制剂(STI)对鲢肌肉中肌原纤维结合型丝氨酸蛋白酶(MBSP)引起的肌原纤维蛋白降解作用的影响。大豆胰蛋白酶抑制剂经高度纯化后加入肌原纤维中以判断它对MBSP的抑制效果。在不添加STI的情况下,55℃加热30min即可观察... 详细信息

研究了大豆胰蛋白酶抑制剂(STI)对鲢肌肉中肌原纤维结合型丝氨酸蛋白酶(MBSP)引起的肌原纤维蛋白降解作用的影响。大豆胰蛋白酶抑制剂经高度纯化后加入肌原纤维中以判断它对MBSP的抑制效果。在不添加STI的情况下,55℃加热30min即可观察到肌球蛋白重链的分解,延长加热时间则可检测到肌动蛋白及原肌球蛋白的降解。相反,在终浓度为0.75μg·mL-1的STI存在下,包括肌球蛋白重链在内的肌原纤维蛋白降解均能得到有效抑制,表明STI是MBSP的特异性抑制剂。由于肌球蛋白重链及肌动蛋白的完整性是构成鱼糜制品凝胶强度的主要因素,因此,STI的添加有可能提高鲢鱼糜制品的凝胶强度。

关键词：鲢大豆胰蛋白酶抑制剂肌原纤维丝氨酸蛋白酶

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Mechanism of Embrittlement and De-Embrittlement for 2.25Cr-1Mo Steel

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Journal of Iron and Steel Research International 2011年第3期18卷 47-51页

作者： ZHANG xi-liang zhou chang-yu School of Mechanical and Power Engineering Nanjing University of TechnologyNanjing 210009JiangsuChina

The constant embrittlement curve for constant segregation concentration on grain boundary of impurity element P and relationship between equilibrium grain boundary segregation concentration and operation time for 2.25Cr-1Mo steel were derived based on the theory of equilibrium grain boundary *** mechanism of step-cooling test and mechanism of de-embrittlement for 2.25Cr-1Mo steel were *** segregation rate will increase but equilibrium grain boundary segregation concentration of impurity element P will decrease as temperature increases in the range of temper embrittlement *** is one critical temperature of embrittlement corresponding to each embrittlement *** the further heat treating temperature is higher than critical temperature,the heat treating will become a de-embrittlement process;otherwise,it will be an embrittlement *** critical temperature of embrittlement will shift to the direction of low temperature as further *** a result,some stages of step-cooling test would change into a de-embrittlement *** grain boundary desegregation function of impurity element P was deduced based on the theory of element diffusion,and the theoretical calculation and experimental results show that the further embrittlement or de-embrittlement mechanism can be interpreted qualitatively and quantitatively by combining the theory of equilibrium grain boundary segregation with constant embrittlement curve.

关键词： step-cooling test critical embrittlement temperature embrittlement mechanism grain boundary desegregation

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