检索结果-南通市图书馆

Chinese Journal of Polymer Science 2024年第5期42卷 675-682,I0004,I0010页

作者： jiang-Tao Sun Zhi-Yong Fan Yi-Wei Mao Wei Li Wei Zhu Dao-Sheng Cai qing-Song Wei State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430074China National Engineering Research Centre for High Efficiency Grinding Hunan UniversityChangsha410082China Wuhan EasyMFG Technology CO. LTDWuhan430074China

High speed sintering,a new powder-bed fusion additive manufacturing technology,utilizes infrared lights(IR)to intensely heat and melt polymer *** presence of defects such as porosity,which is associated with particle coalescence,is highly dependdent on the level of energy *** study investigate the influcence of energy input on porosity and its subsequent effects on the mechanical properties and microstructures of PEBA *** parts were manufactured with a variety of lamp powers,resulting in a range of energy input levels spanning from low to ***,they underwent testing using Archimedes’method,followed by tensile *** porosity,mechanical characteristics,and energy input exhibit a strong correlation;inadequate energy input was the primary cause of pore *** the reduced IR light power resulted in the following outcomes:porosity,ultimate tensile strength,and elongation of 1.37%,7.6 MPa,and 194.2%,*** the energy input was further increased,the porosity was reduced to as low as 0.05%and the ultimate tensile strength and elongation were increased to their peak values of 233.8%and 9.1 MPa,respectively.

关键词： High speed sintering Additive manufacturing Energy input Powder bed fusion PEBA

Plastid engineering with an efficient RNAi delivery system based on bacteriophage MS2 virus-like particles enhances plant resistance to cotton bollworm

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2024年第7期17卷 987-989页

作者： Chunmei jiang Jinqiu Fu Fujun Li Kai Xia Shengchun Li Ling chang Ralph Bock jiang Zhang State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei Hongshan LaboratoryHubei UniversityWuhan 430062China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen518000China Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476Potsdam-GolmGermany

Dear Editor,RNA-based pesticides are approaching the market,offering great potential to control agricultural pests such as the coleopteran insect Diabrotica virgifera virgifera(Head et al.,2017).However,application to lepidopteran pests has been hampered by their inconsistent response to RNA interference(RNAi).As a notorious lepidoptera pest,Helicoverpa armigera feeds on over 300 species of host plants(Fu et al.,2022).Although transgenicplants expressingdouble-stranded RNAs or microRNAs that target essential insect genes can inhibit the growth of larvae,complete protection of the plants and efficient killing of this insect have not been achieved(Bally et al.,2020;Chung et al.,2021;Li et al.,2023).The relatively low RNAi efficiency in lepidopterans is mainly attributable to the degradation and intracellular sequestration of double-stranded RNA(Shukla et al.,2016;Zhu and Palli,2020).To overcome these obstacles and improve RNAi efficiency in ***,we attempted to deliver RNAi molecules using a bacteriophage MS2 virus-like particle(VLP)-based delivery system(Wang et al.,2016).

关键词： overcome offering approaching

Liposomalα-cyperone targeting bone resorption surfaces suppresses osteoclast differentiation and osteoporosis progression via the PI3K/Akt axis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 2949-2959页

作者： Lin Yang Xueying An Wang Gong Wenshu Wu Bin Liu Xiaoyan Shao Yansi Xian Rui Peng Baosheng Guo qing jiang Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic SurgeryNanjing Drum Tower Hospital Clinical College of Nanjing Medical University321 Zhongshan RoadNanjing 210008China Branch of National Clinical Research Center for Orthopedics Sports Medicine and RehabilitationNanjing 210008China State Key Laboratory of Pharmaceutical Biotechnology Medical SchoolNanjing University&Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Osteoporosis is a metabolic dysregulation of bone that occurs mainly in postmenopausal women,and the hyperfunction of osteoclasts is the primary contributor to postmenopausal ***,the development of effective therapeutic drugs and precise delivery systems remains a challenge in the field of anti-absorption ***,we reported theα-cyperone(α-CYP)for anti-osteoporosis and developed a liposome-based nano-drug delivery system ofα-CYP,that specifically targets the bone resorption ***,we found that theα-CYP,one of the major sesquiterpenes of Cyperus rotundus L.,attenuated the progression of osteoporosis in ovariectomized(OVX)mice and down-regulated the expression of phosphorylated proteins of phosphoinositide 3-kinase(PI3K)and protein kinase B(Akt),causing down-regulation of osteoclast-related genes/proteins and curbing osteoclast ***,α-CYP reversed the activation of osteoclastic differentiation and enhanced osteoporosis-related proteins expression caused by PI3K/Akt agonist(YS-49).More importantly,we adopted the osteoclastic resorption surface targeting peptide Asp8 and constructed the liposome(lipαC@Asp8)to deliverα-CYP to osteoclasts and confirmed its anti-osteoporosis effect and enhanced osteoclast inhibition by blocking PI3K/Akt *** conclusion,this study demonstrated thatα-CYP inhibits osteoclast differentiation and osteoporosis development by silencing PI3K/Akt pathway,and the liposome targeting delivery systems loaded withα-CYP might provide a novel and effective strategy to treat osteoporosis.

关键词： osteoporosis α-cyperone osteoclast phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) liposome

Molecular surface functionalization of In_(2)O_(3) to tune interfacial microenvironment for enhanced catalytic performance of CO_(2) electroreduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 1242-1250页

作者： Suwen WangQiang GaoCui Xu Shuai jiang Mengyang Zhang Xianjun Yin Hui-qing Peng Bin Liu Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringCollege of ChemistryBeijing University of Chemical TechnologyBeijing 100029China

Indium-based materials(e.g.,In_(2)O_(3))are a class of promising non-noble metal-based catalysts for electroreduction of carbon dioxide(CO_(2)).However,competitive hydrogen reduction reaction(HER)on indium-based catalysts hampers CO_(2) reduction reaction(CO_(2)RR)*** herein tune the interfacial microenvironment of In_(2)O_(3) through chemical graft of alkyl phosphoric acid molecules using a facile solution-processed strategy for the first time,which is distinguished from other researches that tailor intrinsic activity of In_(2)O_(3) *** surface functionalization of alkyl phosphoric acids over In_(2)O_(3) is demonstrated to remarkably boost CO_(2) *** example,octadecylphosphonic acid modified In_(2)O_(3) exhibits Faraday efficiency for H_(2) H_(2) H_(2)(FE)of as low as 6.6%and FEHCOOH of 86.5%at-0.67 V ***,which are far superior to parent In_(2)O_(3) counterparts(FE of 24.0%and FEHCOOH of 63.1%).Moreover,the enhancing effect of alkyl phosphoric acid functionalization is found to be closely related to the length of alkyl *** virtue of comprehensive experimental characterizations and molecular dynamics simulations,it is revealed that the modification of alkyl phosphoric acids significantly alters the interface microenvironment of the electrocatalyst,which changes the electrocatalyst surface from hydrophilic and aerophobic to hydrophobic and *** this case,the water molecules are pushed away and more CO_(2) molecules are trapped,increasing local CO_(2) concentration at In_(2)O_(3) active sites,thus leading to the significantly enhanced CO_(2)RR and suppressed *** work highlights the importance of regulating the interfacial microenvironment of inorganic catalysts by molecular surface functionalization as a means for promoting the electrochemical performance in electrosynthesis and beyond.

关键词： carbon dioxide(CO_(2))electroreduction interfacial microenvironment molecular surface functionalization In_(2)O_(3)catalyst water and CO_(2)diffusion

Thickening progression mechanism of silica fume-oil well cement composite system at high temperatures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第4期21卷 2793-2805页

作者： Hang Zhang Miao-Miao Hu Peng-Peng Li Guo-qing Liu qing-Lu chang Jie Cao Ming Liu Wen-Hua Xu Xiu-Jian Xia Jin-Tang Guo School of Chemical Engineering and Technology Tianjin University Zhejiang Institute of Tianjin University Haihe Laboratory of Sustainable Chemical Transformations CNPC Engineering Technology R&D Company Limited

This work studied the thickening progression mechanism of the silica fume-oil well cement composite system at high temperatures(110-180.C) in order to provide a theoretical guidance for the rational application of silica fume in the cementing engineering. Results showed that silica fume seldom affected the thickening progression of oil well cement slurry at 110-120.C, but when temperature reached above130.C, it would aggravate the bulging degree of thickening curves and significantly extend the thickening time, meanwhile causing the abnormal “temperature-based thickening time reversal” and“dosage-based thickening time reversal” phenomena in the range of 130-160.C and 170-180.C respectively. At 130-160.C, the thickening time of oil well cement slurry was mainly associated with the generation rate of calcium hydroxide(CH) crystal. The introduced silica fume would be attracted to the cement minerals' surface that were hydrating to produce CH and agglomerate together to form an“adsorptive barrier” to hinder further hydration of the inner cement minerals. This “adsorptive barrier”effect strengthened with the rising temperature which extended the thickening time and caused the occurrence of the “temperature-based thickening time reversal” phenomenon. At 170-180.C, the pozzolanic activity of silica fume significantly enhanced and considerable amount of C-S-H was generated, thus the “temperature-based thickening time reversal” vanished and the “dosage-based thickening time reversal” was presented.

关键词： Silica fume Oil well cement Thickening time reversal Pozzolanic reaction Adsorptive barrier CH and C−S−H

Al-doped ZnO/WO_(3) heterostructure films prepared by magnetron sputtering for isopropanol sensors

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第1期43卷 247-256页

作者： Wei-Xiang Gao Xue-Ting chang Xiao-Jie Zhu Jun-Feng Li Ying-chang jiang Dong-Sheng Wang Chuan-Xiao Yang Shi-Bin Sun College of Logistics Engineering Shanghai Maritime UniversityShanghai 201306China College of Ocean Science and Engineering Shanghai Maritime UniversityShanghai 201306China Institute of Logistics Science and Engineering Shanghai Maritime UniversityShanghai 201306China

Metal oxide semiconductors(MOSs) are ideal sensing materials for detecting volatile organic compounds due to their low cost, diversity, high stability, and ease of production. However, it remains a grand challenge to develop the MOSs-based gas sensors for sensing isopropanol with desired performance via a simple, effective,and controllable method. Herein, we reported the preparation of the Al-doped Zn O(AZO)/WO_(3) heterostructure films by directly depositing the AZO coating onto the WO_(3) coating using a strategy of magnetron sputtering. The AZO/WO_(3) heterostructure films were constructed by numbers of irregular nanoparticles that were interconnected with each other. The AZO/WO_(3) heterostructure films-based gas sensors exhibited excellent isopropanolsensing performance with high response, promising selectivity, low detection limit, fast response rate, wide detection range, and ideal reproducibility. The promising isopropanol-sensing performance of the AZO/WO_(3) heterostructure films arises mainly from their high uniformity, unique microstructures with high surface roughness,and the construction of the heterostructure between the AZO and WO_(3) coatings. This work provides a versatile approach to prepare the MOSs-based heterostructure films for assembling the gas sensors.

关键词： Metal oxide semiconductors Gas sensors Aldoped ZnO/WO_(3) Heterostructure films Isopropanol Magnetron sputtering

A novel framework for the carbon reduction performance of power grids:A case study of provincial power grids within the China Central Power Grid

在线全文

学校读者我要写书评

暂无评论

Frontiers of Engineering Management 2024年第3期11卷 455-468页

作者： Lei jiang Chen LING qing YANG Pietro BARTOCCI Shusong BA Shuangquan LIU China-EUInstituteforCleanandRenewableEnergy Huazhong University of Science and TechnologyWuhan 430074China StateKeyLaboratoryofCoalCombustion HuazhongUniversityof Science and TechnologyWuhan 430074China RISE Processum AB SE-89122ÖrnsköldsvikSweden HSBC Business School Peking UniversityShenzhen 518055China SystemOperationDepartment. YunnanPowerGridCo.LtdKunming 650011China

Power grids play a crucial role in connecting electricity suppliers and *** facilitate efficient power transmission and energy management,significantly contributing to the transition toward low-carbon practices across both upstream and downstream *** managing carbon reduction in the power industry is essential for enhancing carbon reduction efficiency and achieving dual-carbon *** studies have focused on the outcomes of carbon reduction efforts rather than the management ***,when power grids prioritize the process of carbon reduction in their management,they are more likely to achieve better *** address this gap,we propose an evaluation model for managing carbon reduction activities in power grids,comprising the carbon management efficiency(CME)module based on the maturity model and the carbon reduction efficiency(CRE)module based on the entropy *** CME module provides a scorecard corresponding to a detailed and continuous evaluation model for carbon management processes to calculate its ***,the CRE module relates carbon reduction results to the development direction of the government and power grid,allowing for effective adjustments and updates based on actual *** evaluation model was applied to provincial power grids within the China Central Power *** results reveal that despite some fluctuations in carbon reduction performance,provincial power grids within the China Central Power Grid have made continuous progress in carbon reduction *** to the synergy model,there is evidence suggesting that power grids are steadily improving their carbon reduction performance,and a more organized approach would lead to a greater degree of *** evaluation model applies to power grids,and its framework can be extended to other industries,providing a theoretical reference for evaluating their carbon reduction efforts.

关键词： power grid carbon reduction evaluation model maturity model synergy model

A new deformable cable for rock support in high stress tunnel:Steel pipe shrinkable energy-absorbing cable

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2024年第8期34卷 1083-1093页

作者： Xuezhen Wu Mingzhu Zhao qing Ye Yujing jiang Tao Deng Hanfang Zheng Gang Wang Zhenchang Guan College of Civil Engineering Fuzhou UniversityFuzhou 350108China School of Engineering Nagasaki UniversityNagasaki 852-8521Japan Key Laboratory of Underground Engineering Fujian University of TechnologyFuzhou 350118China

High stress in surrounding rock will lead to serious problems,e.g.,rock burst in hard rock and large deformation in soft *** applied support system under high in-situ stress conditions should be able to carry high load and also accommodate large deformation without experiencing severe *** this paper,a specially designed energy-absorbing component for rock bolt and cable that can solve the above problems was *** energy-absorbing component can provide support resistance by plastic deformation of the metal including constraint annulus and compression *** practical engineering,two forms were *** was installed in the surrounding rock by reaming,and the other was installed directly outside the surrounding *** the dilation of the surrounding rock,the relative displacement of constraint annulus and compression pipe occurs,resulting in deformation *** resistance is transmitted to the rock bolt or cable,providing support *** lab test and numerical simulation showed that the energy-absorbing component can perfectly achieve the large deformation effect,the deformation amount is as high as 694 mm,and the bearing capacity is stable at 367 *** field application tests were carried out in the mining roadway of Xinjulong coal mine,and the results showed that the new type of cable can ensure itself not to break under the condition of large deformation of the surrounding *** energy-absorbing component has the superiorities of performing large constant resistance and controllable deformation to effectively control the unpredictable disasters such as large deformation in soft rock and rock burst in hard rock encountered in deep strata.

关键词： Energy-absorbing cable Numerical simulation Lab test Load capacity Ultimate displacement

Identification of P-type plasma membrane H^(+)-ATPases in common wheat and characterization of TaHA7 associated with seed dormancy and germination

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第7期23卷 2164-2177页

作者： Bingli jiang Wei Gao Yating jiang Shengnan Yan Jiajia Cao Litian Zhang Yue Zhang Jie Lu Chuanxi Ma Cheng chang Haiping Zhang Key Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow&Huai River Valley Ministry of Agriculture and Rural Affairs/College of AgronomyAnhui Agricultural UniversityHefei 230036China

The P-type plasma membrane(PM)H^(+)-ATPases(HAs)are crucial for plant development,growth,and *** HAs have been thoroughly characterized in many different ***,despite their importance,the functions of HAs in germination and seed dormancy(SD)have not been validated in ***,we identified 28 TaHA genes(TaHA1-28)in common wheat,which were divided into five *** examination of gene expression in strong-and weak-SD wheat varieties led to the discovery of six candidate genes(TaHA7/-12/-14/-16/-18/-20).Based on a single nucleotide polymorphism(SNP)mutation(C/T)in the TaHA7 coding region,a CAPS marker(HA7)was developed and validated in 168 wheat varieties and 171 Chinese mini-core collections that exhibit diverse germination and SD *** further verified the roles of the two allelic variations of TaHA7 in germination and SD using wheat mutants mutagenized with ethyl methane sulphonate(EMS)in‘Jimai 22’and‘Jing 411’backgrounds,and in transgenic Arabidopsis ***7 appears to regulate germination and SD by mediating gibberellic acid(GA)and abscisic acid(ABA)signaling,metabolism,and *** results presented here will enable future research regarding the TaHAs in wheat.

关键词： wheat P-type plasma membrane H^(+)-ATPase seed dormancy abscisic acid gibberellin

Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-qing Zhang Fanyang Kong Xiangyu Kong Tingting jiang Muyuan Ma Shaojiang Zheng Junli Guo Keping Xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China Hainan Clinical Medical Research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and ***,its tumor-suppressive mechanisms remain largely ***,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its *** expression and its association with clinicopathologic characteristics of PDA patients were analyzed using *** mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and Western blot *** biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal *** expression was reduced in human PDA cell lines and *** UTX expression was associated with poor differentiation and prognosis in *** UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the ***,UTX expression was trans-activated by GATA6 ***6-mediated PDA progression could be blocked,at least partially,by silencing UTX *** conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and ***,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX