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Intracellular enzyme-activatable prodrug for real-time monitoring of chlorambucil delivery and imaging

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Chinese Chemical Letters 2017年第6期28卷 1345-1351页

作者： Meng Ni Wen-Jun Zeng Xin Xie Ze-Lin Chen Hao Wu chang-min yu Bo-Wen Li College of Materials Science & Engineering South China University of Technology C uangzhou 510640 China

Carboxylesterase,a necessary enzyme in various mammalian cells,has been employed in various biological ***,we designed and synthesized a novel carboxylesterase-based prodrug,which can realize simultaneous drug-release imaging and cancer *** prodrug comprises three parts：coumarin as the fluorophore and the cleavable architecture,chlorambucil as the anticancer drug,and acetyl group as the enzyme-responsive *** presence of carboxylesterase leads to the activation of coumarin fluorescence,and this fluorescence serves as the reporting signal for assessing the enzyme level and drug ***,the prodrug was incorporated in liposome for monitoring drug release and chemotherapeutic effect in living *** internalization by HeLa cells,the prodrug can release chlorambucil and exhibit high *** approach may provide some helpful insights for enhancing therapeutic effect and tracking the release of prodrug.

关键词： Prodrug Carboxylesterase Chlorambucil Fluorescent imaging Liposomes

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： mingyi yu Faith Teo En Ning chang Liu yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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捕虾桁拖网网囊网目的选择性研究

水产学报 1999年第2期23卷 186-192页

作者：孙满昌王玉明上海水产大学工程技术学院!200090

当网囊网目分别为 40mm、45mm和 5 0mm时 ,哈氏仿对虾的 5 0 %选择体长分别为85 .88、90 .2 6、95 .32mm ;中华管鞭虾的 5 0 %选择体长为 87.5 8、88.0 9、92 .5 6mm ;鹰爪虾的 5 0 %选择体长为 85 .0 4、85 .96、88.32mm。三种虾类的 5... 详细信息

当网囊网目分别为 40mm、45mm和 5 0mm时 ,哈氏仿对虾的 5 0 %选择体长分别为85 .88、90 .2 6、95 .32mm ;中华管鞭虾的 5 0 %选择体长为 87.5 8、88.0 9、92 .5 6mm ;鹰爪虾的 5 0 %选择体长为 85 .0 4、85 .96、88.32mm。三种虾类的 5 0 %选择体长 (L0 .5)和网囊网目内径 (Me)的线性回归方程为 ,哈氏仿对虾 :L0 .5=48.0 3+0 .94Me ;中华管鞭虾 :L0 .5=67.0 +0 .498Me ;鹰爪虾 :L0 .5=71.68+0 .32 8Me ;三种虾混合 :L0 .5=60 .5 9+0 .636Me。在实际应用中 ,将网囊网目大小由现在的 2 0～30mm提高到 35～ 40mm是有必要的。在此网目大小的范围内 ,哈氏仿对虾、中华管鞭虾、鹰爪虾的5 0 %选择体长分别为 80 .93～ 85 .63mm、84.43～ 86.92mm、83.16～ 84.8mm。

关键词：虾类桁拖网网囊网目选择性

盆底康复治疗仪治疗女性盆底功能障碍性疾病的临床效果分析

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中国医疗器械信息 2021年第18期27卷 148-149页

作者：常玉敏辽宁省锦州市妇婴医院辽宁锦州121000

目的:分析女性盆底功能障碍性疾病与盆底康复治疗仪治疗的临床效果。方法:对照组妇女产后采用盆底康复治疗仪进行产后恢复,观察组在此基础上并行健康宣教,比较两组治疗效果和尿失禁、子宫脱垂发生率、盆底肌肌力恢复、性生活质量、子宫... 详细信息

目的:分析女性盆底功能障碍性疾病与盆底康复治疗仪治疗的临床效果。方法:对照组妇女产后采用盆底康复治疗仪进行产后恢复,观察组在此基础上并行健康宣教,比较两组治疗效果和尿失禁、子宫脱垂发生率、盆底肌肌力恢复、性生活质量、子宫脱垂康复情况。结果:在治疗疗效中,观察组患者的康复效果更佳,即观察组总疗效率为90.00%,对照组为66.67%,差异有统计学意义(P<0.05);观察组产后妇女尿失禁、子宫脱垂发生率显著低于对照组产后妇女,且观察组产后妇女盆底肌肌力恢复、性生活质量、子宫脱垂康复情况也高于对照组,差异均具有统计学意义(P<0.05)。结论:盆底康复治疗仪治疗已经得到了广泛推广,并在调研中能够取得较好的应用效果。特别是针对于女性盆底功能障碍性疾病的改善具有积极效用,降低了尿失禁、子宫脱垂发生率,提升了盆底肌肌力恢复、性生活质量、子宫脱垂的康复情况,值得肯定。

关键词：盆底康复治疗仪女性盆底功能障碍性疾病

基于LTCC技术的电磁混合耦合宽阻带滤波器设计

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微波学报 2019年第4期35卷 26-29页

作者：赵子豪戴永胜罗雨常钰敏南京理工大学电子工程与光电技术学院

针对复杂电磁干扰,采用电磁耦合相消产生传输零点的原理,提出一种基于电磁耦合相消的宽阻带滤波器。对电路谐振单元进行奇偶模分析,在ADS软件中设计电路,然后在HFSS软件中对该电路进行三维仿真优化,最后采用LTCC材料进行生产。该器件采... 详细信息

针对复杂电磁干扰,采用电磁耦合相消产生传输零点的原理,提出一种基于电磁耦合相消的宽阻带滤波器。对电路谐振单元进行奇偶模分析,在ADS软件中设计电路,然后在HFSS软件中对该电路进行三维仿真优化,最后采用LTCC材料进行生产。该器件采用左右对称结构,以降低设计复杂度和元件体积;利用电磁耦合相消原理确定零点位置,调整谐振间距实现零点控制;加入源负载耦合,以实现第4个传输零点,增强选择性和阻带宽度。最终设计的宽阻带滤波器物理尺寸为3.2 mm×1.6 mm×0.89 mm,实物测试结果表明该器件阻带范围广且通带具有高陡峭性。

关键词：电磁混合耦合谐振单元奇偶模分析源负载宽阻带

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FC交换机中优先级技术的研究和实现

测控技术 2015年第12期34卷 100-102,107页

作者：李大鹏常于敏中航工业西安航空计算技术研究所陕西西安710065

针对光纤通道(FC)交换机,研究并设计了一种三级优先级实施策略,保证高优先级数据以最快的速度从交换机调度输出。重点对输入端口VOQ机制、Crossbar分布式调度和输出端口控制等关键技术进行了描述,并基于Xilinx平台对交换机优先级的有效... 详细信息

针对光纤通道(FC)交换机,研究并设计了一种三级优先级实施策略,保证高优先级数据以最快的速度从交换机调度输出。重点对输入端口VOQ机制、Crossbar分布式调度和输出端口控制等关键技术进行了描述,并基于Xilinx平台对交换机优先级的有效性进行了验证。验证结果表明,该策略满足FC交换机优先级调度要求。所做的研究为自主化FC交换机产品的研制奠定了有效的基础,也对采用FPGA实现各种网络协议具有积极的借鉴意义。

关键词：光纤通道优先级交换机分布式调度

Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang Dai Guoyao yue Yiman Zhang Lulu Li Zhong-Zhen yu Peng min Hao-Bin Zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

A mechanical reinforced and antifreezing polyacrylate hydrogel electrolyte for high-performance zinc-ion batteries

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Nano Research 2025年第1期18卷 341-350页

作者： Zili Zhang Ruolin Wang Hongfei Lu Di Zhang yu Zhao Jing Xu Bin Sun Zhi-min Dang Yang Jin School of Electrical and Information Engineering Zheng Zhou UniversityZhengzhou 450001China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The operation of aqueous zinc-ion batteries in flexible energy storage field is plagued by the uncontrollable growth of Zn-dendrite and inevitable freeze of water below 0 ℃.Therefore,it is necessary to design a hydrogel electrolyte with good mechanical property and freezing resistance to uniform the Zn-deposition and resist flexibility loss at low *** find that the mechanical property(strength and toughness)of hydrogel electrolyte has a significant impact on the suppression of dendrite growth and the uniform deposition of zinc ***,a polyacrylate hydrogel is prepared in one step by ultraviolet(UV)curing method with Zn(CF_(3)SO_(3))_(2)salt and polyvinyl alcohol(PVA)addition to increase the antifreezing ability and mechanical *** adsorption of water molecules by 2-hydroxyethyl acrylate(HEA)and PVA reduces the freezing point of the hydrogel,which is beneficial for enhancing the electrochemical stability at low *** this basis,the Zn-symmetrical battery with hydrogel electrolyte has a long lifespan of 4710 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2)at room ***,the hydrogel electrolyte exhibits an outstanding stability at low temperature of^(-2)0 ℃,the lifespan of symmetrical battery reaches to 4000 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2).The assembled full cell with NaV3O8·1.5H_(2)O(NVO)cathode and hydrogel electrolyte possesses a high capacity retention ratio of 77%after 10,000 cycles at^(-2)0 ℃.The flexible cell can power light-emitting diode(LED)lamp under bending,warping and cutting without liquid leakage and an electronic watch at the operating temperature of^(-2)0 ℃.

关键词： zinc ion battery hydrogel electrolyte mechanical enhancement freezing resistance

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南朝鲜的光学工业

光学仪器 1989年第2期11卷 38-41页

作者：孙长明于凤云上海光学仪器研究所

本文简要介绍了南朝鲜光学工业的发展概况,主要光学企业的现状及其主要产品,并从产品结构和出口情况浅析了南朝鲜对光学工业发展政策的演变和趋势。

关键词：光学工业韩国光学仪器