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Fatal community-acquired bloodstream infection caused by Klebsiella variicola:A case report

World Journal of Clinical Cases 2022年第8期10卷 2474-2483页

作者： Da-Li long Yu-Hui Wang Jin-long Wang Si-Jie mu Li Chen Xian-Qing Shi Jian-Quan Li Intensive Care Unit Guizhou Provincial People's HospitalGuiyang 550000Guizhou ProvinceChina NHC Key Laboratory of Pulmonary Immune Related Disease Guizhou Provincial People's HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND Klebsiella pneumoniae(***)is an infective microorganism of worldwide concern because of its varied manifestations and life-threatening *** analyses have revealed that subspecies of *** exhibit higher virulence and ***,infections with Klebsiella subspecies are often misdiagnosed and underestimated in the clinic because of difficulties in distinguishing *** from its subspecies using routine *** case study reports the rapid and fatal effects of *** *** SUMMARY A 52-year-old male patient was febrile and admitted to *** excluded viral and fungal causes along with mycoplasma/chlamydia and parasitic *** cultures revealed blood-borne *** sensitive to carbapenem antibiotics,although corresponding treatment failed to improve the patient’s *** condition worsened and death occurred within 72 h of symptom onset from sepsis *** of the PMseq-DNA Pro high throughput gene detection assay was implemented with results obtained after death showing a mixed infection of *** and Klebsiella variicola(***).Clinical evidence suggested that *** rather than *** contributed to the patient’s poor *** This is the first case report to show patient death from Klebsiella subspecies infection within a short period of *** case provides a timely reminder of the clinical hazards posed by Klebsiella subspecies and highlights the limitations of classical laboratory methods in guiding anti-infective therapies for complex ***,this report serves as reference for physicians diagnosing similar diseases and provides a recommendation to employ early genetic detection to aid patient diagnosis and management.

关键词： Community-acquired bloodstream infection Mixed infection Klebsiella variicola Klebsiella pneumoniae High throughput gene detection Case report

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Estimation of the rational water area for controlling wind erosion in the dried-up basin of the Ebinur Lake and its effect detection

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Chinese Science Bulletin 2006年第A01期51卷 68-74页

作者： BAO Anming mu Guijin ZHANG Yi FENG Xianwei chang Cun YIN Xiaojun Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China Xinjiang Key Laboratory for Application of Remote Sensing and Geographical Information System Urumqi 830011 China Planning and Design Administration Bureau Xinjiang Bureau of Hy drology and Water Resources Urumqi 830000 China

埃比纳·莱克区域被描述为“一个格林迷宫”在“ Xinjiang MapRecords：河的记录“然而，在 1910 出版了在这个区域的生态学和环境严重由于人的活动的影响被堕落了在期间最近 40 年。渴起来，有 107.4 km^2 的一个区域的湖盆在它的西... 详细信息

埃比纳·莱克区域被描述为“一个格林迷宫”在“ Xinjiang MapRecords：河的记录“然而，在 1910 出版了在这个区域的生态学和环境严重由于人的活动的影响被堕落了在期间最近 40 年。渴起来，有 107.4 km^2 的一个区域的湖盆在它的西北的部分形成，是没有植被，盖住 byunconsolidated 淤泥沉积物，并且在北方 Xinjiang 成为了灰尘天气的主要灰尘来源之一，并且有 4.8x10 ~ 6t 的年度数量的灰尘被大风从有 164 天的 Alataw 山脉差距从这个区域吹一年里的发生的大风。为在弄干起来的湖盆在湖区域和有效地控制的风侵蚀改进生态学的埃比纳·莱克的合理的水区域和流入在在弄干起来的湖盆分析在沉积物的小粒的作文之间的当前的生态的问题和关系以后用水平衡方程被估计并且灰尘天气，和最近的年里的生态的效果被监视。为在弄干起来的湖盆在湖区域和有效地控制的风侵蚀改进生态学的 theEbinur 湖的水区域应该至少是 800 km^2，这被考虑，并且湖应该在 7.92x10 ~ 上的再装的表面流量和地下水的年度体积 8 m^3。

关键词： Ebinur湖水域生态环境尘暴

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Conditional nonlinear optimal perturbation: Applications to stability, sensitivity, and predictability

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Science China Earth Sciences 2009年第7期52卷 883-906页

作者： DUAN WanSuo mu mu State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Conditional nonlinear optimal perturbation (CNOP) is a nonlinear generalization of linear singular vector (LSV) and features the largest nonlinear evolution at prediction time for the initial perturbations in a given constraint. It was proposed initially for predicting the limitation of predictability of weather or climate. Then CNOP has been applied to the studies of the problems related to predictability for weather and climate. In this paper, we focus on reviewing the recent advances of CNOP's applications, which involves the ones of CNOP in problems of ENSO amplitude asymmetry, block onset, and the sensitivity analysis of ecosystem and ocean's circulations, etc. Especially, CNOP has been primarily used to construct the initial perturbation fields of ensemble forecasting, and to determine the sensitive area of target observation for precipitations. These works extend CNOP's applications to investigating the nonlinear dynamical behaviors of atmospheric or oceanic systems, even a coupled system, and studying the problem of the transition between the equilibrium states. These contributions not only attack the particular physical problems, but also show the superiority of CNOP to LSV in revealing the effect of nonlinear physical processes. Consequently, CNOP represents the optimal precursors for a weather or climate event; in predictability studies, CNOP stands for the initial error that has the largest negative effect on prediction; and in sensitivity analysis, CNOP is the most unstable (sensitive) mode. In multi-equilibrium state regime, CNOP is the initial perturbation that induces the transition between equilibriums most probably. Furthermore, CNOP has been used to construct ensemble perturbation fields in ensemble forecast studies and to identify sensitive area of target observation. CNOP theory has become more and more substantial. It is expected that CNOP also serves to improve the predictability of the realistic predictions for weather and climate events play

关键词： optimal perturbation predictability stability sensitivity

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Study on fault induced rock bursts

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Journal of China University of Mining and Technology 2008年第3期18卷 321-326页

作者： LI Zhi-hua DOU Lin-ming LU Cai-ping mu Zong-long CAO An-ye School of Mines China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China State Key Laboratory of Coal Resource and Mine Safety China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

In order to study the rules of rock bursts caused by faults by means of mechanical analysis of a roof rock-mass balanced structure and numerical simulation about fault slip destabilization, the effect of coal mining operation on fault plane stresses and slip displacement were studied. The results indicate that the slip displacement sharply increases due to the decrease of normal stress and the increase of shear stress at the fault plane when the working face advances from the footwall to the fault itself, which may induce a fault rock burst. However, this slip displacement will be very small due to the increase of normal stress and the decrease of shear stress when the working face advances from the hanging wall to the fault itself, which results in a very small risk of a fault rock burst.

关键词： fault slip destabilization rock burst numerical simulation normal stress shear stress

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Can Adaptive Observations Improve Tropical Cyclone Intensity Forecasts?

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Advances in Atmospheric Sciences 2014年第2期31卷 252-262页

作者： QIN Xiaohao mu mu State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences

In order to investigate whether adaptive observations can improve tropical cyclone （TC） intensity forecasts,observing system simulation experiments （OSSEs） were conducted for 20 TC cases originating in the western North Pacific during the 2010 season according to the conditional nonlinear optimal perturbation （CNOP） sensitivity,using the fifth version of the PSU/NCAR mesoscale model （MM5） and its 3DVAR assimilation system.A new intensity index was defined as the sum of the number of grid points within an allocated square centered at the corresponding forecast TC central position,that satisfy constraints associated with the Sea Level Pressure （SLP）,near-surface horizontal wind speed,and accumulated convective *** higher the index value is,the more intense the TC *** impacts of the CNOP sensitivity on the intensity forecast were then *** OSSE results showed that for 15 of the 20 cases there were improvements,with reductions of forecast errors in the range of 0.12％-8.59％,which were much less than in track *** indication,therefore,is that the CNOP sensitivity has a generally positive effect on TC intensity forecasts,but only to a certain *** conclude that factors such as the use of a coupled model,or better initialization of the TC vortex,are more important for an accurate TC intensity forecast.

关键词： adaptive observation tropical cyclone intensity forecast conditional nonlinear optimal perturbation

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Well-Posedness for a New Two-Component Integrable System

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Journal of Mathematical Research with Applications 2014年第3期34卷 349-361页

作者： Qiong long Chunlai mu Pan ZHENG Shouming ZHOU College of Mathematics and Statistics Chongqing University College of Mathematics Chongqing Normal University

In this paper, we consider a new two-component integrable system with cubic nonlinearity, which can be deduced by a curve flow and it is integrable with its Lax pair, biHamiltonian structure, and infinitely many conservation laws. We mainly establish the local well-posedness of this system in a range of the Besov spaces Bs p,rwith s > max{2 +1p,52}.

关键词： Besov space two-component integrable system local well-posedness.

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Using the Lund-Potsdam-Jena Model to Understand the Different Responses of Three Woody Plants to Land Use in China

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Advances in Atmospheric Sciences 2013年第2期30卷 515-524页

作者： SUN Guodong mu mu State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 Key Laboratory of Ocean Circulation and Wave Institute of Oceanology Chinese Academy of Sciences Qingdao 266071

In this study, the approach of conditional nonlinear optimal perturbation related to initial perturbation （CNOP-I） was employed to investigate the maximum variations in plant amount for three main woody plants （a temperate broadleaved evergreen, a temperate broadleaved summergreen, and a boreal needleleaved evergreen） in China. The investigation was conducted within a certain range of land use intensity using a state-of-the-art Lund-Potsdam-Jena dynamic global vegetation model （LPJ DGVM）. CNOP-I represents a class of deforestation and can be considered a type of land use with respect to the initial perturbation. When deforestation denoted by the CNOP-I has the same intensity for all three plants, the variation in plant amount of the boreal needleleaved evergreen in northern China is greater than the variation in plant amount of both the temperate broadleaved evergreen and temperate broadleaved summergreen in southern China. As deforestation intensity increases, the plant amount variation in the three woody plant functional types carbon changes, in a nonlinear fashion. The impact of land use on plant functional types is minor because the interaction between climate condition and land use is not considered in the LPJ model. Finally, the different impacts of deforestation on net primary production of the three plant functional types were analyzed by modeling gross primary production and autotrophic respiration. Our results suggest that the CNOP-I approach is a useful tool for exploring the nonlinear and different responses of terrestrial ecosystems to land use.

关键词： conditional nonlinear optimal perturbation initial perturbation CNOP-I terrestrial ecosys-tem land use

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Impact of permafrost degradation on embankment deformation of Qinghai-Tibet Highway in permafrost regions

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Journal of Central South University 2015年第3期22卷 1079-1086页

作者：彭惠马巍穆彦虎金龙 State Key Laboratory of Frozen Soil Engineering Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Science Key Laboratory of Highway Construction & Technology in Permafrost Regions Ministry of TransportCCCC First Highway Consultants Co. Ltd. University of Chinese Academy of Science

Based on long-term monitoring data, the relationships between permafrost degradation and embankment deformation are analyzed along the Qinghai-Tibet Highway(QTH). Due to heat absorbing effect of asphalt pavement and climate warming,permafrost beneath asphalt pavement experienced significant warming and degradation. During the monitoring period, warming amplitude of the soil at depth of 5 m under asphalt ranged from 0.21 °C at the XD1 site to 0.5 °C at the KL1 site. And at depth of 10 m, the increase amplitude of ground temperature ranged from 0.47 °C at the NA1 site to 0.07 °C at the XD1 site. Along with ground temperature increase, permafrost table beneath asphalt pavement decline considerably. Amplitude of permafrost table decline varied from 0.53 m at the KL1 site to 3.51 m at the NA1 site, with mean amplitude of 1.65 m for 8 monitoring sites during the monitoring period. Due to permafrost warming and degradation, the embankment deformation all performed as settlement at these sites. At present, those settlements still develop quickly and are expected to continue to increase in the future. The embankment deformations can be divided into homogeneous deformation and inhomogeneous deformation. Embankment longitudinal inhomogeneous deformation causes the wave deformations and has adverse effects on driving comfort and safety, while lateral inhomogeneous deformation causes longitudinal cracks and has an adverse effect on stability. Corresponding with permafrost degradation processes,embankment settlement can be divided into four stages. For QTH, embankment settlement is mainly comprised of thawing consolidation of ice-rich permafrost and creep of warming permafrost beneath permafrost table.

关键词： Qinghai-Tibet Highway(QTH) permafrost degradation embankment deformation thawing settlement

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Why are children less affected than adults by severe acute respiratory syndrome coronavirus 2 infection?

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Cellular & Molecular Immunology 2022年第5期19卷 555-557页

作者： chang Kyung Kang Hyun mu Shin Wan Beom Park Hang-Rae Kim Department of Internal Medicine Seoul National University College of MedicineSeoul03080Republic of Korea Department of Biomedical Sciences Seoul National University College of MedicineSeoul03080Republic of Korea BK21 FOUR Biomedical Science Project Seoul National University College of MedicineSeoul03080Republic of Korea Medical Research Institute Seoul National University College of MedicineSeoul03080Republic of Korea WideRiver Institute of Immunology Seoul National UniversityHongcheon25159Republic of Korea Department of Anatomy&Cell Biology Seoul National University College of MedicineSeoul03080Republic of Korea

An adequate immune response to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is crucial to not only clear the virus but also prevent tissue *** children generally experience a milder course of coronavirus... 详细信息

关键词： respiratory acute infection

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Effect of freeze-thaw cycles on uniaxial mechanical properties of cohesive coarse-grained soils

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Journal of Mountain Science 2019年第9期16卷 2159-2170页

作者： QU Yong-long CHEN Guo-liang NIU Fu-jun NI Wan-kui mu Yan-hu LUO Jing College of Geology Engineering and Geomatics Chang' an University Xi'an 710054 China China Gold Group Tibet Tyrone Mining Development Co. Ltd. Tibet 850000 China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Lanzhou 730000 China South China Institute of Geotechnical Engineering School of Civil Engineering and Transportation South China University of Technology Guangzhou 510641 China

Freeze-thaw cycles are closely related to the slope instability in high-altitude mountain regions. In this study, cohesive coarse-grained soils were collected from a high-altitude slope in the Qinghai–Tibet Plateau to study the effect of cyclic freeze-thaw on their uniaxial mechanical properties. The soil specimens were remolded with three dry densities and three moisture contents. Then, after performing a series of freeze-thaw tests in a closed system without water supply, the soil specimens were subjected to a uniaxial compression test. The results showed that the stress-strain curves of the tested soils mainly performed as strain-softening. The softening feature intensified with the increasing dry density but weakened with an increase in freeze-thaw cycles and moisture content. The uniaxial compressive strength, resilient modulus, residual strength and softening modulus decreased considerably with the increase of freeze-thaw cycles. After more than nine freeze-thaw cycles, these four parameters tended to be stable. These parameters increased with the increase of dry density and decreased with the increasing moisture content, except for the residual strength which did not exhibit any clear variation with an increase in moisture content. The residual strength, however, generally increased with an increase in dry density. The soil structural damage caused by frozen water expansion during the freeze-thaw is the major cause for the changes in mechanical behaviors of cohesive coarse-grained soils. With results in this study, the deterioration effect of freeze-thaw cycles on the mechanical properties of soils should be considered during the slope stability analysis in high-altitude mountain regions.

关键词： Freeze thaw cycles Residual strength Resilient modulus Softening modulus Uniaxial compressive strength Slope stability

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